850 research outputs found
Extended morphometric analysis of neuronal cells with Minkowski valuations
Minkowski valuations provide a systematic framework for quantifying different
aspects of morphology. In this paper we apply vector- and tensor-valued
Minkowski valuations to neuronal cells from the cat's retina in order to
describe their morphological structure in a comprehensive way. We introduce the
framework of Minkowski valuations, discuss their implementation for neuronal
cells and show how they can discriminate between cells of different types.Comment: 14 pages, 18 postscript figure
Should Subsidies to Urban Passenger Transport be Increased? A Spatial CGE Analysis for a German Metropolitan Area
Confronting system barriers for ST- elevation MI in low and middle income countries with a focus on India
© 2017 Our previous research found seven specific factors that cause system delays in ST-elevation Myocardial infarction management in developing countries. These delays, in conjunction with a lack of organized STEMI systems of care, result in inefficient processes to treat AMI in developing countries. In our present opinion paper, we have specifically explored the three most pertinent causes that afflict the seven specific factors responsible for system delays. In doing so, we incorporated a unique strategy of global STEMI expertise. With this methodology, the recommendations were provided by expert Indian cardiologist and final guidelines were drafted after comprehensive discussions by the entire group of submitting authors. We expect these recommendations to be utilitarian in improving STEMI care in developing countries
The copy number variant involving part of the \u3b17 nicotinic receptor gene contains a polymorphic inversion.
The \u3b17 nicotinic acetylcholine receptor gene (CHRNA7) is located at 15q13\u2013q14 in a region that is strongly linked to the P50 sensory gating deficit, an endophenotype of schizophrenia and bipolar disorder. Part of the gene is a copy number variant, due to a duplication of exons 5\u201310 and 3\u2032 sequence in CHRFAM7A, which is present in many but not all humans. Maps of this region show that the two genes are in opposite orientation in the individual mainly represented in the public access human DNA sequence database (Build 36), suggesting that an inversion had occurred since the duplication. We have used fluorescent in situ hybridization to investigate this putative inversion. Analysis of interphase chromosomes in 12 individuals confirms the occurrence of an inversion and indicates that CHRFAM7A exists in both orientations with similar frequency. We showed that the 2\u2009bp deletion polymorphism in exon 6 of CHRFAM7A is in strong linkage disequilibrium with the inversion polymorphism (r2=0.82, CI 0.53\u20131.00, P=0.00003), which can therefore be used as a surrogate marker. Previous associations of endophenotypes of schizophrenia with the 2\u2009bp deletion might therefore be due to the orientation of the duplicon containing CHRFAM7A
Transport of a quantum degenerate heteronuclear Bose-Fermi mixture in a harmonic trap
We report on the transport of mixed quantum degenerate gases of bosonic 87Rb
and fermionic 40K in a harmonic potential provided by a modified QUIC trap. The
samples are transported over a distance of 6 mm to the geometric center of the
anti-Helmholtz coils of the QUIC trap. This transport mechanism was implemented
by a small modification of the QUIC trap and is free of losses and heating. It
allows all experiments using QUIC traps to use the highly homogeneous magnetic
fields that can be created in the center of a QUIC trap and improves the
optical access to the atoms, e.g., for experiments with optical lattices. This
mechanism may be cascaded to cover even larger distances for applications with
quantum degenerate samples.Comment: 7 pages, 8 figure
Mutations associated with a 17-gene leukemia stem cell score and the score’s prognostic relevance in the context of the European LeukemiaNet classification of acute myeloid leukemia
© 2020 Ferrata Storti Foundation. Leukemia stem cells (LSC) are more resistant to standard chemotherapy and their persistence during remission can cause relapse, which is still one of the major clinical challenges in the treatment of acute myeloid leukemia (AML). A better understanding of the mutational patterns and the prognostic impact of molecular markers associated with stemness could lead to better clinical management and improve patients’ outcomes. We applied a previously described 17-gene expression score comprising genes differently expressed between LSC and leukemic bulk blasts, for 934 adult patients with de novo AML, and studied associations of the 17-gene LSC score with clinical data and mutation status of 81 genes recurrently mutated in cancer and leukemia. We found that patients with a high 17-gene score were older and had more mutations. The 17-gene score was found to have a prognostic impact in both younger (aged \u3c 60 years) and older (aged ≥60 years) patients with AML. We also analyzed the 17-gene LSC score in the context of the 2017 European LeukemiaNet genetic-risk classification and found that for younger patients the score refined the classification, and identified patients currently classified in the European LeukemiaNet Favorable-risk category who had a worse outcome
Identification of the TeV Gamma-ray Source ARGO J2031+4157 with the Cygnus Cocoon
The extended TeV gamma-ray source ARGO J2031+4157 (or MGRO J2031+41) is
positionally consistent with the Cygnus Cocoon discovered by -LAT at GeV
energies in the Cygnus superbubble. Reanalyzing the ARGO-YBJ data collected
from November 2007 to January 2013, the angular extension and energy spectrum
of ARGO J2031+4157 are evaluated. After subtracting the contribution of the
overlapping TeV sources, the ARGO-YBJ excess map is fitted with a
two-dimensional Gaussian function in a square region of , finding a source extension =
1.80.5. The observed differential energy spectrum is
photons cm
s TeV, in the energy range 0.2-10 TeV. The angular extension is
consistent with that of the Cygnus Cocoon as measured by -LAT, and the
spectrum also shows a good connection with the one measured in the 1-100 GeV
energy range. These features suggest to identify ARGO J2031+4157 as the
counterpart of the Cygnus Cocoon at TeV energies. The Cygnus Cocoon, located in
the star-forming region of Cygnus X, is interpreted as a cocoon of freshly
accelerated cosmic rays related to the Cygnus superbubble. The spectral
similarity with Supernova Remnants indicates that the particle acceleration
inside a superbubble is similar to that in a SNR. The spectral measurements
from 1 GeV to 10 TeV allows for the first time to determine the possible
spectrum slope of the underlying particle distribution. A hadronic model is
adopted to explain the spectral energy distribution.Comment: 16 pages, 3 figures, has been accepted by ApJ for publicatio
Adding genetic risk score to family history identifies twice as many high-risk men for prostate cancer: Results from the prostate cancer prevention trial
Outcomes with ibrutinib by line of therapy and post-ibrutinib discontinuation in patients with chronic lymphocytic leukemia: Phase 3 analysis
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