42 research outputs found

    Mechanistic-empirical models for better consideration of subgrade and unbound layers influence on pavement performance

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    It has been reported that the pavement performance predicted by the current mechanistic-empirical pavement design shows low or no sensitivity to subgrade and unbound layers. This issue has raised wide attention. Targeting this problem, this paper summarizes the process used by the authors to find better models of the influence of subgrade and unbound base course layers on the performance of flexible and rigid pavements. A comprehensive literature review is first conducted and the findings are categorized. It is found that the resilient modulus, permanent deformation, shear strength, and erosion are key factors. In particular, the properties that provide greater sensitivity are 1) the moisture-dependency of the modulus, shear strength, and permanent deformation; 2) stress-dependency of the modulus and permanent deformation; and 3) cross-anisotropy of the modulus. A number of unbound layer/subgrade models have been located and categorized. Three criteria are developed to identify the candidate models in terms of the degree of susceptibility, degree of accuracy, and ease of development. The first two criteria are used to evaluate the collected unbound layer/subgrade models, while associated development and implementation issues are planned as subsequent work. Two models that the authors previously developed are selected as examples to illustrate the improvement of the performance prediction, including the moisture-sensitive, stress-dependent, and cross-anisotropic modulus model for unbound layers and stress-dependent mechanistic-empirical permanent deformation model for unbound base layers. These two models are verified through laboratory tests and numerical simulations. Moreover, they are compared to their counterparts in the AASHTOWare Pavement ME Design. The advantages of accuracy and sensitivity to the operational conditions (e.g. moisture, traffic stress, and load-induced/particle-induced anisotropy) are obvious. In addition to these two models, the development of the shear strength model and erosion model are sketched. The candidate models need further development and implementation, which address issues such as hierarchical inputs, calibration/validation, and implementation. These are the on-going and planned work on this topic to better incorporate the influence of subgrade and unbound layers so as to contribute to the improvement of pavement designs

    RECYCLING AND REUSE OF MATERIALS IN TRANSPORTATION PROJECTS —CURRENT STATUS AND POTENTIAL OPPORTUNITIES INCLUDING EVALUATION OF RCA CONCRETE PAVEMENTS ALONG AN OKLAHOMA INTERSTATE HIGHWAY (FHWA-OK-18-04)

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    Oklahoma Department of Transportation (ODOT) is committed to protect and enhance human and natural environment while developing a safe, economical, and effective transportation system. The first objective of this research was to evaluate the availability of the recycled materials and develop strategies for increasing use of recycled materials in ODOT transportation construction projects. In this objective, an extensive literature search was conducted to acquire information pertaining to properties, current practices, and available field investigations of the commonly used recycled materials. Use of recycled concrete aggregate in concrete paving mixtures (RCA-CPM) was determined to be the major focus in this research as applications of RCA-CPM by ODOT and other DOTs have been reported as a sustainable and durable construction practice. Subsequently, a review of the key findings pertaining to RCA material properties and effects of RCA on portland cement concrete pavement (PCCP) performance was performed. Additionally, a life cycle assessment addressing all the three aspects of sustainability (i.e., economic, social, and environmental) was performed to do a comparative assessment between RCA-PCCP and plain PCCP and project the benefits of using RCA-CPM. The second objective was to evaluate the long-term performance of existing PCCP made with RCA in Oklahoma. A jointed plain concrete pavement (JPCP) and a continuously reinforced concrete pavement (CRCP) section were selected and evaluated through various tests covering different aspects, which includes visual survey, determination of mechanical properties, petrographic examination, and evaluation of the existing base through falling weight deflectometer (FWD). From the lab and field studies, it was verified that good base support, strong load transfer, and shorter joint spacing are essential design considerations for JPCP made of RCA-PCC. CRCP using effective anti-corrosion measures might be more suitable for implementing RCA-PCC; CRCP could better protect the base from erosion caused by higher differential energy and help restrain high drying and thermal volume change of RCA-PCC.Final Report October 2016-September 2018N

    0-6839: Designing Pavements to Support the Heavy Loads in the Energy Development Areas

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    0-6839In recent years, rapid energy development in Texas has caused significant damage to many farm-to-market (FM) roads, which traditionally have a thin asphalt surface layer plus a stabilized base directly over the subgrade. These roadways were often rehabilitated with full-depth reclamation (FDR), and often 2 to 3 percent cement was added to the pulverized existing materials. These roadways performed well under normal traffic loads but failed dramatically under the energy-sector truck loads. Figure 1 shows the damaged FM roads. The impact of overloading traffic on pavement damage is not only limited to FM roads; it also has significant influence on the pavement life of state highways and even interstate highways. There is an urgent need to repair many of these badly damaged roadways in all energy development areas

