467 research outputs found
Academic Performance and Behavioral Patterns
- Author
- A Duff
- A Furnham
- A Furnham
- A Lepp
- A Mayer
- A Singh
- A Stopczynski
- AC Karpinski
- AF Newcomb
- B Sacerdote
- CF Manski
- D GaĆĄeviÄ
- DE Lavin
- DH Saklofske
- DJ Zimmerman
- DR Marburger
- DW Johnson
- E Cohn
- E Kumbasar
- EA Kolek
- EE Noftle
- EK Gray
- F Fruyt De
- F Lievens
- FL Oswald
- FT Leong
- G Curcio
- H Cho
- H Yang
- HA Hill
- HP Chow
- HR Bernard
- J Brocato
- J Chen
- J Hommes
- J Lane
- J Leach
- J-P Vandamme
- J-V TomĂĄs-Miquel
- JA Paul
- JJ Al-Menayes
- JJ Al-Menayes
- JJ Valletta
- JW Lounsbury
- K Cleemput Van
- KA Barchard
- KM OâConnor
- KR White
- KW Bauer
- L Buckalew
- L Stanca
- LC Freeman
- LR Goldberg
- M Credé
- M Goff
- M Komarraju
- M Owens
- M Tayseer
- MA Conard
- ME Haines
- MG Rothstein
- ML Blerkom Van
- MM Maqableh
- MP Vitale
- MS DeBerard
- N Eagle
- N Eagle
- NT Nghe
- P Hair
- P Phillips
- P Sapiezynski
- P Sapiezynski
- PA Kirschner
- PH Langford
- PV Marsden
- R Junco
- R Junco
- R Stinebrickner
- R Wang
- RA Smith
- RN Wolfe
- RT Sparrowe
- S Ainin
- S Akgun
- SD Ridgell
- SE Carrell
- SE Gump
- SJ Dollinger
- SL Thomas
- SM Stewart
- SR Sirin
- SV Paunonen
- SV Paunonen
- T Chamorro-Premuzic
- T Chamorro-Premuzic
- T Farsides
- T-F Lin
- TE Rizzuto
- TF Van de Mortel
- TH Macan
- TJ Prociuk
- TT Baldwin
- V Kassarnig
- V Sekara
- VV Busato
- W Mischel
- WC Jacobsen
- YC Yuan
- Ă Diseth
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Identifying the factors that influence academic performance is an essential
part of educational research. Previous studies have documented the importance
of personality traits, class attendance, and social network structure. Because
most of these analyses were based on a single behavioral aspect and/or small
sample sizes, there is currently no quantification of the interplay of these
factors. Here, we study the academic performance among a cohort of 538
undergraduate students forming a single, densely connected social network. Our
work is based on data collected using smartphones, which the students used as
their primary phones for two years. The availability of multi-channel data from
a single population allows us to directly compare the explanatory power of
individual and social characteristics. We find that the most informative
indicators of performance are based on social ties and that network indicators
result in better model performance than individual characteristics (including
both personality and class attendance). We confirm earlier findings that class
attendance is the most important predictor among individual characteristics.
Finally, our results suggest the presence of strong homophily and/or peer
effects among university students
Stellar Coronal and Wind Models: Impact on Exoplanets
- Author
- A Maggio
- A Morgenthaler
- A Morgenthaler
- A Reiners
- A Reiners
- A Reiners
- A Strugarek
- A Telleschi
- A. Skumanich
- AA Pevtsov
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA Vidotto
- AA West
- AF Lanza
- B Holst van der
- B Holst van der
- B Zieger
- BA Nicholson
- BE Wood
- BE Wood
- BE Wood
- BE Wood
- BE Wood
- BJ Wargelin
- BO Demory
- C Catala
- C Garraffo
- C Johnstone
- C. P. Johnstone
- CM Johns-Krull
- CM Johns-Krull
- CP Folsom
- CP Johnstone
- CP Johnstone
- D Arzoumanian
- D Bisikalo
- D Buzasi
- D Falceta-Gonçalves
- D Lai
- E Shkolnik
- EF Guinan
- EJ Gaidos
- F Bagenal
- G Anglada-Escudé
- G Scandariato
- GAJ Hussain
- GAJ Hussain
- GAJ Hussain
- GHJ Oord van den
- GW Pneuman
- H Lammer
- H Lammer
- H Washimi
- I Baraffe
- I Pillitteri
- I Ribas
- I. Ribas
- IA Waite
- IA Waite
- IA Waite
- Ignasi Ribas
- IV Sokolov
- J Donati
- J Donati
- J Donati
- J Donati
- J Llama
- J Morin
- J Morin
- J Morin
- J Morin
- J Sanz-Forcada
- J Zendejas
- Jackie Villadsen
- JD Alvarado-GĂłmez
- Jeremy Lim
- JF Donati
- JF Donati
- JF Donati
- JF Donati
- JF Donati
- JF Donati
- JF Donati
- JF Donati
- JF Donati
- JF Donati
- JH Debes
- JI Zuluaga
- JJG Lima
- JM GrieĂmeier
- JM GrieĂmeier
- JV Hollweg
- K Tsinganos
- KG Kislyakova
- L Hartmann
- L. Mestel
- M Guedel
- M Guedel
- M GĂŒdel
- M Jardine
- M Jardine
- MG Sterenborg
- ML Khodachenko
- ML Khodachenko
- N Pizzolato
- NJ Wright
- O Cohen
- O Cohen
- O. Cohen
- O. Cohen
- P Lang
- P Petit
- P Petit
- P Testa
- R Fares
- R Fares
- R Fares
- R Fares
- R Keppens
