Charge-state distribution of Li ions from the β\beta decay of laser-trapped 6^{6}He atoms

Background: The accurate determination of atomic final states following nuclear $\beta$ decay plays an important role in many experiments. In particular, the charge state distributions of ions following nuclear $\beta$ decay are important for determinations of the $\beta-\nu$ angular correlation with improved precision. Purpose: Our measurement aims at providing benchmarks to test theoretical calculations. Method: The kinematics of Li$^{n+}$ ions produced following the $\beta$ decay of $^6{\rm He}$ within an electric field were measured using $^6{\rm He}$ atoms in the metastable $(1s2s,~{^3S_1})$ and in the $(1s2p,~{^3P_2})$ states confined by a magneto-optical trap. The electron shake-off probabilities were deduced including their dependence on ion energy. Results: We find significant discrepancies on the fractions of Li ions in the different charge states with respect to a recent calculation and discuss a plausible explanation. We also point out that there is no explanation for a large discrepancy between the same calculation and a previous measurement of the Li-ion energy dependence of the charge distribution from decays of the electronic ground state

The QUEST initiative anemia study in ESRD: rationale and study protocol

No abstrac

An unusual case of multiple endocrine neoplasia type 1 and the role of 111In-pentetreotide scintigraphy

A 50-year-old woman is described with a very unusual combination of MEN-1 syndrome with a negative family history. At first she had been treated because of a clinically non-functioning pituitary adenoma in the maxillary sinus. Six years later a carcinoid tumour was discovered by means of 111In-pentreotide scintigraphy

Subsequent Event Risk in Individuals with Established Coronary Heart Disease:Design and Rationale of the GENIUS-CHD Consortium

BACKGROUND: The "GENetIcs of sUbSequent Coronary Heart Disease" (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with duration of follow up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (HR 1.15 95% CI 1.14-1.16) per 5-year increase, male sex (HR 1.17, 95% CI 1.13-1.21) and smoking (HR 1.43, 95% CI 1.35-1.51) with risk of subsequent CHD death or myocardial infarction, and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and non-genetic determinants of subsequent event risk in individuals with established CHD, in order to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Publisher Copyright: © 2021 The Authors, some rights reserved.Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-alpha and/or IFN-omega are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-alpha and/or IFN-omega (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-beta. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-alpha and/or IFN-omega are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals 80 years. By contrast, auto-Abs neutralizing IFN-beta do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases.Peer reviewe

Le Journal de Normandie (1785-1789), l'étranger et l'outre-mer : les horizons géographiques d'un journal de province à la veille de la Révolution

Wauters Eric. Le Journal de Normandie (1785-1789), l'étranger et l'outre-mer : les horizons géographiques d'un journal de province à la veille de la Révolution. In: Annales de Normandie, 45ᵉ année, n°3, 1995. pp. 301-325

La presse départementale en l'an II

Éric Wauters, The Departmental Press in the Year II. The study is based on three regions : the East, the Southwest and Normandy. From a quantitative standpoint, the number of titles and circulation in the Year II were slightly superior to the levels of the second half of 1792 and of the Year III, the two most difficult periods for the departmental press. All things considered, the departmental press did less to form public opinion than to mirror its most active and visible manifestations, that of the political élite. A journal would appear when the élite were nearly united in their opinions. Divisions between the élite, on the other hand, were harmful to the press.Éric Wauters, La stampa dipartimentale nell'anno II. Lo studio verte su tre insiemi regionali : l'Est, il Sud-Ovest, la Normandia. Sul piano quantitativo (numéro di titoli, tiratura), l'anno II costitui un pianerottolo appena superiore ai livelli della seconda meta del 1792 e dell'anno III, eppure i due momenti più difficili per la stampa dipartimentale. Sul contenuto, la stampa dipartimentale formô meno l'opinione pubblica che ne rifletesse la parte più attiva di quest'opinione, quella dell' « elite » politica. Quando quest' ultima era pressappoco unita, usciva un giornale, allorché le divisioni interne furono nocive alla stampa.Éric Wauters, La presse départementale en l'an II. L'étude porte sur trois ensembles régionaux : l'Est, le Sud-Ouest, la Normandie. Au plan quantitatif (nombre de titres, tirage), l'an II constitue un palier légèrement supérieur aux niveaux de la deuxième moitié de 1792 et de l'an III, les deux moments les plus difficiles pour la presse départementale. Sur le fond, la presse départementale forma moins l'opinion publique qu'elle ne refléta la partie la plus active de cette opinion, celle des élites politiques. Quand ces dernières étaient à peu près unies un journal apparaissait, alors que les divisions en leur sein furent nuisibles à la presse.Wauters Éric. La presse départementale en l'an II. In: Annales historiques de la Révolution française, n°303, 1996. pp. 1-35

La dialectique province-Paris dans la presse des départements : entre vie politique locale et réseaux nationaux d'opinion

Éric Wauters, The Dialectics between the Provinces and Paris in the Departmental Press : astride Local Politics and National Networks of Opinion Circulation of information during the Revolution was not simply pyramid-shaped, from the capital downwards to the provinces. The distribution of the local press reflects firstly the cultural or economic influence of certain cities. Relaying essentially national news, the press tended next to bring together new groups inspired by similar ideological bents or similar class leanings. How did these groups liaise among themselves, or with the capital, and thus forge a national current of opinion ? A large-scale national survey on the distribution of news between the capital and the provinces on the one hand, and between the departments on the other, would doubtless help us better understand the mechanism of the formation of public opinion.La circulation de l'information pendant la Révolution n'obéit pas à un simple schéma pyramidal, de la capitale vers la province. La distribution de la presse locale traduit d'abord l'influence culturelle ou économique de quelques villes. Diffusant une information essentiellement nationale, la presse tend, ensuite, à créer de nouveaux groupes qui se constituent autour des mêmes sensibilités idéologiques ou des mêmes intérêts de classes. Comment ces groupes s'articulent-ils entre eux ou avec la capitale, pour constituer un courant d'opinion nationale? Une vaste enquête nationale sur la distribution des nouvelles, entre la capitale et la province d'une part, entre les départements d'autre part, permettrait sans doute de mieux connaître les mécanismes de formation de l'opinion publique.Wauters Éric. La dialectique province-Paris dans la presse des départements : entre vie politique locale et réseaux nationaux d'opinion. In: Annales historiques de la Révolution française, n°330, 2002. Provinces-Paris. pp. 71-85

La société civile et les institutions

Wauters Eric. La société civile et les institutions. In: Annales de Normandie, 46ᵉ année, n°1, 1996. La Révolution en Haute-Normandie. pp. 45-55