75 research outputs found
Science-Technology-Society (STS): a new paradigm in Science Education
- Author
- Association for Science Education.
- Barnes B.
- Barnes D.
- Bell B.
- Bentley D.
- Blades D.W.
- Bruner J.S.
- Bybee R.
- Carin S.
- Carroll T.M.
- Carson R.
- Commoner B.
- Ehrlich P.R.
- Ehrlich P.R.
- Ernest P.
- Fishbein M.
- Mansour N.
- Marshall H.H.
- Martin B.
- Matthews M.R.
- Nasser Mansour
- National Science Teachers Association
- National Science Teachers Association.
- Ramsey F.P.
- Roth W.M.
- Schwab J.
- Scott P.
- Skinner B.F.
- Waks L.J.
- Yager R.E.
- Yager R.E.
- Za'Rour G.I.
- Publication venue
- 'SAGE Publications'
- Publication date
- 24/06/2013
- Field of study
publication-status: Publishedtypes: ArticleChanges in the past two decades of goals for science education in schools have induced new orientations in science education worldwide. One of the emerging complementary approaches was the science-technology-society (STS) movement. STS has been called the current megatrend in science education. Others have called it a paradigm shift for the field of science education. The success of science education reform depends on teachers' ability to integrate the philosophy and practices of current programs of science education reform with their existing philosophy. Thus, when considering the STS approach to science education, teacher beliefs about STS implementation require attention. Without this attention, negative beliefs concerning STS implementation and inquiry learning could defeat the reform movements emphasizing STS. This article argues the role of STS in science education and the importance of considering science teachers' beliefs about STS in implementing significant reforms in science education
A parametric study on the dynamic response of planar multibody systems with multiple clearance joints
- Author
- A. Tasora
- A.A. Shabana
- B. Brogliato
- B. Brogliato
- B. Miedema
- B.M. Kwak
- C. Glocker
- C. Glocker
- C. Innocenti
- D.T. Greenwood
- E.J. Haug
- F. Farahanchi
- F. Pfeifer
- F. Pfeiffer
- F. Pfeiffer
- G. Gilardi
- H. Hertz
- H.M. Lankarani
- J. Ambrósio
- J. Ambrósio
- J. Baumgarte
- J. Pang
- J. Rhee
- J.-S. Pang
- J.A. Zukas
- J.C. Trinkle
- J.J. Moreau
- J.M. McCarthy
- M. Anitescu
- M. Anitescu
- M. Förg
- M.T. Bengisu
- N. Srivastava
- O.A. Bauchau
- P. Flores
- P. Flores
- P. Flores
- P. Flores
- P. Flores
- P. Flores
- P. Flores
- P. Flores
- P. Flores
- P. Flores
- P.D. Panagiotopoulos
- P.E. Nikravesh
- P.E. Nikravesh
- P.E. Nikravesh
- Paulo Flores
- R.C. Smith
- R.I. Leine
- R.R. Ryan
- R.S. Haines
- S. Dubowsky
- S. Dubowsky
- S. Dubowsky
- S. Erkaya
- S. Erkaya
- S. Wiggins
- S.P. Timoshenko
- T. Kakizaki
- W. Goldsmith
- W. Wu
- W.M. Mansour
- W.W. Gear
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2010
- Field of study
A general methodology for dynamic modeling and analysis of multibody systems with multiple clearance joints is presented and discussed in this paper. The joint components that constitute a real joint are modeled as colliding bodies, being their behavior influenced by geometric and physical properties of the contacting surfaces. A continuous contact force model, based on the elastic Hertz theory together with a dissipative term, is used to evaluate the intra-joint contact forces. Furthermore, the incorporation of the friction phenomenon, based on the classical Coulomb’s friction law, is also discussed. The suitable contact-impact force models are embedded into the dynamics of multibody systems methodologies. An elementary mechanical system is used to demonstrate the accuracy and efficiency of the presented approach, and to discuss the main assumptions and procedures adopted. Different test scenarios are considered with the purpose of performing a parametric study for quantifying the influence of the clearance size, input crank speed and number of clearance joints on the dynamic response of multibody systems with multiple clearance joints. Additionally, the total computation time consumed in each simulation is evaluated in order to test the computational accuracy and efficiency of the presented approach. From the main results obtained in this study, it can be drawn that clearance size and the operating conditions play a crucial role in predicting accurately the dynamic responses of multibody systems.Fundação para a Ciência e a Tecnologia (FCT
2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation
- Author
- Aguinaga L. (Luis)
- Akar J.G. (Joseph G.)
