Channel Model of Molecular Communication via Diffusion in a Vessel-like Environment Considering a Partially Covering Receiver

By considering potential health problems that a fully covering receiver may cause in vessel-like environments, the implementation of a partially covering receiver is needed. To this end, distribution of hitting location of messenger molecules (MM) is analyzed within the context of molecular communication via diffusion with the aim of channel modeling. The distribution of these MMs for a fully covering receiver is analyzed in two parts: angular and radial dimensions. For the angular distribution analysis, the receiver is divided into 180 slices to analyze the mean, standard deviation, and coefficient of variation of these slices. For the axial distance distribution analysis, Kolmogorov- Smirnov test is applied for different significance levels. Also, two different implementations of the reflection from the vessel surface (i.e., rollback and elastic reflection) are compared and mathematical representation of elastic reflection is given. The results show that MMs have tendency to spread uniformly beyond a certain ratio of the distance to the vessel radius. By utilizing the uniformity, we propose a channel model for the partially covering receiver in vessel-like environments and validate the proposed model by simulations

Transmitter localization in vessel-like diffusive channels using ring-shaped molecular receivers

© 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.Molecular communication via diffusion in vessellike environment targets critical applications such as detection of abnormal and unhealthy cells. In this work, we derive the analytical formulation of the channel model for diffusion dominated movement, considering ring-shaped (i.e., patch) observing receivers and Poiseuille flow with the aim of localization of the transmitter cell. Then, we derive formulations using this channel model for two different application scenarios. We assume that the emission start time is known in the first scenario, and unknown in the second one. We successfully localize the transmitter cell using a single receiver for the first scenario, whereas two receivers are used to localize the transmitter cell in the second scenario. Lastly, the devised analytical framework is validated with simulations.Postprint (author's final draft

Temperature Effects Explain Continental Scale Distribution of Cyanobacterial Toxins

Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect effects of temperature were the main drivers of the spatial distribution in the toxins produced by the cyanobacterial community, the toxin concentrations and toxin quota. Generalized linear models showed that a Toxin Diversity Index (TDI) increased with latitude, while it decreased with water stability. Increases in TDI were explained through a significant increase in toxin variants such as MC-YR, anatoxin and cylindrospermopsin, accompanied by a decreasing presence of MC-LR. While global warming continues, the direct and indirect effects of increased lake temperatures will drive changes in the distribution of cyanobacterial toxins in Europe, potentially promoting selection of a few highly toxic species or strains.Peer reviewe

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Performance analysis of power adjustment methods in molecular communication via diffusion [Difuzyon ile moleküler iletisimdeki guç ayarlama metodlarinin performans analizi]

In this paper, performance of binary concentration shift keying (BCSK), BCSK with power adjustment (BCSK-PA), and BCSK with consecutive power adjustment (BCSK-CPA) are analyzed in terms of bit error rate (BER), energy, and memory within the context of molecular communication via diffusion. As the communication environment, vessel-like environment is realized. The results show that BCSK-PA outperforms BCSK and BCSK-CPA in BER and energy analysis. Yet, it is outperformed by BCSK and BCSK-CPA in memory requirements. BCSK-CPA performs between BCSK and BCSK-PA in all three analysis that shows BCSK-CPA is a nice option to have comparatively low BER and energy usage when the system has low memory requirement. © 2018 IEEE.Postprint (author's final draft

Performance analysis of power adjustment methods in molecular communication via diffusion [Difuzyon ile moleküler iletisimdeki guç ayarlama metodlarinin performans analizi]

In this paper, performance of binary concentration shift keying (BCSK), BCSK with power adjustment (BCSK-PA), and BCSK with consecutive power adjustment (BCSK-CPA) are analyzed in terms of bit error rate (BER), energy, and memory within the context of molecular communication via diffusion. As the communication environment, vessel-like environment is realized. The results show that BCSK-PA outperforms BCSK and BCSK-CPA in BER and energy analysis. Yet, it is outperformed by BCSK and BCSK-CPA in memory requirements. BCSK-CPA performs between BCSK and BCSK-PA in all three analysis that shows BCSK-CPA is a nice option to have comparatively low BER and energy usage when the system has low memory requirement. © 2018 IEEE