84 research outputs found
The Neighborhood’s Catalogue: Lower East Side Planning and Design File
- Publication venue
- UWM Digital Commons
- Publication date
- 01/01/1981
- Field of study
This catalogue was designed to support the process of slow redevelopment over time, combined with conservation of diverse social and historical continuity and the exploration of new land and building uses. The catalogue shows how to involve neighborhoods in participation, supportive design, incremental planning and phased development. This project was made possible by a grant from the National Endowment for the Arts. Reprinted in 1987.https://dc.uwm.edu/caupr_mono/1047/thumbnail.jp
Recommended from our members
Genome-wide association study identifies 30 loci associated with bipolar disorder.
- Author
- Abbott Liam
- Agerbo Esben
- Akil Huda
- Albani Diego
- Alliey-Rodriguez Ney
- Als Thomas D
- Anjorin Adebayo
- Antilla Verneri
- Awasthi Swapnil
- Badner Judith A
- Barchas Jack D
- Bass Nicholas
- Bauer Michael
- Belliveau Richard
- Bergen Sarah E
- Boks Marco P
- Boocock James
- Breen Gerome
- Budde Monika
- Bunney William
- Burmeister Margit
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M
- Bækvad-Hansen Marie
- Bøen Erlend
- Casas Miquel
- Cerrato Felecia
- Cervantes Pablo
- Chambert Kimberly
- Charney Alexander W
- Chen Danfeng
- Churchhouse Claire
- Clarke Toni-Kim
- Coleman Jonathan RI
- Coryell William
- Craig David W
- Cruceanu Cristiana
- Curtis David
- Czerski Piotr M
- Dale Anders M
- de Jong Simone
- de Leeuw Christiaan A
- Degenhardt Franziska
- Del-Favero Jurgen
- DePaulo J Raymond
- Djurovic Srdjan
- Dobbyn Amanda L
- Dumont Ashley
- Elvsåshagen Torbjørn
- Escott-Price Valentina
- Fan Chun Chieh
- Fischer Sascha B
- Flickinger Matthew
- Foroud Tatiana M
- Forstner Andreas J
- Forty Liz
- Frank Josef
- Fraser Christine
- Freimer Nelson B
- Frisén Louise
- Gade Katrin
- Gage Diane
- Garnham Julie
- Gaspar Héléna A
- Giambartolomei Claudia
- Goldstein Jaqueline
- Gordon Scott D
- Gordon-Smith Katherine
- Green Elaine K
- Green Melissa J
- Greenwood Tiffany A
- Grove Jakob
- Guan Weihua
- Guzman-Parra José
- Hamshere Marian L
- Hautzinger Martin
- Heilbronner Urs
- Herms Stefan
- Hipolito Maria
- Hoffmann Per
- Holland Dominic
- Holmans Peter A
- Huckins Laura
- Jamain Stéphane
- Johnson Jessica S
- Juréus Anders
- Mattheisen Manuel
- McQuillin Andrew
- Pavlides Jennifer M Whitehead
- Pedersen Carsten Bøcker
- Pedersen Marianne Giørtz
- Pers Tune H
- Richards Alexander L
- Ripke Stephan
- Stahl Eli A
- Steinberg Stacy
- Trubetskoy Vassily
- Trzaskowski Maciej
- Wang Yunpeng
- Publication venue
- eScholarship, University of California
- Publication date
- 01/05/2019
- Field of study
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10-8) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder
The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies
- Author
- A Abyzov
- A Micheil Innes
- A Sugathan
- A Tarasov
- AC Tabet
- Aggie W Nieuwint
- Alex V Levin
- Andrea Hanson-Kahn
- Andrea L Gropman
- Anna Wilson
- Annelies Dheedene
- AW Higgins
- Benjamin B Currall
- Bert B A de Vries
- Bert Callewaert
- BJ O'Roak
- Björn Menten
- Blair Stevens
- Bregje W van Bon
- Brett H Graham
- Brynn Levy
- BV North
- C Cardoso
- C Chiang
- C DeSanto
- C Floris
- C Hanscom
- C Ravel
- C Schluth-Bolard
- Carlo L Marcelis
- Caroline Antolik
- Carrie Hanscom
- Catarina M Seabra
- Catharina M L Volker-Touw
- Chester W Brown
- Cinthya J Zepeda Mendoza
- CJ Ellaway
- Claire Redin
- Colby Chiang
- Conny M van Ravenswaaij-Arts
- CR Marshall
- Cristin Griffis
- Cynthia C Morton
- Cynthia Lim
- D Warburton
- D Warburton
- Daniela Giachino
- Danielle Perrin
- David A Koolen
- David J Harris
- David R FitzPatrick
- Dawn L Earl
- Debra Rita
- Dezso David
- DG Lupiáñez
- DG Lupiáñez
- Diane Lucente
- Diane Masser-Frye
- Dorothy P Warburton
- Edward J Lose
- Edwin Cuppen
- Elizabeth Beyer
- Elyse Mitchell
- Emily Moe
- Emmanuelle Lemyre
- Eric C Liao
- Erica Spiegel
- Erik C Thorland
- Erika Aberg
- Ernie M H F Bongers
- Eva H Brilstra
- F Jin
- F Xia
- F Zhang
- Filip Roelens
- Fowzan S Alkuraya
- Giorgia Mandrile
- Giulia Pregno
- Graciela Moya
- H Brand
- H Brand
- H Engels
- H Li
- H Saitsu
- Haibo Li
- Han G Brunner
- Harrison Brand
- Heather Fisher
- Heather L Ferguson
- Helen Cox
- Hennie T Brüggenwirth
- Hong Li
- I Iossifov
- I Iossifov
- I Splawski
- Ian Blumenthal
- Ineke van Der Burgt
- Ivo Renkens
- J Cotney
- J Huddleston
- J Ibn-Salem
- J Nielsen
- J Weischenfeldt
- JA Rosenfeld
- James F Gusella
- Jayla Ruliera
- JC Darnell
- Jennelle C Hodge
- Jerome Korzelius
- Jessie C Jacobsen
- Jiddeke van de Kamp
- Joan F Atkin
- Jodi D Hoffman
- John P Johnson
- Jonathan A Bernstein
- Joseph T Glessner
- Joseph V Thakuria
- JR Dixon
- JS Berg
- Julia Tagoe
- Karen W Gripp
- Kathleen Leppig
- Katy Phelan
- KE Samocha
- Ken Corning
- KH Utami
- Kwame Anyane-Yeboa
- LA Lettice
- Lauren Margolin
- Linda Reis
- Liya R Mikami
- M Ascano Jr.