- Badhwar V. (Vinay)
- Brugada J. (Josep)
- Calkins H. (Hugh)
- Camm J. (John)
- Cappato R. (Riccardo)
- Chen P.-S. (Peng-Sheng)
- Chen S.-A. (Shih-Ann)
- Chung M.K. (Mina)
- Curtis A.B. (Anne B.)
- d'Avila A. (André)
- Davies D.W. (D. Wyn)
- Day J.D. (John D.)
- Di Biase L. (Luigi)
- Duytschaever M. (Mattias)
- Edgerton J.R. (James R.)
- Ellenbogen K.A. (Kenneth)
- Ellinor P.T. (Patrick)
- Ernst S. (Sabine)
- Fenelon G. (Guilherme)
- Gerstenfeld E.P. (Edward P.)
- Groot N.M.S. (Natasja) de
- Haines D.E. (David E.)
- Haissaguerre M. (Michel)
- Helm R.H. (Robert H.)
- Hindricks G. (Gerhard)
- Hylek E. (Elaine)
- Jackman W.M. (Warren M.)
- Jalife J. (Jose)
- Kalman J.M. (Jonathan M.)
- Kautzner J. (Josef)
- Kim Y.-H. (Young-Hoon)
- Kottkamp H. (Hans)
- Kuck K.H. (Karl Heinz)
- Kumagai K. (Koichiro)
- Lee R. (Richard)
- Lewalter T. (Thorsten)
- Lindsay B.D. (Bruce D.)
- Macle L. (Laurent)
- Mansour M. (Moussa)
- Marchlinski F.E. (Francis E.)
- Michaud G.F. (Gregory F.)
- Nakagawa H. (Hiroshi)
- Natale A. (Andrea)
- Nattel S. (Stanley)
- Nielsen J.C.
- Okumura K. (Ken)
- Packer D.L. (Douglas L.)
- Pokushalov E. (Evgeny)
- Reynolds M.R. (Matthew R)
- Saad E.B. (Eduardo B.)
- Sanders P. (Prashanthan)
- Scanavacca M. (Mauricio)
- Schilling R. (Richard)
- Tondo C. (Claudio)
- Tsao H.-M. (Hsuan-Ming)
- Verma A. (Atul)
- Wilber D.J. (David J.)
- Yamane T. (Teiichi)
- Publication venue
- 'Elsevier BV'
- Publication date
- 15/09/2017
- Field of study
Production of pizero and eta mesons at large transverse momenta in pp and pBe interactions at 530 and 800 GeV/c
- Author
- A. Gribushin
- A. Gribushin
- A. Maul
- A. Zembrzuski
- A.G. Clark
- A.L.S. Angelis
- A.P. Contogouris
- A.P. Contogouris
- B. Choudhary
- B. Y. Oh
- B.A. Kniehl
- C. Bromberg
- C. Bromberg
- C. Johnstone
- C. Lirakis
- C. Yosef
- D. Garelick
- D. Pellett
- D. Skow
- D. Striley
- D. Weerasundara
- D.E. Groom
- E. Engels
- E. Engels Jr.
