Favoriser la mobilité et l'accès aux ressources urbaines : la transmission de compétences spatiales dans le cadre de l'accompagnement individualisé de jeunes en difficulté

Cette communication s'appuie sur des travaux de thèse portant sur la matérialisation des politiques publiques menées dans les champs des transports et de l'aménagement du territoire et, en particulier, ses effets en termes d'inégalités sociales de mobilité. Ce lien est analysé et questionné au moyen de la notion de motilité et ses trois composantes : les accès, les compétences et les projets. Elle fournit un outil d'analyse et de compréhension d'une mobilité qu'il s'agit dès lors de considérer dans son ensemble, et non plus uniquement en termes de déplacements ou d'accès

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Search for stop and higgsino production using diphoton Higgs boson decays

Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass

Search for anomalous production of events with three or more leptons in pp collisions at √s = 8TeV

Published by the American Physical Society under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published articles title, journal citation, and DOI.A search for physics beyond the standard model in events with at least three leptons is presented. The data sample, corresponding to an integrated luminosity of 19.5fb-1 of proton-proton collisions with center-of-mass energy s=8TeV, was collected by the CMS experiment at the LHC during 2012. The data are divided into exclusive categories based on the number of leptons and their flavor, the presence or absence of an opposite-sign, same-flavor lepton pair (OSSF), the invariant mass of the OSSF pair, the presence or absence of a tagged bottom-quark jet, the number of identified hadronically decaying τ leptons, and the magnitude of the missing transverse energy and of the scalar sum of jet transverse momenta. The numbers of observed events are found to be consistent with the expected numbers from standard model processes, and limits are placed on new-physics scenarios that yield multilepton final states. In particular, scenarios that predict Higgs boson production in the context of supersymmetric decay chains are examined. We also place a 95% confidence level upper limit of 1.3% on the branching fraction for the decay of a top quark to a charm quark and a Higgs boson (t→cH), which translates to a bound on the left- and right-handed top-charm flavor-violating Higgs Yukawa couplings, λtcH and λctH, respectively, of |λtcH|2+|λctH|2<0.21

Measurement of associated W plus charm production in pp collisions at √s=7 TeV

Peer reviewe

Le ticagrélor : un nouvel inhibiteur réversible des récepteurs P2Y12. Intérêt par rapport aux autres antiagrégants plaquettaires

Les maladies cardiovasculaires représentent actuellement la principale cause de mortalité dans les pays développés. Elles sont responsables de 180000 décès par an en France. Depuis quelques années, ce nombre est en baisse, certainement grâce aux campagnes de prévention et à la prise en charge thérapeutique. Les antiagrégants plaquettaires jouent un rôle essentiel dans le traitement médicamenteux des thromboses artérielles et repose principalement sur l'association d'un inhibiteur de la cyclo-oxygénase, tel que l'acide acétyl-salicylique et un inhibiteur des récepteurs P2Y12, tels que les thiénopyridines (ticlopidine, clopidogrel, prasugrel). Le ticagrélor appartient à une nouvelle famille d'antiagrégants plaquettaires : les cyclo-pentyltriazopyrimidines. Il inhibe de manière sélective et réversible les récepteurs P2Y12 de l'ADP et ne nécessite pas de métabolisation pour être actif après administration par voie orale. Ces caractéristiques lui permettent d'agir plus rapidement, avec une inhibition de l'agrégation plaquettaire plus importante et de retrouver plus rapidement une activité plaquettaire normale en cas de nécessité d'arrêt du traitement, comme le montre l'étude ONSET/OFFSET. Lors de l'étude RESPOND le ticagrélor, en s'affranchissant du métabolisme par le CYT 2C19 dont le polymorphisme est à l'origine de différence de sensibilité interindividuelle au clopidogrel, n'a révélé aucun phénomène de résistance. L'étude internationale PLATO réalisée chez 18624 patients durant une année a démontré une réduction de la mortalité globale (p=0,010), de la survenue d'infarctus du myocarde (p=0,00023) et de thromboses de stent (p=0,0068) en comparaison au clopidogrel, sans augmenter significativement le nombre d'hémorragies. Néanmoins, cet antiagrégant plaquettaire nécessite une prise biquotidienne, ce qui peut entraîner une mauvaise observance du traitement. Cela peut représenter un frein à son utilisation de même que l'apparition importante de dyspnées révélée au cours de l'étude PLATO (13,9%, p<0,0001). Le ticagrélor a obtenu l'AMM européenne en décembre 2010 pour la prévention secondaire des événements athérothrombotiques, en association avec une prise d'acide acétyl-salicylique, chez les patients atteints de syndromes coronariens aigus. Cependant, en France, le service médical rendu a été jugé insuffisant par la Haute Autorité de Santé, et des études complémentaires sont nécessaires pour préciser la place du ticagrélor par rapport aux autres anti-agrégants. En effet, le ticagrélor pourrait avoir une efficacité supérieure chez les diabétiques ou les insuffisants rénaux

Chorea as the presenting manifestation of primary Sjögren's syndrome in a child

International audienceA 12-year-old boy presented with subacute chorea (Figure). He had no personal or familial medical history. Chorea occurred without any history of fever or infection, and rapidly worsened over 3 weeks. Examination was otherwise normal. Cranial magnetic resonance imaging and cerebrospinal fluid examination were normal. Diagnosis of chorea associated with primary Sjögren syndrome was made according to American-European Consensus Group criteria,1 because of the association of xerophthalmia (Schirmer test <5 mm in 5 minutes), positive antinuclear antibodies (1:320) with anti–Sjögren syndrome A specificity, and focal lymphocytic infiltration on salivary gland histology (two infiltrates containing at least 50 lymphocytes in a 4-mm2 glandular section, focus score = 2). Screening for other causes of chorea was negative, specifically including anticardiolipin and antistreptococcal antibodies. There were no other clinical manifestations of Sjögren syndrome. The patient was treated symptomatically with tetrabenazine and valproic acid. Chorea gradually improved within 6 months, until he became asymptomatic and without any treatment