- M De Gregori
- M Franke
- M Fromer
- M Krzywinski
- M Meyerson
- M Takagi
- M Zweier
- M Zweier
- MA Mencarelli
- Marc D'Hooghe
- Margo Grady
- Maria de la Concepcion A Yerena-de Vega
- Marjolijn C Jongmans
- Mark A Hayden
- Markus J van Roosmalen
- Mary-Alice Abbott
- Mary-Anne Anderson
- Matthew A Deardorff
- Matthew J Waterman
- Matthew R Stone
- MB Rasmussen
- ME Talkowski
- ME Talkowski
- ME Talkowski
- ME Talkowski
- Megan E Mortenson
- Melita Irving
- Michael E Talkowski
- Michael J Macera
- Michael W McClellan
- Mira Irons
- MJ Chaisson
- MJ Hawrylycz
- MJ Landrum
- Monika W Hubshman
- N Brunetti-Pierri
- N Le Meur
- NC Durand
- Nicole de Leeuw
- O Perche
- Omar A Abdul-Rahman
- PA Jacobs
- Pamela Gerrol
- Patrick Rump
- Peter M Kroisel
- Pino J Poddighe
- PJ Stephens
- Poornima Manavalan
- R Andersson
- Ranad Shaheen
- Raul E Piña Aguilar
- Rebecca Sparkes
- Rhett Adley
- Robert J Hopkin
- Roberto T Zori
- Ron Hochstenbach
- Rosamund Hill
- Ryan L Collins
- S De Rubeis
- S Djebali
- S Köhler
- S Köhler
- S Petrovski
- S Petrovski
- S Vergult
- Salmo Raskin
- Samantha L P Schilit
- Sandhya Parkash
- Sandra Janssens
- Sarah Vergult
- SC Baca
- Shahrin Pereira
- Shehla Mohammed
- SJ Funderburk
- SJ Sanders
- Sjors Middelkamp
- SM McDermott
- SM Purcell
- Sofia L Alcaraz-Estrada
- SS Rao
- Stephen G Kahler
- Susan P Pauker
- Susan Wiley
- T Kleefstra
- Tamara Mason
- Tamison Jewett
- Tammy Kammin
- Tarja Mononen
- Tina Bartell
- TN Turner
- Tom Cushing
- Ton van Essen
- Troy Gliem
- VA McKusick
- Vamsee Pillalamarri
- W Lu
- Wigard P Kloosterman
- William Lawless
- William Rhead
- WP Kloosterman
- Y Deng
- Yu An
- Yves Lacassie
- Zehra Ordulu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 14/11/2016
- Field of study
Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their characterization has largely been restricted to cytogenetic resolution. We explored the landscape of BCAs at nucleotide resolution in 273 subjects with a spectrum of congenital anomalies. Whole-genome sequencing revised 93% of karyotypes and demonstrated complexity that was cryptic to karyotyping in 21% of BCAs, highlighting the limitations of conventional cytogenetic approaches. At least 33.9% of BCAs resulted in gene disruption that likely contributed to the developmental phenotype, 5.2% were associated with pathogenic genomic imbalances, and 7.3% disrupted topologically associated domains (TADs) encompassing known syndromic loci. Remarkably, BCA breakpoints in eight subjects altered a single TAD encompassing MEF2C, a known driver of 5q14.3 microdeletion syndrome, resulting in decreased MEF2C expression. We propose that sequence-level resolution dramatically improves prediction of clinical outcomes for balanced rearrangements and provides insight into new pathogenic mechanisms, such as altered regulation due to changes in chromosome topology
Measurement of the inclusive isolated-photon cross section in pp collisions at √s = 13 TeV using 36 fb−1 of ATLAS data
- Author
- Aad G.
- Abbott B.
- Abbott D. C.
- Abdinov O.
- Abed Abud A.
- Abeling K.
- Abhayasinghe D. K.
- Abidi S. H.
- AbouZeid O. S.
- Abraham N. L.
- Abramowicz H.
- Abreu H.
- Abulaiti Y.
- Acharya B. S.
- Achkar B.
- Adachi S.
- Adam Bourdarios C.
- Adam L.
- Adamczyk L.
- Adamek L.
- Adelman J.
- Adersberger M.
- Adiguzel A.
- Adorni S.
- Adye T.
- Affolder A. A.
- Afik Y.
- Agapopoulou C.
- Agaras M. N.
- Aggarwal A.
- Agheorghiesei C.
- Aguilar-Saavedra J. A.
- Ahmadov F.
- Ahmed W. S.
- Ai X.
- Aielli G.
- Akatsuka S.
- Akilli E.
- Akimov A. V.
- Al Khoury K.
- Alberghi G. L.
- Albert J.
- Alconada Verzini M. J.
- Alderweireldt S.
- Aleksa M.
- Aleksandrov I. N.
- Alexa C.
- Alexandre D.
- Alexopoulos T.
- Alfonsi A.
- Alhroob M.
- Ali B.
- Alimonti G.
- Alison J.
- Alkire S. P.
- Allaire C.
- Allbrooke B. M. M.
- Allen B. W.
- Allport P. P.
- Aloisio A.
- Alonso A.
- Alonso F.
- Alpigiani C.
- Alshehri Azzah Aziz B.
- Alvarez Estevez M.
- Alviggi M. G.
- Amaral Coutinho Y.
- Ambler A.
- Ambroz L.
- Amelung C.
- Amidei D.
- Amor Dos Santos S. P.
- Amoroso S.
- Amrouche C. S.
- An F.
- Anastopoulos C.
- Andari N.
- Andeen T.
- Anders C. F.
- Anders J. K.
- Andreazza A.
- Andrei V.
- Anelli C. R.
- Angelidakis S.
- Angerami A.
- Anisenkov A. V.
- Annovi A.
- Antel C.
- Anthony M. T.
- Antonelli M.
- Antrim D. J. A.
- Anulli F.
- Aoki M.
- Aparisi Pozo J. A.
- Aperio Bella L.
- Arabidze G.
- Araque J. P.
- Araujo Ferraz V.
- Araujo Pereira R.
- Araya S. Tapia
- Arcangeletti C.
- Arce A. T. H.
- Arduh F. A.
- Arguin J-F.
- Argyropoulos S.
- Arling J.-H.
- Armbruster A. J.
- Armitage L. J.
- Armstrong A.
- Arnaez O.
- Arnold H.
- Artamonov A.
- Artoni G.
- Artz S.
- Asai S.
- Asbah N.
- Asimakopoulou E. M.
- Asquith L.
- Assamagan K.
- Astalos R.
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- Azuelos G.
- Baca M. J.
- Bachacou H.
- Bachas K.
- Backes M.
- Backman F.
- Bagnaia P.
- Bahmani M.
- Bahrasemani H.
- Bailey A. J.
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- Åkesson T. P. A.
- Šforza F.
- Ženiš T.
- Živković L.
- Publication venue
- Institute of Physics Publishing
- Publication date
- 01/01/2019
- Field of study
The differential cross section for isolated-photon production in pp collisions is measured at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC using an integrated luminosity of 36.1 fb. The differential cross section is presented as a function of the photon transverse energy in different regions of photon pseudorapidity. The differential cross section as a function of the absolute value of the photon pseudorapidity is also presented in different regions of photon transverse energy. Next-to-leading-order QCD calculations from Jetphox and Sherpa as well as next-to-next-to-leading-order QCD calculations from Nnlojet are compared with the measurement, using several parameterisations of the proton parton distribution functions. The predictions provide a good description of the data within the experimental and theoretical uncertainties. [Figure not available: see fulltext.
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
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- Bond Nicholas A.
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- Tinnin Lee
- Tippet William Thomas
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- Trauger John
- Trejo Edwin Gregorio
- Truong Justin Hoang Vinh
- Tsukamoto Christine L.
- Tufail Yasir
- Tumlinson Jason
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- Voorzaat Piet
- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Walker Jr. Frederick E.
- Wander Michel
- Warfield Christine K.
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- Wasiak Francis C.
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- Wehner James
- Weiler Kevin R.
- Weilert Mark
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- Wells Martyn
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- Whitehouse Paul
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- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
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- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
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- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
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- Yu Gene
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- Zonak Stephanie
- Zondag Elisabeth
- Álvarez-Márquez Javier
- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
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- Andredesz Carol
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- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
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- Arachchi Harindra
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- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
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- Benard Michael Anthony
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- Bercovitz John
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- Bethel Graeme
- Beugelsdijk Tony J.
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- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
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- Blitshsteyn Berta
- Blomstrom David B.
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- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
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- Brandriff Brigitte F.
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- Buczek Donald
- Budd Claire
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- Bunker Nathan
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- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
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- Cahill Patrick
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- Callen David F.
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- Campo Kevin
- Canning Bruno
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- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
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- Christensen Mari
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- Chu Joseph
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- Chung A
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- Colayco Rick
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- Dathorne Stephanie R.
- Daum Christopher
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- De Anda Claudia
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- Deloukas Panos
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- Devlin Laurie
- Dewar Ken
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- Ding Hao
- Ding Keyue
- Ding Li
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- Dixon Kami
- Do Long
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- Doggett Norman A.
- Dong Hui
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- Dooley Kathy
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- Gallegos Celsa
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- Gammon Stuart
- Gao Anwu
- Gao Jimei
- Gao Quan
- Gao Yang
- Gao Yimei
- Garcia Carmen
- Garcia Emilio
- Garcia Marvin
- Garcia Ricardo M, III
- Garcia-Martinez Antonio
- Gardner Alison
- Gardner Alison
- Garduno Consuelo
- Gardyna Steph
- Garner Patrick
- Garner Toni T.
- Garnes Jeffrey A.
- Garnett Jane
- Garza Melissa
- Gatewood Joseph M.
- Gatland Leigh
- Gatland Lindsay
- Gattung Stacie
- Gay Laura
- Gearin Gary
- Gebreyesus Binyam
- Gelein Cynthia
- Gelpke Maartin
- Gench Stephanie L.
