142 research outputs found
<a name="home"></a>Prevalence of the A1555G (12S rRNA) and tRNA Ser(UCN) mitochondrial mutations in hearing-impaired Brazilian patients
- Author
- Alves-Silva J
- Brown MD
- Bykhovskaya Y
- Bykhovskaya Y
- Bykhovskaya Y
- Chen YS
- Estivill X
- Guan MX
- Guan MX
- Hamasaki K
- Hutchin TP
- Ingman M
- K. Lezirovitz
- Kunkel LM
- Kupka S
- M. Spinelli
- M.C.C. Braga
- Maca-Meyer N
- Marazita ML
- Nye JS
- P.A. Otto
- Pandya A
- Pandya A
- Prezant TR
- R.C. Mingroni-Netto
- R.S. Abreu-Silva
- Reid FM
- S. Pirana
- Scott DA
- Sue CM
- Tekin M
- Tiranti V
- Torroni A
- Usami S
- V.A. Della-Rosa
- Wallace DC
- Østergaard E
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Rescue of Photoreceptor Degeneration by Curcumin in Transgenic Rats with P23H Rhodopsin Mutation
- Author
- A Goel
- A Goel
- AL Cheng
- B Lal
- B Romier
- BB Aggarwal
- BB Aggarwal
- BL Zhao
- BM Tam
- BM Tam
- C Manach
- C Rivolta
- CE Harper
- CH Sung
- DG Cogan
- DJ Roof
- F Hakimuddin
- F Yang
- FH Verhoeff
- GB Reddy
- Geereddy Bhanuprakash Reddy
- GM Acland
- H Hatcher
- HF Mendes
- HF Mendes
- IM MacDonald
- J Jiang
- J Perez-Jimenez
- JC Rochet
- JD Malhotra
- JE Olsson
- Jeffrey A. Jamison
- JH Lin
- Jonathan H. Lin
- JP Chapple
- JS Jurenka
- L Adlerz
- L Rossi
- M Garcia-Alloza
- M Gorbatyuk
- M Gorbatyuk
- M Khajavi
- M Khajavi
- ME Egan
- Mike O. Karl
- MM Dohadwala
- MM LaVail
- MN Mandal
- MN Mandal
- MN Mandal
- MN Mandal
- NS Dejneka
- P Roy
- P Suryanarayana
- R Pullakhandam
- R Zhang
- Radha Ayyagari
- Rajendra Kadam
- RG Weleber
- RK Koenekoop
- RS Rajan
- RS Rajan
- RS Saliba
- S Awasthi
- S Kaushal
- S Machida
- SJ Zunino
- SM Noorwez
- TP Dryja
- TP Dryja
- TP Dryja
- U Bhattacharya
- U Pandya
- Uday B. Kompella
- V Vasireddy
- V Vasireddy
- Venkata R. M. Chavali
- Victory T. Joseph
- Vidyullatha Vasireddy
- WW Hauswirth
- Y Goto
- Z Ignatova
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
The P23H mutation in the rhodopsin gene causes rhodopsin misfolding, altered trafficking and formation of insoluble aggregates leading to photoreceptor degeneration and autosomal dominant retinitis pigmentosa (RP). There are no effective therapies to treat this condition. Compounds that enhance dissociation of protein aggregates may be of value in developing new treatments for such diseases. Anti-protein aggregating activity of curcumin has been reported earlier. In this study we present that treatment of COS-7 cells expressing mutant rhodopsin with curcumin results in dissociation of mutant protein aggregates and decreases endoplasmic reticulum stress. Furthermore we demonstrate that administration of curcumin to P23H-rhodopsin transgenic rats improves retinal morphology, physiology, gene expression and localization of rhodopsin. Our findings indicate that supplementation of curcumin improves retinal structure and function in P23H-rhodopsin transgenic rats. This data also suggest that curcumin may serve as a potential therapeutic agent in treating RP due to the P23H rhodopsin mutation and perhaps other degenerative diseases caused by protein trafficking defects
Default-Mode-Like Network Activation in Awake Rodents
- Author
- A Shekhar
- AG Garrity
- AJ Shackman
- AM Kelly
- AN Talalaenko
- BB Biswal
- CD Balaban
- CF Ferris
- Chih-Liang Chin
- DM Smith
- DN Pandya
- EE Abrahamson
- Feng Luo
- GE McClearn
- Gerard B. Fox
- Gerard J. Marek
- HD Critchley
- HS Mayberg
- J Fransson
- Jaymin Upadhyay
- JK Rilling
- JL Vincent
- JP Aggleton
- JS Damoiseaux
- K Masamoto
- K Ono
- KS Sink
- LJ Porrino
- Loan Miller
- M Davis
- M Davis
- M Tsanov
- Mark Day
- MD Greicius
- MD Greicius
- MD Greicius
- ME Raichle
- ME Raichle
- ML Kram
- ML Kram
- MN Baliki
- MW Woolrich
- N Zhang
- P Boveroux
- Paxinos G
- Pedro Antonio Valdes-Sosa
- Prasant Chandran
- S Whitfield-Gabrieli
- Scott J. Baker
- SM Smith
- TJ Balkin
- TP Vahl
- Unal Sakoglu
- WC Drevets
- WW Seeley
- Younglim Lee
- Z Liang
- Publication venue
- Public Library of Science
- Publication date
- 18/11/2011
- Field of study
