Changes in salivary analytes in cows due to the in vitro presence of feed

The effect in a sialochemistry profile of the presence of usually available feed in dairy cows was evaluated by an in vitro experiment. For this purpose, a pooled clean saliva from five healthy dairy cows was incubated five times with a standard feed based on a total mixed ration (F), wheat hay (H), and grass (G). The salivary panel was integrated by biomarkers of stress (cortisol -sCor-, salivary alpha-amylase -sAA-, butyrylcholinesterase -BChE-, total esterase -TEA-, and lipase -Lip-), immunity (adenosine deaminase -ADA-), oxidative status (Trolox equivalent antioxidant capacity -TEAC-, the ferric reducing ability of saliva -FRAS-, the cupric reducing antioxidant capacity -CUPRAC-, uric acid, and advanced oxidation protein products -AOPP-), and enzymes, proteins, and minerals of general metabolism and markers of liver, muscle, and renal damage (aspartate aminotransferase -AST-, alanine aminotransferase -ALP-, γ-glutamyl transferase -gGT-, lactate dehydrogenase -LDH-, creatine kinase -CK-, creatinine, urea, triglycerides, glucose, lactate, total protein, phosphorus, and total calcium). Most of the evaluated analytes showed a coefficient of variations (CV) higher than 15% and/or significant changes compared with the clean saliva when feed was present. Some analytes, such as the oxidative status biomarkers (CV > 80%), AST (CV > 60%), or glucose (CV > 100%), showed significant changes with all the feed types tested. Others showed significant differences only with certain types of feed, such as LDH with F (CV > 60%) or triglycerides with F (CV > 100%) and H (CV > 95%). However, sCor or gGT remained unchanged (CV 0.05) in all the treatments. The presence of feed can produce changes in most of the analytes measured in cows' saliva, being of high importance to consider this factor when saliva is used as a sample to avoid errors in the interpretation of the results. The online version contains supplementary material available at 10.1186/s12917-022-03371-9

On-the-Fly Adaptive Routing for dragonfly interconnection networks

Adaptive deadlock-free routing mechanisms are required to handle variable traffic patterns in dragonfly networks. However, distance-based deadlock avoidance mechanisms typically employed in Dragonflies increase the router cost and complexity as a function of the maximum allowed path length. This paper presents on-the-fly adaptive routing (OFAR), a routing/flow-control scheme that decouples the routing and the deadlock avoidance mechanisms. OFAR allows for in-transit adaptive routing with local and global misrouting, without imposing dependencies between virtual channels, and relying on a deadlock-free escape subnetwork to avoid deadlock. This model lowers latency, increases throughput, and adapts faster to transient traffic than previously proposed mechanisms. The low capacity of the escape subnetwork makes it prone to congestion. A simple congestion management mechanism based on injection restriction is considered to avoid such issues. Finally, reliability is considered by introducing mechanisms to find multiple edge-disjoint Hamiltonian rings embedded on the dragonfly, allowing to use multiple escape subnetworks

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Seguimiento de las guías españolas para el manejo del asma por el médico de atención primaria: un estudio observacional ambispectivo

