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Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia

Whole-genome sequencing reveals host factors underlying critical COVID-19

Author: Abd Elghafar M. S.
Abdel-Aziz M.
Abdelrazik M.
Abdollahi H.
Abdullah T.
Abecasis G. R.
Abedalthagafi M.
Abel L.
Abernathy C.
Abraheem A.
Abul-Husn N. S.
Acquilini D.
Adams C.
Adams E. L.
Adams K.
Adamsara A.
Adanini O.
Adeleye O.
Adra D.
Afilalo J.
Afilalo M.
Afolabi D.
Afrasiabi Z.
Agasou A.
Agrawal S.
Aguero D.
Ahmad N.
Ahmadi S.
Ahmed A.
Ahmed C.
Akeroyd L.
Akhtar M. N.
Akinkugbe O.
Aksentijevich A.
Al-Afghani H.
Al-Awdah L.
Alaamery M.
Alahmadey Z. Z.
Alaverdian D.
Alavere H.
Albader A.
Albaiceta G. M.
Albakri J. K.
AlBardis H.
Albeladi M.
Albesher N.
Albrich W.
AlDhawi N.
Aldridge J.
Aleagha A. E.
Alexander P.
Alfonso J.
Alghamdi B.
Alghamdi J.
Ali A.
Ali A.
Ali I. A. M.
Ali S.
Aliannejad R.
Aljawini N.
AlJohani S.
Alkwai S.
Allan A.
Allan E.
Allan J.
Alldis Z.
Allen L.
Allen M.
Allen S.
Allibone S.
Allison K. S.
Allos R.
Ally S. M.
AlMalik A.
Almalki F.
Almohammed I.
Almutairi M.
Alotaibi S.
Alowayn A. M.
Alqahtani S.
Alqubaishi F.
Alrashed M.
Alshareef A.
Alsolm E.
Alswailm M.
Altabaibeh A.
Alvaro A.
AlZahrani D.
Amin V.
Amirsavadkouhi A.
Amitrano S.
Anastasescu E.
Anderson F.
Anderson J.
Anderson M.
Anderson P.
Anderson S.
Anderson S.
Anderson T.
Andolfo I.
Andretta F.
Andreucci E.
Andrew A.
Andrew B.
Andrew G.
Andrews E.
Andrews S. J.
Anedda F.
Anemoli V.
Annis A.
Antcliffe D.
Antinori A.
Antoni M. D.
Anumakonda V.
Apetri E.
Aquino M.
Arabi Y. M.
Aravindan L.
Arbane G.
Archer K.
Arden T.
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Armstrong L.
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Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2022
Field of study

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

PubliCatt

Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.

