1,227 research outputs found
Quantitative Mass Spectrometry Analysis Using PAcIFIC for the Identification of Plasma Diagnostic Biomarkers for Abdominal Aortic Aneurysm
- Author
- A Dupont
- A Panchaud
- A Panchaud
- A Scherl
- Adelina E. Acosta-Martin
- Alexandre Panchaud
- Annabelle Dupont
- B Akerstrom
- B Zhang
- BB Haab
- Brigitte Jude
- C Tu
- CL Gatlin
- Corinne Gautier
- CS Gan
- David R. Goodlett
- E Kaschina
- FA Hellenthal
- FA Hellenthal
- FJ Miller Jr
- Florence Pinet
- Francis Juthier
- G Ailawadi
- H Liu
- H Ramos
- HG Alcorn
- IM Nordon
- J Chao
- J Chao
- J Golledge
- J Golledge
- K Blackburn
- KA Delaria
- L Dayon
- LC Brown
- MA Kuzyk
- Maggy Chwastyniak
- ML McCormick
- MM Thompson
- N Lamblin
- NL Anderson
- NL Anderson
- NL Anderson
- NL Anderson
- P Giron
- PG Righetti
- Philippe Amouyel
- Philippe Rouet
- R Martinez-Pinna
- S Carbon
- S Urbonavicius
- T Dejouvencel
- T Fortin
- T Myles
- W Xiong
- Publication venue
- Public Library of Science
- Publication date
- 07/12/2011
- Field of study
BACKGROUND: Abdominal aortic aneurysm (AAA) is characterized by increased aortic vessel wall diameter (>1.5 times normal) and loss of parallelism. This disease is responsible for 1-4% mortality occurring on rupture in males older than 65 years. Due to its asymptomatic nature, proteomic techniques were used to search for diagnostic biomarkers that might allow surgical intervention under nonlife threatening conditions. METHODOLOGY/PRINCIPAL FINDINGS: Pooled human plasma samples of 17 AAA and 17 control patients were depleted of the most abundant proteins and compared using a data-independent shotgun proteomic strategy, Precursor Acquisition Independent From Ion Count (PAcIFIC), combined with spectral counting and isobaric tandem mass tags. Both quantitative methods collectively identified 80 proteins as statistically differentially abundant between AAA and control patients. Among differentially abundant proteins, a subgroup of 19 was selected according to Gene Ontology classification and implication in AAA for verification by Western blot (WB) in the same 34 individual plasma samples that comprised the pools. From the 19 proteins, 12 were detected by WB. Five of them were verified to be differentially up-regulated in individual plasma of AAA patients: adiponectin, extracellular superoxide dismutase, protein AMBP, kallistatin and carboxypeptidase B2. CONCLUSIONS/SIGNIFICANCE: Plasma depletion of high abundance proteins combined with quantitative PAcIFIC analysis offered an efficient and sensitive tool for the screening of new potential biomarkers of AAA. However, WB analysis to verify the 19 PAcIFIC identified proteins of interest proved inconclusive save for five proteins. We discuss these five in terms of their potential relevance as biological markers for use in AAA screening of population at risk
Broad Antibody Mediated Cross-Neutralization and Preclinical Immunogenicity of New Codon-Optimized HIV-1 Clade CRF02_AG and G Primary Isolates
- Author
- A Bojak
- A Bojak
- A Ramos
- AM Schultz
- CJPN Petropoulos
- CK Wayne
- DD Richman
- EW Carrow
- FL Graham
- Frank Notka
- G Giaccone
- Hans Wolf
- J Ponten
- J Wild
- Jens Wild
- JK Carr
- JK Carr
- Joseph C. Forbi
- L Deml
- L Stamatatos
- LM Walker
- M Graf
- M Rolland
- ND Russell
- NL Haigwood
- NL Haigwood
- NM Flynn
- OO Taiwo
- P Pitisuttithum
- PD Kwong
- Ralf Wagner
- RI Connor
- S Andre
- SD Frost
- Simon M. Agwale
- SJ Kent
- SM Agwale
- SM Agwale
- SM Agwale
- ST Meloni
- T Vogel
- Terri Wrin
- TS Li
- XG Yu
- Yuntao Wu
- Publication venue
- Public Library of Science
- Publication date
- 04/08/2011
- Field of study