Objetivo Evaluar el grado de seguimiento de las recomendaciones de las versiones de la Guía española para el manejo del asma (GEMA 2009 y 2015) y su repercusión en el control de la enfermedad. Material y métodos Estudio observacional y ambispectivo realizado entre septiembre del 2015 y abril del 2016, en el que participaron 314 médicos de atención primaria y 2.864 pacientes. Resultados Utilizando datos retrospectivos, 81 de los 314 médicos (25, 8% [IC del 95%, 21, 3 a 30, 9]) comunicaron seguir las recomendaciones de la GEMA 2009. Al inicio del estudio, 88 de los 314 médicos (28, 0% [IC del 95%, 23, 4 a 33, 2]) seguían las recomendaciones de la GEMA 2015. El tener un asma mal controlada (OR 0, 19, IC del 95%, 0, 13 a 0, 28) y presentar un asma persistente grave al inicio del estudio (OR 0, 20, IC del 95%, 0, 12 a 0, 34) se asociaron negativamente con tener un asma bien controlada al final del seguimiento. Por el contrario, el seguimiento de las recomendaciones de la GEMA 2015 se asoció de manera positiva con una mayor posibilidad de que el paciente tuviera un asma bien controlada al final del periodo de seguimiento (OR 1, 70, IC del 95%, 1, 40 a 2, 06). Conclusiones El escaso seguimiento de las guías clínicas para el manejo del asma constituye un problema común entre los médicos de atención primaria. Un seguimiento de estas guías se asocia con un control mejor del asma. Existe la necesidad de actuaciones que puedan mejorar el seguimiento por parte de los médicos de atención primaria de las guías para el manejo del asma. Objective: To assess the degree of compliance with the recommendations of the 2009 and 2015 versions of the Spanish guidelines for managing asthma (Guía Española para el Manejo del Asma [GEMA]) and the effect of this compliance on controlling the disease. Material and methods: We conducted an observational ambispective study between September 2015 and April 2016 in which 314 primary care physicians and 2864 patients participated. Results: Using retrospective data, we found that 81 of the 314 physicians (25.8%; 95% CI 21.3–30.9) stated that they complied with the GEMA2009 recommendations. At the start of the study, 88 of the 314 physicians (28.0%; 95% CI 23.4–33.2) complied with the GEMA2015 recommendations. Poorly controlled asthma (OR, 0.19; 95% CI 0.13–0.28) and persistent severe asthma at the start of the study (OR, 0.20; 95% CI 0.12–0.34) were negatively associated with having well-controlled asthma by the end of the follow-up. In contrast, compliance with the GEMA2015 recommendations was positively associated with a greater likelihood that the patient would have well-controlled asthma by the end of the follow-up (OR, 1.70; 95% CI 1.40–2.06). Conclusions: Low compliance with the clinical guidelines for managing asthma is a common problem among primary care physicians. Compliance with these guidelines is associated with better asthma control. Actions need to be taken to improve primary care physician compliance with the asthma management guidelines

Abundant molecular gas in tidal dwarf galaxies: On-going galaxy formation

Original article can be found at : http://www.aanda.org/ Copyright The European Southern Observatory DOI : 10.1051/0004-6361:20011109We investigate the process of galaxy formation as can be observed in the only currently forming galaxies { the so-called Tidal Dwarf Galaxies, hereafter TDGs { through observations of the molecular gas detected via its CO (Carbon Monoxide) emission. These objects are formed of material torn off of the outer parts of a spiral disk due to tidal forces in a collision between two massive galaxies. Molecular gas is a key element in the galaxy formation process, providing the link between a cloud of gas and a bona fide galaxy. We have detected CO in 8 TDGs (two of them have already been published in Braine et al. 2000, hereafter Paper I), with an overall detection rate of 80%, showing that molecular gas is abundant in TDGs, up to a few 108 M . The CO emission coincides both spatially and kinematically with the HI emission, indicating that the molecular gas forms from the atomic hydrogen where the HI column density is high. A possible trend of more evolved TDGs having greater molecular gas masses is observed, in accord with the transformation of HI into H2. Although TDGs share many of the properties of small irregulars, their CO luminosity is much greater (factor 100) than that of standard dwarf galaxies of comparable luminosity. This is most likely a consequence of the higher metallicity (&1/3 solar) of TDGs which makes CO a good tracer of molecular gas. This allows us to study star formation in environments ordinarily inaccessible due to the extreme difficulty of measuring the molecular gas mass. The star formation efficiency, measured by the CO luminosity per H flux, is the same in TDGs and full-sized spirals. CO is likely the best tracer of the dynamics of these objects because some fraction of the HI near the TDGs may be part of the tidal tail and not bound to the TDG. Although uncertainties are large for individual objects, as the geometry is unknown, our sample is now of eight detected objects and we find that the \dynamical" masses of TDGs, estimated from the CO line widths, seem not to be greater than the \visible" masses (HI + H2 + a stellar component). Although higher spatial resolution CO (and HI) observations would help reduce the uncertainties, we find that TDGs require no dark matter, which would make them the only galaxy-sized systems where this is the case. Dark matter in spirals should then be in a halo and not a rotating disk. Most dwarf galaxies are dark matter-rich, implying that they are not of tidal origin. We provide strong evidence that TDGs are self-gravitating entities, implying that we are witnessing the ensemble of processes in galaxy formation: concentration of large amounts of gas in a bound object, condensation of the gas, which is atomic at this point, to form molecular gas and the subsequent star formation from the dense molecular component.Peer reviewe