Intellectual Capital Statement of a Company Operating in a Made to Measure Industry

This article is a case study of a company operating in the MTM (Made to Measure) industry. The main issue of this manuscript is the evaluation and analysis of a company's intellectual capital in three main areas: human capital, structural and relational capital. The starting point was the analysis of the external environment, its opportunities and threats in relation to the identification of the strategic goals of the company. Against the background of these considerations, key business processes and desired business success of a company that contribute to the achievement of defined strategic objectives were identified. The article used the ICS (Intellectual Capital Statement) method without going into too much detail in defining this method in order to limit the size of the manuscript. For a more detailed description of the ICS method readers should refer to the article [Ujwary-Gil 2012]

Photometric science alerts from Gaia

Gaia is the cornerstone mission of the European Space Agency. From late 2013 it will start collecting superb astrometric, photometric and spectroscopic data for around a billion of stars of our Galaxy. While surveying the whole sky down to V=20mag Gaia will be detecting transients and anomalous behaviour of objects, providing near-real-time alerts to the entire astronomical community. Gaia should detected about 6000 supernovae, 1000 microlensing events and many other interesting types of transients. Thanks to its on-board low-dispersion spectrograph the classification of transients will be robust, assuring low false-alert rate. We describe the operation of the Photometric Science Alerts system, outline the scientific possibilities and conclude with an invitation to collaborate in the ground-based follow-up Gaia alerts during the early months of the mission when the outcome of the alerting pipeline needs to be verified

NK cell compartment in patients with coronary heart disease

<p>Abstract</p> <p>Background</p> <p>Viral and bacterial infections have been considered as a risk factor for Coronary Heart Disease (CHD). NK cells, as a first line of defense against those infections, may play a role in CHD development. Thus, the main aim of our study was to determine NK cell compartment in patients with CHD undergoing coronary artery by-pass grafting.</p> <p>Results</p> <p>Ninety three patients with CHD were included into the study; the control group consisted of 49 healthy volunteers. As compared to controls, CHD patients had lower NK cytotoxic activity. CHD group had also a decreased absolute number and percentage of total NK cells and CD3-CD56dim cytotoxic NK subset. In addition, we observed tendency toward lower percentage of the CD3-CD56bright regulatory NK subset and CD3-CD56+IFN-γ+ cells in CHD patients.</p> <p>Conclusion</p> <p>These data indicate that CHD is associated with an impairment of NK cells compartment.</p

A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.

The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world

Genetics of Parkinson’s disease in the Polish population

Introduction. Genetic forms of Parkinson’s disease (PD) often cluster in different ethnic groups and may present with recognisable unique clinical manifestations. Our aim was to summarise the current state of knowledge regarding the genetic causes of PD and describe the first Polish patient with SNCA duplication.Methodology. We searched the electronic database, PubMed, for studies between January 1995 and June 2020 that evaluated genetics in Polish patients with PD, using the search terms ‘Parkinson’s disease, ‘Polish’, ‘genetics’, ‘mutations’, and ‘variants’.Results. In total, 73 publications were included in the review; 11 genes responsible for monogenic forms and 19 risk factor genes have been analysed in the Polish population. Pathogenic variants were reported in four monogenic genes (LRRK2, PRKN, PINK1, and SNCA). Eight genes were associated with PD risk in the Polish population (GBA, TFAM, NFE2L2, MMP12, HLA-DRA, COMT, MAOB, and DBH). Multiplex ligation-dependent probe amplification and Sanger sequencing in PRKN, PINK1, DJ1, LRRK2, and SNCA revealed SNCA duplication in a 43-year-old Polish patient with PD examined by movement disorder specialists.Conclusion. Only a limited number of positive results have been reported in genes previously associated with PD in the Polish population. In the era of personalised medicine, it is important to report on genetic findings in specific populations

GaiaNIR: Combining optical and Near-Infra-Red (NIR) capabilities with Time-Delay-Integration (TDI) sensors for a future Gaia-like mission

ESA recently called for new "Science Ideas" to be investigated in terms of feasibility and technological developments -- for technologies not yet sufficiently mature. These ideas may in the future become candidates for M or L class missions within the ESA Science Program. With the launch of Gaia in December 2013, Europe entered a new era of space astrometry following in the footsteps of the very successful Hipparcos mission from the early 1990s. Gaia is the successor to Hipparcos, both of which operated in optical wavelengths, and Gaia is two orders of magnitude more accurate in the five astrometric parameters and is surveying four orders of magnitude more stars in a vast volume of the Milky Way. The combination of the Hipparcos/Tycho-2 catalogues with the first early Gaia data release will give improved proper motions over a long ~25 year baseline. The final Gaia solution will also establish a new optical reference frame by means of quasars, by linking the optical counterparts of radio (VLBI) sources defining the orientation of the reference frame, and by using the zero proper motion of quasars to determine a non-rotating frame. A weakness of Gaia is that it only operates at optical wavelengths. However, much of the Galactic centre and the spiral arm regions, important for certain studies, are obscured by interstellar extinction and this makes it difficult for Gaia to deeply probe. Traditionally, this problem is overcome by switching to the infra-red but this was not possible with Gaia's CCDs. Additionally, to scan the entire sky and make global absolute parallax measurements the spacecraft must have a constant rotation and this requires that the CCDs operate in TDI mode, increasing their complexity

Frequency of mutations in PRKN, PINK1, and DJ1 in Patients With Early-Onset Parkinson Disease from neighboring countries in Central Europe

INTRODUCTION: Approximately 10% of patients with Parkinson disease (PD) present with early-onset disease (EOPD), defined as diagnosis before 50 years of age. Genetic factors are known to contribute to EOPD, with most commonly observed mutations in PRKN, PINK1, and DJ1 genes. The aim of our study was to analyze the frequency of PRKN, PINK1, and DJ1 mutations in an EOPD series from 4 neighboring European countries: Czech Republic, Germany, Poland, and Ukraine. METHODS: Diagnosis of PD was made based on UK Brain Bank diagnostic criteria in departments experienced in movement disorders (1 from Czech Republic, 1 from Germany, 9 from Poland, and 3 from Ukraine). EOPD was defined as onset at or before 50 years of age. Of the 541 patients recruited to the study, 11 were Czech, 38 German, 476 Polish, and 16 Ukrainian. All cohorts were fully screened with Sanger sequencing for PRKN, PINK1, and DJ1 and multiplex ligation-dependent probe amplification for exon dosage. RESULTS: PRKN homozygous or double heterozygous mutations were identified in 17 patients: 1 Czech (9.1%), 1 German (2.6%), 14 Polish (2.9%), and 1 Ukrainian (6.3%). PINK1 homozygous mutations were only identified in 3 Polish patients (0.6%). There were no homozygous or compound heterozygous DJ1 mutations in analyzed subpopulations. One novel variant in PRKN was identified in the Ukrainian series. CONCLUSION: In the analyzed cohorts, mutations in the genes PRKN, PINK1, and DJ1 are not frequently observed