Author: Abantanga F
Abbas M
Abbo O
Abd El Galeel A
Abd El Hameed OS
Abd El Hamid N
Abd El Salam Y
Abd El Slam M
Abd El-Salam F
Abd Elrasoul Y
Abd-Elrasoul Y
Abdallah E
Abdel-Wahab NYE
AbdelFattah I
Abdelgelil A
Abdelghany S
Abdelkader M
Abdelkareem A
Abdelraheim M
Abdelshafy M
Abdulgawad M
Abdullah AAN
Abdullah NAN
Abebe NS
Abebe NS
Aber A
Abington E
Aboarab A
Aboraya M
Aboraya M
Abouelnasr A
Abouzahra A
Abozaid M
Abozeid K
Abozyed MAF
Abudeeb H
Abuseif M
Acharya P
Adams R
Adebanjo A
Adekoya A
Adel A
Adel A
Ademuyiwa A
Ademuyiwa AO
Adeniran J
Adeniyi A
Adesanya O
Adesina A
Adesuyi A
Adeyeye A
Adham W
Afandy A
Afifi AM
Afzal M
Agalianos C
Agarwal A
Agius M
Aguilar-Jimenez J
Aguilera M
Aguilera O
Ahlqvist S
Ahmed A
Ahmed EA
Ahmed H
Ahmed SM
Aigrain Y
Ajao AE
Akeel N
Akhtar M
Al Awwad S
Al-Aarag AA-R
Al-Azraqi IAA
Al-Faifi JJ
Al-Hameedi HII
Al-Hasani RKMJ
Al-Mallah A
Al-Mousa M
Al-Nahrawi S
Al-Obaedi O
Al-shammari A
Alahmady O
Alakaloko F
Alamoudi U
Albeladi B
Aldalaq A
Aldhafeeri S
Aledrisy M
Alfarsi MA
Alghamdi B
Alghamdi M
Algohary O
Alhabli I
Alhendy M
Ali A
Ali A
Ali H
Ali SS
Alimi Q
Aljiffry M
Aljohani E
Aljohani S
Alkammash A
Alkhabbaz D
Alkhouri M
Allam M
Allegri A
Allen JLY
Allott R
Almallah A
Almoflihi A
Almuallem S
Almy J
Alnawam E
Alnuqaydan SA
Alomar IN
Alqahtani E
Alrahawy M
Alrajraji M
Alrifaie A
AlRowais M
Alsaggaf M
Alsaggaf MU
Altaf A
Altamimi A
Althwainy A
Altoe F
Altwigry AM
Alvarado Jaramillo R
Alvarez Barreda LM
Alwafai MG
Aly AK
Alyami R
AlYoussef I
Alzahrani M
Alzayat T
Amandito R
Ambrozeviciute V
Ameen M
Amer MA
Amin J
Ammar M
Ammar MS
Amreia M
Anandkumar D
Anderson D
Anderson R
Anderson-Knight H
Andersson L
Andres Garcia-Marin J
Ansaloni L
Antar S
Anthoulakis C
Anwar AW
Anwer W
Anyanwu L-J
Aql S
Arachchi PP
Arachchige LAJJ
Aranzabal Durand SY
Araujo R
Ardley R
Arenas A
Arevalo Azmitia JR
Arias Pacheco RD
Arman S
Arnaud AP
Arnaud AP
Arroyo Basto CA
Arulampalam T
Asal M
Asele FA
Ashraf SF
Ashton A
Assouto PA
Ata AAA
Atkinson K
Atobatele K
Attallah NA
Attard M
Attia AM
Aung KP
Austraite A
Awuku-Asabre J
Ayad S
Ayandipo OO
Ayyar S
Azmitia Mendizabal CA
Azodo IA
Azzie G
Badr A
Badwi NM
Badwy A
Baheeg M
Bailey K
Baillie K
Baird A
Bakhaidar M
Baldacchino M
Balila RMH
Balkan AZA
Balmaceda R
Bamicha A
Barakat SAE
Barker T
Barnacle J
Barneo L
Barrionuevo Ojeda RR
Barrios E
Barrios E
Barros De Castro Segundo LC
Barroso de Lima CV
Barry J
Basson S
Batista Lemaire S
Batt J
Beasley W
Beaton C
Behar N
Beisa V
Benevento A
Benger M
Benons N
Beuran M
Beyene R
Bezerra Morais PA
Bezzina M
Bhangu A
Bhargava A
Bharj IS
Bhat S
Bhattacharya S
Bhopal KF
Bin Mahamood A
Birring A
Bjorklund I
Blencowe N
Blower E
Blundell R
Boakye-Yiadom K
Boal M
Boddy A
Bode C
Boereboom C
Boijsen M
Bokhari S
Bonavina L
Bondurri A
Bonnard A
Borda Luque G
Borg E
Borin E
Bortolasi L
Boshnaq M
Botes S
Botto N
Bouali O
Bowe R
Bowley D
Bowman C
Boyce T
Bradulskis S
Bratu R-M
Braungart S
Bray LD
Breitenstein S
Brogden T
Brown D
Brown E
Brown J
Brown J
Browning DRL
Bugaev N
Bugeja R
Bukari M
Burns H
Cabala Chiong JA
Cacurri A
Cadogan DD
Cahill R
Camacho R
Cameron B
Camilleri-Brennan J
Camilleri-Brennan JF
Capleton P
Careta MC
Carlucci M
Carreira J-A
Carreiro De Freitas AV
Castro Mollo M
Cengiz Y
Cengiz Y
Ceriani C
Chachulski W
Chambers A
Chan E
Chan Z
Chandrakumar C
Chang K
Chang KY-C
Chapman A
Chapman SJ
Chen CY
Chen JHC
Chenn R
Chew LS
Chhabra S
Chidambaram S
Chiu S
Chiu SMY
Choi J
Chong BFHK
Chong CL
Chong HY
Chowdhury A
Chun A
Chun T
Chung S
Cirocchi R
Clark DJ
Clark T
Clement KD
Clements JM
Clifford C
Cloro LM
Coasaca Huaraya R
Coccolini F
Cocker DM
Collaborative G
Colombani J-F
Connor K
Contreras Merida SM
Contreras Urquizu M
Contreras Vergara AL
Coomber R
Corro-Diaz Gonzalez S
Costa-Maia J
Court E
Cragg J
Cross K
Cruz H
Cucumazzo S
Currow C
D'aguzan N
D'amours SK
D'cruz R
D'Souza R
Da Silva LA
Dabessa D
Dablouk M
Dablouk MO
Dal Canto M
Dambrauskas Z
Dan I
Danelli P
Daniels I
Daqeeq A
Dar M
Darweesh M
Das A
Das K
Das S
Davenport R
Davies J
Dawnay G
Dawoud H
De Bono P
De Sousa AV
Dean R
Deckelbaum DL
Decker E
Deichsel F
Dempster E
Deputy M
Dervenis C
Despotidis V
Desta S
Devadasar GH
Dharamshi HA
Di Franco F
Di Saverio S
Diab A
Diaconescu I-B
Dias S
Diaz-Zorrilla C
Dickfos M
Dickson L
Dindyal S
Domini E
Donoghue D
dos Santos DV
Doughan S
Doughty J
Drake TM
Driscoll A
Du Plessis D
Dubois A
Duffy L
Dwydar A
Ebdewi H
Ebrahim OS
Eduard P
Edwards J
Edye M
Eisner L
El Ashal G
El Deen KN
El Gendy A
El Kholy A
El Magd AA
El Mesery S
El Sayed GS
El Shoura Y
El-badawy HA
El-Dien KS
El-Hamouly AS
El-Kashef H
El-Ma'doul AS
El-Rabaa S
El-Shahat NS
El-Sheemy H
Elabdin HZ
Elashmawy M
Elazayem AA
Elazoul M
Elbanby E
Elbatahgy A
Elbermawy M
Eldamaty L
Elebute O
Elena G
Elfeki H
Elfil M
Elfouly N
Elfouly Y
Elgebaly A
Elgendy FI
Elhendawy AOA
Elizabeth Lopez C
Elkadsh I
Elkady F
Elkelany A
Elkhadrawi M
Elkholy A
Elkolaly SS
Elkorashy AM
Elmelegy R
Elnemr AE
Elsawahly DME
Elsayed M
Elsayed M
Elsayed N
Elsayed ZM
Elsebaaye AO
Elsehimy M
Elshaer K
Elshaer M
Elshafay AE
Elshanwany S
Elsheikh S
Elsherbiny AS
Elshobary M
Elsiddig M
Elsobky S
Elsorogy DEAA
Elwaey A
Elwakil H
Elwan A
Elzayat I
Elzayat M
Elzayyat I
Elzowawi F
Emadeldin D
Escobar EG
Estupinian S
Etchill E
Etman M
Eysa A
Eyssartier E
Faccincani R
Fadel A
Fahiem A
Fahmy MAB
Fahy C
Fairfield C
Fairfield C
Fakher R
Farah A
Faraz A
Farhad M
Farinella E
Farooq T
Farquharson A
Fattah AA
Faturoti O
Faure A
Fautz T
Fawzy A
Felipe CO
Fergusson S
Fergusson SJ
Fermani C
Fernandez-Bueno F
Fievet L
Findlay-Cooper K
Firdouse M
Fitzgerald JEF
Forno W
Fouad A
Fouad D
Fowler AJ
Fozard T
Frade F
Fraga GP
Francois-Coridon H
Freitas AV
Frisk B
Fujii F
Furqan MM
Gadhvi V
Gaignard E
Galloway S
Gamaly E
Garaycochea O
Garcia Florez LJ
Garcia Torres CP
Garland A
Gash K
Gasteratos K
Gemeah M
Gemenetzis G
George R
Germanos S
Gerosa A
Ghandora N
Ghanem E
Ghanem S
Gharib A
Ghazy AA
Gheith A
Ghetia M
Ghonaim MA
Ghoneem M
Giacci L
Gilbert R
Gilbert RW
Giles J
Gillespie M
Gimzewska M
Giuliani S
Giuriato TF
Glasbey JC
Glover TE
Gobin N
Goh CC
Gohar ME-SAM
Gokani S
Golding D
Gomaa A
Gomah M
Gonzales Stuva JP
Goodstein M
Gosling S
Gosling SG
Gouda A
Gould L
Gouldthorpe C
Gouvas N
Graffeille V
Graffieille V
Grandinetti PP
Grant A
Grasset E
Grassi V
Gratton R
Gravante G
Green N
Griffiths E
Griffiths M
Grossart C
Gudal A
Gudlaugsdottir K
Guevara R
Gumar M
Gunnarsson U
Guo W
Gustafsson U
Gyanchandani N
Habeeb MA
Habeebullah A
Hache-Marliere M
Hafez AT
Hafez M
Hafiz S
Hagar A
Haines S
Hakim H
Hall N
Hall NJ
Hall TF
Hallam S
Hamad MGM
Hamasaki J
Hammad A
Hammad AM
Hampton M
Hanafy M
Hand C
Hanks A
Hanley I
Hanrahan M
Hantour U
Harbord P
Haroun A
Harper E
Harrison EM
Harrison N
Harrison P
Harrison R
Hasan A
Hasheminia A
Hashish A
Hashish M
Hassan A
Hassan A
Hassan A
Hassan M
Hassan S
Hassan Z
Hassanain M
Havemann I
Hawkins W
Heath J
Heffernan D
Hegazy Y
Hemeda D
Hemingway D
Hemmila M
Henderson L
Herrera Puma CM
Herrera N
Herrera-Matta J
Hervieux E
Hettiarachchi TS
Hewage K
Heywood EG
Highcock S
Hinojosa C
Hjertberg M
Ho CW
Ho W
Ho WC
Hogea M
Holton P
Hoogakker E
Horobjowsky A
Hosein S-P
Hosh M
Hossaini S
Houlden C
Howells L
Howie EE
Huaman E
Humm G
Hussain M
Hussein A
Hussein S
Husseini M
Hutch W
Huwait A
Ibraheem HI
Ibrahem AA
Ibrahim I
Ibrahim MH
Ibrahim Y
Idris SAI
Iftikhar Z
Ingabire JDLCA
Iordache F-M
Iqbal FM
Irtan S
Irwin G
Isabel Villegas M
Ismail L
Ismail M
Iyer D
Jabbar A
Jackson P
Jacobe M
Jaffry Z
Jain P
Jara Quezada JH
Jarmin M
Javed O
Jawaid M
Jenner E
Jennings L
Jennings V
Jenvey C
Jeyakumar J
Jha M
Jimenez J
Johnson K
Jokubauskas M
Jokubonis K
Jones C
Jones E
Jones TF
Jordan H
Jotautas V
Jovine E
Juciute S
Jurdell E
Kaafarani H
Kabba J
Kamil R
Kang MK
Karabacak U
Karakahya M
Karandikar S
Karim A
Karkeet M
Karlo R
Karousos D
Karumnas P
Kaselis N
Kasem E
Kazanavicius D
Kefalidi E
Kenibar A
Kennedy ED
Kennedy M
Kennedy R
Kerley R
Kesinger M
Khairy H
Khajanchi M
Khaled H
Khalili M
Khalique A
Khan A
Khan K
Khan S
Khan T
Kharsa S
Khatri C
Khattab K
Khedr AE-RH
Khoja A
Khouri Ferreira SA
Khyrallh A
Kiasat A
Kielty P
Kim MY-H
Kim S-H
Kim SB
Kimaro M
King R
King S
Kinnera SV
Kirishnan A
Kirupagaran A
Kjellin A
Koh C
Koh H
Koh S
Kolosov A
Komolafe O
Kong V
Kontos M
Kosai NR
Kostov E
Kotb AHE-B
Kotecha D
Koumpa F
Kouraklis G
Kretzmann H
Krishna K
Kruspi S
Kulasabanathan K
Kumar BS
Kumar MN
Kumar S
Kumar T
Kushwaha S
Labib P
Lafferty K
Lakhani SM
Lakshmi HN
Lam FY
Lamanna GL
Landolfo G
Lap G
Lasheen A
Lasheen KT
Laugzemys E
Lawal AO
Lawal TA
Lawani I
Lawther R
Lazzarini Cury AD
Leal A
Leal M
Lee C
Leppaniemi A
Leung MF
Lewis J
Li KKK
Li WS
Liew I
Lim G
Lim PJ
Lim SJ
Limache S
Limaye N
Linares Delgado MSDFT
Lintin L
Livesey A
Livingston M
Lockey J
Loizides S
Lopez C
Lopez M
Lopez-Arevalo C
Lossius WJ
Loughran D
Luck J
Luis Rodicio J
Luiz JS
Lund J
Lundgren P-O
Luque L
Lytras D
Ma J
Macchiavello R
Macchitella Y
Macdermid E
Macdonald A
Macdonald E
Macdonald L
Maceviciute K
Macfarlane A
Machaca M
Machain Vega GM
Maffioli A
Magdy B
Magee C
Maghrabi AA
Maharaj G
Mahdi A
Mahdi S
Mahmoud M
Mahmud K
Major CP
Mak T
Makinde M
Malik K
Malik P
Malik TAM
Mamdouh E
Manchego Bautista AC
Mangan C
Manipal CE
Maniscalco A
Mannu GS
Manrique Sila G
Manrrique Sila G
Mansour B
Mapasse D
Maple N
Marcelo Delgado J
Marey A
Marey AS
Marinkovic B
Marinos C
Marks E
Marples L
Marroquin Rodriguez DE
Marshall DC
Marta Modolo M
Martian B-V
Martin A
Mason C
Mauro L
Mayasari M
Mcaleer E
Mcaleer S
Mccarthy K
Mccarthy M
McCullagh D
Mcdonald R
Mcguigan A
Mcintosh R
Mcintyre CJ
Mcintyre N
Mcintyre R
Mckechnie D
Mclachlan G
Mclean AL
McMorran D
Mcnish D
Mcphee A
Mealy K
Mehrez S
Melo R
Mendez M
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Mendoza Arango MC
Mendoza I
Menegussi J
Menshawy A
Mentula P
Mercado Rodriguez L-A
Merlini D
Meshref A
Messa Aguilar WL
Metwally MM
Mihanovic J
Mijuskovic B
Mikalauskas S
Mikwar Z
Milligan W
Minguez G
Minocha A
Mirghani D
Mironescu AS
Mirza A
Mistry A
Mitrasinovic S
Mitroudis N
Mittal A
Mitul AR
Mlotshwa M
Mogan YP
Mohamed I
Mohamed MAEH
Mohamed MM
Mohamed O
Mohameden A
Mohammad A
Mohammed A
Mohammed A
Mohammed MMH
Mohan H
Mohan M
Mokhtar A
Molina G
Monaghan E
Monteleone M
Montes I
Montoya Botero JA
Montrimaite M
Moore R
Morales C
Moreira G
Morgan C
Morsi A
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Morton R
Mosad A
Mosalum O
Mostafa HA
Mousa M
Mouttalib S
Mphatsoe AM
Muller C
Munera A
Munhoz MM
Munipalle PC
Muntean LI
Muralha N
Murphy J
Musa AEK
Mustafa M
Mustafa M-A
Nabawi A
Nada F
Nadkarni S
Nair H
Napolitano L
Naqvi SA
Naqvi T
Naranjo Aristizabal FA
Narvestad JK
Nashaat A
Nasher O
Nasir AA
Nasr A
Nasr M
Nastri G
Nawara C
Nawawi A
Nayel AR
Negida A
Nel D
Nemeth K
Neo YN
Neophytou C
Nepogodiev D
Nesaratnam A
Newton T
Ng S
Ngayu N
Ngwa TE
Nighat B
Nigo S
Nikoloudis N
Niragire A
Niyirera E
Nnajiuba H
Nocito A
Nofal E
Normile C
North AS
Nouh T
Novak A
Nowers J
Nsengimana VJP
Nwokoro C
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Oosterkamp A
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Ortega-Vazquez I
Oshodi O
Osinowo A
Osman M
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Osman O
Osuoji R
Othman M
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Owusu F
Ozkan BB
Pabla G
Pagnozzi J
Pahlsson H-I
Pai S
Palkhi EYA
Palliyil MM
Palma AF
Palomino Castillo VD
Paludi MA
Panait N
Panieri E
Parakh J
Paredes Decoud H
Parent V
Parker J
Parkinson L
Parthiban S
Pasini M
Pata D
Pata F
Pata G
Patel K
Patel P
Patel V
Paul S
Peck FS
Pereira B
Perez Velasquez CI
Periasammy D
Peycelon M
Pezas T
Pezelj N
Phillips N
Pimenta ML
Pino W
Pinto Vianna JG
Pitt SK
Podevin G
Popoola A
Porter J
Poskus T
Powell A
Prabhudesai A
Pranevicius R
Prasad SS
Preckailaite E
Primavesi F
Proctor VK
Psaila J
Psarianos K
Punja V
Puttick M
Puyana JC
Qadir MRM
Quayle J
Quintero Riaza VM
Rabie M
Rackauskas R
Radic M
Rahmawati FN
Rajan R
Rajjoub Y
Rakauskas R
Rakita I
Ramarez Cabrera CC
Ramazzini P
Ramcharn M
Ramos-De La Medina A
Ramzi S
Rangarajan M
Raptis DA
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Rasendran A
Rashad M
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Rashwan H
Raslan A
Raslan C
Rausa E
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Rayne S
Raza I
Razek T
Razmdjou S
Recinos G
Reddy Y
Rees CM
Regalado F
Reinisch KB
Restrepo J
Reza L
Riauka R
Riaz A
Richards J
Richardson L
Rivas R
Robertson AGN
Robertson N
Rodriguez Castro M
Rodriguez L
Rodriguez-Uria R
Roi D
Romani Pozo DA
Roncali S
Rooney H
Rosas Moran AE
Roslani AC
Roth J
Rotundo A
Roy S
Royson H
Rslan A
Rudzenskaite A
Saad M
Saad S
Sabeeh L
Sabry A
Sadek A
Sadig N
Saeed AM
Saeed H
Saeed M
Safa H
Sakr A
Sakr R
Salah O
Salama M
Salama Y
Saleh O
Salleh A
Sallinen V
Salma M
Samaraweera DI
Samih H
Samir A
Sampson C
Samuel D
Samy S
Sarmah P
Sarsik S
Sarwary S
Satoskar R
Satoskar S
Sauvat F
Sava J
Sayed A
Sayma EA
Scalabre A
Schadde E
Schivo D
Schmid R
Schmitt F
Schoewe C
Scott M
Segovia Lohse HA
Seif M
Seifelnasr O
Seisa M
Senanayake WSMKJ
Sgroi G
Shaalan M
Shabkah A
Shah A
Shah J
Shah R
Shaikh S
Shaker H
Shaker R
Shaker R
Shalaby A
Shalhoub J
Shamsi G
Shamsi GS
Shariffuddin AM
Shatkar V
Shawki M
Sheehan J
Shehata S
Sherif MA
Sherman T
Sheshe A
Sheth S
Shimy G
Shiwani H
Shu Yip SB
Shu S
Shukla J
Sieda B
Sierra S
Siguantay M
Silvani P
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Simoes RL
Singh P
Singh S
Sinha S
Sinha Y
Sion M
Sishuba N
Sivaganesh S
Skardziukaite A
Skehan J
Skelly B
Slade R
Smart NJ
Smith C
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Snaith AC
Snyder E
Soares Miguel GP
Sodde P
Soeselo DA
Solar Garcia L
Soley R
Soliman AR
Soltani N
Som R
Song J
Soon WC
Soreide K
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Souaibou YI
Spence R
Spina A
Spurr M
Sreedharan A
Sriram A
Staerkle RF
Starr N
Stasinou T
Stephen A
Stewart D
Stock S
Stoddart M
Strazdas A
Strupas K
Suleiman SI
Summerour V
Sund M
Sunderland G
Sundstrom SM
Sutanto EPR
Sutton P
Swann J
Swaroop M
Sykes M
Szczap A
Szeto CCL
Szeto KJ-Y
Tabiri S
Tade A
Tafazal H
Taha EMS
Taher M
Taiwo O
Tale F
Talukder S
Tammam A
Tan CY
Tan JJ
Tanase A
Tang A
Tarek A
Tatagiba LS
Tawfik G
Taylor F
Teasdale E
Tedjaatmadja C
Telfah MM
Temoche E
Tessera G
Teufelberger G
Tewari S
Th'ng F
Tham JC
Thanusan V
Tharmalingam S
Thomas E
Thompson B
Thomson P
Thorarinsdottir H
Thorell A
Thorsen K
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Tierney G
Tilston TW
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Todd O
Toeema AG
Tolba H
Tolg C
Torrance HDT
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Tracy J
Tugnoli G
Tun AK
Tun M
Turati L
Turner M
Tyler R
Tze RGE
Ubhi HK
Ugalde P
Upchurch E
Urbanavicius L
Urbina Rojas NM
Urbonas T
Urniezius Z
Usaityte A
Utter M
Valente Laufer LA
Van Duren B
Varcada M
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Venskutonis D
Venugopal C
Vergara Celis JM
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Vida LC
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Vivekanantham S
Vlachogiorgos A
Wagener M
Waleed H
Walsh U
Ward AE
Ward S
Warda M
Warren O
Warwick AM
Watson NFS
Watts A
Weber B
Weber P
Weinstein MS
Wheeler J
Whewell H
White T
Wild JRL
Williams E
Williams G
Williams O
Williamson A
Wilson A
Wilson MSJ
Wilson MSJ
Winstanley J
Witherspoon P
Wogensen F
Woin E
Wold TB
Wolf B
Wondimu S
Wong CS
Woodward H
Worku M
Wredberg C
Wright NJ
Xerri T
Yallop L
Yaseen T
Yaseen TM
Yavuz MA
Yee J
Yeo LS
Yeung ENW
Yong CO
Youssef D
Youssef H
Youssif JH
Zachariades D-C
Zakir M
Zalabia MF
Zamarin K
Zani A
Zanini N
Zapata Ponze De Leon M
Zapata Ponze De Leon M
Zardab A
Zegarra S
Zeidan S
Zelada Alvarez II
Zerihun AB
Zhang Z
Zheng F
Zidan H
Zidan M
Ziff O
Zikry M
Zil-E-Ali A
Zilinskas J
Zilinskiene R
Zimmermann EF
Zuber M
Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2018
Field of study

BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112

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The Molecular Epidemiology and Evolution of Murray Valley Encephalitis Virus: Recent Emergence of Distinct Sub-lineages of the Dominant Genotype 1

Author: A Brown
A Niazi
AJ Drummond
AJ Drummond
AJ Schuh
AJ Schuh
Alyssa Pyke
AN Gordon
AT Pyke
Aziz-ur-Rahman Niazi
B Murrell
B Murrell
B Shrestha
BD Lindenbach
Belinda Herring
Beng Hooi Chua
C Johansen
C Taucher
CA Johansen
CH Woelk
Cheryl A. Johansen
CK Chuang
CT Davis
CW Lin
D Darriba
David T. Williams
David W.C. Beasley
DT Williams
DT Williams
DW Beasley
DW Beasley
DW Beasley
E Lee
EF Pettersen
EL French
EL French
FA Rey
FJ May
FX Heinz
G Jerzak
GE Nybakken
GJ Baillie
GJ Fitzsimmons
GM Jenkins
ID Marshall
J Aaskov
J Burrow
J Mackenzie
JA Forbes
JD Brien
JG Peng
John S. Mackenzie
JS Mackenzie
JS Mackenzie
JS Mackenzie
JS Mackenzie
K Arnold
K Morita
K Tamura
K Yoshii
L Heath
LA Selvey
LD Kramer
M Lobigs
M Lobigs
M Poidinger
M Worobey
MA Lawson
MA Mohammed
NA Prow
PC McMinn
PC McMinn
Peter A. Durr
Pond SL Kosakovsky
Pond SL Kosakovsky
PT Nga
R Fritz
RA Mann
RC Gualano
RJ Coelen
RJ Coelen
RJ Hurrelbrink
RJ Hurrelbrink
RM Moudy
S Craig
S Doggett
S Elshuber
S Guindon
SE Roche
SG Anderson
Sinéad M. Diviney
SL Allison
SL Doggett
SL Pond
SP Ma
SS Twiddy
Stephen L. Doggett
SY Shiu
T Oliphant
T Oliphant
TM Colpitts
TT Tan
V Pierre
VC Luca
WD Crill
WR Chen
XL Pan
Y Modis
Publication venue: 'Public Library of Science (PLoS)'
Publication date: 01/01/2015
Field of study

© 2015 Williams et al. Background: Recent increased activity of the mosquito-borne Murray Valley encephalitis virus (MVEV) in Australia has renewed concerns regarding its potential to spread and cause disease. Methodology/Principal Findings: To better understand the genetic relationships between earlier and more recent circulating strains, patterns of virus movement, as well as the molecular basis of MVEV evolution, complete pre-membrane (prM) and Envelope (Env) genes were sequenced from sixty-six MVEV strains from different regions of the Australasian region, isolated over a sixty year period (1951–2011). Phylogenetic analyses indicated that, of the four recognized genotypes, only G1 and G2 are contemporary. G1 viruses were dominant over the sampling period and found across the known geographic range of MVEV. Two distinct sub-lineages of G1 were observed (1A and 1B). Although G1B strains have been isolated from across mainland Australia, Australian G1A strains have not been detected outside northwest Australia. Similarly, G2 is comprised of only Western Australian isolates from mosquitoes, suggesting G1B and G2 viruses have geographic or ecological restrictions. No evidence of recombination was found and a single amino acid substitution in the Env protein (S332G) was found to be under positive selection, while several others were found to be under directional evolution. Evolutionary analyses indicated that extant genotypes of MVEV began to diverge from a common ancestor approximately 200 years ago. G2 was the first genotype to diverge, followed by G3 and G4, and finally G1, from which subtypes G1A and G1B diverged between 1964 and 1994. Conclusions/Significance: The results of this study provides new insights into the genetic diversity and evolution of MVEV. The demonstration of co-circulation of all contemporary genetic lineages of MVEV in northwestern Australia, supports the contention that this region is the enzootic focus for this virus

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Genetic mechanisms of critical illness in COVID-19.

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Openshaw Peter J M
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Pairo-Castineira Erola
Pamela Raggi
Paola Magro
Paolo Cameli
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Parkinson Nick
Pasko Dorota
Patrick Sulem
Patrizia Zucchi
Paul Finernan
Paul Klenerman
Pereira Alexandre C
Peter W Horby
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Pierpaolo Parravicini
Pietro Pinoli
Ponting Chris P
Porteous David J
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Samreen Ijaz
Sandro Mancarella
Sandro Panese
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Sara McDonald
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Saverio Giuseppe Parisi
Saye Khoo
Scott Richard
Semple Malcolm G
Serafina Valente
Serena Ludovisi
Sergio Daga
Seán Keating
Shankar-Hari Manu
Shen Xia
Shih Barbara
Shiranee Sriskandan
Shona C Moore
Silvia Cappelli
Simona Marcantonio
Simone Furini
Sophie Halpin
Sophie Venturelli
Stefania Mantovani
Stefano Baratti
Stefano Ceri
Stefano Rusconi
Stella Aslibekyan
Stephanie Roberts
Stephen R Knight
Summers Charlotte
Susanna Croci
Susanna Guerrini
T Anderson
T Arden
T Baird
T Behan
T Bemand
T Cosier
T Coventry
T Duncan
T Felton
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T Hazleton
T Joefield
T Kannan
T Lawton
T Marsden
T Martin
T McHugh
T Newman
T Nortcliffe
T O Jones
T Pogreban
T Rees
T Samakomva
T Smith
T Smith
T Szakmany
T Varghes
T Williams
T Wood
Tammy Gilchrist
Tenesa Albert
Teresa Filshtein-Sonmez
Thomas M Drake
Thushan de Silva
Tim Walsh
Tom Fletcher
Tom Solomon
Tony Wackett
Trevor Paterson
Tullio Trotta
Turtle Lance
U Poultney
V Amin
V Anumakonda
V Bastion
V Cannons
V Crickmore
V Gopal
V Irvine
V Kasipandian
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V Lake
V Linnett
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V Page
V Parris
V Parris
V Pristopan
V Ratnam
V Rivers
V Sarathy
V Thomas
V Thwaites
V Tuckey
V Turner
V Wagstaff
V Waugh
Valentina Anemoli
Vanessa Sancho-Shimizu
Victoria Shaw
Vitart Veronique
W Harrison
W Khaliq
W Khaliq
W McCormick
W Woodyatt
Walker Susan
Walsh Timothy
Wang Bo
Wei Shen Lim
Wendy S Barclay
William A Paxton
William Greenhalf
Wilson James F
Wrobel Nicola
Wu Yang
X Qiu
Y Baird
Y Choudhury
Y Hussain
Y Jackson
Y Thirlwall
Yang Jian
Yang Zhijian
Z Alldis
Z Belagodu
Z Bradshaw
Z Coton
Z Daly
Z Farzad
Z Fernandez
Z Garland
Z Maqsood
Z Omar
Z Prime
Z Scott
Zechner Marie
Zhai Ranran
Zheng Chenqing
Publication venue: Nature
Publication date: 01/01/2020
Field of study

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

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A novel formulation of inhaled sodium cromoglicate (PA101) in idiopathic pulmonary fibrosis and chronic cough: a randomised, double-blind, proof-of-concept, phase 2 trial

Author: Abel K.
Adamali H.
Adeloye D.
Adeyemi F.
Adeyemi O.
Ahmad S.
Ahmed R.
Ainsworth M.
Al-Sheklly B.
Alamoudi A.
Aljaroof M.
Allan L.
Allen R.
Alli A.
Altmann D.
Anderson D.
Andrews M.
Angyal A.
Antoniades C.
Arbane G.
Armour C.
Armstrong L.
Armstrong N.
Arnold D.
Arnold H.
Ashworth A.
Ashworth M.
Assefa-Kebede H.
Atkin P.
Atkins A.
Atkins H.
Aul R.
Avram C.
Baggott R.
Baguley D.
Baillie J. Kenneth
Baillie J.K.
Bain S.
Bakali M.
Bakau M.
Baldry E.
Baldwin D.
Ballard C.
Bambrough J.
Barker R.E.
Barratt S.
Barrett F.
Basu N.
Batterham R.
Baxendale H.
Bayes H.
Bayley M.
Beadsworth M
Beirne P.
Bell D.
Bell R.
Berry C.
Betts S.
Bhui K.
Bishop L.
Blaikely J.
Bloomfield C.
Bloss A.
Bolger A.
Bolton C.E.
Bonnington J.
Botkai A.
Bourne C.
Bourne M.
Bradley E.
Bramham K.
Brear L.
Breen G.
Breeze J.
Briggs A.
Bright E.
Brightling C.E.
Brightling Christopher E.
Brill S.
Brindle K.
Broad L.
Broome M.
Brown A
Brown A
Brown J.
Brown J.
Brown J.S.
Brown Jeremy S.
Brown M
Brown M.
Brown R.
Brown V.
Brugha T
Brunskill N
Buch M
Bularga A
Bullmore E
Burn D
Burns G
Busby J
Buttress A
Byrne S
Cairns P
Calder P.C.
Calvelo E
Card B
Carr L
Carson G
Carter P
Cavanagh J
Chalder T
Chalder Trudie
Chalmers J.D.
Chalmers James D.
Chambers R.C.
Channon K
Chapman K
Charalambou A
Chaudhuri N
Checkley A
Chen J
Chetham L
Chilvers E.R.
Chinoy H
Chong-James K
Choudhury G
Choudhury N
Chowdhury P
Chowienczyk P
Christie C
Clark C
Clark D
Clarke J
Clift P
Clohisey S
Coburn Z
Cole J
Coleman C
Connell D
Connolly B
Connor L
Cook A
Cooper B
Coupland C
Craig T
Crisp P
Cristiano D
Crooks M.G.
Cross A
Cruz I
Cullinan P
Daines L
Daines Luke
Dalton M
Dark P
Dasgin J
David A
David C
Davies F
Davies G
Davies G.A.
Davies K
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Daynes E
De Silva T
De Soyza A
De Soyza Anthony
Deakin B
Deans A
Defres S
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Dempsey K
Dennis J
Dewar A
Dharmagunawardena R
Diar Bakerly N
Diar Bakerly Nawar
Dipper A
Diver S
Diwanji S.N.
Dixon M
Djukanovic R
Dobson C
Dobson H
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Docherty A.B.
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Dormand N
Dougherty A
Dowling R
Drain S
Dulawan P
Dunn S
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Easom N
Easom Nicholas
Echevarria C
Edwards S
Edwardson C
Elliott A
Elliott B
Ellis Y
Elmer A
Elneima O
Elneima Omer
Evans D
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Evans R.I.
Evans Rachael A.
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Fabbri L
Fairbairn S
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Fallon K
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Hughes A
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Hughes R
Humphries A
Huneke N
Hurst J.R.
Hurst John R.
Hurst R
Husain M
Hussell T
Ibrahim W
Ient A
Ingram L
Ismail K
Jackson T
Jacob J
Jacob Joseph
James W.Y.
Janes S
Jarvis H
Jayaraman B
Jenkins R. Gisli
Jenkins R.G.
Jezzard P
Jiwa K
Johnson C
Johnson S
Johnston D
Jolley C
Jolley C J
Jolley Caroline
Jones D
Jones G
Jones H
Jones I
Jones M
Jones S
Jose S
Kabir T
Kaltsakas G
Kamwa V
Kar P
Kausar Z
Kelly S
Kerr S
Kerr Steven
Key A.L.
Khan F
Khunti K
King B
King C
Kitterick P
Klenerman P
Knibbs L
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Knighton A
Kon O.M.
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Korszun A
Kotanidis C
Koychev I
Kurupati P
Kwan J
Laing C
Lamlum H
Landers G
Langenberg C
Lasserson D
Lawrie A
Lea A
Leavy O.C.
Leavy Olivia C.
Lee D
Lee E
Leitch K
Lenagh R
Lewis J
Lewis K
Lewis K.E.
Lewis Keir
Lewis V
Lewis-Burke N
Light T
Lightstone L
Lim L
Linford S
Lingford-Hughes A
Lipman M
Liyanage K
Lloyd A
Logan S
Lomas D
Lone N.I.
Lone Nazir I.
Loosley R
Lord J.M.
Lord Janet M.
Lota H
Lucey A
MacGowan G
Macharia I
Mackay C
Macliver L
Madathil S
Madzamba G
Magee N
Mairs N
Majeed N
Major E
Malim M
Mallison G
Man W
Mandal S
Mangion K
Mansoori P
Marciniak S
Mariveles M
Marks M
Marks Michael
Marshall B
Martineau A
Maskell N
Matila D
Matthews L
Mayet J
McAdoo S
McAllister-Williams H
McArdle A
McArdle P
McAulay D
McAuley D.F.
McAuley H
McAuley Hamish
McCafferty K
McCann G.P.
McCann Gerry P.
McCauley H
McCourt P
Mcgarvey L
McGinness J
McGovern A
McGuinness H
McInnes I.B.
McIvor E
McIvor K
McMahon A
McMahon M.J.
McMorrow L
Mcnally T
McNarry M
McQueen A
McShane H
Megson S
Meiring J
Menzies D
Michael A
Milligan L
Mills N
Mitchell J
Mohamed A
Molyneaux P.L.
Monteiro W
Morley A
Morrison L
Morriss R
Morrow A
Moss A
Moss A.J.
Moss P
Mukaetova-Ladinska E
Munawar U
Murali E
Murira J
Nassa H
Neill P
Neubauer S
Neubauer Stefan
Newby D
Newell H
Newton Cox A
Nicholson T
Nicoll D
Nolan C.M.
Noonan M.J.
Novotny P
Nunag J
Nyaboko J
O'Brien L
Odell N
Ogg G
Olaosebikan O
Oliver C
Omar Z
Openshaw P.J.M.
Openshaw Peter J. M.
Osbourne R
Ostermann M
Overton C
Oxton J
Pacpaco E
Paddick S
Papineni P
Paradowski K
Pareek M
Parekh D
Parekh Dhruv
Parfrey H
Pariante C
Parker S
Parkes M
Parmar J
Parvin R
Patale S
Patel B
Patel M
Patel S
Pathmanathan B
Pavlides M
Pearl J.E.
Peckham D
Pendlebury J
Peng Y
Pennington C
Peralta I
Perkins E
Peto T
Petousi N
Petrie J
Pfeffer P
Pfeffer Paul
Phipps J
Pimm J
Piper Hanley K
Pius R
Plein S
Plekhanova T
Poinasamy K
Poinasamy Krisnah
Polgar O
Poll L
Porter J.C.
Portukhay S
Powell N
Price A
Price C
Price D
Price L
Prickett A
Quaid S
Quigley J
Quint J
Qureshi H
Rahman M
Rahman N
Rahman Najib M.
Ralser M
Raman B
Raman Betty
Ramos A
Rangeley J
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Regan K
Richards A
Richardson M
Richardson Matthew
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Rowland M.J.
Rowland Matthew
Rowland-Jones S.L.
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Rudan I
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Russell R
Sabit R
Sage E.K.
Samani N
Samuel R
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Saralaya D
Saratzis A
Sargeant J
Sass T
Sattar N
Saunders K
Saunders R
Saxon W
Sayer A
Schwaeble W
Scott Janet
Scott K
Selby N
Semple M.G.
Semple Malcolm G.
Sereno M
Sereno Marco
Shah A
Shah Ajay M.
Shah K
Shah P
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Sharpe C
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Sheikh A
Sheikh Aziz
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Simpson J
Singapuri A
Singapuri Amisha
Singh C
Singh S
Singh S.J.
Singh Sally J.
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Smith I
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Smith L
Soares M
Southern D
Spears M
Spencer L.G.
Speranza F
Stadon L
Stanel S
Steiner M
Stensel D
Stern M
Stewart I
Stockley J
Stone R
Storrie A
Storton K
Stringer E
Subbe C
Sudlow C
Suleiman Z
Summers C
Summersgill C
Sutherland D
Sykes D.L.
Sykes R
Talbot N
Tan A.L.
Taylor A
Taylor C
Te A
Tedd H
Tee C.J.
Tench H
Terry S
Thackray-Nocera S
Thaivalappil F
Thickett D
Thomas A.K.
Thomas D
Thomas D.C.
Thomas David
Thompson A.A.R.
Thompson T
Thornton T
Thwaites R.S.
Tobin M
Toingson G.F.
Tong C
Toshner M
Toshner Mark
Touyz R
Tripp K.A.
Tunnicliffe E
Turner E
Turtle L
Turton H
Ugwuoke R
Upthegrove R
Valabhji J
Vellore K
Wade E
Wain L.V.
Wain Louise V.
Wajero L.O.
Walder S
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Wallis T
Walmsley S
Walsh J.A.
Walsh S
Watson E
Watson J
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Watson L
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Welch H
Welsh B
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Yousuf A.J.
Zawia A
Zhao B
Zongo O
Publication venue: Elsevier
Publication date: 01/03/2013
Field of study

