695 research outputs found

    Familial Creutzfeldt-Jakob Disease with V180I Mutation

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    Creutzfeldt-Jakob disease (CJD) is an uncommon neurodegenerative disorder with an incidence of 1 per 1000,000 per year typically characterized by rapidly progressive dementia, ataxia, myoclonus and behavioral changes. Genetic prion diseases, which develop due to a mutations in the prion protein gene (PRNP), account for an estimated 10 to 15% of all CJD cases. We report a 75-yr-old woman with familial CJD carrying a V180I mutation which features late onset, slow progression, no periodic sharp wave complexes on electroencephalography, and extensive cortical ribboning with spared the cerebellum and the medial occipital lobes posterior to the parieto-occipital sulcus on MRI. To our knowledge, this is the first documented case of a point mutation at codon 180 in South Korea

    Collider Signatures of Neutrino Masses and Mixing from R-parity Violation

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    R-parity violation in the supersymmetric standard model can be the source of neutrino masses and mixing. We analyze the neutrino mass matrix coming from either bilinear or trilinear R-parity violation and its collider signatures, assuming that the atmospheric and solar neutrino data are explained by three active neutrino oscillations. Taking the gauge mediated supersymmetry breaking mechanism, we show that the lightest neutralino decays well inside the detector and the model could be tested by observing its branching ratios in the future colliders. In the bilinear model where only the small solar neutrino mixing angle can be accommodated, the relation, 10310^3 BR(Îœe±τ∓\nu e^\pm \tau^\mp) ∌\sim BR(ΜΌ±τ∓\nu \mu^\pm \tau^\mp) ≈\approx BR(Μτ±τ∓\nu \tau^\pm \tau^\mp), serves as a robust test of the model. The large mixing angle solution can be realized in the trilinear model which predicts BR(Îœe±τ∓\nu e^\pm \tau^\mp) ∌\sim BR(ΜΌ±τ∓\nu \mu^\pm \tau^\mp) ∌\sim BR(Μτ±τ∓\nu \tau^\pm \tau^\mp). In either case, the relation, BR(ejje jj) â‰Ș\ll BR(ÎŒjj\mu jj) ∌\sim BR(τjj\tau jj), should hold to be consistent with the atmospheric neutrino and CHOOZ experiments.Comment: 24pages, Late

    Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

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    Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

    Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation