Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials

Objectives: Researchers worldwide are actively engaging in research activities to search for preventive and therapeutic interventions against coronavirus disease 2019 (COVID-19). Our aim was to describe the planning of randomized controlled trials (RCTs) in terms of timing related to the course of the COVID-19 epidemic and research question evaluated. Study Design and Setting: We performed a living mapping of RCTs registered in the WHO International Clinical Trials Registry Platform. We systematically search the platform every week for all RCTs evaluating preventive interventions and treatments for COVID-19 and created a publicly available interactive mapping tool at https://covid-nma.com to visualize all trials registered. Results: By August 12, 2020, 1,568 trials for COVID-19 were registered worldwide. Overall, the median ([Q1–Q3]; range) delay between the first case recorded in each country and the first RCT registered was 47 days ([33–67]; 15–163). For the 9 countries with the highest number of trials registered, most trials were registered after the peak of the epidemic (from 100% trials in Italy to 38% in the United States). Most trials evaluated treatments (1,333 trials; 85%); only 223 (14%) evaluated preventive strategies and 12 postacute period intervention. A total of 254 trials were planned to assess different regimens of hydroxychloroquine with an expected sample size of 110,883 patients. Conclusion: This living mapping analysis showed that COVID-19 trials have relatively small sample size with certain redundancy in research questions. Most trials were registered when the first peak of the pandemic has passed

Prophylactic evaluation of shoulder’s proprioception in elite swimmers

International audienc

Assessment of preoperative noninvasive ventilation before lung cancer surgery: The preOVNI randomized controlled study

International audienc

Impact of the spatial distribution of the atmospheric forcing on water mass formation in the Mediterranean Sea

International audienceThe impact of the atmospheric forcing on the winter ocean convection in the Mediterranean Sea was studied with a high-resolution ocean general circulation model. The major areas of focus are the Levantine basin, the Aegean-Cretan Sea, the Adriatic Sea, and the Gulf of Lion. Two companion simulations differing by the horizontal resolution of the atmospheric forcing were compared. The first simulation (MED16-ERA40) was forced by air-sea fields from ERA40, which is the ECMWF reanalysis. The second simulation (MED16-ECMWF) was forced by the ECMWF-analyzed surface fields that have a horizontal resolution twice as high as those of ERA40. The analysis of the standard deviations of the atmospheric fields shows that increasing the resolution of the atmospheric forcing leads in all regions to a better channeling of the winds by mountains and to the generation of atmospheric mesoscale patterns. Comparing the companion ocean simulation results with available observations in the Adriatic Sea and in the Gulf of Lion shows that MED16-ECMWF is more realistic than MED16-ERA40. In the eastern Mediterranean, although deep water formation occurs in the two experiments, the depth reached by the convection is deeper in MED16-ECMWF. In the Gulf of Lion, deep water formation occurs only in MED16-ECMWF. This larger sensitivity of the western Mediterranean convection to the forcing resolution is investigated by running a set of sensitivity experiments to analyze the impact of different time-space resolutions of the forcing on the intense winter convection event in winter 1998-1999. The sensitivity to the forcing appears to be mainly related to the effect of wind channeling by the land orography, which can only be reproduced in atmospheric models of sufficient resolution. Thus, well-positioned patterns of enhanced wind stress and ocean surface heat loss are able to maintain a vigorous gyre circulation favoring efficient preconditioning of the area at the beginning of winter and to drive realistic buoyancy loss and mixing responsible for strong convection at the end of winter