Background Cough can be a debilitating symptom of idiopathic pulmonary fibrosis (IPF) and is difficult to treat. PA101 is a novel formulation of sodium cromoglicate delivered via a high-efficiency eFlow nebuliser that achieves significantly higher drug deposition in the lung compared with the existing formulations. We aimed to test the efficacy and safety of inhaled PA101 in patients with IPF and chronic cough and, to explore the antitussive mechanism of PA101, patients with chronic idiopathic cough (CIC) were also studied. Methods This pilot, proof-of-concept study consisted of a randomised, double-blind, placebo-controlled trial in patients with IPF and chronic cough and a parallel study of similar design in patients with CIC. Participants with IPF and chronic cough recruited from seven centres in the UK and the Netherlands were randomly assigned (1:1, using a computer-generated randomisation schedule) by site staff to receive PA101 (40 mg) or matching placebo three times a day via oral inhalation for 2 weeks, followed by a 2 week washout, and then crossed over to the other arm. Study participants, investigators, study staff, and the sponsor were masked to group assignment until all participants had completed the study. The primary efficacy endpoint was change from baseline in objective daytime cough frequency (from 24 h acoustic recording, Leicester Cough Monitor). The primary efficacy analysis included all participants who received at least one dose of study drug and had at least one post-baseline efficacy measurement. Safety analysis included all those who took at least one dose of study drug. In the second cohort, participants with CIC were randomly assigned in a study across four centres with similar design and endpoints. The study was registered with ClinicalTrials.gov (NCT02412020) and the EU Clinical Trials Register (EudraCT Number 2014-004025-40) and both cohorts are closed to new participants. Findings Between Feb 13, 2015, and Feb 2, 2016, 24 participants with IPF were randomly assigned to treatment groups. 28 participants with CIC were enrolled during the same period and 27 received study treatment. In patients with IPF, PA101 reduced daytime cough frequency by 31·1% at day 14 compared with placebo; daytime cough frequency decreased from a mean 55 (SD 55) coughs per h at baseline to 39 (29) coughs per h at day 14 following treatment with PA101, versus 51 (37) coughs per h at baseline to 52 (40) cough per h following placebo treatment (ratio of least-squares [LS] means 0·67, 95% CI 0·48–0·94, p=0·0241). By contrast, no treatment benefit for PA101 was observed in the CIC cohort; mean reduction of daytime cough frequency at day 14 for PA101 adjusted for placebo was 6·2% (ratio of LS means 1·27, 0·78–2·06, p=0·31). PA101 was well tolerated in both cohorts. The incidence of adverse events was similar between PA101 and placebo treatments, most adverse events were mild in severity, and no severe adverse events or serious adverse events were reported. Interpretation This study suggests that the mechanism of cough in IPF might be disease specific. Inhaled PA101 could be a treatment option for chronic cough in patients with IPF and warrants further investigation

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Tilley J
Tinker N
Tiongson GF
Tobin M
Tomlinson J
Tong C
Toshner M
Toshner M
Toshner M
Toshner M
Toshner M
Touyz R
Treibel T
Tripp KA
Tunnicliffe E
Tunnicliffe EM
Turnbull A
Turner E
Turner K
Turner S
Turner V
Turney S
Turtle L
Turtle L
Turton H
Ugoji J
Ugwuoke R
Upthegrove R
Valabhji J
Venson B
Ventura M
Vere J
Vickers C
Vinson B
Vogiatzis I
Wade E
Wade P
Wain LV
Wain LV
Wain LV
Wain LV
Wain LV
Wain LV
Wain LV
Wain LV
Wain LV
Wainwright T
Wajero LO
Walder S
Walker S
Walker S
Walker S
Walker S
Wall E
Wallis T
Walmsley S
Walsh JA
Walsh S
Warburton L
Ward TJC
Warwick K
Wassall H
Waterson S
Watson E
Watson J
Watson L
Webster M
Welch C
Welch H
Welsh B
Wessely S
West S
Weston H
Wheeler H
White S
Whitehead V
Whitney J
Whittaker S
Whittam B
Whitworth V
Wight A
Wild JM
Wild JM
Wild JM
Wild JM
Wilkins M
Wilkinson D
Wilkinson D
Williams B
Williams J
Williams N
Williams N
Williams N
Williams-Howard SA
Willicombe M
Willis G
Willoughby J
Wilson A
Wilson D
Wilson D
Wilson I
Window N
Witham M
Witham M
Wolf-Roberts R
Wood C
Woodhead F
Woods J
Wootton DG
Wootton DG
Wootton DG
Wootton DG
Wormleighton J
Worsley J
Wraith D
Wright C
Wright L
Wright S
Wyles J
Wynn E
Wynter I
Xie C
Xu M
Xu M
Yasmin N
Yasmin S
Yates T
Yates T
Yip KP
Young A
Young B
Young S
Yousuf A
Zawia A
Zeidan L
Zhao B
Zheng B
Zongo O
Publication venue: Oxford University Press (OUP)
Publication date: 18/12/2023
Field of study

