3D terrain mapping and filtering from coarse resolution data cubes extracted from real-aperture 94 GHz radar

Funding: William D. Harcourt was funded by the Engineering and Physical Sciences Research Council (EPSRC; grant number: EP/R513337/1) and the Scottish Alliance for Geoscience, Environment and Society (SAGES).Accurate, high-resolution 3-D mapping of environmental terrain is critical in a range of disciplines. In this study, we develop a new technique, called the PCFilt-94 algorithm, to extract 3-D point clouds from coarse-resolution millimeter-wave radar data cubes and quantify their associated uncertainties. A technique to noncoherently average neighboring waveforms surrounding each AVTIS2 range profile was developed to reduce speckles and was found to reduce point cloud uncertainty by 13% at long range and 20% at short range. Furthermore, a Voronoi-based point cloud outlier removal algorithm was implemented, which iteratively removes outliers in a point cloud until the process converges to the removal of 0 points. Taken together, the new processing methodology produces a stable point cloud, which means that: 1) it is repeatable even when using different point cloud extraction and filtering parameter values during preprocessing and 2) is less sensitive to overfiltering through the point cloud processing workflow. Using an optimal number of ground control points (GCPs) for georeferencing, which was determined to be 3 at close ranges (3 km), point cloud uncertainty was estimated to be approximately 1.5 m at 1.5 km to 3 m at 3 km and followed a Lorentzian distribution. These uncertainties are smaller than those reported for other close-range radar systems used for terrain mapping. The results of this study should be used as a benchmark for future application of millimeter-wave radar systems for 3-D terrain mapping.Peer reviewe

220GHz wideband 3D imaging radar for concealed object detection technology development and phenomenology studies

Part of the research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 312745.We present a 220 GHz 3D imaging ‘Pathfinder’ radar developed within the EU FP7 project CONSORTIS (Concealed Object Stand-Off Real-Time Imaging for Security) which has been built to address two objectives: (i) to de-risk the radar hardware development and (ii) to enable the collection of phenomenology data with ~1 cm3 volumetric resolution. The radar combines a DDS-based chirp generator and self-mixing multiplier technology to achieve a 30 GHz bandwidth chirp with such high linearity that the raw point response is close to ideal and only requires minor nonlinearity compensation. The single transceiver is focused with a 30 cm lens mounted on a gimbal to acquire 3D volumetric images of static test targets & materials.Publisher PD

A 220 GHz 3D imaging radar with sub-cm3 voxel resolution for security applications

Radars operating at high millimetre and sub-millimetre wave frequencies are promising candidates for security applications such as people screening since they offer the possibility to form 3D images through clothing with sufficient resolution to detect concealed objects. High spatial resolution of order 1 cm can be achieved using practically sized antennas and high range resolution can be achieved using wideband FMCW chirps, e.g. 30 GHz, to yield 0.5 cm range bins. We present a 220 GHz test-bed ‘Pathfinder’ radar which achieves sub-cm3 voxel resolution with very high signal fidelity. The radar is used to de-risk technology under development for next generation people screening systems.Postprin

Second generation of AVTIS FMCW millimeter wave radars for mapping volcanic terrain

The second generation AVTIS ground-based millimeter wave instruments designed for monitoring topography of volcanic lava domes are solid state 94 GHz FMCW rastered, real beam radars operating at ranges of up to ~7 km with a range resolution of ~2.5 m. Operating ten times faster than the prototype with reduced power consumption suitable for battery powered portable use as well as installation at a telemetered site under solar power, we examine their performance as tools for monitoring topography over time and report on the operational statistics both as a radar sensor and as a means of generating digital elevation maps.Publisher PD

Submillimetre wave 3D imaging radar for security applications

There is ongoing worldwide interest in finding solutions to enhance the security of civilians at airports, borders and high risk public areas in ways which are safe, ethical and streamlined. One promising approach is to use submillimetre wave 3D imaging radar to detect concealed threats as it offers the advantages of high volumetric resolution (~1 cm3) with practically sized antennas (<0.5 m) such that even quite small objects can be resolved through clothing. The Millimetre Wave Group at the University of St Andrews has been developing submillimetre wave 3D imaging radars for security applications since 2007. A significant goal is to achieve near real-time frame rates of at least 10 Hz, to cope with dynamic scenes, over wide fields of view at short range with high pixel counts. We review the radar systems we have developed at 340 and 220 GHz and the underpinning technologies which we have employed to realise these goals.PostprintNon peer reviewe

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD

Plio‐Quaternary exhumation history of the central Nepalese Himalaya: 2. Thermokinematic and thermochronometer age prediction model

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95647/1/tect1875.pd

A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p≤5×10−7). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10−8) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2×10−8) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5×10−8; rs1229984-ADH1B, p = 7×10−9; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility

Measurement of Branching Fraction and Dalitz Distribution for B0->D(*)+/- K0 pi-/+ Decays

We present measurements of the branching fractions for the three-body decays B0 -> D(*)-/+ K0 pi^+/-$and their resonant submodes$B0 -> D(*)-/+ K*+/- using a sample of approximately 88 million BBbar pairs collected by the BABAR detector at the PEP-II asymmetric energy storage ring. We measure: B(B0->D-/+ K0 pi+/-)=(4.9 +/- 0.7(stat) +/- 0.5 (syst)) 10^{-4} B(B0->D*-/+ K0 pi+/-)=(3.0 +/- 0.7(stat) +/- 0.3 (syst)) 10^{-4} B(B0->D-/+ K*+/-)=(4.6 +/- 0.6(stat) +/- 0.5 (syst)) 10^{-4} B(B0->D*-/+ K*+/-)=(3.2 +/- 0.6(stat) +/- 0.3 (syst)) 10^{-4} From these measurements we determine the fractions of resonant events to be : f(B0-> D-/+ K*+/-) = 0.63 +/- 0.08(stat) +/- 0.04(syst) f(B0-> D*-/+ K*+/-) = 0.72 +/- 0.14(stat) +/- 0.05(syst)Comment: 7 pages, 3 figures submitted to Phys. Rev. Let