Creation of an effective vaccine for HIV has been an elusive goal of the scientific community for almost 30 years. Neutralizing antibodies are assumed to be pivotal to the success of a prophylactic vaccine but previous attempts to make an immunogen capable of generating neutralizing antibodies to primary āstreet strainā isolates have resulted in responses of very limited breadth and potency. The objective of the study was to determine the breadth and strength of neutralizing antibodies against autologous and heterologous primary isolates in a cohort of HIV-1 infected Nigerians and to characterize envelopes from subjects with particularly broad or strong immune responses for possible use as vaccine candidates in regions predominated by HIV-1 CRF02_AG and G subtypes. Envelope vectors from a panel of primary Nigerian isolates were constructed and tested with plasma/sera from the same cohort using the PhenoSense HIV neutralizing antibody assay (Monogram Biosciences Inc, USA) to assess the breadth and potency of neutralizing antibodies. The immediate goal of this study was realized by the recognition of three broadly cross-neutralizing sera: (NG2-clade CRF02_AG, NG3-clade CRF02_AG and NG9- clade G). Based on these findings, envelope gp140 sequences from NG2 and NG9, complemented with a gag sequence (Clade G) and consensus tat (CRF02_AG and G) antigens have been codon-optimized, synthesized, cloned and evaluated in BALB/c mice. The intramuscular administration of these plasmid DNA constructs, followed by two booster DNA immunizations, induced substantial specific humoral response against all constructs and strong cellular responses against the gag and tat constructs. These preclinical findings provide a framework for the design of candidate vaccine for use in regions where the HIV-1 epidemic is driven by clades CRF02_AG and G
Utility of a thematic network in primary health care: a controlled interventional study in a rural area
- Author
- A Fernandez Carro
- Angel Olea Movilla
- CM van Woerkum
- DC McDuffee
- EE Westberg
- Gerardo Torres Torres
- J Black
- JA Byrnes
- Javier Lozano Garcia
- JG Marshall
- JL Dorsch
- JosƩ Cordero Guevara
- M Beniger
- M Hawa Attourah
- M SƔnchez-Ramos
- Maria JesĆŗs Coma del Corral
- MJ Coma
- MJ Coma del Corral
- MJ Coma del Corral
- MJ Coma del Corral
- MU Bers
- NL Bennett
- Pedro Abaigar LuquĆn
- R DĆaz-Alersi
- RD Gantenbein
- S Jabbour
- S Rauch
- V Steiner
- VR Curran
- VR Curran
- Publication venue
- BioMed Central
- Publication date
- 01/01/2005
- Field of study
BACKGROUND: UniNet is an Internet-based thematic network for a virtual community of users (VCU). It supports a virtual multidisciplinary community for physicians, focused on the improvement of clinical practice. This is a study of the effects of a thematic network such as UniNet on primary care medicine in a rural area, specifically as a platform of communication between specialists at the hospital and doctors in the rural area. METHODS: In order to study the effects of a thematic network such as UniNet on primary care medicine in a rural area, we designed an interventional study that included a control group. The measurements included the number of patient displacements due to disease, number of patient hospital stays and the number of prescriptions of drugs of low therapeutic utility and generic drug prescriptions by doctors. These data were analysed and compared with those of the control center. RESULTS: Our study showed positive changes in medical practice, reflected in the improvement of the evaluated parameters in the rural health area where the interventional study was carried out, compared with the control area. We discuss the strengths and weaknesses of UniNet as a potential medium to improve the quality of medical care in rural areas. CONCLUSION: The rural doctors had an effective, useful, user-friendly and cheap source of medical information that may have contributed to the improvement observed in the medical quality indices
Sphygmomanometers and thermometers as potential fomites of Staphylococcus haemolyticus: biofilm formation in the presence of antibiotics
- Author
- Ana LuĆza Mattos-Guaraldi
- Bruna Pinto Ribeiro Sued
- Chaieb K
- Cohen HA
- Foka A
- Fredheim EG
- Giormezis N
- Gomes DLR
- Gomes DLR
- Hussain Z
- Iorio NL
- Iorio NL
- Jong-Hyun K
- JosƩ Augusto Adler Pereira