Archivio della Ricerca - Università degli Studi di Siena

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity

Author: A. Abraheem
A. Agasou
A. Ahmed
A. Ali
A. Allan
A. Altabaibeh
A. Alvaro
A. Aspinwall
A. Ayers
A. Bamford
A. Barron
A. Bashyal
A. Bellini
A. Bociek
A. Botello
A. Bowes
A. Brady
A. Brayne
A. Brown
A. Brown
A. Butler
A. Carter
A. Collins
A. Cowley
A. Cowton
A. Cowton
A. Cox
A. Crew
A. Dance
A. Daniel
A. Daniels
A. Dela Rosa
A. Drummond
A. Durie
A. E. Heron
A. Easthope
A. Easthorpe
A. Evans.
A. Fofano
A. Gales
A. Ganesan
A. Gardner
A. Garg
A. Gherman
A. Gordon
A. Gratrix
A. Gulati
A. Gupta
A. Haigh
A. Haldeos
A. Harrison
A. Harvey
A. Hayes
A. Higham
A. Higham
A. Hilldrith
A. Holden
A. Hormis
A. Hutcheon
A. Javaid
A. Joseph
A. Kaliappan
A. Katary
A. Kay
A. Kayani
A. Kent
A. Kirkby
A. Knight
A. Kubisz-Pudelko
A. Kuravi
A. Lewis
A. Loveridge
A. Lyle
A. Mayer
A. McAlpine
A. McCarthy
A. McGregor
A. McGregor
A. Meikle
A. Mitchell
A. Mitra
A. Morris
A. Morrison
A. Naranjo
A. Nicholson
A. Nicholson
A. Noakes
A. Patel
A. Pickard
A. Price
A. Puxty
A. Quinn
A. Quinn
A. Raithatha
A. Rattray
A. Reddy
A. Reed
A. Reyes
A. Rose
A. Rose
A. Rostron
A. Roy
A. Roynon-Reed
A. S. Raj
A. Salberg
A. Sanderson
A. Serrano-Ruiz
A. Solesbury
A. Sukha
A. Swain
A. Tariq
A. Thomas
A. Thomas
A. Todd
A. Tomas
A. Tridente
A. Tucci
A. Turnbull
A. Uriel
A. Ustianowski
A. Vochin
A. Vuylsteke
A. Waite
A. Walden
A. Whileman
A. Wilkinson
A. Williams
A. Williams
A. Wilson
A. Zak
A. Zaki
Achille Iolascon
Adam Brown
Adam Krętowski
Adriana Roży
Agnese Verzuri
Agnieszka Adamek
Agnieszka Bielska
Agostino Ognibene
Agostino Riva
Ailsa Golightly
Alan Maclean
Albert Tenesa
Aleksandra Berkan-Kawinska
Aleksandra Jezela-Stanek
Aleksandra Starosz
Alessandra Guarnaccia
Alessandra Renieri &amp
Alessandra Stella
Alessandra Vergori
Alessandro Pancrazzi
Alessia Giorli
Alice Donati
Alison Meynert
Alistair Nichol
Anders Larsson
Andrea Antinori
Andrea Cossarizza
Andrea Gabbuti
Andrea Tommasi
Andrew D. Bretherick
Andrew Law
Andrew Stenhouse
Andrzej Eljaszewicz
Andrzej Horban
Andy Law
Angelica Pagliazzi
Angie Fawkes
Anke Hinney
Anna Canaccini
Anna Kruk
Anna Maria Pinto
Anna Moniuszko-Malinowska
Anna Parfieniuk-Kowerda
Anna Piekarska
Anna Szałkowska
Annarita Giliberti
Anne Richmond
Antonella D. ’Arminio Monforte
Antonella Vincenti
Antonia Ho
Antonio Di Biagio
Antonio Perrella
Arianna Emiliozzi
Arianna Gabrieli
Arsalin Azzadin
Asma Al Thani &amp
Athanasios Kousathanas
Audrey Coutts
Axel Schmidt
Axel Schmidt
B. Anwar
B. Attwood
B. Baines
B. Blackledge
B. Borislavova
B. Chandler
B. Charles
B. Creagh-Brown
B. David
B. Deacon
B. Deacon
B. Digby
B. Faulkner
B. Fuller
B. Gumbrill
B. Gurung
B. Hadebe
B. Hairsine
B. Hopkins
B. Johnson
B. Lenagh
B. Masunda
B. Ogg
B. Patel
B. Player
B. Purewal
B. Scholefield
B. Shelley
B. Sloan
B. Thomas
B. Wadams
B. Welsh
B. Wilkinson
B. Winter-Goodwin
B. Yates
Barbara Rossetti
Barbara Shih
Barbara Sobala-Szczygiel
Beata Puzanowska
Benedetta Romanin
Björn Jensen
Bo Wang
Brent Richards
Bruno Frediani
C. Adams
C. Ahmed
C. Almaden-Boyle
C. Ashbrook-Raby
C. Basikolo
C. Battle
C. Beazley
C. Beith
C. Borra
C. Brandwood
C. Brantwood
C. Burnett
C. Castro Delgado
C. Clark
C. Clulow
C. Collins
C. Cruz
C. Davis
C. Demetriou
C. Dennis
C. Dexter
C. Downes
C. Eastgate
C. Finch
C. Gibson
C. Gorman
C. Hays
C. Hewitt
C. Holl
C. Howcroft
C. Humphrey
C. Jackson
C. Jardine
C. Jennings
C. Jones
C. Kaye
C. Lynch
C. Lyons
C. McCulloch
C. McParland
C. McParland
C. Murphy
C. Parmar
C. Pawley
C. Phillips
C. Phillips
C. Pothecary
C. Pothecary
C. Prendergast
C. Price
C. Rishton
C. Shovelton
C. Sicat
C. Stuart
C. Summers
C. Swan
C. Thompson
C. Thorpe
C. Tibke
C. Tierney
C. Vigurs
C. Wells
C. Whitton
C. Whyte
C. Wrey Brown
Carlo Maj
Carmelo Piscopo
Caroline Abernathy
Caterina Lo Rizzo
Ce Dunmore
Cecilia Costa
Ceilia Boz
Cesira Nencioni
Chadi Saad
Charles Hinds
Charlotte Summers
Chenqing Zheng
Chiara Barbieri
Chiara Fallerini
Chiara Gabbi
Chiara Spertilli Raffaelli
Chris P. Ponting
Chris Ponting
Christian Herr
Christof Winter
Christoph D. Spinner
Clark D. Russell
Claudia Suardi
Claudio Ferri
Clemens M. Wendtner
Cristina Mussini
D. Antcliffe
D. Bakthavatsalam
D. Banach
D. Baptista
D. Bell
D. Branney
D. Brealey
D. Brealey
D. Butcher
D. Butcher
D. Childs
D. Clarke
D. Collier
D. Collier
D. Cristiano
D. Dawson
D. Donaldson
D. Duffin
D. Golden
D. Griffin
D. Hawcutt
D. Hope
D. Horner
D. Kallon
D. Kaye
D. Kelly
D. Loader
D. Lomas
D. Martin
D. McGlynn
D. McLaughlanv
D. Melia
D. Menzies
D. Mullan
D. Pogson
D. Potla
D. Potoczna
D. Purohit
D. Raynard
D. Salutous
D. Salutous
D. Scaletta
D. Shaw
D. Skinner
D. Smyth
D. Strachan
D. Tetla
D. Thornton
D. Trodd
D. Vedage
D. Walker
D. Warren
D. Williams
D. Wood
D. Wright
Daniela Francisci
Danilo Tacconi
Danny McAuley
David Bennett
David Harrison
David Maslove
Davide Grassi
Davide Romani
Dawn Law
Diana Alaverdian
Diana Martonik
Diego Ripamonti
Domenico A. Coviello
Dorota Pasko
Dorota Zarębska-Michaluk
E. Abaleke
E. Allan
E. Anastasescu
E. Andrews
E. Apetri
E. Beech
E. Beranova
E. Bevan
E. Black
E. Brinkworth
E. Collins
E. Combes
E. Davies
E. Dobson
E. Dooks
E. Fisher
E. Gendall
E. Goff
E. Goodwin
E. Gordon
E. Heeney
E. Horsley
E. Hughes
E. Johnson
E. Jude
E. Knights
E. Lee
E. London
E. Maccacari
E. Massey
E. McKenna
E. Meadows
E. Moncur
E. Morino
E. Mwaura
E. Peasgood
E. Perkins
E. Radford
E. Raith
E. Salciute L. Grauslyte
E. Smith
E. Smithson
E. Stoddard
E. Stones
E. Thomas
E. Tilney
E. Timlick
E. Treus Gude
E. Virgilio
E. Watson
E. Wilby
E. Wraith
Edoardo Conticini
Elena Andreucci
Elena Bargagli
Elena Desanctis
Elisa Benetti
Elisa Frullanti
Elisabetta Menatti
Elisabetta Schiaroli
Ellie Mcmaster
Elvina Gountouna
Emanuele Catena
Enrico Cabri
Enrico Martinelli
Erika Fiorentini
Erola Pairo-Castineira
Erola Pairo-Castineira
Esther Duncan
Eugenia Quiros-Roldan
Eva C. Schulte
Eva C. Schulte
F. Anderson
F. Auld
F. Bibi
F. Davies
F. Farquhar
F. Fisher
F. Hurford
F. Kibutu
F. McNeela
F. Moore
F. Nasir
F. Trim
F. Wakinshaw
F. Williams
Fabian Brand
Fabio Lena
Faisal Almalki
Federica Gaia Miraglia
Federico Anedda
Federico Franchi
Ferdinando Giannattasio
Filip Taneski
Filippo Aucella
Filippo Biscarini
Fiona Griffiths
Floriana Valentino
Francesca Andretta
Francesca Ariani
Francesca Colombo
Francesca Fava
Francesca Gatti
Francesca Mari
Francesca Minnai
Francesca Montagnani
Francesca Vichi
Francesco Bianchi
Francesco Brancati
Francesco Castelli
Francesco Menichetti
Francesco Paciosi
Francesco Raimondi
Francesco Vladimiro Segala
Francis P. Crawley
Franco Maggiolo
Franco Marinangeli
G. Andrew
G. Arbane
G. Bell
G. Bercades
G. Croston
G. Debreceni
G. Durrant
G. Hambrook
G. Hobden
G. Houston
G. Hughes
G. Jones
G. Lubimbi
G. Maloney
G. Martir
G. Millen
G. Mills
G. O’Connor
G. Randell
G. Sadera
G. Seddon
G. Sera Howe
G. Sloane
G. Subramanian
G. Tsinaslanidis
G. Turner
G. Watson
G. Wray
Gabriela Sokołowska
Gabriella Coiro
Gabriella Doddato
Gabriella Maria Squeo
GEN-COVID Multicenter Study
Genni Spargi
GenOMICC Consortium
Giada Beligni
Gian Piero Caldarelli
Gianfranco Parati
Giovanna Morelli
Giulia Gori
Giuseppe Fiorentino
Giuseppe Merla
Giusy Tiseo
Graeme Grimes
Guillaume Butler-Laporte
Guillaume Butler-Laporte
H. Bancroft
H. Bates
H. Belfield
H. Blackman
H. Blakemore
H. Brooke
H. Button
H. Coles
H. Curgenven
H. Filipe
H. Fox
H. Golding
H. Hill
H. Holcombe
H. Houlden
H. Jeffrey
H. Kent
H. Langton
H. McGuinness
H. Meghari
H. Millward
H. Moore
H. Parker
H. Prady
H. Quinn
H. Rangarajan
H. Rehman
H. Reschreiter
H. Riley
H. Sainsbury
H. Savill
H. Sturgeon
H. T-Michael
H. Tench
H. Tiveran
H. Turner
H. Whittle
H. Willis
H. Wood
Hadeel AlBardis
Hamdi Mbarek
Hanning Mal
Helen Szoor-McElhinney
Hugh Montgomery
Hugo Zeberg
Hugo Zeberg
I. Ali Mohamed Ali
I. Balagosa
I. Birkinshaw
I. Burn
I. Chadbourn
I. D. Clement
I. Edmond
I. Frost
I. Hass
I. Hussain
I. Lancoma-Malcolm
I. Leadbitter
I. Nagra
I. Otaha
I. Otahal
I. Turner-Bone
I. Welters
I. White
I. Wynter
Ilaria Meloni
Ilaria Rancan
Immacolata Andolfo
Isabella Zanella
Iwona Mozer-Lisewska
J. Allan
J. Barker
J. Bewley
J. Biddle
J. Birch
J. Birch
J. Bradley-Potts
J. Brent Richards
J. brown
J. Bryant
J. Butler
J. Camsooksai
J. Camsooksai
J. Carter
J. Caterson
J. Cebrian Suarez
J. Cockerill-Taylor
J. Cole
J. Colley
J. Cooper
J. Cupitt
J. Cuttler
J. Daglish
J. Dawson
J. Dearden
J. Deery
J. Donnachie
J. Dykes
J. Easton
J. Fernandez Roman
J. Finn
J. Fletcher
J. Frankham
J. Gaylard
J. Gill
J. Godden
J. Goodsell
J. Gregory
J. Greig
J. Gurasashvili
J. Hardy
J. Harris
J. Hatton
J. Hawes
J. Highgate
J. Hornsby
J. Hulme
J. Hunt
J. Hutter
J. Ingham
J. Jones
J. Jones
J. K. Baillie
J. Kassam
J. Kenneth Baillie
J. Kenneth Baillie
J. Kenneth Baillie
J. Keshet-price
J. Liew
J. Little
J. Mallinson
J. Martin
J. Matthews
J. McCormick
J. Medhora
J. Melville
J. Moreno Cuesta
J. Morgan
J. Naisbitt
J. North
J. Parkin
J. Pendlebury
J. Perez
J. Perry
J. Pheby
J. Philbin
J. Pinnell
J. Queiroz
J. Radhakrishnan
J. Reid
J. Rhodes
J. Riches
J. Ritzema
J. Ruddy
J. Ryan-Smith
J. Scriven
J. Scriven
J. Scriven
J. Shiel
J. Singh
J. Singleton
J. Smith
J. Sowter
J. Strickley
J. Summers
J. Taylor
J. Tebbutt
J. Texeira
J. Thomas
J. Thrush
J. Tomlinson
J. Valentine
J. Whiteside
J. Wilkins
J. Willson
J. Zamikula
Jacek Bogocz
Jacob Rosén
James F. Wilson
James Furniss
James Furniss
Jane Weaver
Jen Meikle
Jerzy Jaroszewicz
Jessica Nordlund
Jian Yang
Joanna Chorostowska-Wynimko
Jochen Schneider
Johanna Erber
John Kenneth Baillie
Johnny Millar
Jonathan Millar
Jörn Walter
Julia Fazaal
Julia Schröder
Julian Knight
Junghyun Jung
Justyna Kowalska
Justyna Raczkowska
K. Archer
K. Austin’
K. Baines
K. Bauchmuller
K. Beaumont
K. Beesley
K. Black
K. Burns
K. Burt
K. Cawley
K. Cawthron
K. Connolly
K. Convery
K. Criste
K. Dale
K. Darlington
K. Davies
K. Dent
K. Douglas
K. Duffy
K. Elliott
K. Elston
K. English
K. Fernandes
K. Fletcher
K. Gilbert
K. Golder
K. Hammerton
K. Hanson
K. Hard
K. Harrington
K. Hayes
K. Holding
K. Holdroyd
K. Howard
K. Hugill
K. Inweregbu
K. Jackson-Lawrence
K. Karthik
K. King
K. Knowles
K. Lang
K. Liyanage
K. Manso
K. Netherton
K. Postlethwaite
K. Potts
K. Prager
K. Praman
K. Priestley
K. Pritchard
K. Puxty
K. Reid
K. Riches
K. Rooney
K. Sellick
K. Shuker S. Greer
K. Simpson
K. Simpson
K. Slevin
K. Smith
K. Sollesta
K. Stammers D. Fottrell-Gould
K. Stroud
K. Sweet
K. Tatham
K. Turner
K. Webster
K. White
K. Williams
K. Xavier
Kamil Grubczak
Karolina Chwialkowska
Katarzyna Hafezi
Kathy Rowan
Kathy Rowan
Katia Capitani
Katja Hanslin Anna Gradin
Kerstin U. Ludwig
Kerstin U. Ludwig
Kirstie Morrice
Konrad Rawlik
Kristina Zguro
Krzysztof Simon
Krzysztof Tomasiewicz Małgorzata Pawłowska
L. Abel
L. Akeroyd
L. Allen
L. Armstrong
L. Barclay
L. Benham
L. Botfield
L. Bough
L. Brimfield
L. Bunni
L. Cabrelli
L. Cagova
L. Catlow
L. Ding
L. Ferguson
L. Folkes
L. Foster
L. Garner
L. Gemmell
L. Georg
L. Glass
L. Glass
L. Gledhill
L. Grimmer
L. Gurr
L. Harrison
L. Hodgson
L. Hudig
L. Keating
L. Kittridge
L. Lankester
L. Lennon
L. Lim
L. Ma
L. Marshall
L. Matupe
L. Mc Morrow
L. McQuillan
L. Mew
L. Mostoles
L. Mwaura
L. Newey
L. Ortiz-Ruiz de Gordoa
L. Ortiz-Ruizdegordoa
L. O’Brien
L. O’Malley
L. O’Neill
L. Park
L. Pippard
L. Prentice
L. Rad
L. Ramos
L. Riddles
L. Roche
L. Roche
L. Rooney
L. Rosaroso
L. Shaw
L. Smith
L. Stevenson
L. Symon
L. Thomis
L. Thornton
L. Thrasyvoulou
L. Ting
L. Tonks
L. Turner
L. van Koutrik
L. Wilcox
L. Wild
L. Wilding
L. Woods
L. Wren
L. Zitter
Laura Bergantini
Laura Di Sarno
Lee Murphy
Leonardo Croci
Leonardo Gianluca Lacerenza
Letizia Attala
Lia Crotti
Lisa Knopp
Lombardi Stefania
Lorenzo Salerni
Lorna Donnelly
Louise Cullum
Louise Macgillivray
Loukas Moutsianas
Lowell Ling
Luca Cantarini
Luca Guidelli
Luca Masucci
Lucia Vietri
Lucija Klaric
Luisa Tavecchia
M. Abdelrazik
M. Al-Moasseb
M. Balasubramaniam
M. Bellamy
M. Birt
M. Blunt
M. Bokhari
M. Bolton
M. Brady
M. Breekes
M. Brett
M. Bromley
M. Bruce
M. Brunton
M. Burton
M. Callaghan
M. Carmody
M. Carnahan
M. Casey
M. Casey
M. Caswell
M. Chablani
M. Clapham
M. Clark
M. Clark
M. Coulding
M. Croft
M. Cunningham
M. Davey
M. Davies
M. Davies
M. Edward
M. Elhassan
M. Elsaadany
M. Faulkner
M. Forsey
M. Frise
M. Gellamucho
M. Gill
M. Gummadi
M. Halkes
M. Harkins
M. Hill
M. Hobrok
M. Holland
M. Home
M. Hussain
M. Jackson
M. Jacqui
M. K. Phull
M. Kent
M. Khan
M. Latif
M. Leigh
M. Lopez Martinez
M. Lyons
M. Male
M. Marani
M. Margarson
M. Marotti
M. Matharu
M. McDonald
M. McLaughlin
M. McMahon
M. McPhail
M. Meredith
M. Mpelembue
M. Msiska
M. Mulcahy
M. Nauman Akhtar
M. Newton
M. Oblak
M. Odam
M. Ostermann
M. Patel
M. Peiu
M. Penacerrada
M. Peters
M. Popescu
M. Poulaka
M. Purewal
M. Raj
M. Robinson
M. Sangombe
M. Shankar-Hari
M. Sim
M. Slaughter
M. Smith
M. Spivey
M. T. Hijazi
M. Taylor
M. Taylor
M. Taylor
M. Taylor
M. Taylor
M. Templeton
M. Thankachen
M. Thirumaran
M. Thomas
M. Tolson
M. Usher
M. Varghese
M. Verlande
M. Vertue
M. Watters
M. White
M. Williams
M. Wills
M. Woodruff
M. Young
Maaike Swets
Maciej Bura
Maddalena Fratelli
Magdalena Niemira
Magdalena Ochab
Malak Abedalthagafi Manal Alaamery
Malcolm G. Semple
Manola Pisani
Manu Shankar-Hari
Marc M. Berger
Marcello Maffezzoni
Marcin Moniuszko
Marco Castori
Marco Falcone
Marco Feri
Marco Gori
Marco Mandalà
Marco Rizzi
Marco Tanfoni
Marco Vecchia
Margherita Baldassarri
Mari Ward
Maria Antonietta Mazzei
Maria Antonietta Mencarelli
Maria Bandini
Maria Lorubbio
Maria Palmieri
Maria Teresa La Rovere
Marie Zechner
Marie Zechner
Mario Capasso
Mario Tumbarello
Mario U. Mondelli
Markus M. Nöthen
Marta Colaneri
Marta Corridi
Mary Ann Belli
Massimiliano Fabbiani
Massimo Antonio Di Pietro
Massimo Carella
Massimo Girardis
Massimo Vaghi
Matteo Bassetti
Matteo Della Monica
Matteo Siano
Maurizio Bussotti
Maurizio Sanarico
Maurizio Sanguinetti
Maurizio Spagnesi
Max Head Fourman
Max Head Fourman
Melania Degli Antoni
Menè Roberto
Michael Hultström
Michael Hultström
Miklos Lipcsey
Miklós Lipcsey
Mirco Lenzi
Mirella Bruttini
Miriam Lucia Carriero
Miriana D’Alessandro
Mirjam Lista
Miroslaw Czuczwar
Mirosław Kwasniewski
Mohamed Fawzy
Moneera Alsuwailm
Monika Pazgan-Simon
N. Ahmad
N. Bandla
N. Baxter
N. Bhatia
N. Boyle
N. Capps
N. Clarke
N. Crisp
N. Davidson
N. Dormand
N. Grau
N. Harris
N. Jacques
N. Keenan
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Wadha Al-Muftah
WES/WGS Working Group Within the HGI
Wiktoria Izdebska
Wilna Oosthuyzen
X. Qiu
Xia Shen
Y. Baird
Y. Choudhury
Y. Hussain
Y. Jackson
Y. Thirlwall
Yanara Marincevic-Zuniga
Yang Wu
Yaser Al-Sarraj
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Z. Fernandez
Z. Garland
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Z. Omar
Z. Prime
Z. Scott
Zhijian Yang
Publication venue
Publication date: 01/01/2022
Field of study