- Geng Jianing
- Georgescu Anca
- Geotina Amy
- Ghori Jilur
- Ghose Sayantan
- Gibbs Ben
- Gibbs Richard A.
- Gibson Diane
- Gibson Elizabeth
- Gifford Mary
- Gil Isaias
- Gilbert James
- Gilby Lisa
- Gill Rachel
- Gillet Will
- Gillson Christopher
- Gilna Paul
- Gimmel Verena
- Gingrich Jeff
- Giovanelli Kira
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- Glithero Rebecca
- Glöckner Gernot
- Gnerre Sante
- Gnirke Andreas
- Gold Darren
- Golinveaux Kristen
- Gomez Maria
- Gong Guanghui
- Gong Jinying
- Gonzales Eidelyn
- Gonzalez Guillermo B.
- Gooderham April
- Goodstadt Leo
- Goodstein David
- Goodwin Lynne A.
- Gordon Catherine
- Gordon Laurie A.
- Gordon Seth
- Gorton Matthew
- Gorvad Ann
- Gould Christine
- Goyea Ernest
- Goyette Audra
- Grady Deborah I.
- Grady Michelle L.
- Grafham Darren
- Graham Joe
- Grandbois Edward
- Grant Jennifer
- Grant Michael
- Grant Susan
- Graves Tina A.
- Gray Bruce
- Gray Emma
- Gray Lain
- Green Lisa
- Greenhalgh James
- Greenhill Joe
- Gregg Philippa
- Gregory Simon
- Grewal Nennu
- Gribble Susan
- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
- Grigoriev Igor
- Grimwood Jane
- Grocock Russell
- Groza Matthew
- Gu Jingli
- Gu Jun
- Gu Jun
- Gu Wenyi
- Gu Wenyi
- Gu Xiaochang
- Guan Qiaoning
- Guarin Hannibal
- Guel Metzalli
- Guerra William
- Guevara Whitney V.
- Gui Qi
- Gunaratne Preethi
- Gunning Kate
- Guo Daorong
- Guo Jane
- Guo Lili
- Gustafson Erik
- Guthrie Ian
- Guyer Mark
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- Ha Chi
- Hafez Nabil
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- Hagopian Daniel
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- Hajek Patrick
- Hall Brett Lynn
- Hall Brittany
- Hall Jennifer
- Hall Rebekah
- Hall-Tamly Gretta
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- Hamada Junko
- Hamilton Cerissa
- Hamilton Keelan A.
- Hamilton Matt
- Hamlett John
- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
- Han Shunsheng
- Han Xurong
- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
- Harper David
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- Hashimoto Wakako
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- Haugen Eric
- Haussler David
- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
- Hawkins Trevor
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- Heitmann Katja
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- Hepa Victor
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- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
- Holden Jane
- Holdgate Janet
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- Holmes Sarah
- Holroyd Simon
- Holtz Ann
- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
- Honan Tracy
- Hood Leroy
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- Hornischer Klaus
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- Hosono Katsuhiro
- Hosseini Roya
- Hou Shunfang
- Hou Xiaodi
- Houde Nathan
- Howard Philip
- Howard Stephanie R.
- Howden Philip
- Howe Kevin
- Howell Gareth
- Howell Latoya Lynette
- Howells Sally Lucinda
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- Hu Jie
- Hu Songnian
- Huang Fang
- Huang Guyang
- Huang Katherine
- Huang Mei
- Huang Wayne
- Huang Wei
- Huang Wei
- Huang Wei
- Huang Zhengping
- Hubbard Timothy
- Huber James W.
- Huckle Elizabeth
- Hue Heather
- Hughes Jaime
- Hughes Jennifer
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- Hunt Paul
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- Hunter Giselle
- Hunter Rov, II
- Hupman Matt
- Huynh Sandy
- Hyde David
- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
- Ingram Drew
- Inoue Shuuji
- Isak Amber
- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
- Isozaki Emi
- Israni Sanjay
- Ito Fumiaki
- Ito Noriko
- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
- Iwatsu Mikiko
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- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
- Jacintho Mark
- Jackson Laronda R.
- Jackson Terri
- Jacob Leni Susan
- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
- Jeffery Kim
- Jeffrey Colin
- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
- Jia Xingchang
- Jiang Lu
- Jiang Yanrui
- Jiang Ziyou
- Jimenez Alberto
- Jin Jian
- Jin Yetao
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- Johnson Cheryl
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- Johnson David
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- Jones Abigail
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- Jones Micheil
- Jones Myrna D.
- Jones Steven
- Jong Pieter De
- Jordan Yun
- Joseph Shirin
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- Jung Eugine
- Järke Doris
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- Karunaratne Kanchi
- Kasprzyk Arek
- Katayama Takujiro
- Kato Takako
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- Kay Michael
- Kaye Danielle
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- Keefe Damian
- Keen Gifford
- Keenan Stephen
- Kegelmeyer Laura
- Kegg Lisa
- Kelley Simon
- Kells Cristyn
- Kelly Shayna P.
- Kelly Susan H.
- Kershaw Joanna
- Kettleborough Ross
- Keys David
- Khan Arsi
- Khan Umer F.
- Khan Ziad Mohid
- Khine Susu
- Khurama Divya
- Kidd Cathy
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- Kieu Alix
- Kim Jennifer
- Kim Joomyeong
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- Klingle Gillian
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- Kobayashi Mai
- Kodira Chinnappa
- Kohlberg Sara
- Kojima Kazuyasu
- Kolbe William
- Kong Yi
- Korf Ian
- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
- Kudoh Jun
- Kuehl Jennifer
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- Kulish Larissa
- Kuroki Yoko
- Kwan Chinnie
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- Lad Heena
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- Laing Michael
- Laird Gavin
- Lam Edward
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- Lamar Betty
- Lambart Christine
- Lamble Ralph
- Lamerdin Jane E.
- Lander Eric S.
- Landers Tom
- Langford Cordelia
- Lansang Christine
- Lao Victoria
- Lapidus Alla
- Larke Ben
- Lato Bernadette
- Latreille Phil
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- Lee Byung-in
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- Legall Fitzherbert Henderson, III
- Leger Jean Pierre
- Lehman Karl
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- Lehrach Hans
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- Lei Meng
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- Leongamornlert Daniel
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- Levan Jaclyn M.
- Leversha Margaret
- Levine Rosie
- Levy Andrew
- Levy Michaël
- Lewis Doreen
- Lewis Ernest K.
- Lewis Keith
- Lewis Lakeshia C.
- Lewis Lora R.
- Lewis Tammy
- Leyba Tina
- Li Changfeng
- Li Chenji
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- Li Shuangli
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- Li Zhangwan
- Lieuallen Kim
- Lightning Julia
- Lim Meng K.
- Lindblad-Toh Kerstin
- Lindo Ken
- Lindquist K.
- Lindsay Sarah
- Lindstrom Kirsten
- LIne Matthew
- Ling Wei
- Linkowski Albert
- Linsdell Sally
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- Liu Boyong
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- Liu Haili
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- Liu Jing
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- Liu Yu
- Liu Zhanwei
- Liyanage Dhammika
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- Lock Victoria
- Lock William
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- London Pamela
- Longden Ian
- Longmire Johnathan L.
- Lopez Frederick
- Lopez John
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- Lopez Lora
- Loraine Howard
- Lord Rachel
- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
- Loveland Jane
- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
- Lu Tao
- Lu Xiuhua
- Lu Yongxiang
- Lu Yontao T.
- Lu Yue
- Lucas Robert
- Lucas Susan
- Lucier Alice
- Lucier Raymond L.
- Ludeman Thom
- Lui Annie
- Lundgren Lyndsey
- Luo Chunqing
- Luo Chunqing
- Lv Gang
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- Lynch Daniel
- Löhnert Tschong-Hun
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- Mabbitt Richard
- Macdonald Pendexter
- Machrus Migdad
- Macht Madison
- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
- Maglott Donna
- Maheshwari Manjula
- Mahindartne Mathew
- Mahmoodi Venus
- Mahnke Ryan
- Mailey Brian
- Major John
- Malfatti Stephanie
- Malloy Kevin
- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
- Manohar Chitra
- Mapua Patricia
- Marabella Dick
- Mardis Elaine R.