    The Effect of Human Factor H on Immunogenicity of Meningococcal Native Outer Membrane Vesicle Vaccines with Over-Expressed Factor H Binding Protein

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    The binding of human complement inhibitors to vaccine antigens in vivo could diminish their immunogenicity. A meningococcal ligand for the complement down-regulator, factor H (fH), is fH-binding protein (fHbp), which is specific for human fH. Vaccines containing recombinant fHbp or native outer membrane vesicles (NOMV) from mutant strains with over-expressed fHbp are in clinical development. In a previous study in transgenic mice, the presence of human fH impaired the immunogenicity of a recombinant fHbp vaccine. In the present study, we prepared two NOMV vaccines from mutant group B strains with over-expressed wild-type fHbp or an R41S mutant fHbp with no detectable fH binding. In wild-type mice in which mouse fH did not bind to fHbp in either vaccine, the NOMV vaccine with wild-type fHbp elicited 2-fold higher serum IgG anti-fHbp titers (P = 0.001) and 4-fold higher complement-mediated bactericidal titers against a PorA-heterologous strain than the NOMV with the mutant fHbp (P = 0.003). By adsorption, the bactericidal antibodies were shown to be directed at fHbp. In transgenic mice in which human fH bound to the wild-type fHbp but not to the R41S fHbp, the NOMV vaccine with the mutant fHbp elicited 5-fold higher serum IgG anti-fHbp titers (P = 0.002), and 19-fold higher bactericidal titers than the NOMV vaccine with wild-type fHbp (P = 0.001). Thus, in mice that differed only by the presence of human fH, the respective results with the two vaccines were opposite. The enhanced bactericidal activity elicited by the mutant fHbp vaccine in the presence of human fH far outweighed the loss of immunogenicity of the mutant protein in wild-type animals. Engineering fHbp not to bind to its cognate complement inhibitor, therefore, may increase vaccine immunogenicity in humans

    Meningococcal Factor H Binding Proteins in Epidemic Strains from Africa: Implications for Vaccine Development

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    Epidemics of meningococcal meningitis are common in sub-Saharan Africa. Most are caused by encapsulated serogroup A strains, which rarely cause disease in industrialized countries. A serogroup A polysaccharide protein conjugate vaccine recently was introduced in some countries in sub-Saharan Africa. The antibodies induced, however, may allow replacement of serogroup A strains with serogroup W-135 or X strains, which also cause epidemics in this region. Protein antigens, such as factor H binding protein (fHbp), are promising for prevention of meningococcal serogroup B disease. These proteins also are present in strains with other capsular serogroups. Here we report investigation of the potential of fHbp vaccines for prevention of disease caused by serogroup A, W-135 and X strains from Africa. Four fHbp amino acid sequence variants accounted for 81% of the 106 African isolates studied. While there was little cross-protective activity by antibodies elicited in mice by recombinant fHbp vaccines from each of the four sequence variants, a prototype native outer membrane vesicle (NOMV) vaccine from a mutant with over-expressed fHbp elicited antibodies with broad protective activity. A NOMV vaccine has the potential to supplement coverage by the group A conjugate vaccine and help prevent emergence of disease caused by non-serogroup A strains

    Colorimetric nanofibers as optical sensors

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    Sensors play a major role in many applications today, ranging from biomedicine to safety equipment, where they detect and warn us about changes in the environment. Nanofibers, characterized by high porosity, flexibility, and a large specific surface area, are the ideal material for ultrasensitive, fastresponding, and user-friendly sensor design. Indeed, a large specific surface area increases the sensitivity and response time of the sensor as the contact area with the analyte is enlarged. Thanks to the flexibility of membranes, nanofibrous sensors cannot only be applied in high-end analyte detection, but also in personal, daily use. Many different nanofibrous sensors have already been designed; albeit, the most straightforward and easiest-to-interpret sensor response is a visual change in color, which is of particular interest in the case of warning signals. Recently, many researchers have focused on the design of so-called colorimetric nanofibers, which typically involve the incorporation of a colorimetric functionality into the nanofibrous matrix. Many different strategies have been used and explored for colorimetric nanofibrous sensor design, which are outlined in this feature article. The many examples and applications demonstrate the value of colorimetric nanofibers for advanced optical sensor design, and could provide directions for future research in this area

    Review of risk from potential emerging contaminants in UK groundwater

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