- Juliana Nunes Ramos
- Kim JS
- KƔtia Regina Netto dos Santos
- Lowbury EJ
- Lynch SV
- Maki DG
- Marks LR
- Mattos-Guaraldi AL
- Mehta G
- Nascimento TC
- Paula Marcele Afonso Pereira
- Pereira PMA
- Raphael Hirata JĆŗnior
- Saito Y
- Santos KRN
- Schuenck RP
- Stepanovic S
- SĆ©rgio Henrique Seabra
- Tabe Y
- Van Belkum A
- Vanessa Batista Binatti
- VerƓnica Viana Vieira
- Yuri Vieira Faria
- Zargaran D
- Zulfiqar A
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at ā s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya ST
- Arcangeletti C
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Artz S
- Asai S
- Asawatavonvanich T
- Asbah N
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Augsten K
- Avolio G
- Ayoub MK
- Azuelos G
- Bachacou H
- Bachas K
- Backes M
- Backman F
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Balaji S
- Baldin EM
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- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
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- Barberio EL
- Barberis D
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- Barisits M-S
- Barkeloo J
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- Basso MJ
- Bates RL
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- Beddall A
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- Bitadze A
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- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Boeriu OEV
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- Bogavac D
- Bogdanchikov AG
- Bohm C
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- Bokan P
- Bold T
- Bolz AE
- Bomben M
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- Bonilla JS
- Boonekamp M
- Booth CD
- Borecka-Bielska HM
- Borgna LS
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fbā1 of ā s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Graves' disease is associated with a defective expression of the immune regulatory molecule galectin-9 in antigen-presenting dendritic cells
- Author
- Ana Ramos-Levi
- Ana RodrĆguez-MuƱoz
- Ana Serrano
- AP Weetman
- BS Prabhakar
- C Blaser
- C Mao
- D Cooper
- FC Chou
- Francisco SƔnchez-Madrid
- GA Rabinovich
- H de la Fuente
- Hortensia de la Fuente
- ID Mascanfroni
- J van der Leij
- L Bartalena
- L Monney
- LV Norling
- M Demetriou
- M Kanzaki
- M Marazuela
- M Ruiz-Riol
- M Seki
- M Seki
- MA Toscano
- Miguel Sampedro-NuƱez
- MĆ³nica Marazuela
- N Figueroa-Vega
- N Figueroa-Vega
- NL Perillo
- Roberto GonzƔlez-Amaro
- S Katoh
- S Leskela
- Silke Appel
- Susanna Leskela
- T Arikawa
- T Imaizumi
- WM Wiersinga
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Introduction
Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function of galectin-1 and galectin-9 (Gal-1, Gal-9) in dendritic cells (DCs) from patients with AITD.
Materials and Methods
Peripheral blood samples from 25 patients with Gravesā disease (GD), 11 Hashimotoās thyroiditis (HT), and 24 healthy subjects were studied. Thyroid tissue samples from 44 patients with AITD and 22 patients with goiter were also analyzed. Expression and function of Gal-1 and Gal-9 was assessed by quantitative RT-PCR, immunofluorescence and flow cytometry.
Results
A diminished expression of Gal-9, but not of Gal-1, by peripheral blood DCs was observed in GD patients, mainly in those with GravesĀ“ ophthalmopathy, and a significant negative association between disease severity and Gal-9 expression was detected. In addition, the mRNA levels of Gal-9 and its ligand TIM-3 were increased in thyroid tissue from AITD patients and its expression was associated with the levels of Th1/Th12/Th17 cytokines. Immunofluorescence studies proved that intrathyroidal Gal-9 expression was confined to DCs and macrophages. Finally, in vitro functional assays showed that exogenous Gal-9 had a suppressive effect on the release of Th1/Th2/Th17 cytokines by DC/lymphocyte autologous co-cultures from both AITD patients and healthy controls.
Conclusions
The altered pattern of expression of Gal-9 in peripheral blood DCs from GD patients, its correlation with disease severity as well as its ability to suppress cytokine release suggest that Gal-9 could be involved in the pathogenesis of AITDThis work was supported by grants from
the Fondo de Investigaciones Sanitarias (FISS) PI10/
02521 and S2010/BMD-2328 TIRONET (Comunidad
de Madrid), Spain (to MM) and the Fondo de
CooperaciĆ³n Internacional en Ciencia y TecnologĆa
(FONCICYT) 95395, European Union-MĆ©xico (to
RGA
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at ās = 7 TeV with the ATLAS detector
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- Bingul A
- Bini C
- Black CW
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- Castillo IS
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- Castro NF
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- Chernyatin V
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- Demirkoz B
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- Deviveiros PO
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- Di Domenico A
- Di Donato C
- Di Girolamo A
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- Ekelof T
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- Enari Y
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- Endner OC
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- Errede D
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- Errede S
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- Escalier M
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- Esch H
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- Escobar C
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- Espinal Curull X
- Espinal Curull X
- Esposito B
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- Etienne F
- Etienne F
- Etienvre AI
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- Etzion E
- Etzion E
- Evans H
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- Fabbri L
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- Facini G
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- Fajardo LSG
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- Fakhrutdinov RM
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- Falciano S
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- Faltova J
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- Fang Y
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- Farooque T
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- Farrell S
- Farrell S
- Farrington SM
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- Farthouat P
- Farthouat P
- Fassi F
- Fassi F
- Fassnacht P
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- Fassouliotis D
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- Favareto A
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- Fayard L
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- Federic P
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- Fedin OL
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- Fedorko W
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- Fehling-Kaschek M
- Fehling-Kaschek M
- Feigl S
- Feigl S
- Feligioni L
- Feligioni L
- Feng C
- Feng C
- Feng EJ
- Feng EJ
- Feng H
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- Fenyuk AB
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- Fernando W
- Fernando W
- Ferrag S
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- Ferrando BMS
- Ferrando J
- Ferrando J
- Ferrara V
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- Ferrari A
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- Ferrari P
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- Ferretti C
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- Fiascaris M
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- Fiedler F
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- Filipcic A
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- Filipuzzi M
- Filipuzzi M
- Filthaut F
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- Fincke-Keeler M
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- Fiolhais MCN
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- Fiorini L
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- Firan A
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- Fischer J
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- Fisher MJ
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- Fitzgerald EA
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- Flechl M
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- Fleck I
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- Fleischmann P
- Fleischmann P
- Fleischmann S
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- Fletcher G
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- Fletcher GT
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- Flick T
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- Floderus A
- Floderus A
- Florez Bustos AC
- Flowerdew MJ
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- Formica A
- Formica A
- Forti A
- Forti A
- Fortin D
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- Fournier D
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- Francavilla P
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- Franchini M
- Franchini M
- Franchino S
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- Francis D
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- Franklin M
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- Franz S
- Franz S
- Fraternali M
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- Fratin S
- Fratina S
- French ST
- French ST
- Friedrich C
- Friedrich C
- Friedrich F
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- Froidevaux D
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- Frost JA
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- Fukunaga C
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- Fulsom BG
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- Fuster J
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- Gabizon O
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- Gabrielli A
- Gabrielli A
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- Gadatsch S
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- Gadomski S
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- Gagliardi G
- Gagliardi G
- Gagnon P
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- Galea C
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- Galhardo B
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- Gallas EJ
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- Gallo V
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- Gallop BJ
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- Gallus P
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- Gandrajula RP
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- Gao J
- Gao YS
