Paper Session I-A - Neutral Particle Beam Overview

The goal of the Neutral Particle Beam (NPB) technology program is to develop a multimission directed energy weapon (DEW) system which can function as an effective component in a Strategic Defense System. The NPB has the capability to be used as both a weapon and discriminator platform. It can kill missiles and reentry vehicles in the boost, post-boost, and mid-course portion of an ICBM trajectory as well as discriminated objects during the midcourse phase. Objects from those boosters and buses not engaged in the boost and post boost phase would be engaged once the reentry vehicles and decoys have been deployed, i.e. during the midcourse phase of the trajectory. The NPB can be used to provide a passive, active, and interactive discrimination capability against these targets. Passive discrimination is accomplished by viewing visible, ultraviolet (UV) and/or infrared (IR) emissions from targets and decoys using on-board acquisition sensors. Active discrimination is accomplished by illuminating targets and decoys with a laser tracker on-board the NPB; while Interactive discrimination is accomplished by illuminating the target with the NPB which results in the emission of X-rays and neutrons which are proportional to the mass of the target. These emitted particles are measured by a free flying detector to determine the mass of the objects. During the discrimination process target state vectors (position and velocity) can be determined which can be handed over to space-based or ground-based interceptors. All the sensors are on the same platform. This reduces data processing since sensor-to-sensor correlation is not required

Regional Development: An Econometric Study of the Role of Water Development in Effectuating Population and Income Changes

Twelve measures of regional economic growth, including populations and three measures of income were compared for areas with and without water investment in 246 counties and 42 water resources subareas in the states of Utah, Colorado, New Mexico, Montana, Wyoming, Idaho, and Nevada. Simple mean omparisons for these measures compiled for the decades of 1940-1950, 1950-1960, and 1960-1970 failed to support the hypothesis that economic growth of those counties and subareas receiving water investment was significantly highter than in those areas which did not, with the possible exception of the 1940-1950 decade. This result is obciously tempered by the fact that with-without comparisons taken on a cross-sectional basis may be inaccurage to the extent that spatial units used in the analysis are not homogenous in all respects but the presence or absence of water investment. Population, farm income, median family income, and per acre agricultural land values as measures of economic growth were regressed on various classes of water investment (Total, M&1, Recreation, and Irrigation investment, and other related variables) for the spatial units. Results obtained from this analysis were inconclusive with respect to the hypothesized role of water investment in effectuating economic growth. For small areas in New Mexico where more detailed records of water investment were available, a nine equation econometric model was estimated using a three-stage least squares analysis. As specified, this model facilitated an examination of the interactive effect of water development as a causal variable and as an endogenous variable which responds to other growth inducements. Test statistics for multi-equation systems are only indicative, and the statistical results were nonconclusive, although expected signs on the coefficients were obtained in most instances. Input-output and economic base-models were used to examine two case studies of water investment in Western Coloado. The objective was to demonstrate the methodology and the magnitudes of change in regional economic activity (gross regional output, exports, income, and employment) which could be associated with major irrigation-type water developments. In this analysis it was found that total gross output attributable to the projects ranged from zero in the petroleum and mining sectors to a high of 260,302 in the dairy industry. Multiplicative effects on employment income and gross economic activity ranged from 1.06 to 2.30 times their initial magnitude. Income and employment multipliers were of similar magnitude. it should be recognized that these estimates cannot e viewed in the same manner as similar growth increments at the national level, as would typically be done, because of the strong possibility of regional offsets occurring in other regions not participating in water development. To the extent that growth in other areas is reduced by the growth of a particular region, these reductions should be subtracted from the growth measured in the latter set of regions. In all tests conducted no conclusive evidence was found taht water development causes regions to grow faster than those regions which did not receive water investment. This is not to say that growth in those regions receiving water investment was not higher than it would have been had the investment not been made. However, it does provide evidence that, an average among the regions included within this analysis, that those areas which did not receive major water investments grow at a faster rate than those which did. Thus, the input-output approach shows potential inpacts from water investment in a general equilibrium context, but rest son the assumption that other concurrent events which could produce similar or offsetting effects in the region are held constant. The cross-section analysis measures total changes in a regional economy overtime, but the multiplicity of events, other than water investment, may obscure the effects of water investment

The genomes of two key bumblebee species with primitive eusocial organization

Background: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats. Results: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits. Conclusions: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation

Long-lived magnetism on chondrite parent bodies

publisher: Elsevier articletitle: Long-lived magnetism on chondrite parent bodies journaltitle: Earth and Planetary Science Letters articlelink: http://dx.doi.org/10.1016/j.epsl.2017.07.035 content_type: article copyright: © 2017 The Authors. Published by Elsevier B.V.© 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). The attached file is the published version of the article

Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

The ‘Sepsis Six’ bundle was promoted as a deliverable tool outside of the critical care settings, but there is very little data available on the progress and change of sepsis care outside the critical care environment in the UK. Our aim was to compare the yearly prevalence, outcome and the Sepsis Six bundle compliance in patients at risk of mortality from sepsis in non-intensive care environments. Patients with a National Early Warning Score (NEWS) of 3 or above and suspected or proven infection were enrolled into four yearly 24-h point prevalence studies, carried out in fourteen hospitals across Wales from 2016 to 2019. We followed up patients to 30 days between 2016–2019 and to 90 days between 2017 and 2019. Out of the 26,947 patients screened 1651 fulfilled inclusion criteria and were recruited. The full ‘Sepsis Six’ care bundle was completed on 223 (14.0%) occasions, with no significant difference between the years. On 190 (11.5%) occasions none of the bundle elements were completed. There was no significant correlation between bundle element compliance, NEWS or year of study. One hundred and seventy (10.7%) patients were seen by critical care outreach; the ‘Sepsis Six’ bundle was completed significantly more often in this group (54/170, 32.0%) than for patients who were not reviewed by critical care outreach (168/1385, 11.6%; p < 0.0001). Overall survival to 30 days was 81.7% (1349/1651), with a mean survival time of 26.5 days (95% CI 26.1–26.9) with no difference between each year of study. 90-day survival for years 2017–2019 was 74.7% (949/1271), with no difference between the years. In multivariate regression we identified older age, heart failure, recent chemotherapy, higher frailty score and do not attempt cardiopulmonary resuscitation orders as significantly associated with increased 30-day mortality. Our data suggests that despite efforts to increase sepsis awareness within the NHS, there is poor compliance with the sepsis care bundles and no change in the high mortality over the study period. Further research is needed to determine which time-sensitive ward-based interventions can reduce mortality in patients with sepsis and how can these results be embedded to routine clinical practice

Comprehensive molecular characterization of gastric adenocarcinoma

Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein–Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also knownasPD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies

Integrated genomic characterization of oesophageal carcinoma

Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus. Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas. Oesophageal adenocarcinomas strongly resembled the chromosomally unstable variant of gastric adenocarcinoma, suggesting that these cancers could be considered a single disease entity. However, some molecular features, including DNA hypermethylation, occurred disproportionally in oesophageal adenocarcinomas. These data provide a framework to facilitate more rational categorization of these tumours and a foundation for new therapies

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good