674 research outputs found
Differential spatial repositioning of activated genes in Biomphalaria glabrata snails infected with Schistosoma mansoni
- Author
- A Zarjou
- AE Lockyer
- AE Lockyer
- AE Lockyer
- AN Miller
- C Li
- C Perrin
- CM Adema
- CS Richards
- D Zink
- E Odoemelam
- EC Odoemelam
- EV Volpi
- H Bierne
- HA Foster
- HA Foster
- Halime D. Arican-Goktas
- I Szczerbal
- IS Mehta
- JA Croft
- JM Bridger
- Joanna M. Bridger
- KJ Livak
- KJ Meaburn
- KJ Meaburn
- KK1 Geyer
- L Chitsulo
- LA Hertel
- M Cremer
- M Knight
- M Knight
- Malcolm K. Jones
- Matty Knight
- MG Castillo
- N Raghavan
- N Raghavan
- P Fraser
- PF Basch
- S Fneich
- S Jin
- SD Bernal
- TP Yoshino
- UK Hahn
- UK Hahn
- W Ittiprasert
- W Ittiprasert
- W Ittiprasert
- Wannaporn Ittiprasert
- Y Hu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/09/2014
- Field of study
Copyright @ 2014 Arican-Goktas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This article has been made available through the Brunel Open Access Publishing Fund.Schistosomiasis is an infectious disease infecting mammals as the definitive host and fresh water snails as the intermediate host. Understanding the molecular and biochemical relationship between the causative schistosome parasite and its hosts will be key to understanding and ultimately treating and/or eradicating the disease. There is increasing evidence that pathogens that have co-evolved with their hosts can manipulate their hosts' behaviour at various levels to augment an infection. Bacteria, for example, can induce beneficial chromatin remodelling of the host genome. We have previously shown in vitro that Biomphalaria glabrata embryonic cells co-cultured with schistosome miracidia display genes changing their nuclear location and becoming up-regulated. This also happens in vivo in live intact snails, where early exposure to miracidia also elicits non-random repositioning of genes. We reveal differences in the nuclear repositioning between the response of parasite susceptible snails as compared to resistant snails and with normal or live, attenuated parasites. Interestingly, the stress response gene heat shock protein (Hsp) 70 is only repositioned and then up-regulated in susceptible snails with the normal parasite. This movement and change in gene expression seems to be controlled by the parasite. Other differences in the behaviour of genes support the view that some genes are responding to tissue damage, for example the ferritin genes move and are up-regulated whether the snails are either susceptible or resistant and upon exposure to either normal or attenuated parasite. This is the first time host genome reorganisation has been seen in a parasitic host and only the second time for any pathogen. We believe that the parasite elicits a spatio-epigenetic reorganisation of the host genome to induce favourable gene expression for itself and this might represent a fundamental mechanism present in the human host infected with schistosome cercariae as well as in other host-pathogen relationships.NIH and Sandler Borroughs Wellcome Travel Fellowshi
How to minimise the effect of tumour cell content in detection of aberrant genetic markers in neuroblastoma
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2011
- Field of study
Background:Clinical heterogeneity reflects the complexity of genetic events associated with neuroblastoma (NB). To identify the status of all described genetic loci with possible prognostic interest, high-throughput approaches have been used, but only with tumour cell content >60%. In some tumours, necrotic, haemorrhagic and/or calcification areas influence the low amount of neuroblasts. We evaluated the effect of tumour cell content in the detection of relevant aberrant genetic markers (AGM) diagnosed by fluorescence in situ hybridisation (FISH) on tissue microarrays (TMA) in NB.Methods:Two hundred and thirty-three MYCN non-amplified primary NB included in 12 TMAs were analysed.Results:Presence of AGM reduced event-free survival (EFS) (P=0.004) as well as overall survival (OS) (P=0.004) of patients in the whole cohort. There were no differences in prognostic impact of presence of AGM according to tumour cell content.Conclusion:We propose the use of FISH to diagnose AGM of all NB samples having the above-mentioned areas to determine patient risk
The radial arrangement of the human chromosome 7 in the lymphocyte cell nucleus is associated with chromosomal band gene density
- Author
- A Bolzer
- A Ono
- AM Boutanaev
- B Dutrillaux
- BA Boggs
- C Federico
- C Federico
- C Federico
- C Federico
- C Federico
- Catia Daniela Cantarella
- CM Clemson
- Concetta Federico
- D Zink