During wakefulness and in absence of performing tasks or sensory processing, the default-mode network (DMN), an intrinsic central nervous system (CNS) network, is in an active state. Non-human primate and human CNS imaging studies have identified the DMN in these two species. Clinical imaging studies have shown that the pattern of activity within the DMN is often modulated in various disease states (e.g., Alzheimer's, schizophrenia or chronic pain). However, whether the DMN exists in awake rodents has not been characterized. The current data provides evidence that awake rodents also possess ‘DMN-like’ functional connectivity, but only subsequent to habituation to what is initially a novel magnetic resonance imaging (MRI) environment as well as physical restraint. Specifically, the habituation process spanned across four separate scanning sessions (Day 2, 4, 6 and 8). At Day 8, significant (p<0.05) functional connectivity was observed amongst structures such as the anterior cingulate (seed region), retrosplenial, parietal, and hippocampal cortices. Prior to habituation (Day 2), functional connectivity was only detected (p<0.05) amongst CNS structures known to mediate anxiety (i.e., anterior cingulate (seed region), posterior hypothalamic area, amygdala and parabracial nucleus). In relating functional connectivity between cingulate-default-mode and cingulate-anxiety structures across Days 2-8, a significant inverse relationship (r = −0.65, p = 0.0004) was observed between these two functional interactions such that increased cingulate-DMN connectivity corresponded to decreased cingulate anxiety network connectivity. This investigation demonstrates that the cingulate is an important component of both the rodent DMN-like and anxiety networks
The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor
- Author
- A Carriere
- A Godzik
- A Godzik
- A Kazi
- A Minden
- A White
- AL Morris
- AS Dhillon
- BR Stockwell
- C Colovos
- DN Dhanasekaran
- DR Anderson
- E ter Haar
- ED Lowe
- F Brisdelli
- F Folmer
- FZ Chen
- G Manning
- G Pearson
- GR Fanger
- H Mett
- H Ni
- H Tak
- Ingebrigt Sylte
- IS Samuels
- IV Klevernic
- J Bain
- J Bain
- JF Gaucher
- JS Arthur
- JS Gutkind
- JU Bowie
- K Ono
- KW Underwood
- L Chang
- L Holm
- L Jaroszewski
- L New
- L New
- M Buxade
- M Gaestel
- M Gaestel
- M Imajo
- M Nisar
- M Perander
- M Selkti
- MA Argiriadi
- Mahmud Tareq Hassan Khan
- MN Sultankhodzhaev
- MN Sultankhodzhaev
- MT Khan
- N Dhanasekaran
- N Gerits
- N Gerits
- N Gerits
- N Gerits
- N Gerits
- N Pandya
- N Ronkina
- N Ronkina
- OM Seternes
- P Gonzalez
- P Sun
- PP Roux
- Q Li
- R Cheng
- R Luthy
- RA Laskowski
- RC Hillig
- RJ Davis
- S Kostenko
- S Kostenko
- Sergiy Kostenko
- SP Davies
- TP Garrington
- Ugo Moens
- Y Cheng
- Y Shi
- Z Chen
- Publication venue
- SP Birkhäuser Verlag Basel
- Publication date
- 01/01/2010
- Field of study
The mitogen-activated protein kinase-activated protein kinase MK5 is ubiquitously expressed in vertebrates and is implicated in cell proliferation, cytoskeletal remodeling, and anxiety behavior. This makes MK5 an attractive drug target. We tested several diterpenoid alkaloids for their ability to suppress MK5 kinase activity. We identified noroxoaconitine as an ATP competitor that inhibited the catalytic activity of MK5 in vitro (IC50 = 37.5 μM; Ki = 0.675 μM) and prevented PKA-induced nuclear export of MK5, a process that depends on kinase active MK5. MK5 is closely related to MK2 and MK3, and noroxoaconitine inhibited MK3- and MK5- but not MK2-mediated phosphorylation of the common substrate Hsp27. Molecular docking of noroxoaconitine into the ATP binding sites indicated that noroxoaconitine binds more strongly to MK5 than to MK3. Noroxoaconitine and derivatives may help in elucidating the precise biological functions of MK5 and may prove to have therapeutic values
Hemispheric Asymmetry in White Matter Connectivity of the Temporoparietal Junction with the Insula and Prefrontal Cortex
- Author
- A Anwander
- Aaron Kucyi
- AB Chica
- AD Craig
- AD Friederici
- AV Apkarian
- B Fischl
- BA Vogt
- BA Vogt
- BJ He
- CJ Honey
- CJ Starr
- D Saur
- DN Pandya
- E Heiervang
- E Kaplan
- F Cauda
- F Doricchi
- F Tensaouti
- FJ Friedrich
