Efficacy of usage of intraarterial regional hyperglycemia at therapy of oral cavity cancer

Проведено дослідження з визначення вмісту лактату в ракових пухлинах порожнини рота під впливом внутрішньоартеріальної регіонарної гіперглікемії. Виявлено, що посилення протипухлинного ефекту відбувається внаслідок рН-залежного підвищення чутливості пухлинних клітин до лікарського впливу.A study was conducted to determine the content of lactate in cancerous tumors of the oral cavity under the influence of intraarterial regional hyperglycemia, and an antitumor effect would be increased due to the pH-dependent increase in the sensitivity of tumor cells to the medicinal effect

Liver procurement as part of multiple organ procurement

Departamentul de Chirurgie Generală şi Transplant Hepatic “Dan Setlacec”, Institutul Clinic Fundeni, Bucureşti, România, Al XII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova cu participare internațională 23-25 septembrie 2015Scop: Prelevarea hepatică, etapă premergătoare transplantului hepatic, parte din prelevarea multiorgan, contribuie prin acuratețea și corectitudinea intervenției la obținerea unei grefe hepatice de bună calitate cu rezultate bune ale transplantului atît imediate cât și pe termen lung. Lucrarea de față își propune să evidențieze importantul rol al identificării variantelor anatomice și adaptarea metodelor de prelevare în funcție de acestea.Material şi metode: Pe parcursul perioadei 1 ianuarie 2000-16 iunie 2015 s-au efectuat în Centrul nostru 666 prelevări multiorgan. O importanță deosebită a fost acordată recunoașterii variantelor anatomice arteriale, acestea adaugând un grad de dificultate procedurii, dar fiind totodată esențiale pentru asigurarea succesului intervenției. Rezultate: Caracteristicile heterogene ale donatorilor au obligat la aplicarea unei game variate de tehnici de prelevare, adaptate fiecărei situații, așa cum au fost descrise în lucrarea de față, un pas cheie pentru obținerea unei grefe viabile pentru transplant. Concluzii: Multiplele tehnici de prelevare hepatică pot fi aplicate cu succes când sunt adaptate fiecarui donator, scurtând timpul de prelevare și furnizând o grefă de cea mai bună calitate.Purpose: Liver procurement, the preliminary stage of liver transplantation, is a part of multi-organ procurement, and it contributes, with its accuracy and correctness to the high quality liver graft, with the best results in the transplantation process (both immediate and long term). This paper is framed to enlighten the important role of identification of anatomical variants and the selection of the procurement technique that suits most. Material and methods: During 1st Jan 2000-16th Jun 2015 a number of 666 multi-organ procurements were performed in our center. A special attention was paid in recognizing of anatomical variants of blood vessels (especially arterial blood vessels), which added a high degree of difficulty to the procedures, but was considered to be vital in order to ensure the success of the intervention. Results: Heterogeneous characteristics of donors imposed the implementation of a variety of sampling techniques, adapted on each situation as was described in the paper, an essential step to obtain a viable liver / organ graft suitable for the transplant. Conclusions: The multiple methods of liver procurement can be successfully applied when it is adapted to each of the donors, thus shortening the actual time of the liver harvesting, delivering the best quality of the new liver graft

Grounds for Mind Implants U-impl-Махі with Lack Height of Alveolar Process

На основі ретроспективного аналізу помилок у плануванні імплантації в ділянці дефіциту кісткової тканини та помилок при виконанні хірургічного та ортопедичного протоколів, обґрунтована доцільність встановлення імплантатів U-impl-Махі при атрофії альвеолярного відростка верхньої і нижньої щелепи по висоті.Authors analyzed retrospective results experience of using dental implants U-impl-Maxi with lack height of alveolar process. Presented clinical cases were selected in order to show mistakes of surgical technique, which may be reason of complication on surgeon-stage or prosthetic-stage implantation

The effectiveness of emergency obstetric referral interventions in developing country settings : a systematic review

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Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries

Blood flow generates wall shear stress (WSS) which alters endothelial cell (EC) function. Low WSS promotes vascular inflammation and atherosclerosis whereas high uniform WSS is protective. Ivabradine decreases heart rate leading to altered haemodynamics. Besides its cardio-protective effects, ivabradine protects arteries from inflammation and atherosclerosis via unknown mechanisms. We hypothesised that ivabradine protects arteries by increasing WSS to reduce vascular inflammation. Hypercholesterolaemic mice were treated with ivabradine for seven weeks in drinking water or remained untreated as a control. En face immunostaining demonstrated that treatment with ivabradine reduced the expression of pro-inflammatory VCAM-1 (p<0.01) and enhanced the expression of anti-inflammatory eNOS (p<0.01) at the inner curvature of the aorta. We concluded that ivabradine alters EC physiology indirectly via modulation of flow because treatment with ivabradine had no effect in ligated carotid arteries in vivo, and did not influence the basal or TNFα-induced expression of inflammatory (VCAM-1, MCP-1) or protective (eNOS, HMOX1, KLF2, KLF4) genes in cultured EC. We therefore considered whether ivabradine can alter WSS which is a regulator of EC inflammatory activation. Computational fluid dynamics demonstrated that ivabradine treatment reduced heart rate by 20 % and enhanced WSS in the aorta. In conclusion, ivabradine treatment altered haemodynamics in the murine aorta by increasing the magnitude of shear stress. This was accompanied by induction of eNOS and suppression of VCAM-1, whereas ivabradine did not alter EC that could not respond to flow. Thus ivabradine protects arteries by altering local mechanical conditions to trigger an anti-inflammatory response

Precise measurement of the W-boson mass with the CDF II detector

We have measured the W-boson mass MW using data corresponding to 2.2/fb of integrated luminosity collected in proton-antiproton collisions at 1.96 TeV with the CDF II detector at the Fermilab Tevatron collider. Samples consisting of 470126 W->enu candidates and 624708 W->munu candidates yield the measurement MW = 80387 +- 12 (stat) +- 15 (syst) = 80387 +- 19 MeV. This is the most precise measurement of the W-boson mass to date and significantly exceeds the precision of all previous measurements combined

Measurement of the t t-bar production cross section in the dilepton channel in pp collisions at sqrt(s) = 7 TeV

The t t-bar production cross section (sigma[t t-bar]) is measured in proton-proton collisions at sqrt(s) = 7 TeV in data collected by the CMS experiment, corresponding to an integrated luminosity of 2.3 inverse femtobarns. The measurement is performed in events with two leptons (electrons or muons) in the final state, at least two jets identified as jets originating from b quarks, and the presence of an imbalance in transverse momentum. The measured value of sigma[t t-bar] for a top-quark mass of 172.5 GeV is 161.9 +/- 2.5 (stat.) +5.1/-5.0 (syst.) +/- 3.6(lumi.) pb, consistent with the prediction of the standard model.Comment: Replaced with published version. Included journal reference and DO

Search for Neutral Higgs Bosons in Events with Multiple Bottom Quarks at the Tevatron

The combination of searches performed by the CDF and D0 collaborations at the Fermilab Tevatron Collider for neutral Higgs bosons produced in association with b quarks is reported. The data, corresponding to 2.6 fb-1 of integrated luminosity at CDF and 5.2 fb-1 at D0, have been collected in final states containing three or more b jets. Upper limits are set on the cross section multiplied by the branching ratio varying between 44 pb and 0.7 pb in the Higgs boson mass range 90 to 300 GeV, assuming production of a narrow scalar boson. Significant enhancements to the production of Higgs bosons can be found in theories beyond the standard model, for example in supersymmetry. The results are interpreted as upper limits in the parameter space of the minimal supersymmetric standard model in a benchmark scenario favoring this decay mode.Comment: 10 pages, 2 figure

Combined search for the quarks of a sequential fourth generation

Results are presented from a search for a fourth generation of quarks produced singly or in pairs in a data set corresponding to an integrated luminosity of 5 inverse femtobarns recorded by the CMS experiment at the LHC in 2011. A novel strategy has been developed for a combined search for quarks of the up and down type in decay channels with at least one isolated muon or electron. Limits on the mass of the fourth-generation quarks and the relevant Cabibbo-Kobayashi-Maskawa matrix elements are derived in the context of a simple extension of the standard model with a sequential fourth generation of fermions. The existence of mass-degenerate fourth-generation quarks with masses below 685 GeV is excluded at 95% confidence level for minimal off-diagonal mixing between the third- and the fourth-generation quarks. With a mass difference of 25 GeV between the quark masses, the obtained limit on the masses of the fourth-generation quarks shifts by about +/- 20 GeV. These results significantly reduce the allowed parameter space for a fourth generation of fermions.Comment: Replaced with published version. Added journal reference and DO