- E Lukasova
- ED Andrulis
- EV Volpi
- G Bernardi
- G DâOnofrio
- H Tanabe
- H Tanabe
- HA Foster
- I Solovei
- IHGSC (International Human Genome Sequencing Consortium)
- J Ferreira
- J Strouboulis
- J Zhou
- JA Croft
- JJ Roix
- JM Bridger
- K Kupper
- KE Brown
- L Andreozzi
- M Cockell
- M Costantini
- M Neusser
- N Gilbert
- N Sadoni
- NV Petrova
- Patrizia Di Mare
- PS Masny
- S Boyle
- S DâAntoni
- S Saccone
- S Saccone
- S Saccone
- S Saccone
- Sabrina Tosi
- Salvatore Saccone
- SW Scherer
- T Cremer
- TS Furey
- U Francke
- WA Bickmore
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 17/04/2008
- Field of study
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Springer-Verlag 2008.In the nuclei of human lymphocytes, chromosome territories are distributed according to the average gene density of each chromosome. However, chromosomes are very heterogeneous in size and base composition, and can contain both very gene-dense and very gene-poor regions. Thus, a precise analysis of chromosome organisation in the nuclei should consider also the distribution of DNA belonging to the chromosomal bands in each chromosome. To improve our understanding of the chromatin organisation, we localised chromosome 7 DNA regions, endowed with different gene densities, in the nuclei of human lymphocytes. Our results showed that this chromosome in cell nuclei is arranged radially with the gene-dense/GC-richest regions exposed towards the nuclear interior and the gene-poorest/GC-poorest ones located at the nuclear periphery. Moreover, we found that chromatin fibres from the 7p22.3 and the 7q22.1 bands are not confined to the territory of the bulk of this chromosome, protruding towards the inner part of the nucleus. Overall, our work demonstrates the radial arrangement of the territory of chromosome 7 in the lymphocyte nucleus and confirms that human genes occupy specific radial positions, presumably to enhance intra- and inter-chromosomal interaction among loci displaying a similar expression pattern, and/or similar replication timing
MHD models of Pulsar Wind Nebulae
- Author
- A Gruzinov
- A Melatos
- A Spitkovsky
- A Spitkovsky
- AA Abdo
- AA Abdo
- AID Hoffmann
- AS Wilson
- B-I Jun
- BM Gaensler
- BM Gaensler
- BM Gaensler
- C-Y Ng
- CF Gammie
- D Horns
- D Volpi
- DJ Helfand
- DV Khangoulian
- E Amato
- E Amato
- E Amato
- E Swaluw van der
- E Swaluw van der
- E Swaluw van der
- E Swaluw van der
- E Trussoni
- EV Gotthelf
- F Aharonian
- F Bocchino
- F Camilo
- FC Michel
- FC Michel
- FJ Lu
- G Castelletti
- GD Schmidt
- GG Pavlov
- GG Pavlov
- I Contopoulos
- JD Gelfand
- JG Kirk
- JJ Hester
- JJ Hester
- JJ Hester
- JJ Hester
- JK Truelove
- JM Blondin
- K Mori
- K Mori
- L Zanna Del
- L Zanna Del
- L Zanna Del
- M Lyutikov
- M Vigelius
- MC Begelman
- MC Begelman
- MC Begelman
- MC Begelman
- MC Weisskopf
- MF Bietenholz
- MF Bietenholz
- MJ Rees
- MP Veron-Cetty
- N Bucciantini
- N Bucciantini
- N Bucciantini
- N Bucciantini
- N Bucciantini
- N Bucciantini
- N Bucciantini
- N Bucciantini
- N Bucciantini
- N Camus
- O Kargaltsev
- OC Jager de
- OC Jager de
- P Hickson
- P Slane
- R Bandiera
- R Bandiera
- R Dodson
- R Kothes
- R Willingale
- RW Romani
- RW Romani
- S Shibata
- SES Ferreira
- SP Reynolds
- SS Komissarov
- SS Komissarov
- SS Komissarov
- SV Bogovalov
- SV Bogovalov
- SV Bogovalov
- SV Bogovalov
- SV Bogovalov
- T DeLaney
- T Temim
- T Velusamy
- VS Beskin
- Y Lyubarsky
- Y Lyubarsky
- Y Lyubarsky
- YE Lyubarsky
- YE Lyubarsky
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 26/05/2010
- Field of study
Pulsar Wind Nebulae (PWNe) are bubbles or relativistic plasma that form when
the pulsar wind is confined by the SNR or the ISM. Recent observations have
shown a richness of emission features that has driven a renewed interest in the
theoretical modeling of these objects. In recent years a MHD paradigm has been
developed, capable of reproducing almost all of the observed properties of
PWNe, shedding new light on many old issues. Given that PWNe are perhaps the
nearest systems where processes related to relativistic dynamics can be
investigated with high accuracy, a reliable model of their behavior is
paramount for a correct understanding of high energy astrophysics in general. I
will review the present status of MHD models: what are the key ingredients,
their successes, and open questions that still need further investigation.Comment: 18 pages, 5 figures, Invited Review, Proceedings of the "ICREA
Workshop on The High-Energy Emission from Pulsars and their Systems", Sant
Cugat, Spain, April 12-16, 201
Evidence for the h_b(1P) meson in the decay Upsilon(3S) --> pi0 h_b(1P)
- Author
- Adametz A.