- Mareth David
- Mariano Marisa
- Marinelli Lisa
- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
- Marroquin Christian
- Marsden Paul
- Marsh Victoria
- Martin Christopher
- Martin Joel
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- Martinez Diego
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- Maslen Gareth
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- Matsuda Fumihiko
- Matsumoto Shuko
- Matsushita Yoshitaka
- Matthews Charles D.
- Matthews Lucy
- Matthews Nick
- Matthews Paul
- Matthews Sterling D.
- Mauceli Evan
- Maunes Cynthia
- Maupin Rachel
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- McCann Owen
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- McClay Joseph
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- McGurn Phil
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- McLaren Stuart
- McLay Kirsten
- McLean James
- McLellan Michael D.
- McLeod Michael P.
- McMurdo John
- McMurray Amanda
- McMurray Des
- McMurray Kimberly
- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
- McPherson John D.
- McVicker Graham
- McWilliams Natalie
- Mead Kelly
- Meador Michael G.
- Medina Catherine
- Mehta Nalini
- Meidi Patrick
- Meier Elke
- Meincke Linda J.
- Mejima Mio
- Meldrim James
- Melsopp Craig
- Mendez Sylvia
- Meneus Louis
- Meng Shanshan
- Menuge Noel
- Mercado Christian
- Mercado George
- Mercado Iracema C.
- Mercer Simon
- Merritt Christina E.
- Mesirov Jill P.
- Metzker Michael Lee
- Meyer Rekha
- Meyer Rick
- Miah Asab
- Michaelis Evelyn
- Micklem Gos
- Mieczkowski Carl
- Mier Maggie
- Miguel Trini
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- Mihalkanin Danielle
- Mihova Tanya
- Miles Simon
- Mileur Mason W.
- Miller Christie
- Miller Donald
- Miller Nancy
- Milne Sarah
- Miner George R.
- Miner Sheri
- Miner Tracie
- Minja Emmanuel
- Minoshima Shinsei
- Minx Patrick J.
- Misra Monica
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- Morgan Margaret B.
- Morita Hiroko
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- Morton Jerry
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- Mott Richard
- Moyzis Robert K.
- Mu Feng
- Mukherjee Shibani
- Mullenger Ian
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- Mulrain Leon
- Munday Brian
- Munday Elaine
- Mundt Mark O.
- Mungall Andy
- Munidasa Mala
- Munk A. Christine
- Munk Christie A.
- Munson Glen
- Murakami Katsuhiko
- Murayama Yuji
- Murnane Clare
- Murphy Matthew B.
- Murphy Michael
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- Nagamine Kentaro
- Nagao Syunsuke
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- Nair Latha
- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
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- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
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- Naylor Jerome
- Nazareth Lynne V.
- Neal Dearl D.
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- Nelson Catherine
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- Nelson Deborah A.
- Nelson Joanne
- Nelson Kathryn
- Nelson Ward
- Nesbitt Ryan
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- Ng Bee
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- Nguyen Natalie M.
- Nguyen Ngoc Bich
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- Ning Zemin
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- Norbu Nyima
- Nordsiek Gabriele
- Norris Sarah Louise
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- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
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- Ohno Saho
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- Ohtsubo Masafumi
- Oinn Tom
- Okoawo Ose
- Okui Michiyo
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- Okwuonu Geoffrey O.
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- Oliver Hayley
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- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
- Oomori Nobuhiro
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- Oragunye Njideka
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- Ovcharenko Ivan
- Overton-Larty Emma
- Oviedo Rodolfo J.
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- Ozawa Ritsuko
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- Pace Araceli C.
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- Padki Anuradha
- Pahlavan Shane
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- Palazzolo Michael
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- Pan Jiaofeng
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- Panasenko Vladimir
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- Parker Stephen
- Parkin Christopher
- Parkin Kim
- Parks Kenya L.
- Parry-Brown Ginny
- Parson-Quintana Beverly
- Pasternak Shiran
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- Patel Dina
- Patel Jalpa N.
- Patel Ritesh
- Patel Shripa
- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
- Paulson Edward
- Payton Brett A.
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- Pearman Charlene
- Pearson Danita
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- Peck Anna
- Peck Richard
- Pedan John
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- Pelletier Eric
- Peng Vivian
- Peng Vivian
- Peng Yi
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- Pennacchio Len A.
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- Percy Chantel
- Perez Agapito
- Perez Lesette M.
- Perito Andrew
- Perrault Isabelle
- Perrier Rene
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- Perrin William
- Pesavento Brad
- Peters Anna
- Peters Leonard G.
- Peterson Jane
- Peterson Karl
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- Pettett Roger
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- Pfeiffer Joyce
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- Phulchung Tenzin
- Phunkang Pema
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- Piqani Bruno
- Piscia C.
- Pitesky Maurice
- Pitluck Sam
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- Poliakov Alex
- Pollard Martin
- Polman Jos
- Ponting Chris P.
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- Porter Keith
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- Potter Christopher
- Potter Simon
- Poundstone Pat
- Pourrajabi Nima M.
- Powell Don
- Powell Jason
- Prado Daisy
- Prange Christa
- Prathalingham Radhika
- Predki Paul
- Prigmore Elena
- Primus Eltrick L.
- Primus Jennifer
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- Qiang Boqin
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- Qiao Zhenyong
- Qin Xiang
- Quail Michael
- Quan Glenda
- Quarrie Hannah
- Quiles Miyo M.
- Quince Chris
- Quiroz Juana B.
- Qureshi Matloob
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- Rachlin Eric K.
- Rachupka Anthony
- Radionenko Maxim
- Rajagopal Mohan
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- Reily Amy D.
- Reinhardt Astrid
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- Reiter Charlie
- Ren Shuangxi
- Ren Shuangxi
- Ren Yanru
- Retterer James
- Rice Alex
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- Rice Peter
- Rice Stephen
- Richard Suzzanne
- Richards Stephen
- Richardson Kristi
- Richardson Paul
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- Ridler Kerry
- Riethman Harold
- Riethoven Lyn
- Rigby Rachel
- Riley B.E
- Rise Cecil
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- Rodriguez Alex
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- Rule James
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- Sabo Aniko
- Saenphimmachak Channakhone
- Safdar Kamal
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- Sakaldasis George
- Salamov Azaf
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- Salter Natalie
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- Sanders Brent
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- Sanders Wendi
- Santibanez Jireh
- Santoyo-Lopez Javier
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- Sawhill William W.
- Saxman Eric
- Scarpelli Claude
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- Schatzkamer Kyriena L.
- Scherer Steven Edward
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- Sonnhammer Erik
- Sorelle Richard P.
- Sotheran Elizabeth
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- Stalvey Malinda
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- Steffen David
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- Stultz Janet
- Sturdy John
- Su Xiaohu
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- Subramanian Sandhya
- Sudbrak Ralf
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- Sulston John
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- Sun Hui
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- Sun Jiandong
- Sun Jiu Qin
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- Sun Yue
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- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
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- Swainson Chris
- Swann Mark
- Swarbreck David
- Swearengen-Shahid Sharhonda
- Sycamore Neil
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- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
- Tagney Matthew
- Tahara Takashi
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- Takano Nobuhiro
- Takaoka Tori
- Takayanagi Atsushi
- Takenaka Tracy
- Talamas Jessica
- Tam Serena
- Tamerisa Kavitha S.
- Tamirisa Aparna
- Tan Olivia
- Tan Steven
- Tan Xinyu
- Tan Xinyu
- Tang Hongli
- Tang Xiangjun
- Tansey Jennifer
- Tao Ran
- Tapia Roxanne
- Taring Elizabeth
- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
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- Taylor Kate
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- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
- Tenzin Pema
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- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
- Theodore Joumathe
- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
- Thomas Daryl J.
- Thomas Karen
- Thomas Nicole
- Thomas Paulette
- Thomas Ruth
- Thomas Shereen
- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
- Thoulutsang Yama
- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
- Tian Wei
- Tian Yan
- Tian Yong
- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
- Tran-Gyamfi Mary
- Trani Lee
- Trankiem Margie
- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
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- Trong Stephan
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- Tu Yuefeng
- Tubby Ben
- Tufarelli Cristina
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- Ueland Stephanie
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- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
- Upson Darren
- Urban Jeremy B.
- Ureta-Vidal Abel
- Ureta-Vidal Abel
- Usmani Kamran
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- Vassiliev Helen
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- Wall Melanie
- Wall Randy E.
