La agresividad en los escolares del segundo grado de primaria de la Institución Educativa Privada American School, San Martín de Porres 2019

La presentación investigación tuvo como objetivo determinar el nivel de agresividad en los estudiantes del segundo grado de primaria de la institución educativa “American School”-San Martin de Porres 2016, investigación básica, diseño descriptivo y enfoque cuantitativo; la muestra estuvo conformada por 30 estudiantes de la Institución Educativa privada American School San Martin de Porres, la técnica que se utilizó fue la observación y el instrumento de recolección de datos fue una ficha de observación; para la validez de los instrumentos se utilizó el juicio de expertos y para la confiabilidad del instrumento se utilizó el coeficiente de confiabilidad Kuder Richardson cuyo valor fue de ,840 se concluyó que la agresividad en los estudiantes de segundo grado de primaria está en el nivel moderado con 46,67 %

La agresividad escolar

La agresividad es todo acto que dañe la integridad de uno más sujetos. La agresividad puede ser tanto física, verbal o psicológicamente. Causando un daño directo, bajando la autoestima y causando traumas emocionales muchas veces no es detectado a tiempo al agresor y termina en desenlaces Irrevocables. (Suicidios, etc.) .Por ello es muy importante la comunicación en la familia para detectar a tiempo cualquier tipo de agresión que se presente y tratar y corregir el comportamiento agresivo

Nutrición de Vanilla planifolia A. post estrés abiótico

La vainilla (Vanilla planifolia Andrews) es una orquídea que produce frutos aromáticos comestibles, lo que la posiciona como uno de los legados agro biológicos más trascendentales de las culturas de Mesoamérica. (Fernández, 2014). El objetivo de la investigación fue estimular la recuperación de una plantación de Vanilla planifolia Andrews en el Municipio de Tihuatlán, Ver. México, después de estas sometida a estés por sequía. Se seleccionando esquejes estresados que estaban sanos con yemas viables con al menos un cm de diámetro y 80 cm de largo; se desinfectaron antes de la siembra, se reguló la luz y se establecieron los tutores. Para motivar la recuperación se emplearon dos sistemas de nutrición, una convencional y otra orgánica. Las variables de respuesta evaluadas fueron: longitud de planta, número de hojas, grosor de tallo, raíces aéreas, entrenudos, concentración de clorofila y Número de brotes por esqueje. El resultado final fue que no se encontró una diferencia estadísticamente significativas entre los dos sistemas de nutrición por lo que se concluye que la recuperación del cultivo de vainilla puede ser provocara por ambos, sin embargo es mejor mantener un manejo completamente orgánico por diversos beneficios a la salud, ambientales, sociales y económicos

Formación en habilidades blandas en instituciones de educación superior. reflexiones educativas, sociales y políticas.

Las habilidades blandas son actualmente uno de los conceptos de mayor interés en diferentes disciplinas científicas y académicas, debido a su impacto en múltiples procesos individuales, sociales, políticos y culturales. El objetivo de la presente investigación, fue diseñar una estrategia de fortalecimiento de habilidades blandas para programas de educación superior, que contribuya en el desarrollo de estas competencias en la comunidad académica, para fomentar la empleabilidad y la inmersión laboral. La metodología desarrollada fue de carácter cualitativo, con un enfoque hermenéutico, aplicado a través de entrevistas semiestructuradas a un grupo de docentes universitarios. Partiendo de la labor docente y sus experiencias exitosas en el aula, se describe la importancia de estas competencias en la formación integral y su articulación con el sector laboral. Además, se problematizan y discuten algunas estrategias pedagógicas para la adquisición y fortalecimiento de estas habilidades en el estudiantado. Se concluye que las soft skills contribuyen al desarrollo personal y colectivo de las sociedades contemporáneas, de manera que se hace imperante reformular el sistema educativo, basado en los principios de transformación social, la globalización, el mercado laboral y la cuarta revolución industrial

Appalachian Spring

A large mural that was created by 19 studio art and education students in 2009. Renowned Latina artist Judith Baca worked alongside the students.https://scholarworks.moreheadstate.edu/university_art_collection/1090/thumbnail.jp

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

The Omicron, or Pango lineage B.1.1.529, variant of SARS-CoV-2 carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection from severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple mRNA vaccinated healthcare workers (HCW) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple vaccinated individuals, but magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCW who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants, but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529

Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response

Determining the protection an individual has to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VoCs) is crucial for future immune surveillance, vaccine development, and understanding of the changing immune response. We devised an informative assay to current ELISA-based serology using multiplexed, baited, targeted proteomics for direct detection of multiple proteins in the SARS-CoV-2 anti-spike antibody immunocomplex. Serum from individuals collected after infection or first- and second-dose vaccination demonstrates this approach and shows concordance with existing serology and neutralization. Our assays show altered responses of both immunoglobulins and complement to the Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617.1) VoCs and a reduced response to Omicron (B1.1.1529). We were able to identify individuals who had prior infection, and observed that C1q is closely associated with IgG1 (r > 0.82) and may better reflect neutralization to VoCs. Analyzing additional immunoproteins beyond immunoglobulin (Ig) G, provides important information about our understanding of the response to infection and vaccination

Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study

Background We hypothesised that host-response biomarkers of viral infections might contribute to early identification of individuals infected with SARS-CoV-2, which is critical to breaking the chains of transmission. We aimed to evaluate the diagnostic accuracy of existing candidate whole-blood transcriptomic signatures for viral infection to predict positivity of nasopharyngeal SARS-CoV-2 PCR testing.Methods We did a nested case-control diagnostic accuracy study among a prospective cohort of health-care workers (aged ≥18 years) at St Bartholomew’s Hospital (London, UK) undergoing weekly blood and nasopharyngeal swab sampling for whole-blood RNA sequencing and SARS-CoV-2 PCR testing, when fit to attend work. We identified candidate blood transcriptomic signatures for viral infection through a systematic literature search. We searched MEDLINE for articles published between database inception and Oct 12, 2020, using comprehensive MeSH and keyword terms for “viral infection”, “transcriptome”, “biomarker”, and “blood”. We reconstructed signature scores in blood RNA sequencing data and evaluated their diagnostic accuracy for contemporaneous SARS-CoV-2 infection, compared with the gold standard of SARS-CoV-2 PCR testing, by quantifying the area under the receiver operating characteristic curve (AUROC), sensitivities, and specificities at a standardised Z score of at least 2 based on the distribution of signature scores in test-negative controls. We used pairwise DeLong tests compared with the most discriminating signature to identify the subset of best performing biomarkers. We evaluated associations between signature expression, viral load (using PCR cycle thresholds), and symptom status visually and using Spearman rank correlation. The primary outcome was the AUROC for discriminating between samples from participants who tested negative throughout the study (test-negative controls) and samples from participants with PCR-confirmed SARS-CoV-2 infection (test-positive participants) during their first week of PCR positivity.Findings We identified 20 candidate blood transcriptomic signatures of viral infection from 18 studies and evaluated their accuracy among 169 blood RNA samples from 96 participants over 24 weeks. Participants were recruited between March 23 and March 31, 2020. 114 samples were from 41 participants with SARS-CoV-2 infection, and 55 samples were from 55 test-negative controls. The median age of participants was 36 years (IQR 27–47) and 69 (72%) of 96 were women. Signatures had little overlap of component genes, but were mostly correlated as components of type I interferon responses. A single blood transcript for IFI27 provided the highest accuracy for discriminating between test-negative controls and test-positive individuals at the time of their first positive SARS-CoV-2 PCR result, with AUROC of 0·95 (95% CI 0·91–0·99), sensitivity 0·84 (0·70–0·93), and specificity 0·95 (0·85–0·98) at a predefined threshold (Z score >2). The transcript performed equally well in individuals with and without symptoms. Three other candidate signatures (including two to 48 transcripts) had statistically equivalent discrimination to IFI27 (AUROCs 0·91–0·95).Interpretation Our findings support further urgent evaluation and development of blood IFI27 transcripts as a biomarker for early phase SARS-CoV-2 infection for screening individuals at high risk of infection, such as contacts of index cases, to facilitate early case isolation and early use of antiviral treatments as they emerge