- G Committeri
- G Vallar
- GJ Parker
- H Johansen-Berg
- HW Powell
- I Weissman-Fogel
- Irit Weissman-Fogel
- J Decety
- J Downar
- J Downar
- J Downar
- J Downar
- J Downar
- J Downar
- J Mazziotta
- JD Schmahmann
- JD Schmahmann
- K Friston
- Karen D. Davis
- KD Davis
- KS Taylor
- LL Symonds
- M Catani
- M Corbetta
- M Jenkinson
- M Moayedi
- M Petrides
- M Thiebaut de Schotten
- M Thiebaut de Schotten
- M Thiebaut de Schotten
- M Urbanski
- M Urbanski
- Massieh Moayedi
- MD Fox
- MM Mesulam
- Mojgan Hodaie
- N Medford
- P Hagmann
- P Loui
- P Mukherjee
- PW Halligan
- PY Geha
- R Langner
- RB Mars
- RB Mars
- RM Umarova
- S Jbabdi
- S Malinen
- SB Eickhoff
- SM Smith
- SM Smith
- SM Smith
- TD Wager
- TE Behrens
- TE Behrens
- TP Naidich
- TV Salomons
- U Blankstein
- U Ture
- V Tomassini
- WW Seeley
- Y Iturria-Medina
- Yong He
- Publication venue
- Public Library of Science
- Publication date
- 19/04/2012
- Field of study
The temporoparietal junction (TPJ) is a key node in the brain's ventral attention network (VAN) that is involved in spatial awareness and detection of salient sensory stimuli, including pain. The anatomical basis of this network's right-lateralized organization is poorly understood. Here we used diffusion-weighted MRI and probabilistic tractography to compare the strength of white matter connections emanating from the right versus left TPJ to target regions in both hemispheres. Symmetry of structural connectivity was evaluated for connections between TPJ and target regions that are key cortical nodes in the right VAN (insula and inferior frontal gyrus) as well as target regions that are involved in salience and/or pain (putamen, cingulate cortex, thalamus). We found a rightward asymmetry in connectivity strength between the TPJ and insula in healthy human subjects who were scanned with two different sets of diffusion-weighted MRI acquisition parameters. This rightward asymmetry in TPJ-insula connectivity was stronger in females than in males. There was also a leftward asymmetry in connectivity strength between the TPJ and inferior frontal gyrus, consistent with previously described lateralization of language pathways. The rightward lateralization of the pathway between the TPJ and insula supports previous findings on the roles of these regions in stimulus-driven attention, sensory awareness, interoception and pain. The findings also have implications for our understanding of acute and chronic pains and stroke-induced spatial hemineglect
Hippocampal - diencephalic - cingulate networks for memory and emotion: An anatomical guide
- Author
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Aggleton JP
- Allen GV
- Allen GV
- Amaral DG
- Baleydier C
- Ballantine HT
- Ballantine HT
- Carlesimo GA
- Catani M
- Christiansen K
- Christiansen K
- Clarke HF
- Célérier A
- Da Silva FL
- Dalgleish T
- Delay J
- Dillingham CM
- Dillingham CM
- Domesick VB
- Etkin A
- Etkin A
- Fan Y
- Feldman RP
- Fernández G
- Friedman DP
- Furtak SC
- Gabriel M
- Gabriel M
- Gaffan D
- Gaffan EA
- Granziera C
- Greicius MD
- Harding A
- Henry J
- Hollocks MJ
- Honda Y
- Hopkins DA
- Hornberger M
- Insausti R
- Insausti R
- Isaacson RL
- Jones BF
- Jones DK
- Keene CS
- Kelly D
- Kobayashi Y
- Kobayashi Y
- Kopelman MD
- Kwon HG
- Kötter R
- Lavenex P
- Lewin W
- Livingston KE
- MacLean PD
- MacLean PD
- Maguire E
- Mashour GA
- Mathiasen ML
- McHugh SB
- McMackin D
- Meibach RC
- Meibach RC
- Metzler-Baddeley C
- Minoshima S
- Morris R
- Mufson EJ
- Naber PA
- Neave N
- Nelson AJ
- Nestor PJ
- O’Mara SM
- Pandya DN
- Papez JW
- Parvizi J
- Pessoa L
- Poppenk J
- Powell TP
- Prasad JA
- Raichle ME
- Ranganath C
- Rolls ET
- Roxo MR
- Rudebeck SR
- Saunders RC
- Saunders RC
- Scoville WB
- Seki M
- Shah A
- Shenhav A
- Shibata H
- Shibata H
- Shibata H
- Shibata H
- Shibata H
- Shibata H
- Shibata H
- Sigurdsson T
- Small SA
- Spiers HJ
- Sripanidkulchai K
- Strange BA
- Sugar J
- Suzuki WL
- Swanson LW
- Tan RH
- Taube JS
- Teuber HL
- Tsivilis D
- Turner E
- Valenstein E
- Van der Horst L
- Van der Werf YD
- Van Groen T
- Van Groen T
- Van Groen T
- Van Groen T
