Effects of English Pop Music on Pakistani Teenagers: An Online Survey Study

This study investigates the effects of English pop music on the language of Pakistani youth. Online survey through questionnaire method has been employed to ascertain the myth and reality of the established notions. It questions the existing hypothesis and contention held by the researchers that teenagers, when interacted in the English language with their peers, often utter offensive slangs. This trend was considered to be more prevalent among male subjects as compared to female community in Pakistan. One of the key reasons noticed was an addiction to English pop music and hence was selected for the present study. Daily interactions of hundred teen males and females, addicted to English pop music, were observed randomly. All the respondents solved the questionnaire via Facebook IDs.  The collected results were analysed through social science software SPSS 20. Application of paired sample t-test revealed astonishingly contradictory results. The hypothesis cherished earlier proved that female teenagers use more abusive language and slangs than males. Keywords: English pop music, Abusive slangs, SPSS 20 Software, Online poll, t-Tes

Pengaruh Gerakan Literasi Sekolah terhadap Minat Baca dan Keterampilan Membaca Siswa di SD

Pendidikan adalah upaya untuk meningkatkan perasaan dan moral seseorang. Agar proses pendidikan berjalan dengan baik, ada beberapa komponen yang harus dipenuhi. Penelitian ini bertujuan untuk melihat bagaimana Pendidikan terdiri dari banyak hal, termasuk kurikulum, paket pengajaran, guru, staf, siswa, aliansi, fasilitas pendidikan, teknik, evaluasi hasil belajar, dan anggaran pendidikan. Standar pendidikan suatu negara menentukan kemajuan negara. Menggunakan metode studi sastra, para peneliti akan mengumpulkan dan menganalisis data dari berbagai sumber, seperti studi sebelumnya, laporan, dan dokumentasi. Hasil penelitian mereka berhasil menganalisis informasi yang relevan dari berbagai sumber tertulis, seperti buku, artikel, dan jurnal.Studi telah menunjukkan bahwa gerakan literasi sekolah dapat meningkatkan minat siswa dan kecanduan membaca

Pengembangan Potensi Pariwisata Kampung Wisata Haji Dorani dengan Peningkatan Brand Awareness

Malaysia is a multicultural country. This indicates the diversity of human resources. This proper management of human resources can make Malaysia's tourist attraction attractive. Especially in Sungai Haji Dorani Village, Sungai Besar. This study aims to analyze the management of tourism brand awareness in Kampung Sungai Haji Dorani, Selangor. Data analysis methods used include analysis of the distribution of Kuala Selangor residents based on ethnicity and the way they interact. Data collection techniques are carried out by means of observation, interviews and recording. Secondary data obtained by analysis and recording of literature. The existence of diversity makes people more heterogeneous and can exchange ideas. Tourism is an activity that affects the economic conditions of the community. Malaysia occupies the 29th position out of 140 countries in the field of tourism. This country develops tourism with various models. One of them developed in Kuala Selangor is a homestay program in the Sungai Haji Dorani Kampung area. The nuances and daily activities of the residents offered are the main attraction of tourism there

In silico targeting of colony-stimulating factor-1 receptor: delineating immunotherapy in cancer

Aim: Delineate structure-based inhibition of colony-stimulating factor-1 receptor (CSF1R) by small molecule CSF1R inhibitors in clinical development for target identification and potential lead optimization in cancer therapeutics since CSF1R is a novel predictive biomarker for immunotherapy in cancer. Methods: Compounds were in silico modelled by induced fit docking protocol in a molecular operating environment (MOE, MOE.v.2015). The 3-dimensional (3D) X-ray crystallized structure of CSF1R kinase (Protein Databank, ID 4R7H) was obtained from Research Collaboratory for Structural Bioinformatics (RSCB) Protein Databank. The 3D conformers of edicotinib, DCC-3014, ARRY-382, BLZ-945, chiauranib, dovitinib, and sorafenib were obtained from PubChem Database. These structures were modelled in Amber10:EHT molecular force field, and quick prep application was used to correct and optimize the structures for missing residues, H-counts, termini capping, and alternates. The binding site was defined within the vicinity of the co-crystallized ligand of CSF1R kinase. The compounds were docked by the triangular matcher placement method and ranked by the London dG scoring function. The docked poses were further refined by the induced fit method. The pose with the lowest binding score (ΔG) was used to model the ligand interaction profile in Discovery Studio Visualizer v17.2. The co-crystallized ligand was docked in its apo conformation, and root-mean-square deviation was computed to validate the docking protocol. Results: All 7 CSF1R inhibitors interact with residue Met637 exhibiting selectivity except for edicotinib. The inhibitors maintain CSF1R in an auto-inhibitory conformation by interacting with Asp797 of the Asp-Phe-Gly (DFG) motif and/or hindering the conserved salt bridge formed between Glu633 and Lys616 thus stabilizing the activation loop, or interacting with tryptophan residue (Trp550) in the juxtamembrane domain. DCC-3014, ARRY-382, BLZ-945, and sorafenib bind with the lowest binding energy with CSF1R kinase. Conclusions: Pyrimidines are potent inhibitors that interact with CSF1R residues. DCC-3014 and ARRY-382 exhibit exceptional pharmaceutical potential exhibiting great structural stability and affinity