- Adye T.
- Ahmed H.
- Alam M. S.
- Albert J.
- Allen M. T.
- Alwyn K. E.
- Andreassen R.
- Angelini C.
- Anh TV
- Anulli F.
- Arnaud N.
- Asgeirsson D. J.
- Aston D.
- Atmacan H.
- Ayad R.
- Bailey D.
- Baldini-Ferroli R.
- Band H. R.
- Banerjee Sw.
- Bard D. J.
- Barlow R. J.
- Bartoldus R.
- Batignani G.
- Behera P. K.
- Bellis M.
- Ben-Haim E.
- Benitez J. F.
- Bernard D.
- Bernlochner F. U.
- Bettarini S.
- Bettoni D.
- Bevan A. J.
- Bhuyan B.
- Bianchi F.
- Biasini M.
- Biassoni P.
- Bingham I.
- Blinov V. E.
- Bloom P. C.
- Blount N. L.
- Bomben M.
- Bondioli M.
- Bonneaud G. R.
- Bozzi C.
- Brau J.
- Briand H.
- Brown D. N.
- Brown D. N.
- Buenger C.
- Burchat P. R.
- Buzykaev A. R.
- Cakir IT
- Calabrese R.
- Calcaterra A.
- Calderini G.
- Campagnari C.
- Carpinelli M.
- Cartaro C.
- Casarosa G.
- Castanheira MTD
- Castelli G.
- Cavoto G.
- Cenci R.
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- Chauveau J.
- Chavez C. A.
- Chen C.
- Chen X. R.
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- Cibinetto G.
- Clark P. J.
- Cochran J.
- Coleman J. P.
- Contri R.
- Convery M. R.
- Corwin L. A.
- Cowan G.
- Cowan R.
- Crawley H. B.
- Cremaldi L.
- Curry S.
- Dallapiccola C.
- Dasu S.
- Dauncey P. D.
- Davier M.
- Davis C. L.
- de Monchenault G. Hamel
- De Nardo G.
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- Denig A. G.
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- Wisniewski W. J.
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- Wu X.
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- Wulsin H. W.
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- Yamaoka J.
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- Yang T.
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- Yang U. K.
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- Yang Y. C.
- Yao W-M
- Yao W. -M.
- Yarritu A. K.
- Yeche Ch.
- Yeh G P
- Yeh G. P.
- Yi K
- Yi K.
- Yoh J
- Yoh J.
- Yorita K
- Yorita K.
- Yoshida T
- Yoshida T.
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- Yushkov A. N.
- Zallo A.
- Zanetti A
- Zanetti A.
- Zanetti A.
- Zeng Y
- Zeng Y.
- Zeng Y.
- Ziegler V.
- Zucchelli S.
- Zucchelli S. Stradling AR
- Zucchelli SVazquez F.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2011
- Field of study
Using a sample of 122 million Upsilon(3S) events recorded with the BaBar
detector at the PEP-II asymmetric-energy e+e- collider at SLAC, we search for
the hbâ(1P) spin-singlet partner of the P-wave chi_{bJ}(1P) states in the
sequential decay Upsilon(3S) --> pi0 h_b(1P), h_b(1P) --> gamma eta_b(1S). We
observe an excess of events above background in the distribution of the recoil
mass against the pi0 at mass 9902 +/- 4(stat.) +/- 2(syst.) MeV/c^2. The width
of the observed signal is consistent with experimental resolution, and its
significance is 3.1sigma, including systematic uncertainties. We obtain the
value (4.3 +/- 1.1(stat.) +/- 0.9(syst.)) x 10^{-4} for the product branching
fraction BF(Upsilon(3S)-->pi0 h_b) x BF(h_b-->gamma eta_b).Comment: 8 pages, 4 postscript figures, submitted to Phys. Rev. D (Rapid
Communications
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of âs = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pTâ„20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60â€pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2â€{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at âs=8TeV
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- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wyatt TR
- Wynne BM
- Xella S
- Xiao M
- Xu D
- Xu L
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- Yao W-M
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- Yen AL
- Yildirim E
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
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- Youssef S
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- Yusuff I
- Zabinski B
- Zaidan R
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- Zanzi D
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- Zemla A
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- Zenin O
- Zenis T
- Zerwas D
- Zhang D
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- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fbâ1of data collected in protonâproton collisions at âs=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adam ER
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- Agustoni M
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- Ahsan M
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- Akesson TPA
- Akimoto G
- Akimov AV
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- Aleksandrov IN
- Alessandria F
- Alexa C
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- Allbrooke BMM
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- Allport PP
- Allwood-Spiers SE
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- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or Ï lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, Ï, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan ÎČ in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Preservation of large-scale chromatin structure in FISH experiments
- Author
- A Fraschini
- A Kurz
- AF Dernburg
- AK Raap
- AS Belmont
- AT Sumner
- CC Robinett
- Claudia Hepperger
- CS Osborne
- D Sproul
- DL Spector
- E Linden
- EV Volpi
- F Mongelard
- G Cheng
- H Telenius
- H Yokota
- HA Foster
- I Kobliakova
- I Solovei
- IT Young
- JA Croft
- JA Kiernan
- JB Lawrence
- JJ Roix
- JM Bridger
- Johann von Hase
- KE Brown
- M Cremer
- MJ Hendzel
- MN Nikiforova
- N Faust
- NL Mahy
- NL Mahy
- P Rabbitts
- PJ Verschure
- PV Guillot
- R Mayer
- RD Shelby
- RR Williams
- S Boyle
- S Chambeyron
- S Dietzel
- S Kozubek
- S Stadler
- Simone Otten
- Steffen Dietzel
- SW Hell
- T Cremer
- T Cremer
- T Kanda
- TC Hsu
- W Deng
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2006
- Field of study
The nuclear organization of specific endogenous chromatin regions can be investigated only by fluorescence in situ hybridization (FISH). One of the two fixation procedures is typically applied: (1) buffered formaldehyde or (2) hypotonic shock with methanol acetic acid fixation followed by dropping of nuclei on glass slides and air drying. In this study, we compared the effects of these two procedures and some variations on nuclear morphology and on FISH signals. We analyzed mouse erythroleukemia and mouse embryonic stem cells because their clusters of subcentromeric heterochromatin provide an easy means to assess preservation of chromatin. Qualitative and quantitative analyses revealed that formaldehyde fixation provided good preservation of large-scale chromatin structures, while classical methanol acetic acid fixation after hypotonic treatment severely impaired nuclear shape and led to disruption of chromosome territories, heterochromatin structures, and large transgene arrays. Our data show that such preparations do not faithfully reflect in vivo nuclear architecture. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available in the online version of this article at http://dx.doi.org/10.1007/s00412-006-0084-2 and is accessible for authorized users
Observation of associated near-side and away-side long-range correlations in âsNN=5.02ââTeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
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- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alvarez Gonzalez B
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov A
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- Antonaki A
- Antonelli M
- Antonov A
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- Anulli F
- Aoki M
- Aperio Bella L
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce AT
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- Arguin JF
- Argyropoulos S
- Arik E
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- Armbruster AJ
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- Arnal V
- Artamonov A
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- Arutinov D
- Asai S
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- Astbury A
- Atkinson M
- ATLAS Collaboration The
- Auerbach B
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- Backus Mayes J
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- Bailey DC
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- Camarri P
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- Caminal Armadans R
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- Capeans Garrido MD
- Caprini I
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- Carter AA
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- Carvalho J
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- Castro NF
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- Chernyatin V
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- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- ZivkoviÄ L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (ÎÏ) and pseudorapidity (Îη) are measured in âsNN=5.02ââTeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1ââÎŒb-1 of data as a function of transverse momentum (pT) and the transverse energy (ÎŁETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Îη|<5) ânear-sideâ (ÎÏâŒ0) correlation that grows rapidly with increasing ÎŁETPb. A long-range âaway-sideâ (ÎÏâŒÏ) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ÎŁETPb, is found to match the near-side correlation in magnitude, shape (in Îη and ÎÏ) and ÎŁETPb dependence. The resultant ÎÏ correlation is approximately symmetric about Ï/2, and is consistent with a dominant cosâĄ2ÎÏ modulation for all ÎŁETPb ranges and particle pT
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