- Van Groen T
- Van Kesteren MT
- Van Strien NM
- Vann SD
- Vann SD
- Vann SD
- Vann SD
- Vann SD
- Vertes RP
- Vertes RP
- Victor M
- Vogt BA
- Vogt BA
- Vogt BA
- Vogt BA
- Vogt BA
- Warburton EC
- Warburton EC
- Wei PH
- Weible AP
- Witter MP
- Wright NF
- Wright NF
- Wright NF
- Xiang JZ
- Xiao D
- Yukie M
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/01/2017
- Field of study
This review brings together current knowledge from tract tracing studies to update and reconsider those limbic connections initially highlighted by Papez for their presumed role in emotion. These connections link hippocampal and parahippocampal regions with the mammillary bodies, the anterior thalamic nuclei, and the cingulate gyrus, all structures now strongly implicated in memory functions. An additional goal of this review is to describe the routes taken by the various connections within this network. The original descriptions of these limbic connections saw their interconnecting pathways forming a serial circuit that began and finished in the hippocampal formation. It is now clear that with the exception of the mammillary bodies, these various sites are multiply interconnected with each other, including many reciprocal connections. In addition, these same connections are topographically organised, creating further subsystems. This complex pattern of connectivity helps explain the difficulty of interpreting the functional outcome of damage to any individual site within the network. For these same reasons, Papez’s initial concept of a loop beginning and ending in the hippocampal formation needs to be seen as a much more complex system of hippocampal–diencephalic–cingulate connections. The functions of these multiple interactions might be better viewed as principally providing efferent information from the posterior medial temporal lobe. Both a subcortical diencephalic route (via the fornix) and a cortical cingulate route (via retrosplenial cortex) can be distinguished. These routes provide indirect pathways for hippocampal interactions with prefrontal cortex, with the preponderance of both sets of connections arising from the more posterior hippocampal regions. These multi-stage connections complement the direct hippocampal projections to prefrontal cortex, which principally arise from the anterior hippocampus, thereby creating longitudinal functional differences along the anterior–posterior plane of the hippocampus
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
- Barbiellini G
- Barclay SE
- Baret B
- Barish BC
- Barker D
- Barkett K
- Barnard M
- Barnes J
- Barone F
- Barr B
- Barrios-Marti J
- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
- BenZvi SY
- Berat C
- Berenji B
- Berge D
- Berger BK
- Berger E
- Bergmann G
- Berisso M Gomez
- Berley D
- Bernal A
- Bernardini E
- Bernardini MG
- Bernhard S
- Bernrhr K
- Bero JJ
- Beroiz M
- Berry CPL
- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhattacharya D
- Biagi S
- Biermann PL
- Bilenko IA
- Billingsley G
- Billman CR
- Binder G
- Bindig D
- Birch J
- Birney R
- Birnholtz O
- Biscans S
- Biscoveanu S
- Bisht A
- Bissaldi E
- Bissaldi E
- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
- Blackwell R
- Blaess SG
- Blagorodnova N
- Blair CD
- Blair DG
- Blair RM
- Blanchard P
- Blanco A
- Bland PA
- Blandford RD
- Blaufuss E
- Blazek J
- Bleve C
- Bloemen S
- Bloom ED
- Blot S
- Bock O
- Bode N
- Boer M
- Bogaert G
- Bohacova M
- Bohe A
- Bohm C
- Boisson C
- Bolmont J
- Bond IA
- Bondu F
- Bonifazi C
- Bonilla E
- Bonino R
- Bonnand R
- Bonnefoy S
- Bonoli S
- Booler T
- Boom BA
- Bordas P
- Bork R
- Bormuth R
- Borner M
- Borodai N
- Bos F
- Boschi V
- Bose D
- Bose S
- Boser S
- Bossie K
- Botner O
- Bottacini E
- Bottcher M
- Botti AM
- Botticella MT
- Bouffanais Y
- Bourbeau E
- Bourbeau J
- Bourret S
- Bouwhuis MC
- Bozzi A
- Bozzo E
- Brack J
- Bradaschia C
- Bradascio F
- Brady PR
- Branchesi M
- Brancus I
- Brandt S
- Brau JE
- Braun J
- Braun J
- Bravo O Martinez
- Brayeur L
- Breeveld AA
- Bregeon J
- Bregeon J
- Brenzke M
- Bretz H-P
- Bretz T
- Briant T
- Bridgeman A
- Briechle FL
- Briggs MS
- Brillet A