- E. Laenen
- E. Laenen
- E. Prebys
- F. Aversa
- F. Lobkowicz
- F. Lobkowicz
- G. Alverson
- G. Alverson
- G. Alverson
- G. Alverson
- G. Donaldson
- G. Drake
- G. Fanourakis
- G. Ginther
- G. Marchesini
- G. Osborne
- G.D. Lafferty
- H.-L. Lai
- H.L. Lai
- J. Bacigalupi
- J. Binnewies
- J. Breitweg
- J. Breitweg
- J. Collins
- J. Collins
- J. Collins
- J. Dunlea
- J. Ftacnik
- J. Huston
- J. Huston
- J. J. Whitmore
- J. Kuehler
- J. Mansour
- J.F. Owens
- J.F. Owens
- K. Hartman
- L. Apanasevich
- L. Apanasevich
- L. Apanasevich
- L. Apanasevich
- L. Apanasevich
- L. Apanasevich
- L. de Barbaro
- L. Sorrell
- M. Begel
- M. Bonesini
- M. Fontannaz
- M. Fontannaz
- M. Fontannaz
- M. Glaubman
- M. Zieliński
- N. Kidonakis
- N. Kidonakis
- N. Kidonakis
- N. Varelas
- N.A. McCubbin
- P. Aurenche
- P. Aurenche
- P. Chang
- P. Gutierrez
- P. Lukens
- P. Shepard
- P. Slattery
- R. Jesik
- R. Miller
- R. Roser
- R. Shivpuri
- R.P. Feynman
- S. Blusk
- S. Catani
- S. Catani
- S. M. Tripathi
- T. Ferbel
- T. Yasuda
- V. Kapoor
- V. Koreshev
- V. Zutshi
- W. Baker
- W. DeSoi
- W. Długosz
- W. H. Chung
- W. Toothacker
- W.M. Geist
- X.-N. Wang
- Y. Zhang
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 23/04/2002
- Field of study
We present results on the production of high transverse momentum pizero and
eta mesons in pp and pBe interactions at 530 and 800 GeV/c. The data span the
kinematic ranges: 1 < p_T < 10 GeV/c in transverse momentum and 1.5 units in
rapidity. The inclusive pizero cross sections are compared with next-to-leading
order QCD calculations and to expectations based on a phenomenological
parton-k_T model.Comment: RevTeX, 63 pages, 25 figures, to be submitted to Phys. Rev.
Measurement of the forward-backward asymmetry in Λ0b and Λ¯0b baryon production in pp¯ collisions at s√=1.96 TeV
- Author
- Abazov V.M.
- Abbott B.
- Acharya B.S.
- Adams M.
- Adams T.
- Agnew J.P.
- Alexeev G.D.
- Alkhazov G.
- Alton A.
- Askew A.
- Atkins S.
- Augsten K.
- Avila C.
- Badaud F.
- Bagby L.
- Baldin B.
- Bandurin D.V.
- Banerjee S.
- Barberis E.
- Baringer P.
- Bartlett J.F.
- Bassler U.
- Bazterra V.
- Bean A.
- Begalli M.
- Bellantoni L.
- Beri S.B.
- Bernardi G.
- Bernhard R.
- Bertram I.
- Besanifmmode çelse çon M.
- Beuselinck R.
- Bhat P.C.
- Bhatia S.
- Bhatnagar V.
- Blazey G.
- Blessing S.
- Bloom K.
- Boehnlein A.
- Boline D.
- Boos E.E.
- Borissov G.
- Borysova M.
- Brandt A.
- Brandt O.
- Brock R.
- Bross A.
- Brown D.
- Bu X.B.
- Buehler M.
- Buescher V.
- Bunichev V.
- Burdin S.
- Buszello C.P.
- Camacho-Pérez E.
- Casey B.C.K.
- Castilla-Valdez H.
- Caughron S.
- Chakrabarti S.
- Chan K.M.
- Chandra A.
- Chapon E.
- Chen G.
- Cho S.W.
- Choi S.
- Choudhary B.
- Cihangir S.
- Claes D.
- Clutter J.
- Cooke M.
- Cooper W.E.
- Corcoran M.
- Couderc F.
- Cousinou M.-C.
- Cutts D.
- Das A.
- Davies G.
- de Jong S.J.
- De La Cruz-Burelo E.
- Demina R.
- Denisov D.
- Denisov S.P.
- Desai S.
- Deterre C.
- DeVaughan K.
- Diehl H.T.
- Diesburg M.
- Ding P.F.
- Dominguez A.
- Dubey A.
- Dudko L.V.
- Duperrin A.
- Dutt S.
- Déliot F.
- Eads M.
- Edmunds D.
- Ellison J.
- Elvira V.D.
- Enari Y.
- Evans H.
- Evdokimov A.
- Evdokimov V.N.
- Fauré A.
- Feng L.
- Ferbel T.
- Fiedler F.
- Filthaut F.
- Fisher W.
- Fisk H.E.
- Fortner M.
- Fox H.
- Fuess S.
- Garbincius P.H.
- Garcia-Bellido A.
- García-González J.A.
- Gavrilov V.
- Geng W.
- Gerber C.E.
- Gershtein Y.
- Ginther G.
- Gogota O.
- Golovanov G.
- Grannis P.D.
- Greder S.
- Greenlee H.
- Grenier G.
- Gris Ph.
- Grivaz J.-F.
- Grohsjean A.
- Grünendahl S.
- Grünewald M.W.
- Guillemin T.
- Gutierrez G.
- Gutierrez P.
- Haley J.
- Han L.
- Harder K.
- Harel A.
- Hauptman J.M.
- Hays J.
- Head T.
- Hebbeker T.
- Hedin D.
- Hegab H.
- Heinson A.P.
- Heintz U.
- Hensel C.
- Heredia-De La Cruz I.
- Herner K.
- Hesketh G.
- Hildreth M.D.
- Hirosky R.
- Hoang T.
- Hobbs J.D.
- Hoeneisen B.
- Hogan J.
- Hohlfeld M.
- Holzbauer J.L.
- Howley I.
- Hubacek Z.
- Hynek V.
- Iashvili I.
- Ilchenko Y.
- Illingworth R.
- Ito A.S.
- Jabeen S.
- Jaffré M.
- Jayasinghe A.
- Jeong M.S.
- Jesik R.
- Jiang P.
- Johns K.
- Johnson E.
- Johnson M.
- Jonckheere A.
- Jonsson P.
- Joshi J.
- Jung A.W.
- Juste A.
- Kajfasz E.
- Karmanov D.
- Katsanos I.
- Kaur M.
- Kehoe R.
- Kermiche S.
- Khalatyan N.
- Khanov A.
- Kharchilava A.
- Kharzheev Y.N.
- Kiselevich I.
- Kohli J.M.
- Kozelov A.V.
- Kraus J.
- Kumar A.
- Kupco A.
- Kurifmmode eckcelse ca T.
- Kuzmin V.A.
- Lammers S.
- Lebrun P.
- Lee H.S.
- Lee S.W.
- Lee W.M.
- Lei X.
- Lellouch J.
- Li D.
- Li H.
- Li L.
- Li Q.Z.
- Lim J.K.
- Lincoln D.
- Linnemann J.
- Lipaev V.V.
- Lipton R.
- Liu H.
- Liu Y.
- Lobodenko A.
- Lokajicek M.
- Lopes de Sa R.
- Luna-Garcia R.
- Lyon A.L.
- Maciel A.K.A.
- Madar R.
- Magaña-Villalba R.
- Malik S.
- Malyshev V.L.
- Mansour J.
- Martínez-Ortega J.
- McCarthy R.
- McGivern C.L.
- Meijer M.M.
- Melnitchouk A.
- Menezes D.
- Mercadante P.G.
- Merkin M.
- Meyer A.
- Meyer J.
- Miconi F.
- Mondal N.K.
- Mulhearn M.
- Nagy E.
- Narain M.
- Nayyar R.
- Neal H.A.
- Negret J.P.
- Neustroev P.
- Nguyen H.T.
- Nunnemann T.
- Orduna J.
- Osman N.
- Osta J.
- Pal A.
- Parashar N.
- Parihar V.
- Park S.K.