MENGOPTIMALKAN KESEJAHTERAAN SUMBERDAYA MANUSIA (SDM) DI KELURAHAN BUMI AYU

The Field Work Lecture was held in the Bumi Ayu Village, Dumai Selatan District, Dumai City, Riau for 40 days from 10 July to 18 August 2023. The Bumi Ayu Village was chosen as the destination to carry out the KKN.  The village's abundant potential is one of the goals to be able to improve the quality of Human Resources (HR), as well as cultivate and also develop potential in the village.  Activities are carried out with a process of socialization and observation to find out and develop the potential of existing villages.  The Real Work Lecture work program is carried out sequentially, starting with discussions between the Field Work Lecture group and village officials and the local community, especially with the people concerned. Real Work Lectures are carried out in stages starting from planning, implementation and evaluation at the end of each activity carried out.  The results achieved from the Real Work Lecture program which was carried out as a whole were increasing human resources, which were useful for developing the potential of local villages.  In the environmental sector, greening activities and processing organic waste into liquid soap received a positive response and active participation from the people of the Bumi Ayu Village, Dumai Selatan District, Dumai City, Riau

LITERASI KEUANGAN MELALUI PENDEKATAN EDUKATIF DAN PARTISIPATIF

Bank Syariah merupakan bank yang mendasarkan pada prinsip- prinsip Syariah. Prinsip- prinsip Syariah tersebut wajib senantiasa dipatuhi oleh Bank Syariah mulai dari pendirian hingga dengan operasionalnnya, tercantum pula dalam perihal ini permodalan Bank Syariah. Berkaitan dengan permodalan, modal Bank Syariah tidak boleh berasal dari sumber yang diharamkan secara Syariah, sebab perihal itu nanti hendak menimbulkan bercampurnya suatu yang haram dengan yang halal. Suatu yang halal wajib secara tegas dipisahkan dengan yang haram, demikian pula kebalikannya. Penelitian ini menggunakan data sekunder sebagaisumbernya. Data sekunder adalah   data   yang   diperoleh   dari   sumber yang sudah ada.  Dalam pengumpulan data peneliti menggunakan teknik library research (studi   kepustakaan)

Pomegranate peels waste hydrolyzate optimization by response surface methodology for bioethanol production

Unwanted agricultural waste is largely comprised of lignocellulosic substrate which could be transformed into sugars. The production of bioethanol from garbage manifested an agreeable proposal towards waste management as well as energy causation. The goal of this work is to optimize parameters for generation of bioethanol through fermentation by different yeast strains while Saccharomyces cerevisiae used as standard strain. The low cost fermentable sugars from pomegranate peels waste (PPW) were obtained by hydrolysis with HNO3 (1 to 5%). The optimum levels of hydrolysis time and temperature were elucidated via RSM (CCD) ranging from 30 to 60 min and 50 to 100 °C respectively. The result shows that optimum values (g/L) for reducing sugars was 61.45 ± 0.01 while for total carbohydrates was 236 ± 0.01. These values were found when PPW was hydrolyzed with 3% HNO3, at 75 °C for one hour. The hydrolyzates obtained from the dilute HNO3 pretreated PPW yielded a maximum of 0.43 ± 0.04, 0.41 ± 0.03 g ethanol per g of reducing sugars by both Metchnikowia sp. Y31 and M. cibodasensis Y34 at day 7 of ethanologenic experiment. The current study exhibited that by fermentation of dilute HNO3 hydrolyzates of PPW could develop copious amount of ethanol by optimized conditions

Twenty-three unsolved problems in hydrology (UPH) – a community perspective

This paper is the outcome of a community initiative to identify major unsolved scientific problems in hydrology motivated by a need for stronger harmonisation of research efforts. The procedure involved a public consultation through on-line media, followed by two workshops through which a large number of potential science questions were collated, prioritised, and synthesised. In spite of the diversity of the participants (230 scientists in total), the process revealed much about community priorities and the state of our science: a preference for continuity in research questions rather than radical departures or redirections from past and current work. Questions remain focussed on process-based understanding of hydrological variability and causality at all space and time scales. Increased attention to environmental change drives a new emphasis on understanding how change propagates across interfaces within the hydrological system and across disciplinary boundaries. In particular, the expansion of the human footprint raises a new set of questions related to human interactions with nature and water cycle feedbacks in the context of complex water management problems. We hope that this reflection and synthesis of the 23 unsolved problems in hydrology will help guide research efforts for some years to come

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens