Lifetime prevalence and help seeking behavior in physical marital violence

OBJECTIVE: To estimate the lifetime prevalence of physical marital violence among women from a low-income urban community and to investigate help-seeking behavior among victims. METHODS: This is the Brazilian pilot cross-sectional study for an international multicenter study conducted in 1999, and is based on a probabilistic cluster sample from the municipality of Embu, São Paulo State. We considered as eligible women aged 15 to 49 years, living with children under age 18 years, who had lived with a husband or partner in lifetime. Information was collected using standardized questionnaires (n=86), administered by trained interviewers. We investigated three types of physical violence: severe (kicking, hitting with fist, beating, and/or use/threat to use weapon), non-severe (slapping in the absence of severe violence), and any type (severe and/or non-severe and/or other physical aggressions spontaneously referred), as well as the type of help sought by the victim (from people or institutions). We calculated frequency and 95% confidence intervals for each type of violence. RESULTS: Subjects reported slapping (32.6%), hitting with fist (17.5%), beating (15,2%), use/threat to use weapon (13.9%), and kicking (10.6%). Prevalence of marital violence was high: 22.1% (13.3-30.9) for severe violence, 10.5% (4.0-17.0) for non-severe violence, and 33.7% (32.7-34.7) for any type of violence. Victims of severe violence were more likely to seek help from the police (36.8%) or from traditional healers (21.1%) than from health care facilities (5.3%), despite the availability of these services in the area. CONCLUSIONS: Physical marital violence is frequent and severe among the population studied, and help was sought preferentially from the police or traditional healers rather than from health care services.OBJETIVO: Estimar a prevalência de violência conjugal física ao longo da vida em mulheres de comunidade urbana de baixa renda e identificar os tipos de ajuda procurados pelas vítimas. MÉTODOS: Trata-se de estudo-piloto brasileiro de corte transversal, vinculado a projeto multicêntrico internacional conduzido em 1999, com amostra probabilística de conglomerados no município de Embu, Estado de São Paulo. Foram considerados elegíveis os domicílios com mulheres de 15 a 49 anos, que residissem com filho/filha <18 anos e tivessem vivido com algum marido/companheiro ao longo da vida. Entrevistadoras treinadas aplicaram questionários padronizados (n=86). Três tipos de violência conjugal física sofrida ao longo da vida foram investigados: grave (chute, soco, espancamento e/ou uso/ameaça de uso de arma), não grave (tapa na ausência de violência grave) e algum tipo (grave e/ou não grave, além de outras formas de agressão física espontaneamente referidas) e os tipos de ajuda procurada (pessoas e instituições). Foram calculadas as freqüências dos tipos de violência e respectivos intervalos de confiança de 95%. RESULTADOS: As entrevistadas referiram tapa (32,6%), soco (17,5%), espancamento (15,2%), uso/ameaça de arma (13,9%) e chute (10,6%). Foram altas as taxas de prevalência de violência conjugal: grave 22,1% (13,3-30,9), não grave 10,5% (4,0-17,0) e algum tipo 33,7% (32,7-34,7). Vítimas de violência grave procuraram ajuda mais freqüentemente da polícia/delegacia (36,8%) ou de curandeiros/benzedeiras/pais de santo (21,1%) que de centros de saúde (5,3%), apesar da disponibilidade desses serviços na região. CONCLUSÕES: A violência conjugal física ao longo da vida é freqüente e grave na comunidade estudada, sendo que a procura de ajuda foi direcionada mais freqüentemente à polícia/delegacia ou a curandeiros/benzedeiras/pais de santo do que a centros de saúde.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de PsiquiatriaUniversidade Presbiteriana Mackenzie Faculdade de PsicologiaUNIFESP, EPM, Depto. de PsiquiatriaSciEL

Multitalented Synthetic Antimicrobial Peptides and Their Antibacterial, Antifungal and Antiviral Mechanisms

: Despite the great strides in healthcare during the last century, some challenges still remained unanswered. The development of multi-drug resistant bacteria, the alarming growth of fungal infections, the emerging/re-emerging of viral diseases are yet a worldwide threat. Since the discovery of natural antimicrobial peptides able to broadly hit several pathogens, peptide-based therapeutics have been under the lenses of the researchers. This review aims to focus on synthetic peptides and elucidate their multifaceted mechanisms of action as antiviral, antibacterial and antifungal agents. Antimicrobial peptides generally affect highly preserved structures, e.g., the phospholipid membrane via pore formation or other constitutive targets like peptidoglycans in Gram-negative and Gram-positive bacteria, and glucan in the fungal cell wall. Additionally, some peptides are particularly active on biofilm destabilizing the microbial communities. They can also act intracellularly, e.g., on protein biosynthesis or DNA replication. Their intracellular properties are extended upon viral infection since peptides can influence several steps along the virus life cycle starting from viral receptor-cell interaction to the budding. Besides their mode of action, improvements in manufacturing to increase their half-life and performances are also taken into consideration together with advantages and impairments in the clinical usage. Thus far, the progress of new synthetic peptide-based approaches is making them a promising tool to counteract emerging infections

Prevalência e procura de ajuda na violência conjugal física ao longo da vida

OBJECTIVE: To estimate the lifetime prevalence of physical marital violence among women from a low-income urban community and to investigate help-seeking behavior among victims. METHODS: This is the Brazilian pilot cross-sectional study for an international multicenter study conducted in 1999, and is based on a probabilistic cluster sample from the municipality of Embu, São Paulo State. We considered as eligible women aged 15 to 49 years, living with children under age 18 years, who had lived with a husband or partner in lifetime. Information was collected using standardized questionnaires (n=86), administered by trained interviewers. We investigated three types of physical violence: severe (kicking, hitting with fist, beating, and/or use/threat to use weapon), non-severe (slapping in the absence of severe violence), and any type (severe and/or non-severe and/or other physical aggressions spontaneously referred), as well as the type of help sought by the victim (from people or institutions). We calculated frequency and 95% confidence intervals for each type of violence. RESULTS: Subjects reported slapping (32.6%), hitting with fist (17.5%), beating (15,2%), use/threat to use weapon (13.9%), and kicking (10.6%). Prevalence of marital violence was high: 22.1% (13.3-30.9) for severe violence, 10.5% (4.0-17.0) for non-severe violence, and 33.7% (32.7-34.7) for any type of violence. Victims of severe violence were more likely to seek help from the police (36.8%) or from traditional healers (21.1%) than from health care facilities (5.3%), despite the availability of these services in the area. CONCLUSIONS: Physical marital violence is frequent and severe among the population studied, and help was sought preferentially from the police or traditional healers rather than from health care services.OBJETIVO: Estimar a prevalência de violência conjugal física ao longo da vida em mulheres de comunidade urbana de baixa renda e identificar os tipos de ajuda procurados pelas vítimas. MÉTODOS: Trata-se de estudo-piloto brasileiro de corte transversal, vinculado a projeto multicêntrico internacional conduzido em 1999, com amostra probabilística de conglomerados no município de Embu, Estado de São Paulo. Foram considerados elegíveis os domicílios com mulheres de 15 a 49 anos, que residissem com filho/filh

Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor

The release of soluble ligands of activating Natural Killer (NK) cell receptors may represent a regulatory mechanism of NK cell function both in physiologic and in pathologic conditions. Here, we identified the extracellular matrix protein Nidogen-1 (NID1) as a ligand of NKp44, an important activating receptor expressed by activated NK cells. When released as soluble molecule, NID1 regulates NK cell function by modulating NKp44-induced IFN-\u3b3 production or cytotoxicity. In particular, it also modulates IFN-\u3b3 production induced by Platelet-Derived Growth Factor (PDGF)-DD following NKp44 engagement. We also show that NID1 may be present at the cell surface. In this form or when bound to a solid support (bNID1), NID1 fails to induce NK cell cytotoxicity or cytokine release. However, analysis by mass spectrometry revealed that exposure to bNID1 can induce in human NK cells relevant changes in the proteomic profiles suggesting an effect on different biological processes

Experimental antiproton nuclear stopping power in H2 and D2

Data about antiprotons slowing down in gaseous targets at very low energies (E<1 keV) show that the stopping power in D2 is lower than in H2; the right way to explain this behavior seems to be through a nuclear stopping power derived from the classical Rutherford formula

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements