Turbulence structure and similarity in the separated flow above a low building in the atmospheric boundary layer

Separated and reattaching flows over sharp-leading-edge bluff bodies are important to investigate in order to improve our understanding of practical flows such as the case of low-rise buildings in the atmospheric boundary layer. In this study, Particle Image Velocimetry measurements of the separated-reattaching flows over the roof surface of a low-rise building model were taken for six different turbulent boundary layer conditions. The results were analyzed to understand how the incident turbulence affects the flow field of the separation bubbles above the low-rise building roof. The mean flow field above the roof-surface was found to be approximately similar across the six terrain conditions using the mean reattachment length in the streamwise direction and the maximum mean thickness of the separated shear layer in the vertical direction. However, the turbulence stresses are not similar which is attributed to high levels of initial turbulence kinetic energy in the separated shear layer. This leads to fundamental differences in the initial development of the separated flow when compared to flows with lower turbulence in the incident stream. The results indicate that the Kelvin-Helmholtz instability may be altered, or perhaps even suppressed, in the initial flow development region. This leads to substantially different turbulence statistics and characteristics within the separated shear layers

Searching for star-planet magnetic interaction in CoRoT observations

Close-in massive planets interact with their host stars through tidal and magnetic mechanisms. In this paper, we review circumstantial evidence for star-planet interaction as revealed by the photospheric magnetic activity in some of the CoRoT planet-hosting stars, notably CoRoT-2, CoRoT-4, and CoRoT-6. The phenomena are discussed in the general framework of activity-induced features in stars accompanied by hot Jupiters. The theoretical mechanisms proposed to explain the activity enhancements possibly related with hot Jupiter are also briefly reviewed with an emphasis on the possible effects at photospheric level. The unique advantages of CoRoT and Kepler observations to test these models are pointed out.Comment: Invited review paper accepted by Astrophysics and Space Science, 13 pages, 5 figure

Material identification in nuclear waste drums using muon scattering tomography and multivariate analysis

The use of muon scattering tomography for the non-invasive characterisation of nuclear waste is well established. We report here on the application of a combination of feature discriminators and multivariate analysis techniques to locate and identify materials in nuclear waste drums. After successful training and optimisation of the algorithms they are then tested on a range of material configurations to assess the system's performance and limitations. The system is able to correctly identify uranium, iron and lead objects on a few cm scale. The system's sensitivity to small uranium objects is also established as 0.90+0.07-0.12, with a false positive rate of 0.12+0.12-0.07

Measuring the Relative Strong Phase in D0→K∗+K−D^0 \to K^{*+} K^- and D0→K∗−K+D^0 \to K^{*-} K^+ Decays

In a recently suggested method for measuring the weak phase $\gamma$ in $B^\pm \to K^\pm (KK^*)_D$ decays, the relative strong phase $\delta_D$ in $D^0 \to K^{*+} K^-$ and $D^0 \to K^{*-} K^+$ decays (equivalently, in $D^0 \to K^{*+} K^-$ and \od \to K^{*+} K^-) plays a role. It is shown how a study of the Dalitz plot in $D^0 \to K^+ K^- \pi^0$ can yield information on this phase, and the size of the data sample which would give a useful measurement is estimated.Comment: 13 pages, latex, 5 figures, submitted to Phys. Rev. D. Appendix and some text on additional resonant contributions adde

Lifetime Differences, direct CP Violation and Partial Widths in D0 Meson Decays to K+K- and pi+pi-

We describe several measurements using the decays D0->K+K- and pi+pi-. We find the ratio of partial widths, Gamma(D0->K+K-)/Gamma(D0->pi+pi-), to be 2.96+/-0.16+/-0.15, where the first error is statistical and the second is systematic. We observe no evidence for direct CP violation, obtaining A_CP(KK) = (0.0+/-2.2+/-0.8)% and A_CP(pipi = (1.9+/-3.2+/-0.8)%. In the limit of no CP violation we measure the mixing parameter y_CP = -0.012+/-0.025+/-0.014 by measuring the lifetime difference between D0->K+ K- or pi+pi- and the CP neutral state, D0->K-pi+. We see no evidence for mixing.Comment: 14 pages postscript, also available through http://w4.lns.cornell.edu/public/CLNS, submitted to PRD, Rapid Communicatio

Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis

Human induced pluripotent stem cells (hiPSCs) hold great potential for modelling human diseases and the development of innovative therapeutic approaches. Here, we report on a novel, simplified differentiation method for forming functional osteoclasts from hiPSCs. The three-step protocol starts with embryoid body formation, followed by hematopoietic specification, and finally osteoclast differentiation. We observed continuous production of monocyte-like cells over a period of up to nine weeks, generating sufficient material for several osteoclast differentiations. The analysis of stage-specific gene and surface marker expression proved mesodermal priming, the presence of monocyte-like cells, and of terminally differentiated multinucleated osteoclasts, able to form resorption pits and trenches on bone and dentine in vitro. In comparison to peripheral blood mononuclear cell (PBMC)-derived osteoclasts hiPSC-derived osteoclasts were larger and contained a higher number of nuclei. Detailed functional studies on the resorption behaviour of hiPSC-osteoclasts indicated a trend towards forming more trenches than pits and an increase in pseudo-resorption. We used hiPSCs from an ARO patient (BIHi002-A, ARO hiPSCs) with compound heterozygous missense mutations p.(G292E) and p.(R403Q) in CLCN7, coding for the Cl(-)/H(+) -exchanger ClC-7, for functional investigations. The patient's leading clinical feature was a brain malformation due to defective neuronal migration. Mutant ClC-7 displayed residual expression and retained lysosomal co-localization with OSTM1, but only ClC-7 harboring the mutation p.(R403Q) gave strongly reduced ion currents. An increased autophagic flux in spite of unchanged lysosomal pH was evident in undifferentiated ARO hiPSCs. ARO hiPSC-derived osteoclasts showed an increased size compared to hiPSCs of healthy donors. They were not able to resorb bone, indicating a loss-of-function effect of the mutations. In summary, we developed a highly reproducible, straightforward hiPSC-osteoclast differentiation protocol. We demonstrated that osteoclasts differentiated from ARO-hiPSCs can be used as a disease model for ARO and potentially also other osteoclast-related diseases

Modeling the Subsurface Structure of Sunspots

While sunspots are easily observed at the solar surface, determining their subsurface structure is not trivial. There are two main hypotheses for the subsurface structure of sunspots: the monolithic model and the cluster model. Local helioseismology is the only means by which we can investigate subphotospheric structure. However, as current linear inversion techniques do not yet allow helioseismology to probe the internal structure with sufficient confidence to distinguish between the monolith and cluster models, the development of physically realistic sunspot models are a priority for helioseismologists. This is because they are not only important indicators of the variety of physical effects that may influence helioseismic inferences in active regions, but they also enable detailed assessments of the validity of helioseismic interpretations through numerical forward modeling. In this paper, we provide a critical review of the existing sunspot models and an overview of numerical methods employed to model wave propagation through model sunspots. We then carry out an helioseismic analysis of the sunspot in Active Region 9787 and address the serious inconsistencies uncovered by \citeauthor{gizonetal2009}~(\citeyear{gizonetal2009,gizonetal2009a}). We find that this sunspot is most probably associated with a shallow, positive wave-speed perturbation (unlike the traditional two-layer model) and that travel-time measurements are consistent with a horizontal outflow in the surrounding moat.Comment: 73 pages, 19 figures, accepted by Solar Physic

Measurement of the cross section for isolated-photon plus jet production in pp collisions at √s=13 TeV using the ATLAS detector

The dynamics of isolated-photon production in association with a jet in proton–proton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fb−1. Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti- algorithm with radius parameter and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photon–jet invariant mass and the scattering angle in the photon–jet centre-of-mass system. Tree-level plus parton-shower predictions from Sherpa and Pythia as well as next-to-leading-order QCD predictions from Jetphox and Sherpa are compared to the measurements

The performance of the jet trigger for the ATLAS detector during 2011 data taking

The performance of the jet trigger for the ATLAS detector at the LHC during the 2011 data taking period is described. During 2011 the LHC provided proton–proton collisions with a centre-of-mass energy of 7 TeV and heavy ion collisions with a 2.76 TeV per nucleon–nucleon collision energy. The ATLAS trigger is a three level system designed to reduce the rate of events from the 40 MHz nominal maximum bunch crossing rate to the approximate 400 Hz which can be written to offline storage. The ATLAS jet trigger is the primary means for the online selection of events containing jets. Events are accepted by the trigger if they contain one or more jets above some transverse energy threshold. During 2011 data taking the jet trigger was fully efficient for jets with transverse energy above 25 GeV for triggers seeded randomly at Level 1. For triggers which require a jet to be identified at each of the three trigger levels, full efficiency is reached for offline jets with transverse energy above 60 GeV. Jets reconstructed in the final trigger level and corresponding to offline jets with transverse energy greater than 60 GeV, are reconstructed with a resolution in transverse energy with respect to offline jets, of better than 4 % in the central region and better than 2.5 % in the forward direction