- Brinkmann M
- Brisbois C
- Brisson V
- Brnzas H
- Brocato E
- Brockill P
- Broderick JW
- Broida JE
- Bron S
- Brooks AF
- Brooks D
- Brostean-Kaiser J
- Brout D
- Brown DA
- Brown DD
- Brown IS
- Bruijn R
- Brun F
- Brun P
- Brunett S
- Brunner J
- Bruun SH
- Bryan M
- Buchanan CC
- Buchholz P
- Buckley DAH
- Buckley-Geer E
- Budnev NM
- Buehler R
- Bueno A
- Bufano F
- Buffa F
- Buikema A
- Buitink S
- Bulgarelli A
- Bulger J
- Bulik T
- Bulik T
- Bulla M
- Bulten HJ
- Buonanno A
- Burgay M
- Burgess JM
- Burgman A
- Burhonov O
- Burke DL
- Burns E
- Burrows DN
- Buscemi M
- Buskulic D
- Buson S
- Bustillo J Caldern
- Busto J
- Butler NR
- Butler RE
- Buttu M
- Buy C
- Byer RL
- Caballero-Garcia MD
- Caballero-Mora KS
- Caballero-Mora KS
- Cabero M
- Cabral J
- Caccianiga L
- Cadonati L
- Cagnoli G
- Cahillane C
- Callister TA
- Calloni E
- CALTECH GROWTH JAGWAR
- Cameron RA
- Camilo F
- Camp JB
- Campana S
- Camuccio R
- Cancio A
- Canepa M
- Canfora F
- Canizares P
- Cannella C
- Cannizzaro G
- Cannon KC
- Cano Z
- Cao H
- Cao J
- Cao XL
- Capaccioli M
- Capano CD
- Capasso M
- Capistrn T
- Capocasa E
- Capone A
- Capozzi D
- Cappellaro E
- Caputo R
- Caramete L
- Caraveo P
- Caraveo PA
- Carbognani F
- Carboni G
- Cardenas B Vargas
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- Li XB
- Li XF
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- Pearlstone BL
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- Piccinni OJ
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- Pierro V
- Pignata G
- Pike S
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- Pillant G
- Pimenta M
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- Pinto IM
- Piotrowski LW
- Piran T
- Piran T
- Piranomonte S
- Pirello M
- Piro AL
- Piro L
- Piron F
- Pirronello V
- Pisanu T
- Pita S
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- Platino M
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- Podesta F
- Podesta RC
- Podsiadlowski P
- Poe M
- Poggiani R
- Poh J
- Poireau V
- Pollmann A Obertacke
- Poolakkil S
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- Popolizio P
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- Possenti A
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- Pozanenko AS
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- Prado RR
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- Principe G
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- Privitera P
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- Prochaska JX
- Prodi GA
- Prokhorov D
- Prokhorov LG
- Prokoph H
- Prouza M
- Prrer M
- Przybylski GT
- Pulone L
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- Quataert E
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- Quimby RM
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- Ramos-Buades A
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- Reimer A
- Reimer O
- Reimer O
- Reitze DH
- Relethford B
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- Ren Z
- Renaud M
- Renzi V
- Reposeur T
- Resconi E
- Resmi L
- Rest A
- Reva IV
- Reyes R De Los
- Reyes SD
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- Rhode W
- Ribeiro T
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- Riccobene G
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- Risse M
- Ristori P
- Rivera A Ramirez
- Riviere C
- Rizi V
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- Robertson NA
- Robertson S
- Robie R
- Robinet F
- Rocchi A
- Rochester LS
- Rodi J
- Rodriguez H
- Rojas D Avila
- Rojas-Bravo C
- Rojo J Rodriguez
- Rol E
- Rolland L
- Rollins JG
- Roma VJ
- Romano R
- Romel CL
- Romer AK
- Romero M Dominguez
- Romie JH
- Romoli C
- Roncoroni MJ
- Rongen M
- Roodman A
- Roques J-P
- Rosa-Gonzlez D
- Rosell A Carnero
- Rosenberg M
- Rosetti S
- Rosinska D
- Ross MP
- Rossi A
- Rosswog S
- Rosswog S
- Roth M
- Rott C
- Roulet E
- Rovero AC
- Rowan S
- Rowell G
- Rowlinson A
- Rowlinson A
- Roy R
- Ruan JJ
- Rudak B
- Ruehl P
- Ruggi P
- Ruhe T
- Ruiter AJ
- Ruiz R Gracia
- Ruiz-Velasco E
- Rulten CB
- Rumyantsev VV
- Rusu F
- Rutins G
- Ryan K
- Rybicki KA
- Ryckbosch D
- Rykoff ES