The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)

Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls

Author: Abel K
Adamali H
Adeloye D
Adeyemi O
Adrego R
Aguilar Jimenez LA
Ahmad Haider N
Ahmad S
Ahmed R
Ahwireng N
Ainsworth M
Al-Sheklly B
Alamoudi A
Ali M
Aljaroof M
All AM
Allan L
Allen RJ
Allerton L
Allsop L
Almeida P
Altmann D
Alvarez Corral M
Amoils S
Anderson D
Antoniades C
Arbane G
Arias A
Armour C
Armstrong L
Armstrong N
Arnold D
Arnold H
Ashish A
Ashworth A
Ashworth M
Aslani S
Assefa-Kebede H
Atkin C
Atkin P
Aul R
Aung H
Austin L
Avram C
Ayoub A
Babores M
Baggott R
Bagshaw J
Baguley D
Bailey L
Baillie JK
Bain S
Bakali M
Bakau M
Baldry E
Baldwin D
Baldwin M
Ballard C
Banerjee A
Bang B
Barker RE
Barman L
Barratt S
Barrett F
Basire D
Basu N
Bates A
Bates M
Batterham R
Baxendale H
Bayes H
Beadsworth M
Beckett P
Beggs M
Begum M
Beirne P
Bell D
Bell R
Bennett K
Beranova E
Bermperi A
Berridge A
Berry C
Betts S
Bevan E
Bhui K
Bingham M
Birchall K
Bishop L
Bisnauthsing K
Blaikely J
Bloss A
Bolger A
Bolton CE
Bonnington J
Botkai A
Bourne C
Bourne M
Bramham K
Brear L
Breen G
Breeze J
Briggs A
Bright E
Brightling CE
Brightling CE
Brill S
Brindle K
Broad L
Broadley A
Brookes C
Broome M
Brown A
Brown CW
Brown J
Brown JS
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Brown V
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Subbe C
Sudlow CL
Suleiman Z
Summers C
Summersgill C
Sutherland D
Sykes DL
Sykes R
Talbot N
Tan AL
Tarusan L
Tavoukjian V
Taylor A
Taylor C
Taylor J
Te A
Tedd H
Tee CJ
Teixeira J
Tench H
Terry S
Thackray-Nocera S
Thaivalappil F
Thamu B
Thickett D
Thomas AK
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Thompson AAR
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Thornton T
Thorpe M
Thwaites RS
Tilley J
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Tiongson GF
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Tomlinson J
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Toshner M
Touyz R
Tripp KA
Tunnicliffe E
Turnbull A
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Turner V
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Ugwuoke R
Upthegrove R
Valabhji J
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Vere J
Vickers C
Vinson B
Vivaldi G
Wade E
Wade P
Wain LV
Wain LV
Wainwright T
Wajero LO
Walder S
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Walsh JA
Walsh S
Warburton L
Ward TJC
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Woods J
Wootton DG
Wormleighton J
Worsley J
Wraith D
Wright C
Wright L
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Wyles J
Wynter I
Xu M
Yasmin N
Yasmin S
Yates T
Yip KP
Young A
Young B
Young S
Yousuf AJ
Zawia A
Zeidan L
Zhao B
Zheng B
Zheng B
Zongo O
Publication venue: 'Elsevier BV'
Publication date: 27/03/2023
Field of study

Background The risk factors for recovery from COVID-19 dyspnoea are poorly understood. We investigated determinants of recovery from dyspnoea in adults with COVID-19 and compared these to determinants of recovery from non-COVID-19 dyspnoea. Methods We used data from two prospective cohort studies: PHOSP-COVID (patients hospitalised between March 2020 and April 2021 with COVID-19) and COVIDENCE UK (community cohort studied over the same time period). PHOSP-COVID data were collected during hospitalisation and at 5-month and 1-year follow-up visits. COVIDENCE UK data were obtained through baseline and monthly online questionnaires. Dyspnoea was measured in both cohorts with the Medical Research Council Dyspnoea Scale. We used multivariable logistic regression to identify determinants associated with a reduction in dyspnoea between 5-month and 1-year follow-up. Findings We included 990 PHOSP-COVID and 3309 COVIDENCE UK participants. We observed higher odds of improvement between 5-month and 1-year follow-up among PHOSP-COVID participants who were younger (odds ratio 1.02 per year, 95% CI 1.01–1.03), male (1.54, 1.16–2.04), neither obese nor severely obese (1.82, 1.06–3.13 and 4.19, 2.14–8.19, respectively), had no pre-existing anxiety or depression (1.56, 1.09–2.22) or cardiovascular disease (1.33, 1.00–1.79), and shorter hospital admission (1.01 per day, 1.00–1.02). Similar associations were found in those recovering from non-COVID-19 dyspnoea, excluding age (and length of hospital admission). Interpretation Factors associated with dyspnoea recovery at 1-year post-discharge among patients hospitalised with COVID-19 were similar to those among community controls without COVID-19. Funding PHOSP-COVID is supported by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19. The views expressed in the publication are those of the author(s) and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health and Social Care. COVIDENCE UK is supported by the UK Research and Innovation, the National Institute for Health Research, and Barts Charity. The views expressed are those of the authors and not necessarily those of the funders