- Partridge R.
- Parua N.
- Patwa A.
- Penning B.
- Perfilov M.
- Peters Y.
- Petridis K.
- Petrillo G.
- Pleier M.-A.
- Podstavkov V.M.
- Popov A.V.
- Prewitt M.
- Price D.
- Prokopenko N.
- Pétroff P.
- Qian J.
- Quadt A.
- Quinn B.
- Ratoff P.N.
- Razumov I.
- Ripp-Baudot I.
- Rizatdinova F.
- Rominsky M.
- Ross A.
- Royon C.
- Rubinov P.
- Ruchti R.
- Sajot G.
- Sanders M.P.
- Santos A.S.
- Savage G.
- Savitskyi M.
- Sawyer L.
- Scanlon T.
- Schamberger R.D.
- Scheglov Y.
- Schellman H.
- Schwanenberger C.
- Schwienhorst R.
- Sekaric J.
- Severini H.
- Shabalina E.
- Shary V.
- Shaw S.
- Shchukin A.A.
- Simak V.
- Skubic P.
- Slattery P.
- Smirnov D.
- Snow G.R.
- Snow J.
- Snyder S.
- Sonnenschein L.
- Soustruznik K.
- Stark J.
- Stoyanova D.A.
- Strauss M.
- Suter L.
- Svoisky P.
- Sánchez-Hernández A.
- Söldner-Rembold S.
- Titov M.
- Tokmenin V.V.
- Tsai Y.-T.
- Tsybychev D.
- Tuchming B.
- Tully C.
- Uvarov L.
- Uvarov S.
- Uzunyan S.
- Van Kooten R.
- van Leeuwen W.M.
- Varelas N.
- Varnes E.W.
- Vasilyev I.A.
- Verkheev A.Y.
- Vertogradov L.S.
- Verzocchi M.
- Vesterinen M.
- Vilanova D.
- Vokac P.
- Wahl H.D.
- Wang M.H.L.S.
- Warchol J.
- Watts G.
- Wayne M.
- Weichert J.
- Welty-Rieger L.
- Williams M.R.J.
- Wilson G.W.
- Wobisch M.
- Wood D.R.
- Wyatt T.R.
- Xie Y.
- Yamada R.
- Yang S.
- Yasuda T.
- Yatsunenko Y.A.
- Ye W.
- Ye Z.
- Yin H.
- Yip K.
- Youn S.W.
- Yu J.M.
- Zennamo J.
- Zhao T.G.
- Zhou B.
- Zhu J.
- Zielinski M.
- Zieminska D.
- Zivkovic L.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2015
- Field of study
We measure the forward-backward asymmetry in the production of Λ0b and Λ¯0b baryons as a function of rapidity in pp¯ collisions at s√=1.96 TeV using 10.4 fb−1 of data collected with the D0 detector at the Fermilab Tevatron collider. The asymmetry is determined by the preference of Λ0b or Λ¯0b particles to be produced in the direction of the beam protons or antiprotons, respectively. The measured asymmetry integrated over rapidity y in the range 0.1<|y|<2.0 is A=0.04±0.07(stat)±0.02(syst)
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018
- Author
- Abajobir A.
- Abbasi N.
- Abbasi S.
- Abbasi-Kangevari M.
- Abbasifard M.
- Abbastabar H.
- Abd-Allah F.
- Abd-Elsalam S.M.
- Abdelalim A.
- Abdoli A.
- Abdollahpour I.
- Abedi A.
- Abolhassani H.
- Abraham B.
- Abreu L.G.
- Abrigo M.R.M.
- Abu-Gharbieh E.
- Abualhasan A.
- Abushouk A.I.
- Accrombessi M.M.K.
- Adabi M.
- Adebayo O.M.
- Adegbosin A.E.
- Adekanmbi V.
- Adetokunboh O.O.
- Adeyinka D.A.
- Adham D.
- Advani S.M.
- Agasthi P.
- Aghaali M.
- Ahmad S.
- Ahmad T.
- Ahmadi K.