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- Wan Ma
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- Wang Ying
- Wang Ying
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- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
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- Weinstock Keith
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- Wells Alan
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- Wen Gaiping
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- Wheatley Carl
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- White Scott P.
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- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
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- Wilkinson Jane
- Wilkinson Jane
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- Williams Andy
- Williams Bill
- Williams Gabrielle A.
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- Williamson Helen
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- Wong Gane K-S
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- Woodeson Sharon
- Woodfine Kathryn
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- Worley Kim Carlyle
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- Wray Paul
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- Wright Debbie
- Wright Kathrine
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- Wright Rita A.
- Wu Chungen
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- Wycoff-Montenegro Melissa
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- Xi Yan
- Xi Yingying
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- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
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- Yoon Vivienne
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- You Bo
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- Younger Ruth
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- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
La mujer es puro cuento: la cultura del género
- Author
- ABBOTT Pamela
- ARDENER Edwin
- BARNARD Alan
- BEAUVOIR Simone de
- BUTLER Judith
- BUTLER Judith
- BUTLER Judith
- BUTLER Judith
- CARRITHERS Michael
- CARRITHERS Michael
- CODE Lorraine
- COLAPINTO John
- DESCOLA Philippe
- DREGER Alice
- DUMONT Louis
- EDHOLM Felicity
- EISENSTEIN Zillah R
- EISENSTEIN Zillah R.
- ERRINGTON Shelly
- FAUSTO-STERLING Anne
- FAUSTO-STERLING Anne
- FOX-KELLER Evelyn
- FRADE Carlos
- FRAISSE Geneviève
- FRASER Nancy
- FRIEDAN Betty
- FRIEDAN Betty
- GOLDMAN Emma
- GREER Germaine
- HARAWAY Donna
- HARDING Sandra
- HARRIS Olivia
- HERTZ Robert
- HOOKS Bell
- KESSLER Suzanne
- LAQUEUR Thomas
- LEACOCK Elenor
- LEWIS Diane K
- LÉVI-STRAUSS Claude
- MacCORMACK Carol P.
- MAUSS Marcel
- McDONALD Maryon
- MEAD Margaret
- MEAD Margaret
- MILLETT Kate
- MITCHELL Juliet
- MITCHELL Juliet
- MOORE Henrietta L.
- MOORE Henrietta L.
- MORRIS Rosalind C.
- NICHOLSON Linda
- NICHOLSON Linda
- OAKLEY Ann
- ORTNER Sherry B.
- OWEN Michelle K.
- PALMA Milagros
- PHILLIPS Anne
- PINE Francis
- REITER Rayna R.
- ROSALDO Michèle Z.
- ROSALDO Michèle Z.
- ROSALDO Michèle Z.
- RUBIN Gayle
- SCOTT Joan W.
- STOLCKE Verena
- STOLER Ann Laura
- STOLER Ann Laura
- STOLLER Robert J.
- STRATHERN Marilyn
- STRATHERN Marilyn
- STRATHERN Marilyn
- THORNTON DILL Bonnie
- TUBERT Silvia
- Verena Stolke
- YANAGISAKO Silvia Junko
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes
- Author
- Adebayo Anjorin
- Aiden Corvin
- Alan F Schatzberg
- Alessandro Serretti
- Alexander W Charney
- Alexey A. Shadrin
- Allan H Young
- Amanda L Dobbyn
- Amanda L Dobbyn
- Amy Perry
- Anders D Børglum
- Anders D Børglum
- Anders D Børglum
- Anders Jureìus
- Anders M Dale
- Anders M Dale
- Anders M Dale
- Anders M Dale
- Anders M. Dale
- Anders M. Dale
- Anders M. Dale
- Andrea Pfennig
- Andreas J Forstner
- Andreas J Forstner
- Andreas J Forstner
- Andreas J Forstner
- Andreas J Forstner
- Andreas J Forstner
- Andreas Reif
- Andres Metspalu
- Andres Metspalu
- Andrew M McIntosh
- Andrew M McIntosh
- Andrew McQuillin
- Andrew McQuillin
- Anil P S Ori
- Anna C Koller
- Anna C Koller
- Anna Maaser
- Anna Maaser
- Anne T Spijker
- Annelie Nordin Adolfsson
- Aree Witoelar
- Aree Witoelar
- Arianna Di Florio
- Arianna Di Florio
- Arne E Vaaler
- Ashley Dumont
- Benjamin M Neale
- Benjamin M Neale
- Benjamin M Neale
- Bernhard T Baune
- Bertram Müller-Myhsok
- Bertram Müller-Myhsok
- Bertram Müller-Myhsok
- Bruno Etain
- Bruno Etain
- Bruno Etain
- Bruno Etain
- Carlos Pato
- Carlos Pato
- Caroline M Nievergelt
- Caroline M Nievergelt
- Carsten Bøcker Pedersen
- Carsten Bøcker Pedersen
- Carsten Bøcker Pedersen
- Catharina Lavebratt
- Cathryn M Lewis
- Cathryn M Lewis
- Cathryn M Lewis
- Ceìline S Reinbold
- Ceìline S Reinbold
- Christiaan A de Leeuw
- Christina M Hultman
- Christine Fraser
- Christine Søholm Hansen
- Christine Søholm Hansen
- Chun Chieh Fan
- Chunyu Liu
- Claire Churchhouse
- Claire Churchhouse
- Claire O’Donovan
- Claire Slaney
- Claudia Giambartolomei
- Cristiana Cruceanu
- Cristiana Cruceanu
- Cristina Saìnchez-Mora
- Cristina Saìnchez-Mora
- Cristina Saìnchez-Mora
- Cynthia Shannon Weickert
- Cynthia Shannon Weickert
- Danfeng Chen
- Danielle Posthuma
- Danielle Posthuma
- David Curtis
- David Curtis
- David M Hougaard
- David M Hougaard
- David St Clair
- David W Craig
- Derek W Morris
- Derek W Morris
- Diane Gage
- Diego Albani
- Dominic Holland
- Dominic Holland
- Donald J MacIntyre
- Donald J MacIntyre
- Douglas H R Blackwood
- Douglas M Ruderfer
- Eduard Vieta
- Elaine K Green
- Eli A Stahl
- Eli A Stahl
- Eli A Stahl
- Eli A Stahl
- Eline J Regeer
- Elliot S Gershon
- Elliot S Gershon
- Engilbert Sigurdsson
- Erlend Bøen
- Esben Agerbo
- Esben Agerbo
- Esben Agerbo
- Euijung Ryu
- Evaristus A Nwulia
- Eystein Stordal
- Eystein Stordal
- Fabian Streit
- Fabio Rivas
- Fan Meng
- Fan Meng
- Felecia Cerrato
- Fermin Mayoral
- Fernando Goes
- Francis J McMahon
- Frank Bellivier
- Frank Bellivier
- Frank Bellivier
- Frank Bellivier
- Franziska Degenhardt
- Franziska Degenhardt
- George Kirov
- Gerome Breen
- Gerome Breen
- Gerome Breen
- Grant W Montgomery
- Gunnar Morken
- Gunnar Morken
- Gustavo Turecki
- Guy A Rouleau
- Guy A Rouleau
- Helena Medeiros
- Helmut Vedder
- Heìleìna A Gaspar
- Heìleìna A Gaspar
- Hoang Nguyen
- Hoang Nguyen
- Howard J Edenberg
- Hreinn Stefansson
- Huda Akil
- Ian Jones
- Ingrid Agartz
- Ingrid Agartz
- Ingrid Agartz
- Ingrid Melle
- Ingrid Melle
- J Raymond DePaulo
- Jack D Barchas
- Jacob Lawrence
- Jakob Grove
- Jakob Grove
- Jakob Grove
- Jakob Grove
- James A Knowles
- James A Knowles
- James B Potash
- James Boocock
- James D McKay
- James L Kennedy
- James L Kennedy
- James L Kennedy
- James L Kennedy
- Jana Strohmaier
- Janet L Sobell
- Janice M Fullerton
- Janice M Fullerton
- Jaqueline Goldstein
- Jennifer M Whitehead Pavlides
- Jens Treutlein
- Jessica S Johnson
- Jessica S Johnson
- Joanna Hauser
- Joanna M Biernacka
- John B Vincent
- John I Nurnberger
- John Kelsoe
- John Kelsoe