Archivio istituzionale della ricerca - Università dell'Insubria

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Author: Aahlin EK
Aamer A
Aaniana K
Ababneh A
Abaliksta T
Abantanga F
Abantanga F
Abbas A
Abbas M
Abbasy J
Abbo O
Abbo O
Abbott T
Abbouch M
Abd El Galeel A
Abd El Hameed OS
Abd El Hamid N
Abd El Salam Y
Abd El Slam M
Abd El-Salam F
Abd Elrasoul Y
Abd-Elmawla M
Abd-Elrasoul Y
Abdallah E
Abdallah E
Abdel-Aty A
Abdel-Hameed N
Abdel-Kader SM
Abdel-Wahab NYE
Abdelaal A
Abdelaty M
Abdelazeam AR
Abdelazim G
Abdelaziz MA
Abdelbadeai K
Abdelfatah A
AbdelFattah I
Abdelgelil A
Abdelghany S
Abdelhady S
Abdelhamed R
Abdelhamid A
Abdelhaq A
Abdelkader M
Abdelkader M
Abdelkader O
Abdelkareem A
Abdelkhalek M
Abdelmageed E
Abdelmotaleb I
Abdelraheim M
Abdelraouf AM
Abdelrouf DM
Abdelshafy M
Abdelshakour M
Abdrabou AK
Abdul-Latif S
Abdulaziz H
Abdulaziz M
Abdulbagi O
Abdulgawad M
Abdulhakeem EM
Abdullah AAN
Abdullah MA
Abdullah N
Abdullah NAN
Abdullah NAN
Abdullahi L
Abdurrazzaaq A
Abebe NS
Abebe NS
Abem OE
Aber A
Abington E
Abiola O
Aboarab A
Aboelella M
Aboelmagd O
Aboelsoud MR
Aboraya M
Aboraya M
Abouelnasr A
Aboul-Naga MS
Abouzahra A
Abouzaid A
Abozaid M
Abozeid K
Abozyed MAF
Abu Qumbos A
Abu-toyour M
Abubakr M
Abudeeb H
Abuowda Y
Abuqwaider E
Abusalem L
Abuseif M
Abushamleh S
Acharya P
Ackom E
Acquah E
Adam A
Adam N
Adams R
Adamu A
Adawi I
Adawi M
Adebanjo A
Adebanjo A
Adebola O
Adedeji A
Adekoya A
Adel A
Adel A
Adel BE
Adel I
Adella FJ
Adelshone A
Ademuyiwa A
Ademuyiwa A
Ademuyiwa AO
Ademuyiwa AO
Ademuyiwa AO
Ademuyiwa AO
Adenekan B
Adeniran J
Adeniran J
Adeniyi A
Adeniyi A
Adesanya O
Adesanya O
Adesina A
Adesina A
Adesuyi A
Adeyeye A
Adeyeye A
Adeyeye A
Adham W
Adhitama N
Adil M
Adisa AO
Adisa AO
Adu-Aryee N
Afana S
Afandy A
Afifi AM
Afzal M
Agalianos C
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Agarwal A
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Agbedinu K
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Aglan A
Aguado Suarez N
Aguilar-Jimenez J
Aguilera M
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Aguilera ML
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Aguilera-Arevalo M-L
Ahlonsou G
Ahlqvist S
Ahlqvist S
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Ahmed A
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Ahmed LAM
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Ahounou EYS
Aigrain Y
Aiyaman C
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Ajai O
Ajao A
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Al Amin S
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Al Awwad S
Al Barrawi FE
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Al Meligy A
Al Rafati AAR
Al Raouf EA
Al Saied G
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Al-Aarag AA-R
Al-Azraqi IAA
Al-Bahrani A
Al-Buhaisi A
Al-Dakka E
Al-Faifi JJ
Al-faqawi M
Al-farram H
Al-Hameedi HII
Al-Hasani RKMJ
Al-khatib A
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Al-Obaedi O
Al-saqqa S
Al-Saqqa SW
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Al-shammari A
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Ali A
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Alrifaie A
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Alsaggaf M
Alsaggaf MU
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Altaf A
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Altarayra M
Althwainy A
Altibi A
Altinel Y
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Altoe F
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Alvarado Jaramillo R
Alvarez Barreda LM
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Amin HAA
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Ammar M
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Andika FFA
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Andriola V
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Angelieri D
Anis E
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Antezana D
Anthoulakis C
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Antoniozzi A
Anwar AW
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Anyanwu L-J
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Aonzo P
Appeadu-Mensah W
Appiah EK
Aql S
Aquilino F
Arachchi PP
Arachchige LAJJ
Arafa O
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Arango MCM
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Aranzabal Durand SY
Araujo R
Arcudi C
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Arevalo Azmitia JR
Arias Pacheco RD
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Armando ChunguiBravo J
Armellini A
Arnaud A
Arnaud AP
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Arnaud AP
Arroyo Basto CA
Arshad MM
Arslan E
Arsyad HM
Arthur T
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Aruldas N
Asal M
Asar YH
Asare-Bediako K
Asele FA
Ashour A
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Ashraf SF
Ashtari M
Ashton A
Asi F
Asilah SMD
Assal A
Assouto PA
Asturia S
Asumah H
Ata A
Ata AAA
Ata AY
Atiyeh A
Atkins ET
Atkinson K
Atobatele K
Attallah NA
Attard M
Attia A
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Augestad KM
Aung KP
Austraite A
Aviles S
Avoka A
Awad I
Awad SA
Awadallah S
Awuku-Asabre J
Ayad S
Ayandipo O
Ayandipo OO
Aydin MC
Ayyar S
Aziz DNA
Aziz MRA
Aziz NA
Azizeldine MG
Azmitia Mendizabal CA
Azodo IA
Azzie G
Azzie G
Azzis O
Baba S
Bachri H
Badawy M
Badenjki MA
Badicel M
Badr A
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Baird A
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Baki BE
Bakr A
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Balila RMH
Balkan AZA
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Balmaceda R
Balmaceda R
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Balogun F
Baltrunas R
Baluch F
Bamford R
Bamicha A
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Banaitis VJ
Bandi A
Bandoh D
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Banipal GS
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Barakat SAE
Barendegere V
Barker T
Barkolias C
Barmayehvar B
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Barroso de Lima CV
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Basir ERM
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Basso SMM
Basson S
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Beamon M
Beasley W
Beaton C
Bedada AG
Bediako-Bowan A
Behar N
Beisa V
Beisa V
Bekhet AH
Bekhet NM
Beleno AEM
Belkouchi A
Belli A
Bello B
Benammi S
Benevento A
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Benger M
Bennai RM
Benons N
Bentounsi Z
Benyaiche C
Berti S
Bertuello I
Beuran M
Beuran M
Beyene R
Bezerra Morais PA
Bezzina M
Bhang A
Bhangu A
Bhangu A
Bhargava A
Bharj IS
Bhat S
Bhatnagar A
Bhattacharya S
Bhopal KF
Bhopal KF
Bianco F
Bigaran A
Billy M
Bin Adnan A
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Bin Ismail MJ
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Borda-Luque G
Borda-Luque G
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Braungart S
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Cengiz TB
Cengiz Y
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Delforge X
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Deputy M
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Dervenis C
Despotidis V
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Devadasar GH
Dharamshi HA
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Di Franco F
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Diab A
Diaconescu B
Diaconescu I-B
Dias S
Diaz Vico T
Diaz-Jover P
Diaz-Zorrilla C
Dick L
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Dijan E
Dimech T
Din F
Dindyal S
Dindyal S
Dione Parreno-Sacdalan M
Dissanayake T
Djivoh F
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Dorisme A
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Elbisomy KH
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Elfouly Y
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Elhusseiny AAE
Elizabeth Lopez C
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Elsabbagh N
Elsameea AA
Elsawahly DME
Elsawy A
Elsayed M
Elsayed M
Elsayed N
Elsayed NAR
Elsayed ZM
Elsebaaye AO
Elsehimy M
Elsemelawy R
Elshaar M
Elshaer K
Elshaer M
Elshaer M
Elshafay AE
Elshami M
Elshanwany S
Elsharkawy AA
Elsheikh S
Elsherbiney S
Elsherbiny AS
Elsherif FA
Elshobary M
Elsiddig M
Elsobky S
Elsorogy DEAA
Elwaey A
Elwakil H
Elwan A
Elwan A
Elwy E
Elzahed N
Elzayat I
Elzayat M
Elzayyat I
Elzowawi F
Emadeldin D
Emadeldin H
Emara E
Emile S
Eng C
English W
Esam A
Escalante Salas MDC
Espin-Basany E
Espinoza F
Essam A
Essam AA
Essam M
Essoun S
Esteban E
Estee MM
Estupinian S
Etchill E
Etchill E
Etienne S
Etman M
Etwire V
Evajelista CV
Evans D
Evans E
Eysa A
Eyssartier E
Ezzat E
Ezzat T
Faboya O
Faccincani R
Fadel A
Fahiem A
Fahim M
Fahmy MAB
Fahy C
Fairfield C
Fairfield C
Fairfield C
Fairfield C
Fakher R
Falaschi F
Falco N
Falzon M
Farag A
Farag S
Farah A
Farahat MM
Faraz A
Fares M
Farhad M
Farhan-Alanie MMH
Farhangmehr N
Farinella E
Farmakis K
Farooq T
Farouk SAM
Farquharson A
Farrugia A
Farrugia A
Faruq A
Fathy AM
Fattah AA
Fatuga A
Faturoti O
Faturoti O
Faure A
Fautz T
Favero A
Fawzy A
Feidantsis T
Felipe CO
Fergany A
Fergusson SJ
Fergusson SJ
Fergusson SJ
Fergusson SJ
Fermani C
Fermani CG
Fernandes C
Fernandez C
Fernandez-Bueno F
Fernandez-Vega L
Ferousis C
Ferrero E
Fievet L
Filatau A
Findlay-Cooper K
Firdouse M
Firdouse M
Firdouse M
Firwana A
Fitsum A
Fitzgerald JE
Fitzgerald JE
Florez Farfan ES
Foco M
Fok CYJ
Fontana T
Foo CC
Forlin L
Forno W
Fouad A
Fouad D
Fouad D
Fourcade L
Fowler AJ
Fozard T
Fozard T
Frade F
Fraga GP
Francisco Roxas M
Franco H
Francois P
Francois-Coridon H
Francone E
Freitas AV
Frey D
Frisk B
Fuentes-Rivera L
Fujii F
Furqan MM
Gaafar S
Gaarder T
Gad A
Gad MO
Gadelkarim M
Gadhvi V
Gado A
Gaignard E
Gaignard E
Gaizauskas V
Gala T
Gala T
Galiqi G
Galleano R
Gallo G
Galloway S
Galvez CP
Gamal D
Gamal E
Gamal H
Gamal S
Gamaly E
Gamil D
Gan C
Gan YY
Gani MA
Garaycochea O
Garcia Bernardo C
Garcia Florez LJ
Garcia Septiem J
Garcia Torres CP
Garcia-Florez L
Garland A
Gash K
Gash K
Gash K
Gastaldi P
Gasteratos K
Gaujoux S
Gavagna L
Gbessi DG
Gemeah M
Gemenetzis G
Gemenetzis G
George R
Germanos S
Germanos S
Gerosa A
Gerosa A
Geuoshy A
Ghaben A
Ghandora N
Ghanem A
Ghanem E
Ghanem S
Ghanem S
Ghannam M
Gharib A
Gharib A
Ghazy AA
Gheith A
Ghetia M
Ghetia M
Ghonaim MA
Ghoneem M
Ghoneim O
Giacci L
Giardino FR
Giavarini L
Giglio MC
Gilbert R
Gilbert RW
Giles J
Gillespie M
Gimzewska M
Giraldo RSR
Giuliani S
Giuliani S
Giuriato TF
Gkiokas G
Glasbey J
Glasbey J
Glasbey JC
GlobalSurg Collaborative
Glover TE
Glover-Addy H
Glynn M
Gobin N
Gobin N
Goh CC
Goh CC
Goh W
Gohar ME-SAM
Gokani S
Goldin E
Golding D
Gomaa A
Gomah M
Gonzales Montejo MS
Gonzales Stuva JP
Gonzalez M
Goodstein M
Gosling S
Gosling SG
Gouda A
Gould L
Gouldthorpe C
Gouvas N
Gouws J
Graffeille V
Graffieille V
Gran M
Grandinetti PP
Grant A
Grasset E
Grasset E
Grassi V
Gratton R
Gravante G
Gravante G
Gray D
Grech N
Green N
Grella MG
Gribauskaite J
Griffiths E
Griffiths E
Griffiths M
Grima T
Grisin E
Grizhja B
Grobler DC
Grosos C
Grossart C