- Rysewyk D
- Saba A
- Sachdev S
- Sadecki T
- Sadeghian L
- Sadler EM
- Sadler EM
- Saffe C
- Saffi SJ
- Saftoiu A
- Sahakian V
- Sai N
- Saito S
- Saito T
- Saito Y
- Sakamaki A
- Sakamoto T
- Sakellariadou M
- Sako M
- Sako S
- Salafia OS
- Salamida F
- Salazar H
- Salazar H
- Salconi L
- Saldaa M
- Saleem M
- Saleh A
- Salemi F
- Salina G
- Salmon L
- Salvadori I
- Salvaterra R
- Samajdar A
- Sammut L
- Sampedro L
- Sampson LM
- Samtleben DFE
- Sanchez B
- Sanchez DA
- Sanchez E
- Sanchez EJ
- Sanchez F
- Sanchez LE
- Sanchez-Losa A
- Sanchez-Lucas P
- Sanchez-Ramirez R
- Sanchis-Gual N
- Sand DJ
- Sandberg V
- Sanders JR
- Sandoval A
- Sandrock A
- Sandroos J
- Sanguineti M
- Sansom EK
- Santander M
- Santangelo A
- Santos E
- Santos EM
- Sapienza P
- Sarazin F
- Sarkar S
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- Sarmento R
- Sarmiento-Cano C
- Sasaki M
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- Satalecka K
- Sathyaprakash BS
- Sato R
- Saulson PR
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- Sauter O
- Savage RL
- Savchenko V
- Sawadsky A
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- Schlegel DJ
- Schlickeiser R
- Schlunder P
- Schmalz SE
- Schmidt BP
- Schmidt D
- Schmidt J
- Schmidt P
- Schmidt T
- Schnabel R
- Schneider A
- Schneider M
- Schneiter M
- Schoenell W
- Schoenen S
- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
- Schovnek P
- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
- Schssler F
- Schubnell M
- Schuette D
- Schulte BW
- Schultz ASB
- Schulz A
- Schulz A
- Schulze S
- Schumacher J
- Schumacher L
- Schutz BF
- Schwalbe SG
- Schwanke U
- Schwemmer S
- Schweyer T
- Sciutto SJ
- Scolnic D
- Scott J
- Scott SM
- Secco LF
- Seckel D
- Seglar-Arroyo M
- Segreto A
- Seidel E
- Seitenzahl IR
- Sekiguchi Y
- Sellers D
- Selsing J
- Sengupta AS
- Sentenac D
- Sequino V
- Sergeev A
- Sergienko Yu P
- Serino M
- Serra G
- Serra-Ricart M
- Serrau M
- Settimo M
- Seunarine S
- Sevilla-Noarbe I
- Seyffert AS
- Sgro C
- Shaddock DA
- Shadkam A
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
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- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
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- Abramowicz H
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- Abusleme Hoffman AC
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- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
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- Zhou Y
- Zhu CG
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- Zhuang X
- Zhukov K
- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
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- Abildgaard MH
- Abudu YP
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- Zimmermann CM
- Ziviani E
- Zoladek T
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- Zorzano A
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- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Combination and summary of ATLAS dark matter searches interpreted in a 2HDM with a pseudo-scalar mediator using 139 fb−1 of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si157.svg"><mml:mrow><mml:msqrt><mml:mrow><mml:mi>s</mml:mi></mml:mrow></mml:msqrt><mml:mo linebreak="goodbreak" linebreakstyle="after">=</mml:mo><mml:mn>13</mml:mn></mml:mrow></mml:math> TeV pp collision data
- Author
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- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
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- Abusleme Hoffman AC
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- Agullo P Martinez
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- Akimov AV
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- Akolkar NN
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- Aleksa M
- Aleksandrov IN
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- Schwartzman A
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- Sebastiani CD
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- Sekhniaidze G
- Sekula SJ
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- Sengupta D