- John P Rice
- John S Strauss
- John S Strauss
- Jolanta Lissowska
- Jonas Bybjerg-Grauholm
- Jonas Bybjerg-Grauholm
- Jonathan R I Coleman
- Jonathan R I Coleman
- Jordan W Smoller
- Jordan W Smoller
- Jordan W Smoller
- Josef Frank
- Josep Antoni Ramos-Quiroga
- Josep Antoni Ramos-Quiroga
- Josep Antoni Ramos-Quiroga
- Josep Antoni Ramos-Quiroga
- Joseì Guzman Parra
- Judith A Badner
- Julie Garnham
- Jun Z Li
- Jurgen Del-Favero
- Kari Stefansson
- Kari Stefansson
- Katherine Gordon-Smith
- Katrin Gade
- Katrin Gade
- Ketil J Oedegaard
- Ketil J Oedegaard
- Kimberly Chambert
- Laura Huckins
- Laura Huckins
- Laura J Scott
- Lena Backlund
- Liam Abbott
- Lili Milani
- Lilijana Oruc
- Lina Martinsson
- Lisa A Jones
- Liz Forty
- Loes M Olde Loohuis
- Louise Friseìn
- Louise Friseìn
- Louise Friseìn
- Maciej Trzaskowski
- Manolis Kogevinas
- Manuel Mattheisen
- Manuel Mattheisen
- Manuel Mattheisen
- Manuel Mattheisen
- Manuel Mattheisen
- Marcella Rietschel
- Marco Boks
- Margarita Rivera
- Margarita Rivera
- Margit Burmeister
- Maria Grigoroiu-Serbanescu
- Maria Hipolito
- Marian L Hamshere
- Marianne Giørtz Pedersen
- Marianne Giørtz Pedersen
- Marianne Giørtz Pedersen
- Marie Bækvad-Hansen
- Marie Bækvad-Hansen
- Marion Leboyer
- Marion Leboyer
- Marion Leboyer
- Mark Frye
- Mark J Daly
- Mark J Daly
- Markus Leber
- Markus M Nöthen
- Markus M Nöthen
- Marta Ribaseìs
- Marta Ribaseìs
- Marta Ribaseìs
- Martin Alda
- Martin Alda
- Martin Hautzinger
- Martin Schalling
- Matthew Flickinger
- Melissa J Green
- Melvin G McInnis
- Merete Nordentoft
- Merete Nordentoft
- Michael Bauer
- Michael Boehnke
- Michael C O’Donovan
- Michael Gill
- Michael J Owen
- Michael Steffens
- Michele T Pato
- Mikael Landeìn
- Mikael Landeìn
- Miquel Casas
- Miquel Casas
- Miquel Casas
- Miquel Casas
- Monika Budde
- Naomi R Wray
- Naomi R Wray
- Nelson B Freimer
- Ney Alliey-Rodriguez
- Niamh Mullins
- Nicholas Bass
- Nicholas Craddock
- Nicholas G Martin
- Nicholas G Martin
- Nicholas J Schork
- Olav B Smeland
- Olav B Smeland
- Olav B Smeland
- Olav Bjerkehagen Smeland
- Olav Bjerkehagen Smeland
- Ole A Andreassen
- Ole A Andreassen
- Ole A. Andreassen
- Ole A. Andreassen
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- Ole Kristian Drange
- Ole Mors
- Ole Mors
- Oleksandr Frei
- Pablo Cervantes
- Pamela B Mahon
- Pamela B Mahon
- Pamela Sklar
- Pamela Sklar
- Pamela Sklar
- Pamela Sklar
- Panos Roussos
- Panos Roussos
- Panos Roussos
- Patrick F Sullivan
- Patrick F Sullivan
- Patrick F Sullivan
- Paul D Shilling
- Peng Zhang
- Per Hoffmann
- Per Hoffmann
- Per Hoffmann
- Per Hoffmann
- Per Ivar Finseth
- Peter A Holmans
- Peter McGuffin
- Peter R Schofield
- Peter R Schofield
- Peter Zandi
- Phil H Lee
- Phil H Lee
- Phil H Lee
- Philip B Mitchell
- Piotr M Czerski
- Preben Bo Mortensen
- Preben Bo Mortensen
- Preben Bo Mortensen
- Preben Bo Mortensen
- Psychiatric Genomics Consortium Bipolar Disorder Working Group
- Qingqin S Li
- Radhika Kandaswamy
- Ralph Kupka
- Ralph Kupka
- Ralph Kupka
- Reneì S Kahn
- Reneì S Kahn
- Richard Belliveau
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- Robert C Thompson
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- Roel A Ophoff
- Roel A Ophoff
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- Sahar Hassani
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- Sarah E Medland
- Sarah Kittel-Schneider
- Sarah V Knott
- Sascha B Fischer
- Sascha B Fischer
- Scott D Gordon
- Sebastian Zollner
- Shaun M Purcell
- Shaun M Purcell
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- Simone de Jong
- Srdjan Djurovic
- Srdjan Djurovic
- Srdjan Djurovic
- Srdjan Djurovic
- Stacy Steinberg
- Stanley J Watson
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- Stefan Herms
- Stefan Herms
- Stefan Herms
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- Stephan Ripke
- Stephan Ripke
- Stephan Ripke
- Stephanie H Witt
- Steve McCarroll
- Steve McCarroll
- Steìphane Jamain
- Steìphane Jamain
- Susan L McElroy
- Susanne Lucae
- Sven Cichon
- Sven Cichon
- Sven Cichon
- Sven Cichon
- Swapnil Awasthi
- Szabolcs Szelinger
- Tatiana M Foroud
- Tatyana Shehktman
- Thomas D Als
- Thomas D Als
- Thomas D Als
- Thomas G Schulze
- Thomas G Schulze
- Thomas G Schulze
- Thomas G Schulze
- Thomas G Schulze
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- Thomas W Mühleisen
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- Thomas W Weickert
- Thomas Werge
- Thomas Werge
- Thomas Werge
- Thorgeir E Thorgeirsson
- Tiffany A Greenwood
- Toni-Kim Clarke
- Torbjørn Elvsåshagen
- Torbjørn Elvsåshagen
- ToÞnu Esko
- ToÞnu Esko
- ToÞnu Esko
- ToÞnu Esko
- Tune H Pers
- Tune H Pers
- Udo Dannlowski
- Urban Ösby
- Urs Heilbronner
- Valentina Escott-Price
- Vassily Trubetskoy
- Verneri Antilla
- Vishwajit Nimgaonkar
- Wade H Berrettini
- Wei Xu
- Wei Xu
- Weihua Guan
- Weiqing Wang
- Weiqing Wang
- William A Scheftner
- William B Lawson
- William Bunney
- William Byerley
- William Coryell
- Wolfgang Maier
- Yunpeng Wang
- Yunpeng Wang
- Yunpeng Wang
- Yunpeng Wang
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/01/2019
- Field of study
Background: Alzheimer's disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. However, it is not established if this relation is of genetic origin. Here, we applied statistical methods based on the conditional false discovery rate (FDR) framework to detect genetic overlap between AD and BIP and utilized this overlap to increase the power to identify common genetic variants associated with either or both traits. Methods: We obtained genome wide association studies data from the International Genomics of Alzheimer's Project part 1 (17,008 AD cases and 37,154 controls) and the Psychiatric Genetic Consortium Bipolar Disorder Working Group (20,352 BIP cases and 31,358 controls). We used conditional QQ-plots to assess overlap in common genetic variants between AD and BIP. We exploited the genetic overlap to re-rank test-statistics for AD and BIP and improve detection of genetic variants using the conditional FDR framework. Results: Conditional QQ-plots demonstrated a polygenic overlap between AD and BIP. Using conditional FDR, we identified one novel genomic locus associated with AD, and nine novel loci associated with BIP. Further, we identified two novel loci jointly associated with AD and BIP implicating the MARK2 gene (lead SNP rs10792421, conjunctional FDR=0.030, same direction of effect) and the VAC14 gene (lead SNP rs11649476, conjunctional FDR=0.022, opposite direction of effect). Conclusions: We found polygenic overlap between AD and BIP and identified novel loci for each trait and two jointly associated loci. Further studies should examine if the shared loci implicating the MARK2 and VAC14 genes could explain parts of the shared and distinct features of AD and BIP
The genetics of the mood disorder spectrum:genome-wide association analyses of over 185,000 cases and 439,000 controls
- Author
- Abbott Liam
- Abbott Liam
- Abdellaoui Abdel
- Abdellaoui Abdel
- Adams Mark J.
- Adams Mark J.
- Adolfsson Annelie Nordin
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Adolfsson Rolf
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Akil Huda
- Akil Huda
- Albani Diego
- Albani Diego
- Alda Martin
- Alda Martin
- Alliey-Rodriguez Ney
- Alliey-Rodriguez Ney
- Als Thomas D.
- Als Thomas D.
- Andlauer Till F.M.
- Andlauer Till F.M.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antilla Verneri
- Arolt Volker
- Arolt Volker
- Awasthi Swapnil
- Awasthi Swapnil
- Bacanu Silviu-Alin
- Bacanu Silviu-Alin
- Backlund Lena
- Backlund Lena
- Badner Judith A.
- Badner Judith A.
- Barchas Jack D.
- Barchas Jack D.
- Bass Nicholas
- Bass Nicholas
- Bauer Michael
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Beekman Aartjan T.F.
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- Bryois Julien
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- Uitterlinden André G.
- Uitterlinden André G.
- Umbricht Daniel
- Umbricht Daniel
- Vaaler Arne E.
- Vaaler Arne E.
- Van der Auwera Sandra
- Van der Auwera Sandra
- van Hemert Albert M.
- van Hemert Albert M.
- Vedder Helmut
- Vedder Helmut
- Vieta Eduard
- Vieta Eduard
- Viktorin Alexander
- Viktorin Alexander
- Vincent John B.
- Vincent John B.
- Visscher Peter M.
- Visscher Peter M.
- Völzke Henry
- Völzke Henry
- Wang Weiqing
- Wang Weiqing
- Wang Yunpeng
- Wang Yunpeng
- Watson Stanley J.
- Watson Stanley J.
- Webb Bradley T.
- Webb Bradley T.
- Weickert Cynthia Shannon
- Weickert Cynthia Shannon
- Weickert Thomas W.
- Weickert Thomas W.
- Weinsheimer Shantel Marie
- Weinsheimer Shantel Marie
- Weissman Myrna M.
- Weissman Myrna M.
- Wellmann Jürgen
- Wellmann Jürgen
- Werge Thomas
- Werge Thomas
- Whitehead Pavlides Jennifer M.
- Whitehead Pavlides Jennifer M.
- Willemsen Gonneke
- Willemsen Gonneke
- Witt Stephanie H.
- Witt Stephanie H.
- Wray Naomi R.
- Wray Naomi R.
- Wu Yang
- Wu Yang
- Xi Hualin S.
- Xi Hualin S.
- Xu Wei
- Xu Wei
- Yang Jian
- Yang Jian
- Young Allan H.
- Young Allan H.
- Zandi Peter
- Zandi Peter
- Zhang Futao
- Zhang Futao
- Zhang Peng
- Zhang Peng
- Zollner Sebastian
- Zollner Sebastian
- Ösby Urban
- Ösby Urban
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/11/2019
- Field of study
Background
Mood disorders (including major depressive disorder and bipolar disorder) affect 10-20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Despite their diagnostic distinction, multiple approaches have shown considerable sharing of risk factors across the mood disorders.
Methods
To clarify their shared molecular genetic basis, and to highlight disorder-specific associations, we meta-analysed data from the latest Psychiatric Genomics Consortium (PGC) genome-wide association studies of major depression (including data from 23andMe) and bipolar disorder, and an additional major depressive disorder cohort from UK Biobank (total: 185,285 cases, 439,741 controls; non-overlapping N = 609,424).
Results
Seventy-three loci reached genome-wide significance in the meta-analysis, including 15 that are novel for mood disorders. More genome-wide significant loci from the PGC analysis of major depression than bipolar disorder reached genome-wide significance. Genetic correlations revealed that type 2 bipolar disorder correlates strongly with recurrent and single episode major depressive disorder. Systems biology analyses highlight both similarities and differences between the mood disorders, particularly in the mouse brain cell-types implicated by the expression patterns of associated genes. The mood disorders also differ in their genetic correlation with educational attainment – positive in bipolar disorder but negative in major depressive disorder.
Conclusions
The mood disorders share several genetic associations, and can be combined effectively to increase variant discovery. However, we demonstrate several differences between these disorders. Analysing subtypes of major depressive disorder and bipolar disorder provides evidence for a genetic mood disorders spectrum
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.
- Author
- Abbott Liam
- Abdellaoui Abdel
- Adams Mark J
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Air Tracy M
- Akil Huda
- Albani Diego
- Alda Martin
- Alliey-Rodriguez Ney
- Als Thomas D
- Andlauer Till F M
- Andlauer Till F M
- Andreassen Ole A
- Anjorin Adebayo
- Antilla Verneri
- Arolt Volker
- Auburger Georg
- Awasthi Swapnil
- Bacanu Silviu-Alin
- Backlund Lena
- Badner Judith A
- Barchas Jack D
- Bass Nicholas
- Bauer Michael
- Baune Bernhard T
- Baune Bernhard T
- Beekman Aartjan T F
- Belliveau Richard
- Bellivier Frank
- Bergen Sarah E
- Berger Klaus
- Berrettini Wade H
- Biernacka Joanna M
- Bigdeli Tim B
- Binder Elisabeth B
- Blackwood Douglas H R
- Boehnke Michael
- Boks Marco
- Boocock James
- Boomsma Dorret I
- Breen Gerome
- Breen Gerome
- Bryois Julien
- Budde Monika
- Bunney William
- Burmeister Margit
- Buttenschøn Henriette N
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D
- Børglum Anders D
- Cabaleiro Fabeiro Francisco J
- Cai Na
- Casas Miquel
- Castelao Enrique
- Cerrato Felecia
- Cervantes Pablo
- Chambert Kimberly
- Charney Alexander W
- Chen Danfeng
- Christensen Jane Hvarregaard
- Churchhouse Claire
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clair David St
- Clarke Toni-Kim
- Clarke Toni-Kim
- Coleman Jonathan R I
- Coleman Jonathan R I
- Colodro-Conde Lucía
- Corvin Aiden
- Coryell William
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nick
- Craig David W
- Crawford Gregory E
- Cruceanu Cristiana
- Czerski Piotr M
- Dale Anders M
- Daly Mark J
- Dannlowski Udo
- Dannlowski Udo
- Davies Gail
- de Diego-Otero Yolanda
- de Geus E. J. C.