- R Pallavicini
- RD Jeffries
- Robert P. Kraft
- Rui F. Pinto
- RVE Lovelace
- S Boro Saikia
- S Boro Saikia
- S Matt
- S. V. Jeffers
- SC Marsden
- SC Marsden
- SG Parsons
- SH Yang
- SK Solanki
- SL Li
- SP Matt
- SR Cranmer
- SR Cranmer
- T Matsakos
- T Matsumoto
- Takuma Matsumoto
- TE Holzer
- Theresa LĂŒftinger
- TK Suzuki
- V Jatenco-Pereira
- V RĂ©ville
- V See
- V. Bourrier
- V. Bourrier
- WH Ip
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 22/09/2017
- Field of study
Surface magnetism is believed to be the main driver of coronal heating and
stellar wind acceleration. Coronae are believed to be formed by plasma confined
in closed magnetic coronal loops of the stars, with winds mainly originating in
open magnetic field line regions. In this Chapter, we review some basic
properties of stellar coronae and winds and present some existing models. In
the last part of this Chapter, we discuss the effects of coronal winds on
exoplanets.Comment: Chapter published in the "Handbook of Exoplanets", Editors in Chief:
Juan Antonio Belmonte and Hans Deeg, Section Editor: Nuccio Lanza. Springer
Reference Work
Inducing institutional change through projects? : Three models of projectified governance
- Author
- Publication venue
- Publication date
- 04/07/2019
- Field of study
The study of short-term projects to implement policy has lately gained ground among scholars of environmental governance and public administration. The increasing reliance on and prevalence of projects, or âprojectificationâ, has spurred critical debates on the ability of projects to contribute to long-term goals, including sustainability, as well as institutional change. Yet, the literature on projectification lacks specificity in terms of how projects are understood, how the relationship between projects and permanent organizations looks like, and how projects can influence institutional orders. The aim of this paper is to systematize the literature in order to uncover the process of transforming project outputs into institutional change. Three models of projectified governance â mechanistic, organic, and adaptive â is presented, providing a conceptual apparatus that advances the study of projects in environmental policy and governance. The paper argues that the adaptive model, with its reliance on multi-scalar networks for the coordination of project activities and knowledge, shows most promise in achieving institutional change to address complex environmental problems.Peer reviewe
Existence of periodic solutions to nonlinear p-regular boundary value problem
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at âs = 7 TeV with the ATLAS detector
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- Abajyan T
- Abbott B
- Abdallah J
- Abdinov O
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- AbouZeid OS
- Abramowicz H
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- Aguilar-Saavedra JA
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- Amelung C
- Ammosov VV
- Amor Dos Santos SP
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- Feigl S
- Feligioni L
- Feligioni L
- Feng C
- Feng C
- Feng EJ
- Feng EJ
- Feng H
- Feng H
- Fenyuk AB
- Fenyuk AB
- Fernando W
- Fernando W
- Ferrag S
- Ferrag S
- Ferrando BMS
- Ferrando J
- Ferrando J
- Ferrara V
- Ferrara V
- Ferrari A
- Ferrari A
- Ferrari P
- Ferrari P
- Ferrari R
- Ferrari R
- Ferrer A
- Ferrer A
- Ferrere D
- Ferrere D
- Ferretti C
- Ferretti C
- Fiascaris M
- Fiascaris M
- Fiedler F
- Fiedler F
- Filipcic A
- Filipcic A
- Filipuzzi M
- Filipuzzi M
- Filthaut F
- Filthaut F
- Fincke-Keeler M
- Fincke-Keeler M
- Finelli KD
- Finelli KD
- Fiolhais MCN
- Fiolhais MCN
- Fiorini L
- Fiorini L
- Firan A
- Firan A
- Fischer J
- Fischer J
- Fisher MJ
- Fisher MJ
- Fitzgerald EA
- Fitzgerald EA
- Flechl M
- Flechl M
- Fleck I
- Fleck I
- Fleischmann P
- Fleischmann P
- Fleischmann S
- Fleischmann S
- Fletcher G
- Fletcher G
- Fletcher GT
- Fletcher GT
- Flick T
- Flick T
- Floderus A
- Floderus A
- Florez Bustos AC
- Flowerdew MJ
- Flowerdew MJ
- Formica A
- Formica A
- Forti A
- Forti A
- Fortin D
- Fortin D
- Fournier D
- Fournier D
- Fox H
- Fox H
- Francavilla P
- Francavilla P
- Franchini M
- Franchini M
- Franchino S
- Franchino S
- Francis D
- Francis D
- Franklin M
- Franklin M
- Franz S
- Franz S
- Fraternali M
- Fraternali M
- Fratin S
- Fratina S
- French ST