- Senthilkumar V
- Serin L
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- Sessa M
- Severini H
- Sforza F
- Sfyrla A
- Shabalina E
- Shaheen R
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- Shan LY
- Shapiro M
- Sharma A
- Sharma AS
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- Sharma S
- Shatalov PB
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- Shaw SM
- Shcherbakova A
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- Shinner JD
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- Shirabe S
- Shiyakova M
- Shlomi J
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- Sinervo P
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- Sinha S
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- Sitnikova E
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- Skaf A
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- Skubic P
- Slawinska M
- Smakhtin V
- Smart BH
- Smiesko J
- Smirnov S Yu
- Smirnov Y
- Smirnova LN
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- Smith EA
- Smith HA
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- Smizanska M
- Smolek K
- Snesarev AA
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- Snoek HL
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- Soldatov E Yu
- Soldevila U
- Solis A Lopez
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- Solovyanov OV
- Solovyev V
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- Sonay A
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- Sopczak A
- Sopio AL
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- Sothilingam V
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- Sugizaki K
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- Sullivan MJ
- Sultan DMS
- Sultanaliyeva L
- Sultansoy S
- Sumida T
- Sun S
- Sun S
- Sur N
- Sutton MR
- Suzuki H
- Svatos M
- Swiatlowski M
- Swirski T
- Sykora I
- Sykora M
- Sykora T
- Sánchez J
- Ta D
- Tackmann K
- Taffard A
- Tafirout R
- Takeva EP
- Takubo Y
- Talby M
- Talyshev AA
- Tam KC
- Tamir NM
- Tanaka A
- Tanaka J
- Tanaka R
- Tanasini M
- Tao Z
- Tapprogge S
- Tarem S
- Tariq K
- Tarna G
- Tartarelli GF
- Tas P
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- Tassi E
- Tate AC
- Tateno G
- Tayalati Y
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- Tee AS
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- Teixeira-Dias P
- Teoh JJ
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- Terron J
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- Testa M
- Teuscher RJ
- Thaler A
- Theiner O
- Themistokleous N
- Theveneaux-Pelzer T
- Thielmann O
- Thomas DW
- Thomas JP
- Thompson EA
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- Thomson E
- Tian Y
- Tikhomirov V
- Tikhonov Yu A
- Timoshenko S
- Timoshyn D
- Ting EXL
- Tipton P
- Tlou SH
- Tnourji A
- Todome K
- Todorova-Nova S
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- Togawa M
- Tojo J
- Tokushuku K
- Tokár S
- Toldaiev O
- Tombs R
- Tomoto M
- Tompkins L
- Topolnicki KW
- Torrence E
- Torres H
- Toscani M
- Tosciri C
- Tost M
- Tovey DR
- Traeet A
- Trandafir IS
- Trefzger T
- Tricoli A
- Trigger IM
- Trincaz-Duvoid S
- Trischuk DA
- Trocmé B
- Troncon C
- Truong L
- Trzebinski M
- Trzupek A
- Tsai F
- Tsai M
- Tsiamis A
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- Tsigaridas S
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- Tsujikawa Y
- Tsukerman II
- Tsulaia V
- Tsuno S
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- Tuna AN
- Turchikhin S
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- Ukegawa F
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- Unal G
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- Undrus A
- Unel G
- Urban J
- Urquijo P
- Usai G
- Ushioda R
- Usman M
- Uysal Z
- Vacavant L
- Vacek V
- Vachon B
- Vadla KOH
- Vafeiadis T
- Vaitkus A
- Valderanis C
- Valente M
- Valentinetti S
- Valero A
- Vallier A
- Van Arneman DR
- Van Daalen TR
- Van Der Graaf A
- Van Gemmeren P
- Van Rijnbach M
- Van Stroud S
- Van Vulpen I
- Vanadia M
- Vandelli W
- Vandenbroucke M
- Vandewall ER
- Vannicola D
- Vannoli L
- Vargas JS Tafoya