- Ahmadi S.
- Ahmed M.B.
- Aichour M.T.E.
- Aji B.
- Akinyemi O.O.
- Aklilu A.
- Akunna C.J.
- Al-Aly Z.
- Al-Mekhlafi H.M.
- Al-Raddadi R.M.
- Alanzi T.M.
- Alcalde-Rabanal J.E.
- Alemu A.
- Alemu B.W.
- Alhassan R.K.
- Alif S.M.
- Alipour V.
- Alizade H.
- Aljunid S.M.
- Almasi-Hashiani A.
- Alvis-Guzman N.
- Amini S.
- Amiri F.
- Amugsi D.A.
- Anber N.H.
- Ancuceanu R.
- Andrei T.
- Anegago M.T.
- Anjomshoa M.
- Ansari F.
- Ansari-Moghaddam A.
- Anteneh Z.A.
- Antriyandarti E.
- Anvari D.
- Anwer R.
- Aqeel M.
- Arab-Zozani M.
- Arabloo J.
- Aremu O.
- Areri H.A.
- Artaman A.
- Arzani A.
- Asaad M.
- Asadi-Aliabadi M.
- Asadi-Pooya A.A.
- Asemahagn M.A.
- Asghari Jafarabadi M.
- Ashebir M.M.
- Ataro Z.
- Athari S.M.
- Athari S.S.
- Atout M.M.W.
- Ausloos M.
- Awoke N.
- Ayala Quintanilla B.P.
- Ayano G.
- Ayanore M.A.
- Aynalem Y.A.
- Ayza M.A.
- Azadmehr A.
- B D.
- Babalola T.K.
- Badawi A.
- Badiye A.D.
- Bahrami M.A.
- Bairwa M.
- Bakkannavar S.M.
- Bali A.O.
- Banik P.C.
- Baraki A.G.
- Barboza M.A.
- Basaleem H.
- Basu S.
- Bayati M.
- Baye B.A.
- Bazmandegan G.
- Bedi N.
- Bekuma T.T.T.
- Bell M.L.
- Bensenor I.M.
- Berhe A.K.
- Berhe K.
- Berhie K.A.
- Bhandari D.
- Bhardwaj N.
- Bhardwaj P.
- Bhattacharjee N.V.
- Bhattacharyya K.
- Bhattarai S.
- Bhutta Z.A.
- Bijani A.
- Bikbov B.
- Bin Zaman S.
- Biondi A.
- Birhanu M.
- Biswas R.K.
- Bockarie M.J.
- Bohlouli S.
- Bohluli M.
- Boloor A.
- Borzouei S.
- Bragazzi N.L.
- Braithwaite D.
- Brunoni A.R.
- Burugina Nagaraja S.
- Butt Z.A.
- Caetano dos Santos F.L.
- Car J.
- Carvalho F.
- Castaldelli-Maia J.M.
- Castañeda-Orjuela C.A.
- Castro F.
- Cevik M.
- Chanie W.F.
- Charan J.
- Chatterjee S.
- Chattu V.K.
- Chaturvedi S.
- Chen S.
- Chin K.L.
- Chowdhury M.A.K.
- Collison M.
- Cook A.J.
- Costa V.M.
- Cromwell E.A.
- Cámera L.A.
- Cárdenas R.
- Dachew B.A.
- Dagne H.
- Dagnew B.
- Dahiru T.
- Dahlawi S.M.A.
- Dai H.
- Dai H.
- Dandona L.
- Dandona R.
- Daneshpajouhnejad P.
- Daoud F.
- Das Gupta R.
- Das J.K.
- Dash A.P.
- Davletov K.
- De Neve J.-W.
- Deeba F.
- Denova-Gutiérrez E.
- Deribe K.
- Desalew A.
- Dessie G.A.
- Dey S.
- Dhimal M.
- Dhungana G.P.
- Dianatinasab M.
- Diaz D.
- Dipeolu I.O.
- Djalalinia S.
- Do H.T.