- de Jong Simone
- de Leeuw Christiaan A
- Deary Ian J
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Del Río Noriega Francisco
- Del-Favero Jurgen
- DePaulo J Raymond
- DePaulo J Raymond
- Derks Eske M
- Direk Nese
- Djurovic Srdjan
- Dobbyn Amanda L
- Dolan Conor V
- Domenici Enrico
- Domschke Katharina
- Dumont Ashley
- Dunn Erin C
- Edenberg Howard J
- Eley Thalia C
- Elvsåshagen Torbjørn
- Escott-Price Valentina
- Escott-Price Valentina
- Esko Tõnu
- Esko Tõnu
- Etain Bruno
- EThorgeirsson Thorgeir
- Fan Chun Chieh
- Finucane Hilary K
- Fischer Sascha B
- Flickinger Matthew
- Florio Arianna Di
- Foo Jerome C
- Foo Jerome C
- Foroud Tatiana M
- Forstner Andreas J
- Forstner Andreas J
- Forstner Andreas J
- Forty Liz
- Frank Josef
- Frank Josef
- Frank Josef
- Fraser Christine
- Freimer Nelson B
- Frisén Louise
- Frye Mark
- Fullerton Janice M
- Gade Katrin
- Gage Diane
- Garnham Julie
- Gaspar Héléna A
- Gaspar Héléna A
- Gershon Elliot S
- Giambartolomei Claudia
- Gil Flores Susana
- Gill Michael
- Gill Michael
- Goes Fernando
- Goes Fernando S
- Goldstein Jaqueline
- González Maria José
- Gordon Scott D
- Gordon Scott D
- Gordon-Smith Katherine
- Grabe Hans J
- Green Elaine K
- Green Melissa J
- Greenwood Tiffany A
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Guan Weihua
- Guzman-Parra Jose
- Hall Lynsey S
- Hamilton Steven P
- Hamshere Marian L
- Hansen Christine Søholm
- Hansen Christine Søholm
- Hansen Thomas F
- Haro González Jesus
- Hauser Joanna
- Hautzinger Martin
- Hayward Caroline
- Heath Andrew C
- Heilbronner Urs
- Heilmann-Heimbach Stefanie
- Herms Stefan
- Herms Stefan
- Herms Stefan
- Hickie Ian B
- Hipolito Maria
- Hoffmann Per
- Hoffmann Per
- Hoffmann Per
- Holland Dominic
- Holmans Peter A
- Homuth Georg
- Horn Carsten
- Hottenga Jouke-Jan
- Hougaard David M
- Hougaard David M
- Howard David M
- Huckins Laura
- Hultman Christina M
- Ising Marcus
- Jamain Stéphane
- Jansen Rick
- Johnson Jessica S
- Jones Ian
- Jones Ian
- Jones Lisa A
- Jones Lisa A
- Jorgenson Eric
- Juréus Anders
- Kahn René S
- Kandaswamy Radhika
- Karlsson Robert
- Kelsoe John
- Kendler Kenneth S
- Kennedy James L
- Kiadeh Farnush Farhadi Hassan
- Kirov George
- Kittel-Schneider Sarah
- Kloiber Stefan
- Knowles James A
- Knowles James A
- Kogevinas Manolis
- Kogevinas Manolis
- Kohane Isaac S
- Koller Anna C
- Kraft Julia
- Kretzschmar Warren W
- Kupka Ralph
- Kutalik Zoltán
- Landén Mikael
- Lavebratt Catharina
- Lawrence Jacob
- Lawson William B
- Leber Markus
- Leboyer Marion
- Lee Phil H
- Levinson Douglas F
- Levy Shawn E
- Lewis Cathryn M
- Lewis Cathryn M
- Lewis Glyn
- Li Jun Z
- Li Qingqin S
- Li Qingqin S
- Li Yihan
- Lind Penelope A
- Lissowska Jolanta
- Liu Chunyu
- Loohuis Loes M Olde
- Lucae Susanne
- Lucae Susanne
- Maaser Anna
- MacIntyre Donald J
- MacIntyre Donald J
- MacKinnon Dean F
- Madden Pamela A F
- Magnusson Patrik K
- Mahon Pamela B
- Maier Robert M
- Maier Wolfgang
- Maier Wolfgang
- Marchini Jonathan
- Martin Nicholas G
- Martin Nicholas G
- Martinsson Lina
- Mattheisen Manuel
- Mattheisen Manuel
- Mayoral Fermin
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- Mbarek Hamdi
- McCarroll Steve
- McElroy Susan L
- McGrath Patrick
- McGuffin Peter
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- McInnis Melvin G
- McIntosh Andrew M
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- McKay James D
- McMahon Francis J
- McQuillin Andrew
- Medeiros Helena
- Medland Sarah E
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- Mehta Divya
- Melle Ingrid
- Meng Fan
- Metspalu Andres
- Metspalu Andres
- Middeldorp Christel M
- Mihailov Evelin
- Milaneschi Yuri
- Milani Lili
- Milani Lili
- Mirza Saira Saeed
- Mitchell Philip B
- Mondimore Francis M
- Montgomery Grant W
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- Moreno-Küstner Berta
- Morken Gunnar
- Morris Derek W
- Mors Ole
- Mors Ole
- Mortensen Preben Bo
- Mortensen Preben Bo
- Mostafavi Sara
- Mullins Niamh
- Mullins Niamh
- Myers Richard M
- Mühleisen Thomas W
- Müller-Myhsok Bertram
- Müller-Myhsok Bertram
- Müller-Myhsok Bertram
- Nauck Matthias
- Neale Benjamin M
- Ng Bernard
- Nguyen Hoang
- Nievergelt Caroline M
- Nimgaonkar Vishwajit
- Nivard Michel G
- Nordentoft Merete
- Nordentoft Merete
- Nurnberger John I
- Nwulia Evaristus A
- Nyholt Dale R
- Nöthen Markus M
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- O'Donovan Claire
- O'Donovan Michael C
- O'Donovan Michael C
- O'Reilly Paul F
- Oedegaard Ketil J
- Ophoff Roel A
- Ori Anil P S
- Orozco Diaz Guillermo
- Oruc Lilijana
- Oskarsson Hogni
- Owen Michael J
- Owen Michael J
- Paciga Sara A
- Paciga Sara A
- Painter Jodie N
- Parra José Guzman
- Pato Carlos
- Pato Michele T
- Pavlides Jennifer M Whitehead
- Pedersen Carsten Bøcker
- Pedersen Carsten Bøcker
- Pedersen Marianne Giørtz
- Pedersen Marianne Giørtz
- Pedersen Nancy L
- Penninx Brenda W J H
- Perez Fermin Perez
- Perlis Roy H
- Perlis Roy H
- Perry Amy
- Pers Tune H
- Peterson Roseann E
- Pettersson Erik
- Peyrot Wouter J
- Pfennig Andrea
- Pistis Giorgio
- Porteous David J
- Posthuma Danielle
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- Potash James B
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- Purcell Shaun M
- Quiroz Jorge A
- Qvist Per
- Ramos-Quiroga Josep Antoni
- Regeer Eline J
- Reif Andreas
- Reinbold Céline S
- Ribasés Marta
- Rice John P
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- Richards Alexander L
- Rietschel Marcella
- Rietschel Marcella
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- Rivas Fabio
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- Rivera Margarita
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- Ruderfer Douglas M
- Ryu Euijung
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- Schalling Martin
- Schatzberg Alan F
- Scheftner William A
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- Serretti Alessandro
- Shehktman Tatyana
- Shen Ling
- Shi Jianxin
- Shilling Paul D
- Shyn Stanley I
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Sinnamon Grant C B
- Sklar Pamela
- Slaney Claire
- Smeland Olav B
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- Smith Daniel J
- Smoller Jordan W
- Smoller Jordan W
- Sobell Janet L
- Spijker Anne T
- Stahl Eli A
- Stefansson Hreinn
- Stefansson Hreinn
- Stefansson Kari
- Stefansson Kari
- Steffens Michael
- Steinberg Stacy
- Steinberg Stacy
- Stordal Eystein
- Strauss John S
- Streit Fabian
- Streit Fabian
- Streit Fabian
- Strohmaier Jana
- Strohmaier Jana
- Strohmaier Jana
- Sullivan Patrick F
- Sullivan Patrick F
- Szelinger Szabolcs
- Sánchez-Mora Cristina
- Tansey Katherine E
- Teismann Henning
- Teumer Alexander
- Thompson Robert C
- Thompson Wesley
- Thomson Pippa A
- Thorgeirsson Thorgeir E
- Tiemeier Henning
- Traylor Matthew
- Treutlein Jens
- Treutlein Jens
- Treutlein Jens
- Trubetskoy Vassily
- Trubetskoy Vassily
- Trzaskowski Maciej
- Trzaskowski Maciej
- Turecki Gustavo
- Uher Rudolf
- Uitterlinden André G
- Umbricht Daniel
- Vaaler Arne E
- Van der Auwera Sandra
- van Hemert Albert M
- Vedde Helmut
- Vieta Eduard
- Viktorin Alexander
- Vincent John B
- Visscher Peter M
- Völzke Henry
- Wang Weiqing
- Wang Yunpeng
- Wang Yunpeng
- Watson Stanley J
- Webb Bradley T
- Weickert Cynthia Shannon
- Weickert Thomas W
- Weinsheimer Shantel Marie
- Weissman Myrna M
- Wellmann Jürgen
- Werge Thomas
- Werge Thomas
- Willemsen Gonneke
- Witt Stephanie H
- Witt Stephanie H
- Witt Stephanie H
- Wray Naomi R
- Wray Naomi R
- Wu Yang
- Xi Hualin S
- Xi Simon
- Xu Wei
- Yang Jian
- Young Allan H
- Zandi Peter
- Zhang Futao
- Zhang Peng
- Zollner Sebastian
- Ösby Urban
- Publication venue
- Mol Psychiatry
- Publication date
- 20/12/2018
- Field of study
Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development
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