Gubeli A
Gudal A
Gudal A
Gudal A
Gudlaugsdottir K
Guevara Torres S
Guevara R
Guglielmo V
Gui D
Gul E
Gulbinas A
Gulcicek OB
Gulielmi A
Gultom PA
Gumar M
Gunaseelan K
Gunawan R
Guner A
Gunnarsson U
Guo W
Gupta A
Gustafsson U
Guzman Duenas C
Gyamfi FE
Gyanchandani N
Gyedu A
Habeeb MA
Habeeb O
Habeebullah A
Hache-Marliere M
Haddad N
Hafez AT
Hafez M
Hafez M
Hafez S
Haffreingue A
Hafiz S
Hagan R
Hagar A
Haines M
Haines S
Hajeh H
Hakim H
Halhouli O
Halhouli O
Halicioglu I
Hall E
Hall N
Hall NJ
Hall TF
Hallam S
Haloho A
Hamad MGM
Hamarshi A
Hamasaki Hamaguchi JL
Hamasaki J
Hamdan A
Hamdan M
Hamed MF
Hamill D
Hammad A
Hammad A
Hammad AM
Hampton M
Hampton MI
Hamsho W
Hanafy M
Hand C
Hanks A
Hanley I
Hanoun S
Hanrahan M
Hanrahan M
Hanrahan M
Hanrahan M
Hantour U
Hantour U
Hany E
Haque M
Har PAL
Haraux E
Harbord P
Haroun A
Harper E
Harrison EM
Harrison EM
Harrison N
Harrison P
Harrison R
Hartford L
Harvey N
Hasan A
Hasan A
Hasan D
Hasanah A
Hasanain D
Hascoet J
Hashad E
Hasheminia A
Hashim A
Hashish A
Hashish M
Haslegrave A
Hassaan A
Hassaan A
Hassan A
Hassan A
Hassan A
Hassan ATA
Hassan I
Hassan M
Hassan OMM
Hassan S
Hassan Z
Hassanain M
Hassanain M
Hassanein AB
Havemann I
Hawkins W
Heard R
Heath J
Heffernan D
Hegazy EM
Hegazy Y
Helene F-C
Helguero-Santin LM
Hemeda D
Hemingway D
Hemmila M
Hemmila M
Henderson L
Henderson L
Heng HE
Henric N
Henry F
Henshall DE
Herebat A
Herikstad R
Herrera Matta JJ
Herrera Puma CM
Herrera N
Herrera-Matta J
Herrod P
Hervieux E
Hervieux E
Hesham O
Hettiarachchi TS
Hewage K
Heywood EG
Highcock S
Hilal K
Hinojosa C
Hjertberg M
Hjertberg M
Hmila S
Ho A
Ho CW
Ho W
Ho WC
Hodonou F
Hogea M
Holte S
Homeida A
Hoogakker E
Horobjowsky A
Hosein S-P
Hosh M
Hossaini S
Hossameldin A
Houlden C
Howells L
Howie EE
Hrora A
Huaman E
Humm G
Hunter K
Hussain M
Hussein A
Hussein S
Husseini M
Husseiny R
Hutch W
Huwait A
Iacono C
Iannone I
Ibraheem AAF
Ibraheem HI
Ibrahem AA
Ibrahem AA
Ibrahim A
Ibrahim A
Ibrahim A
Ibrahim AM
Ibrahim E
Ibrahim EM
Ibrahim I
Ibrahim K
Ibrahim M
Ibrahim MH
Ibrahim Y
Idress T
Idris F
Idris SAI
Iftekhar F
Iftikhar Z
Iftikhar Z
Ignatavicius P
Ihediwa G
Imoro O
Ingabire JCA
Ingabire JCA
Ingabire JCA
Ingabire JDLCA
Ioannidis O
Iordache F-M
Iqbal FM
Iqbal MR
Ireland P
Irtan S
Irtan S
Irwin G
Irwin G
Irwin G
Irwin G
Isabel Villegas M
Ishak N
Iskandar F
Isler V
Ismail A
Ismail L
Ismail L
Ismail L
Ismail L
Ismail L
Ismail M
Ismail M
Ismail MK
Ismail SA
Israelsson L
Ivros N
Iyer D
Iyer D
Iyer D
Jabal MS
Jabbar A
Jaber S
Jackson P
Jacobe M
Jaffry Z
Jaffry Z
Jaich R
Jain P
Jama GM
Jamal L
Janardha KC
Janik M
Jankus T
Jara Quezada JH
Jaradat D
Jarmin M
Jasaitis K
Javaid M
Javed O
Javed O
Jawaid M
Jayathilake AB
Jean-Francois C
Jeffery A
Jeffery A
Jenner E
Jennings L
Jennings V
Jennings V
Jensen E
Jenvey C
Jeo WS
Jeon H
Jeremic L
Jethwani DL
Jeyakumar J
Jeyakumar J
Jha M
Jimenez Carneros V
Jimenez J
Jimenez-Morillas P
Joel LWL
Johanna N
Johnson K
Johnston R
Jokubauskas M
Jokubauskas M
Jokubonis K
Jones C
Jones C
Jones E
Jones TF
Jonnalagadda R
Joosten J
Jordan H
Jose Segura-Sampedro J
Jotautas V
Jotautas V
Jovine E
Jovine E
Jubran AF
Juciute S
Julaihi R
Jurdell E
Kaafarani H
Kabariti R
Kabariti R
Kabba J
Kabongo K
Kache S
Kaci AA
Kadiwar S
Kalakouti E
Kalles V
Kalles V
Kalles V
Kamarajah SK
Kamarulzamil SNA
Kamil R
Kamya S
Kanani A
Kandil AM
Kandil H
Kang MK
Kanta TH
Karabacak U
Karabelias G
Karabulut K
Karahan SR
Karakahya M
Karandikar S
Karandikar S
Kariem N
Karim A
Karim R
Karim S
Karismaningtyas H
Karjiker P
Karkeet M
Karkeet M
Karlo R
Karlo R
Karousos D
Karumnas P
Kaselis N
Kaselis N
Kasem E
Kasem EA
Kasputyte S
Kaul A
Kazanavicius D
Kedar A
Kefalidi E
Keke KR
Kelany M
Kenibar A
Kennedy ED
Kennedy M
Kennedy R
Keogh K
Kerley R
Kershaw S
Kesinger M
Khafagy T
Khairy H
Khairy H
Khajanchi M
Khaled H
Khalifah E
Khalili M
Khalique A
Khallaf S
Khamajeet A
Khan A
Khan K
Khan MA
Khan R
Khan S
Khan T
Khan ZA
Kharsa S
Khatri C
Khatri C
Khattab K
Khedr AE-RH
Khoja A
Khoja A
Khokha D
Khokha V
Khosla S
Khouri Ferreira SA
Khreishi R
Khreishi R
Khulu LB
Khyrallh A
Kiasat A
Kidd T
Kielty P
Kim MY-H
Kim S-H
Kim SB
Kimaro M
Kinandu K
King R
King S
King S
Kinnera SV
Kiran RP
Kirby A
Kirishnan A
Kirupagaran A
Kiudelis M
Kjellin A
Klappenbach R
Knight S
Knight SR
Koay KL
Kobal BB
Koh C
Koh H
Koh PY
Koh S
Koh S
Kojo ATT
Kojo ATT
Kojo ATT
Kolosov A
Komolafe O
Kondrotas P
Kong C
Kong SN
Kong V
Kong V
Konstantina K
Kontos M
Kordorwu HEK
Korkolis D
Kosai NR
Kosai NR
Kose E
Koskenvuo L
Kostov E
Kotb AHE-B
Kotecha D
Koto MZ
Kotobi H
Koumpa F
Kouraklis G
Kourdouli A
Kourdouli A
Kretzmann H
Krishna K
Kruspi S
Kufeji D
Kulasabanathan K
Kuliavas J
Kumar B
Kumar B
Kumar B
Kumar BS
Kumar MN
Kumar S
Kumar S
Kumar S
Kumar S
Kumar T
Kumwenda D
Kushwaha S
Kushwaha S
Kusi K
Kutkevicius J
Kwakyeafriyie P
Kwatiwani C
Kwizera S
Kwok SH-W
Kyereh M
Kyriazanos I
Kyrou G
Kyziridis D
L'Heveder A
La Brocca A
la Medina AR-D
Labib P
Ladukas A
Lafferty K
Lagunavicius K
Lai AC-H
Lakhani SM
Lakshmi HN
Lam FY
Lam JCY
Lam WH
Lamanna GL
Lanau MIV
Lando J
Landolfo G
Landolfo G
Lap G
Lapitan MC
Lapitan MC
Larsen JW
Lasek A
Lasheen A
Lasheen KT
Latif A
Laugzemys E
Laugzemys E
Laurie K
Lauzikas G
Law JH
Lawal A
Lawal AO
Lawal T
Lawal TA
Lawani I
Lawther R
Lazzari G
Lazzari V
Lazzarini Cury AD
Le VTH
Leal A
Leal M
Leanne Almanon C
Lecompte J-F
Lee C
Lee EX
Lee F
Lee K
Lee KC
Lee KY
Lee TSB
Lemaire SB
Leone N
Leong FQH
Leppaniemi A
Leppaniemi A
Leroux J
Leung KW
Leung MF
Leusink A
Lewis J
Li KHG
Li KKK
Li WS
Licari L
Lieske B
Lieske B
Liew I
Liew I
Lilford R
Lilford R
Lim G
Lim H
Lim J
Lim PJ
Lim SJ
Lim SJ
Lim SY
Limache S
Limaye N
Limoges B
Linares Delgado MSDFT
Lintin L
Lipnickas V
Litvin A
Liu Q
Liu Q
Livesey A
Livingston M
Ljuhar D
lo Conte A
loaloa MR
Lockey J
Loizides S
Lokman MAA
Longstaff L
Lopez C
Lopez M
Lopez M
Lopez-Arevalo C
Lorenzon L
Lossius WJ
Loughran D
Low X
Luc AR
Lucia Contreras-Vergara A
Luck J
Luck J
Luck J
Luglio G
Luis Rodicio J
Luiz JS
Lund J
Lund J
Lundgren P-O
Luque L
Luque L
Lytras D
Lytras D
Ma J
Mabitsela ME
Mabrouk M
Macchiavello R
Macchitella Y
Macchitella Y
Macdermid E
Macdonald A
Macdonald E
Macdonald KL
Maceviciute K
Macfarlane A
Machaca M
Machain Vega GM
Machain Vega GM
Maciejec L
Madiba T
Madkor MH
Madrid Barrientos LA
Maffioli A
Maffioli A
Magdy A
Magdy B
Magdy E
Magdy H
Magdy M
Magdy S
Magee C
Maghrabi A
Maghrabi AA
Magri D
Mahanty S
Maharaj G
Mahdi A
Mahdi S
Mahdi S
Maher ME
Mahmoud B
Mahmoud H
Mahmoud M
Mahmoud MA
Mahmoud MI
Mahmoud S
Mahmoud SME
Mahmud K
Maillot B
Maimbo M
Maimbo M
Mairs NG
Maison K
Maistry N
Majauskyte D
Majbar A
Majid AHHA
Majid K
Major CP
Major P
Major P
Mak T
Mak TWC
Makama J
Makinde M
Makupe A
Malaga B
Malavenda M
Malik K
Malik P
Malik TAM
Mamdouh E
Mamdouh R
Manatakis DK
Manchego Bautista AC
Manchego Bautista AC
Manfreda S
Mangan C
Mangan C
Mangiapane M
Manipal CE
Maniscalco A
Mann T
Mannu GS
Mano MJB
Manrique Sila G
Manrique Sila GC
Manriquez-Reyes M
Manrrique Sila G
Mansor EY
Mansour B
Mansour S
Mansuri A
Mao P
Mapasse D
Maple N
Maraie N
Marcelo Delgado J
Marey A
Marey AS
Margaritis M
Maria Garcia-Perez J
Mariani A
Marinkovic B
Marinos C
Marks E
Marples L
Marret J-B
Marroquin Rodriguez DE
Marshall DC
Martian B-V
Martin A
Mas R
Mason C
Mat TNT
Mata LPS
Matheu A
Mathew SW
Matos-Puig R
Mattar O
Matter SM
Mauro L
Mayasari M
Mazelyte R
Mazrimas P
Mazzella A
Mcaleer E
Mcaleer S
Mccarthy K
Mccarthy M
Mccarthy M
McCullagh D
Mcdonald R
McGarvie S
Mcguigan A
McIntosh K
Mcintosh R
Mcintyre CJ
Mcintyre N
Mcintyre R
Mclachlan G
Mclean AL
Mclean K
McMorran D
Mcnish D
Mcphee A
Mealy K
Mehdi A
Mehrez S
Melo Cardozo RA
Melo R
Melo R
Mendel H
Mendez M
Mendez N
Mendoza Arango MC
Mendoza Arango MC
Mendoza Arango MC
Mendoza I
Menegussi J
Mensah E
Menshawy A
Mentula P
Meqbil J
Mercado Rodriguez L-A
Mericliler M
Merlini D
Merlini D
Merlo MS
Mesbah N
Meshref A
Messa Aguilar WL
Messa Aguilar WL
Metwally MM
Migliore M
Mihaljevic AL
Mihaljevic AL
Mihanovic J
Mihanovic J
Mijuskovic B
Mikalauskas S
Mikalauskas S
Mikuckyte D
Mikwar Z
Milligan W
Milligan W
Mingrone P
Minguez Garcia J
Minguez G
Minocha A
Minocha A
Miranda C
Mircea H
Mirghani D
Mironescu A
Mironescu A
Mironescu AS
Mironescu AS
Mirza A
Mirza S
Mistry A
Mitrasinovic S
Mitroudi M
Mitroudis N
Mittal A
Mitul AR
Mitul AR
Miyarde Leon A
Mizzi C
Mizzi S
Mlotshwa M
Moaty M
Mochet S
Modolo MM
Modolo MM
Modolo MM
Moe TT
Mogan YP
Moghazy ME
Mohamed A
Mohamed A
Mohamed AM
Mohamed AR
Mohamed B
Mohamed F
Mohamed I
Mohamed M
Mohamed MA
Mohamed MAEH
Mohamed MM
Mohamed O
Mohamed SR
Mohameden A
Mohammad A
Mohammad A
Mohammed A
Mohammed A
Mohammed AR
Mohammed H
Mohammed MM
Mohammed MMH
Mohammed S
Mohan H
Mohan M
Mohan M
Mok YT
Mokhtar A
Molina G
Monaghan E
Monaghan E
Monrad-Hansen PW
Monteleone M
Monteleone M
Montes I
Montes I
Montoya Botero JA
Montrimaite M
Montrimaite M
Moodley Y
Moore R
Moore R
Mora JJV
Morales C
Morandi E
Moreira G
Moreno SC
Morgan C
Morgan C
Morshedy EM
Morsi A
Morsi M
Morton D
Morton D
Morton R
Mosad A
Mosalum O
Mostafa HA
Mostafa M
Mostafa M
Mousa M
Moussa O
Moustafa A
Mouttalib S
Mowafy B
Mphatsoe AM
Mshelbwala P
Msiska N
Msosa V
Msosa V
Muddebihal U
Mukin ADF
Muktar U
Mukuzunga C
Muller C
Muller C
Muller J
Munera A
Munhoz MM
Munipalle PC
Muntean L
Muntean LI
Muralha N
Murphy J
Murray A
Murutoglu B
Musa AEK
Musleh A
Musowoya J
Mussad A
Mustafa M
Mustafa M
Mustafa M-A
Musyoka CK
Mutabazi A
Mutabazi AZ
Mutabazi AZ
Mutlu D
Mutlu V
Muzio E
Myers J
Mykoniatis I
Nabawi A
Nada F
Nadeem N
Nadkarni S
Naess PA
Nagy GS
Nahar SN
Nair H
Najjar M
Nanthakumaran S
Napolitano L
Napolitano L
Naqvi SA
Naqvi T
Naranjo Aristizaibal FA
Narayanan R
Narayanan R
Narvestad JK
Nashaat A
Nashat M
Nasher O
Nashidengo P
Nasir A
Nasir AA
Nasir WNWM
Nasr A
Nasr M
Nasr M
Nassif D
Nastri G
Natalie H
Nataraja R
Natili A
Navarro A
Nawara C
Nawawi A
Nawawi A
Nayel AR
Nazir M
Ndajiwo A
Ndajiwo A
Ndegwa W
Ndlovu SR
Ndwambi P
Negida A
Negoi I
Nel D
Nemeth K
Neo YN
Neo YT
Neophytou C
Nepogodiev D
Nepogodiev D
Nepogodiev D
Nepogodiev D
Nesaratnam A
Nessa A
Nestorovic M
Nevieraite V
Newton T
Ng JCK
Ng S
Ng YK
Ng ZH
Ngayu N
Ngwa TE
Niazi AK
Nicholson L
Nighat B
Nigo S
Nikberg M
Nikoloudis N
Nikoloudis N
Niragire A
Niranjan N
Nirumal MK
Niska K
Nita GE
Nita GE
Niyirera E
Njokanma I
Nnajiuba H
Nocito A
Nocito A
Nofal E
Noor F
Normile C
Normile C
North AS
Notarnicola M
Notarnicola M
Nouh T
Nouh T
Noukpozounkou B
Novak A
Nowers J
Nsengimana VJP
Nsengiyumva C
Ntirenganya F
Ntirenganya F
Nurqistan HD
Nwabuoku E
Nwinee V
Nwokoro C
Nyberg J
Nymo L
O'Connor DB
O'Connor T
O'Higgins Roche M
O'neill M
O'neill S
O'Neill S
O'Shea M
Obute RD
Occhionorelli S
Odeyemi B
Odeyemi B
Odutola O
Ofner D
Ogunsua O
Ogunyemi A
Oh J
Oh J
Ohene-Yeboah M
Okenabirhie O
Olajide TO
Olaolorun A
Olivier J
Olori S
Olori S
Oludara M
Oludara M
Olugbemi M
Omar AA
Omar ME
Omar MFW
Omara S
Omer OA
Onimowo J
Onuoha C
Oosterkamp A
Opoku-Agyeman R
Oram S
Orchard M
Ortega I
Ortega I
Ortega-Vazquez I
Ortiz N
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Publication venue
Publication date: 15/10/2018
Field of study

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe

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