- French ST
- Friedrich C
- Friedrich C
- Friedrich F
- Friedrich F
- Froidevaux D
- Froidevaux D
- Frost JA
- Frost JA
- Fukunaga C
- Fukunaga C
- Fulsom BG
- Fulsom BG
- Fuster J
- Fuster J
- Gabaldon C
- Gabaldon C
- Gabizon O
- Gabizon O
- Gabrielli A
- Gabrielli A
- Gabrielli A
- Gabrielli A
- Gadatsch S
- Gadatsch S
- Gadomski S
- Gadomski S
- Gagliardi G
- Gagliardi G
- Gagnon P
- Gagnon P
- Galea C
- Galea C
- Galhardo B
- Galhardo B
- Gallas EJ
- Gallas EJ
- Gallo V
- Gallo V
- Gallop BJ
- Gallop BJ
- Gallus P
- Gallus P
- Galster G
- Galster G
- Gan KK
- Gan KK
- Gandrajula RP
- Gandrajula RP
- Gao J
- Gao YS
- Gao YS
- Gaob J
- Garberson F
- Garberson F
- Garcia Navarro JE
- Garcia Navarro JE
- Garcia BRM
- Garcia C
- Garcia C
- Garcia JAB
- Garcia-Sciveres M
- Garcia-Sciveres M
- Gardner RW
- Gardner RW
- Garelli N
- Garelli N
- Garonne V
- Garonne V
- Garrido MDMC
- Gatti C
- Gatti C
- Gaudio G
- Gaudio G
- Gaur B
- Gaur B
- Gauthier L
- Gauthier L
- Gauzzi P
- Gauzzi P
- Gavrilenko IL
- Gavrilenko IL
- Gay C
- Gay C
- Gaycken G
- Gaycken G
- Gazis EN
- Gazis EN
- Ge P
- Ge P
- Gecse Z
- Gecse Z
- Gee CNP
- Gee CNP
- Geerts DAA
- Geerts DAA
- Geich-Gimbel C
- Geich-Gimbel C
- Gellerstedt K
- Gellerstedt K
- Gemme C
- Gemme C
- Gemmell A
- Gemmell A
- Genest MH
- Genest MH
- Gentile S
- Gentile S
- George M
- George M
- George S
- George S
- Gerbaudo D
- Gerbaudo D
- Gershon A
- Gershon A
- Ghazlane H
- Ghazlane H
- Ghodbane N
- Ghodbane N
- Giacobbe B
- Giacobbe B
- Giagu S
- Giagu S
- Giangiobbe V
- Giangiobbe V
- Giannetti P
- Giannetti P
- Gianotti F
- Gianotti F
- Gibbard B
- Gibbard B
- Gibson SM
- Gibson SM
- Gilchriese M
- Gilchriese M
- Gillam TPS
- Gillam TPS
- Gillberg D
- Gillberg D
- Gillman AR
- Gillman AR
- Gingrich DM
- Gingrich M
- Giokaris N
- Giokaris N
- Giordani MP
- Giordani MP
- Giordano R
- Giordano R
- Giorgi FM
- Giorgi FM
- Giraud PF
- Giraud PF
- Giugni D
- Giugni D
- Giuliani C
- Giuliani C
- Giunta M
- Giunta M
- Gjelsten BK
- Gjelsten BK
- Gkialas I
- Gkialas I
- Gladilin LK
- Gladilin LK
- Glasman C
- Glasman C
- Glatzer J
- Glatzer J
- Glazov A
- Glazov A
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- Goddard JR
- Godfrey J
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- Godlewski J
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- Goeringer C
- Goeringer C
- Goessling C
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- Goldfarb S
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- Golubkov D
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- Gomes A
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- Gonalo R
- Goncalo R
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- Gonella L
- Gonzalez de la Hoz S
- Gonzalez de la Hoz S
- Gonzalez Parra G
- Gonzalez Parra G
- Gonzalez BA
- Gonzalez-Sevilla S
- Gonzalez-Sevilla S
- Goossens L
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- Gorbounov PA
- Gorbounov PA
- Gordon HA
- Gordon HA
- Gorelov I
- Gorelov I
- Gorini B
- Gorini B
- Gorini E
- Gorini E
- Gorisek A
- Gorisek A
- Gornicki E
- Gornicki E
- Goshaw AT
- Goshaw AT
- Gostkin MI
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- Gouighri M
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- Goujdami D
- Goujdami D
- Goulette MP
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- Goussiou AG
- Goussiou AG
- Goy C
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- Gozpinar S
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- Grabas HMX
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- Graber L
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- Grabowska-Bold I
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- Grafstroem P
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- Gramling J
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- Gramstad E
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- Grancagnolo S
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- Grancagnoloa F
- Grassi V
- Grassi V
- Gratchev V
- Gratchev V
- Gray HM
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- Graziani E
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- Grebenyuk OG
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- Greenwood ZD
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- Gregersen K
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- Gregor IM
