Port of Rotterdam in Chinese Eyes

The Port of Rotterdam is a typical European organisation that undertakes several activities towards China annually and has a clear understanding of what it has to offer to its Chinese counterparts, but does not always succeed in achieving rapport with those counterparts. This paper studies the identity constructs of the Port of Rotterdam in a selected number of Chinese contexts (central ministries, main ports, etc.). The methodology is narrative analysis using corpora of texts compiled for each context. The core theoretical principle1 is that identity is not a property, but a process of ongoing interaction. The identity of A can only be established in a particular context, by observing the interaction between A and parties in that context. A will thus obtain multiple identities in multiple contexts. The results can be used by the Port of Rotterdam to improve the effectiveness of its delegations to China

A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation

Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose of this multi-laboratory study was to establish the precision and accuracy of basic data dimensions in AUC and validate previously proposed calibration techniques. Three kits of AUC cell assemblies containing radial and temperature calibration tools and a bovine serum albumin (BSA) reference sample were shared among 67 laboratories, generating 129 comprehensive data sets. These allowed for an assessment of many parameters of instrument performance, including accuracy of the reported scan time after the start of centrifugation, the accuracy of the temperature calibration, and the accuracy of the radial magnification. The range of sedimentation coefficients obtained for BSA monomer in different instruments and using different optical systems was from 3.655 S to 4.949 S, with a mean and standard deviation of (4.304 ± 0.188) S (4.4%). After the combined application of correction factors derived from the external calibration references for elapsed time, scan velocity, temperature, and radial magnification, the range of s-values was reduced 7-fold with a mean of 4.325 S and a 6-fold reduced standard deviation of ± 0.030 S (0.7%). In addition, the large data set provided an opportunity to determine the instrument-to-instrument variation of the absolute radial positions reported in the scan files, the precision of photometric or refractometric signal magnitudes, and the precision of the calculated apparent molar mass of BSA monomer and the fraction of BSA dimers. These results highlight the necessity and effectiveness of independent calibration of basic AUC data dimensions for reliable quantitative studies

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose of this multi-laboratory study was to establish the precision and accuracy of basic data dimensions in AUC and validate previously proposed calibration techniques. Three kits of AUC cell assemblies containing radial and temperature calibration tools and a bovine serum albumin (BSA) reference sample were shared among 67 laboratories, generating 129 comprehensive data sets. These allowed for an assessment of many parameters of instrument performance, including accuracy of the reported scan time after the start of centrifugation, the accuracy of the temperature calibration, and the accuracy of the radial magnification. The range of sedimentation coefficients obtained for BSA monomer in different instruments and using different optical systems was from 3.655 S to 4.949 S, with a mean and standard deviation of (4.304 ± 0.188) S (4.4%). After the combined application of correction factors derived from the external calibration references for elapsed time, scan velocity, temperature, and radial magnification, the range of s-values was reduced 7-fold with a mean of 4.325 S and a 6-fold reduced standard deviation of ± 0.030 S (0.7%). In addition, the large data set provided an opportunity to determine the instrument-to-instrument variation of the absolute radial positions reported in the scan files, the precision of photometric or refractometric signal magnitudes, and the precision of the calculated apparent molar mass of BSA monomer and the fraction of BSA dimers. These results highlight the necessity and effectiveness of independent calibration of basic AUC data dimensions for reliable quantitative studies

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.Peer reviewe

Creating corporate space : in search of Chinese corporate identity

coporate identity; China

Extending Network Analysis with Social Inclusions: A Chinese Entrepreneur Building Social Capital

Social network analysis is a highly useful tool to study the way individuals form alliances to cope with their daily tasks on the micro-level. We can map the interaction between the key persons involved into a graph, representing the social network. The result is then a snapshot of who interacts with whom and why/how at the time the data were collected. However, when trying to apply it to a higher level, real life problems, this method of analysis seems to deviate from the way people form networks of relationships in social practice. In social practice, human actors tend to form relationships on the basis of institutional affiliation and inclusion in social groups. This paper intends to use Social Integration (SI) developed at Erasmus University Rotterdam on the basis of Karl Weick's organization theory to enrich current social network theory with a module that links networks on the basis of multiple inclusions of actors in several social-cognitive groups (networks). The expanded model is tested on a Chinese business case. © 2011 Higher Education Press and Springer-Verlag Berlin Heidelberg

Modality in General Linguistic Investigations Conducted in China Prior to 1949

This article focuses on the investigations by Li Jinxi (New Grammar of the National Language. Li Jinxi collected works. Heilongjiang Education Press, Harbin, 1924), Lu Shuxiang (Outline of Chinese Grammar. The Commercial Press, Shanghai, 1942a, Outline of Chinese grammar. Collection of Lu Shuxiang's works. Liaoning Education Press, Shenyang, 1942), Wang Li (Modern Chinese Grammar. Series in Chinese grammar. The Commercial Press, Beijing, 1943, The theory of Chinese grammar. Collection of Wang Li's works. Shandong Education Press, Jinan, 1944) and Gao Mingkai (On Chinese Grammar. Kaiming shudian, Shanghai, 1948). The aim is shedding light on their notable anticipations of contemporary theories on modality. It will be shown that those works were not confined to a language-specific discourse but had the depth and vastness of the best General Linguistics tradition. After an introduction on the relevant seminal tenets on modality, the article presents five sections focussing on a different critical issue as analysed in the literature above. Namely, the attitudinal theme and the relation between sentential and verbal mood (Sect. 6.2); the illocutionary and propositional levels of modality (Sect. 6.3); the notion of modals as a semantic category (Sect. 6.4); the distinction between modalities of moral duty and mere necessity (Sect. 6.5); modal interdefinability and negation scope (Sect. 6.6)