742 research outputs found

    Experimental local realism tests without fair sampling assumption

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    Following the theoretical suggestion of Ref. [1,2], we present experimental results addressed to test restricted families of local realistic models, but without relying on the fair sampling assumption

    Multi-omic analyses in Abyssinian cats with primary renal amyloid deposits

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    The amyloidoses constitute a group of diseases occurring in humans and animals that are characterized by abnormal deposits of aggregated proteins in organs, affecting their structure and function. In the Abyssinian cat breed, a familial form of renal amyloidosis has been described. In this study, multi-omics analyses were applied and integrated to explore some aspects of the unknown pathogenetic processes in cats. Whole-genome sequences of two affected Abyssinians and 195 controls of other breeds (part of the 99 Lives initiative) were screened to prioritize potential disease-associated variants. Proteome and miRNAome from formalin-fixed paraffin-embedded kidney specimens of fully necropsied Abyssinian cats, three affected and three non-amyloidosis-affected were characterized. While the trigger of the disorder remains unclear, overall, (i) 35,960 genomic variants were detected; (ii) 215 and 56 proteins were identified as exclusive or overexpressed in the affected and control kidneys, respectively; (iii) 60 miRNAs were differentially expressed, 20 of which are newly described. With omics data integration, the general conclusions are: (i) the familial amyloid renal form in Abyssinians is not a simple monogenic trait; (ii) amyloid deposition is not triggered by mutated amyloidogenic proteins but is a mix of proteins codified by wild-type genes; (iii) the form is biochemically classifiable as AA amyloidosis.Peer reviewe

    Analysis of pion production data measured by HADES in proton-proton collisions at 1.25 GeV

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    Baryon resonance production in proton-proton collisions at a kinetic beam energy of 1.25 GeV is investigated. The multi-differential data were measured by the HADES Collaboration. Exclusive channels with one pion in the final state (np¤Ç+np\pi^+ and pp¤Ç0pp\pi^0 were put to extended studies based on various observables in the framework of a one-pion exchange model and with solutions obtained within the framework of a partial wave analysis (PWA) of the Bonn-Gatchina group. The results of the PWA confirm the dominant contribution of the ╬ö(1232)\Delta(1232), yet with a sizable impact of the N(1440)N(1440) and non-resonant partial waves.Peer Reviewe

    Hades experiments: investigation of hadron in-medium properties

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    Hadron modifications in nuclear matter are discussed in connection to chiral symmetry restoration and/or hadronic many body effects. Experiments with photon, proton and heavy ion beams are used to probe properties of hadrons embedded in nuclear matter at different temperatures and densities. Most of the information has been gathered for the light vector mesons ¤ü ¤ë and ├Ş. HADES is a second generation experiment operating at GSI with the main aim to study in-medium modifications by means of dielectron production at the SIS18/Bevelac energy range. Large acceptance and excellent particle identification capabilities allows also for measurements of strangeness production. These abilities combined with the variety of beams provided by the SIS18 allow for a characterization of properties of the dense baryonic matter properties created in heavy ion collisions at these energies. A review of recent experimental results obtained by HADES is presented, with main emphasis on hadron properties in nuclear matter.Peer Reviewe

    Message from the President of the United States, transmitting communication of the Secretary of the Interior relating to the boundary line between the United States and the State of Texas

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    48-1JudiciaryBoundary Between the U.S. and Texas. [2166] Survey of line between Texas and Choctaw and Chickasaw countries.1884-5

    Frank D. Yates and others.

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    47-1ClaimsReport : Claim of of F. Yates Pt al. [2065] Transportation in removal of the Whetstone agency from White River to the new Sioux reservation in Dakota: 1872-1873.1882-3

    Arkansas -- losses by Choctaw Treaty

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    25-2Public LandsReport : Memorial of the Arkansas Legis. [333] Ask indemnity for loss of improvements ceded to Choctaw Indians; treaty of 1820.1837-9

    Determination of MSSM Parameters from LHC and ILC Observables in a Global Fit

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    We present the results of a realistic global fit of the Lagrangian parameters of the Minimal Supersymmetric Standard Model assuming universality for the first and second generation and real parameters. No assumptions on the SUSY breaking mechanism are made. The fit is performed using the precision of future mass measurements of superpartners at the LHC and mass and polarized topological cross-section measurements at the ILC. Higher order radiative corrections are accounted for whereever possible to date. Results are obtained for a modified SPS1a MSSM benchmark scenario but they were checked not to depend critically on this assumption. Exploiting a simulated annealing algorithm, a stable result is obtained without any a priori assumptions on the values of the fit parameters. Most of the Lagrangian parameters can be extracted at the percent level or better if theoretical uncertainties are neglected. Neither LHC nor ILC measurements alone will be sufficient to obtain a stable result. The effects of theoretical uncertainties arising from unknown higher-order corrections and parametric uncertainties are examined qualitatively. They appear to be relevant and the result motivates further precision calculations. The obtained parameters at the electroweak scale are used for a fit of the parameters at high energy scales within the bottom-up approach. In this way regularities at these scales are explored and the underlying model can be determined with hardly any theoretical bias. Fits of high-scale parameters to combined LHC+ILC measurements within the mSUGRA framework reveal that even tiny distortions in the low-energy mass spectrum already lead to inacceptable chi^2 values. This does not hold for ``LHC only'' inputs.Comment: 25 pages, 5 figure
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