- Vari R
- Varnes EW
- Varni C
- Varol T
- Varouchas D
- Varriale L
- Varvell KE
- Vasile ME
- Vaslin L
- Vasquez GA
- Vasyukov A
- Vazeille F
- Vazquez JG Panduro
- Veatch J
- Vecchio V
- Veen MJ
- Veliscek I
- Veloce LM
- Veloso F
- Veneziano S
- Ventura A
- Vera AM Rodríguez
- Verbytskyi A
- Verducci M
- Vergara JC Rivera
- Vergis C
- Verkerke W
- Vermeulen JC
- Vernieri C
- Vessella M
- Vetterli MC
- Vgenopoulos A
- Vickey T
- Viehhauser GHA
- Vigani L
- Villa M
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- Vilucchi E
- Vincter MG
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- Vishwakarma A
- Visibile A
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- Vladimirov V
- Voevodina E
- Vogel F
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- Von Ahnen J
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- Vormwald B
- Vorobel V
- Vorobev K
- Vos M
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- Vossebeld JH
- Vozak M
- Vozdecky L
- Vranjes N
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- Vu NK
- Vuillermet R
- Vujinovic O
- Vukotic I
- Wada S
- Wagner C
- Wagner JM
- Wagner W
- Wahdan S
- Wahlberg H
- Wakida M
- Walder J
- Walker R
- Walkowiak W
- Wall A
- Wamorkar T
- Wang AZ
- Wang C
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- Warburton A
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- Wei C
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- Weidberg AR
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- Weingarten J
- Weirich M
- Weiser C
- Wells CJ
- Wenaus T
- Wendland B
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- Wenke NS
- Wermes N
- Wessels M
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- Whiteson D
- Wickremasinghe L
- Wiedenmann W
- Wiel C
- Wielers M
- Wiglesworth C
- Wilbern DJ
- Wilkens HG
- Williams DM
- Williams HH
- Williams S
- Willocq S
- Wilson BJ
- Windischhofer PJ
- Winkel FI
- Winklmeier F
- Winter BT
- Winter JK
- Wittgen M
- Wobisch M
- Wolffs Z
- Wollrath J
- Wolter MW
- Wolters H
- Wongel AF
- Worm SD
- Wosiek BK
- Wozniewski S
- Woźniak KW
- Wraight K
- Wu C
- Wu J
- Wu M
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wu Z
- Wuerzinger J
- Wyatt TR
- Wynne BM
- Wölker R
- Xella S
- Xia L
- Xia M
- Xiang J
- Xie M
- Xie X
- Xin S
- Xiong J
- Xu D
- Xu H
- Xu L
- Xu R
- Xu T
- Xu Y
- Xu Z
- Xu Z
- Yabsley B
- Yacoob S
- Yamaguchi Y
- Yamashita E
- Yamauchi H
- Yamazaki T
- Yamazaki Y
- Yan J
- Yan S
- Yan Z
- Yang HJ
- Yang HT
- Yang S
- Yang T
- Yang X
- Yang X
- Yang Y
- Yang Y
- Yang Z
- Yao W-M
- Yap YC
- Ye H
- Ye H
- Ye J
- Ye S
- Ye X
- Yeh Y
- Yeletskikh I
- Yeo BK
- Yexley MR
- Yin P
- Yorita K
- Younas S
- Young C
- Young CJS
- Yu Y
- Yuan M
- Yuan R
- Yue L
- Zaazoua M
- Zabinski B
- Zaid E
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zang J
- Zanzi D
- Zaplatilek O
- Zeitnitz C
- Zeng H
- Zeng JC
- Zenger DT
- Zenin O
- Zenz S
- Zerradi S
- Zerwas D
- Zhai M
- Zhang B
- Zhang DF
- Zhang J
- Zhang J
- Zhang K
- Zhang L
- Zhang P
- Zhang R
- Zhang S
- Zhang T
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao P
- Zhao T
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Elsevier BV
- Publication date
- 01/07/2024
- Field of study
Results from a wide range of searches targeting different experimental signatures with and without missing transverse momentum (
) are used to constrain a Two–Higgs-Doublet Model (2HDM) with an additional pseudo-scalar mediating the interaction between ordinary and dark matter (2HDM + a). The analyses use up to 139 fb−1 of proton–proton collision data at a centre-of-mass energy
TeV recorded with the ATLAS detector at the Large Hadron Collider during 2015–2018. The results from three of the most sensitive searches are combined statistically. These searches target signatures with large
and a leptonically decaying Z boson; large
and a Higgs boson decaying to bottom quarks; and production of charged Higgs bosons in final states with top and bottom quarks, respectively. Constraints are derived for several common and new benchmark scenarios in the 2HDM + a
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