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- Publication date
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- Field of study
Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate results to policy-relevant administrative and national levels. Additionally, we provide subnational disparity analyses to provide a comprehensive overview of anemia prevalence inequalities within these countries and predict progress toward the World Health Organization’s Global Nutrition Target (WHO GNT) to reduce anemia by half by 2030. Our results demonstrate widespread moderate improvements in overall anemia prevalence but identify only three LMICs with a high probability of achieving the WHO GNT by 2030 at a national scale, and no LMIC is expected to achieve the target in all their subnational administrative units. Our maps show where large within-country disparities occur, as well as areas likely to fall short of the WHO GNT, offering precision public health tools so that adequate resource allocation and subsequent interventions can be targeted to the most vulnerable populations.Peer reviewe
Comparison between simulated and observed LHC beam backgrounds in the ATLAS experiment at Ebeam =4 TeV
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- Publication venue
- IOP Publishing
- Publication date
- 01/01/2018
- Field of study
Results of dedicated Monte Carlo simulations of beam-induced background (BIB) in the ATLAS experiment at the Large Hadron Collider (LHC) are presented and compared with data recorded in 2012. During normal physics operation this background arises mainly from scattering of the 4 TeV protons on residual gas in the beam pipe. Methods of reconstructing the BIB signals in the ATLAS detector, developed and implemented in the simulation chain based on the \textscFluka Monte Carlo simulation package, are described. The interaction rates are determined from the residual gas pressure distribution in the LHC ring in order to set an absolute scale on the predicted rates of BIB so that they can be compared quantitatively with data. Through these comparisons the origins of the BIB leading to different observables in the ATLAS detectors are analysed. The level of agreement between simulation results and BIB measurements by ATLAS in 2012 demonstrates that a good understanding of the origin of BIB has been reached
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018
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- Field of study
The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set
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- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Background
Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables.
Methods
Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set.
Results
Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001).
Conclusions
The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy
Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.
- Author
- Ahmed Munaza
- Aitken Stuart
- Aitman Timothy
- Akawi Nadia
- Al Turki Saeed
- Alachkar Hana
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- Tachmazidou Ionna
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- Tivey Adrian R.
- Tobin Martin D.
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- Valdes Ana
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- Van Kogelenberg Margriet
- Vandersteen Anthony
- Varghese Vinod
- Vasudevan Pradeep
- Veltman Marijke
- Vijayarangakannan Parthiban
- Vijayarangakannan Parthiban
- Visscher Peter M.
- Vogt Julie
- Vogt Julie
- von Ziegenweldt Julie
- Vonk Noordegraaf Anton
- Wain Louise V.
- Wakeling Emma
- Wakeling Emma
- Wallwark Sarah
- Walters James T.R.
- Wang Guangbiao
- Wang Jun
- Wang Yu
- Wanjiku Ivy
- Ward Kirsten
- Warner Timothy Q.
- Wassmer Evangeline
- Wassmer Evangeline
- Waters Jonathon
- Watkins Hugh
- Weber Astrid
- Webster Andrew
- Welch Steve
- Wellesley Diana
- Westbury Sarah
- Wharton John
- Wheeler Elanor
- Whiteford Margo
- Whitehorn Deborah
- Whyte Tamieka
- Widaa Sara
- Wilcox Sarah
- Wilkins Martin
- Wilkinson Emily
- Willcocks Lisa
- Williams Denise
- Williams Hywel
- Williams Nicola
- Williamson Catherine
- Williamson Kathleen A.
- Wilson Crispian
- Wilson Louise
- Wong Kim
- Woods Geoff
- Woods Geoffrey
- Wort John
- Wragg Christopher
- Wright Caroline F.
- Wright Michael
- Xu ChangJiang
- Yang Jian
- Yates Laura
- Yau Michael
- Yeatman Nigel
- Yong Patrick
- Young Tim
- Yu Ping
- Zhang Fend
- Zhang Pingbo
- Publication venue
- AJHG
- Publication date
- 01/01/2019
- Field of study
The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)
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