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- Grenier P
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- Griffiths J
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- Grillo AA
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- Grimm K
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- Grinstein S
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- Gris P
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- Griso SP
- Grivaz J-F
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- Grohs JP
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- Grohsjean A
- Gross AGE
- Gross E
- Grosse-Knetter J
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- Grossi GC
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- Groth-Jensen J
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- Guan L
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- Guescini F
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- Guest D
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- Gueta O
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- Guicheney C
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- Guido E
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- Guindon S
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- Gul U
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- Gumpert C
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- Gutierrez P
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- Gutschow C
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- Guttman N
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- Guyot C
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- Haefner P
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- Hansen JD
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- Hasegawa Y
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- Hawkings RJ
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- Ideal E
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- Igonkina O
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- Zhemchugov A
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- Zibell A
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- Zimmermann C
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- Zurzolo G
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of âs = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentreâofâmassframeisusedtosuppressthelargemultiâjetbackground.ThecrossâsectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at sâ=8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Almond J
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alviggi MG
- Amako K
- Amaral Coutinho Y
- Amelung C
- Amidei D
- Amor Dos Santos SP
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fbâ1 of protonâproton collision data at âs = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via tËâtÏË01 or tËâ bÏ˱1 âbW(â)ÏË01 , where ÏË01 (Ï˱1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of tË â tÏË01 . For a branching fraction of 100%, top squark masses in the range 270â645 GeV are excluded for ÏË01 masses below 30 GeV. For a branching fraction of 50% to either tË â tÏË01 or tË â bÏ˱1 , and assuming the Ï˱1 mass to be twice the ÏË01 mass, top squark masses in the range 250â550 GeV are excluded for ÏË01 masses below 60 GeV
Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at âs=8TeV
- Author
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- Yilmaz M
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- Youssef S
- Yu DR
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- Zemla A
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- Zenin O
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- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
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- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fbâ1of data collected in protonâproton collisions at âs=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV
Both habitat change and local lek structure influence patterns of spatial loss and recovery in a black grouse population
- Author
- A Caizergues
- A Watson
- A Wolff
- AF Zuur
- AH Fielding
- AH Fielding
- AL Drewitt
- Alan H. Fielding
- AP Tharme
- BS Law
- C Lebigre
- CE Grueber
- CK Gowda
- CR Warren
- D Baines
- D Serrano
- D Whitfield
- DJT Douglas
- GX Ludwig
- I Hanski
- IMW Sim
- J Elith
- J Elith
- J Elith