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- Gaob J
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- Garcia Navarro JE
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- Garcia BRM
- Garcia C
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- Gardner RW
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- Garelli N
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- Garonne V
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- Garrido MDMC
- Gatti C
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- Gaudio G
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- Gaur B
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- Gauzzi P
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- Gavrilenko IL
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- Gay C
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- Gaycken G
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- Gazis EN
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- Ge P
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- Gecse Z
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- Gee CNP
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- Geerts DAA
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- Geich-Gimbel C
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- Gellerstedt K
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- Gemme C
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- Genest MH
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- Gentile S
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- George M
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- Gerbaudo D
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- Gershon A
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- Ghazlane H
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- Ghodbane N
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- Giacobbe B
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- Giagu S
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- Giangiobbe V
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- Giannetti P
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- Giokaris N
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- Giordani MP
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- Giordano R
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- Giraud PF
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- Giugni D
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- Giuliani C
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- Gjelsten BK
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- Goshaw AT
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of ās = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentreāofāmassframeisusedtosuppressthelargemultiājetbackground.ThecrossāsectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
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- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or Ļ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, Ļ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan Ī² in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at sā=8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
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- Altheimer A
- Alviggi MG
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- Amelung C
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- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fbā1 of protonāproton collision data at ās = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via tĖātĻĖ01 or tĖā bĻĖĀ±1 ābW(ā)ĻĖ01 , where ĻĖ01 (ĻĖĀ±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of tĖ ā tĻĖ01 . For a branching fraction of 100%, top squark masses in the range 270ā645 GeV are excluded for ĻĖ01 masses below 30 GeV. For a branching fraction of 50% to either tĖ ā tĻĖ01 or tĖ ā bĻĖĀ±1 , and assuming the ĻĖĀ±1 mass to be twice the ĻĖ01 mass, top squark masses in the range 250ā550 GeV are excluded for ĻĖ01 masses below 60 GeV
Reducing corruption in a Mexican medical school: impact assessment across two cross-sectional surveys
- Author
- A Cockcroft
- A Shleifer
- AC Tsai
- AD Barr
- Anne Cockcroft
- Ascensio Villegas-ArrizĆ³n
- Corruption in Slovakia
- D Kaufmann
- Elizabeth Nava-Aguilera
- J Hallak
- J Hallak
- J Ramos
- JL Wofford
- JM Braxton
- JM Braxton
- JosƩ Legorreta-Soberanis
- JosĆ© Ćlvarez-ChĆ”vez
- M Hrabak
- M Lewis
- M Mati
- MA Elzubeir
- N Andersson
- N Mantel
- Neil Andersson
- NL Rumyantseva
- P Jung
- P Monroy
- P Shaw
- R Klitgaard
- Robert J Ledogar
- S Kumar
- S Tanaka
- Sergio Paredes-SolĆs
- SM Glick
- SP Heyneman
- Transparency International
- U Tayal
- VerĆ³nica Delabra-JardĆ³n
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Corruption pervades educational and other institutions worldwide and medical schools are not exempt. Empirical evidence about levels and types of corruption in medical schools is sparse. We conducted surveys in 2000 and 2007 in the medical school of the Autonomous University of Guerrero in Mexico to document student perceptions and experience of corruption and to support the medical school to take actions to tackle corruption.</p> <p>Methods</p> <p>In both 2000 and 2007 medical students completed a self-administered questionnaire in the classroom without the teacher present. The questionnaire asked about unofficial payments for admission to medical school, for passing an examination and for administrative procedures. We examined factors related to the experience of corruption in multivariate analysis. Focus groups of students discussed the quantitative findings.</p> <p>Results</p> <p>In 2000, 6% of 725 responding students had paid unofficially to obtain entry into the medical school; this proportion fell to 1.6% of the 436 respondents in 2007. In 2000, 15% of students reported having paid a bribe to pass an examination, not significantly different from the 18% who reported this in 2007. In 2007, students were significantly more likely to have bribed a teacher to pass an examination if they were in the fourth year, if they had been subjected to sexual harassment or political pressure, and if they had been in the university for five years or more. Students resented the need to make unofficial payments and suggested tackling the problem by disciplining corrupt teachers. The university administration made several changes to the system of admissions and examinations in the medical school, based on the findings of the 2000 survey.</p> <p>Conclusion</p> <p>The fall in the rate of bribery to enter the medical school was probably the result of the new admissions system instituted after the first survey. Further actions will be necessary to tackle the continuing presence of bribery to pass examinations and for administrative procedures. The social audit helped to draw attention to corruption and to stimulate actions to tackle it.</p
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