- JHJ Ward
- JW Pearce-Higgins
- KP Burnham
- KP Burnham
- L Biehl
- L Cardador
- M Cabeza
- M Geary
- M Geary
- M Hancock
- Matthew Geary
- MF Proctor
- MZ Virani
- N Signorell
- NASA Landsat Program
- NASA Landsat Program
- O Razgour
- PK Warren
- RJ Fuller
- RJ Fuller
- RP Freckleton
- S Polasky
- SJ Lane
- SJ Phillips
- SN Woods
- Stuart J. Marsden
- T Ludwig
- T Wiegand
- W Thuiller
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2015
- Field of study
The final publication is available at Springer via http://dx.doi.org/10.1007/s10144-015-0484-3Land use change is a major driver of declines in wildlife populations. Where human economic or recreational interests and wildlife share landscapes this problem is exacerbated. Changes in UK black grouse Tetrao tetrix populations are thought to have been strongly influenced by upland land use change. In a long-studied population within Perthshire, lek persistence is positively correlated with lek size, and remaining leks clustered most strongly within the landscape when the population is lowest, suggesting that there may be a demographic and/or spatial context to the reaction of the population to habitat changes. Hierarchical cluster analysis of lek locations revealed that patterns of lek occupancy when the population was declining were different to those during the later recovery period. Response curves from lek-habitat models developed using MaxEnt for periods with a declining population, low population, and recovering population were consistent across years for most habitat measures. We found evidence linking lek persistence with habitat quality changes and more leks which appeared between 1994 and 2008 were in improving habitat than those which disappeared during the same period. Generalised additive models (GAMs) identified changes in woodland and starting lek size as being important indicators of lek survival between declining and low/recovery periods. There may also have been a role for local densities in explaining recovery since the population low point. Persistence of black grouse leks was influenced by habitat, but changes in this alone did not fully account for black grouse declines. Even when surrounded by good quality habitat, leks can be susceptible to extirpation due to isolation
Predictive validity of the Brazilian version of the Expected Treatment Outcome Scale in cocaine-dependent outpatients at a drug treatment referral center
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures
- Author
- A Saunders
- AC Seila
- AF Stewart
- AS Belmont
- B Schuster-Böckler
- B Villeponteau
- B Villeponteau
- Bauke Ylstra
- C Hou
- C Naughton
- C Naughton
- Catherine Naughton
- D Sproul
- DS Gilmour
- DS Gilmour
- EP Nora
- F Pedone
- G Bernardi
- GD Cimino
- GN Giaever
- H Caron
- H Tabuchi
- H Weintraub
- I BermĂșdez
- Ioulia K Mati
- J Filipski
- James G Prendergast
- JK Stock
- JR Dixon
- LF Liu
- LJ Core
- M Costantini
- M Dunaway
- M Ljungman
- M Ljungman
- M Merkenschlager
- M Mizutani
- M Mizutani
- Mark Bradley
- MC Schultz
- MJ Lercher
- MP Marsden
- MT Tomic
- MV Blagosklonny
- N Gilbert
- N Hay
- Nick Gilbert
- Nicolaos Avlonitis
- P Preker
- Paul P Eijk
- R MĂ©tivier
- R Versteeg
- RD Kornberg
- RK Sachs
- RR Sinden
- RS Joshi
- S Chambeyron
- Samuel Corless
- Scott L Cockroft
- WA Saffran
- Y Hu
- Y Zhou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating gene expression and DNA replication. However, DNA supercoiling at a genomic scale in human cells is uncharacterized. To map supercoiling we used biotinylated-trimethylpsoralen as a DNA structure probe to show the genome is organized into supercoiling domains. Domains are formed and remodeled by RNA polymerase and topoisomerase activities and are flanked by GC-AT boundaries and CTCF binding sites. Under-wound domains are transcriptionally active, enriched in topoisomerase I, âopenâ chromatin fibers and DNaseI sites, but are depleted of topoisomerase II. Furthermore DNA supercoiling impacts on additional levels of chromatin compaction as under-wound domains are cytologically decondensed, topologically constrained, and decompacted by transcription of short RNAs. We suggest that supercoiling domains create a topological environment that facilitates gene activation providing an evolutionary purpose for clustering genes along chromosomes
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