On the front foot : Indigenous leadership in Aotearoa/New Zealand higher education

Despite increasing representation in higher education, Māori leaders are still seeking to overcome historical inequities and racial discrimination. This study investigates the circumstances of Māori leadership in higher education from a strength-based standpoint, highlighting the critical role Māori academics fulfil in senior leadership positions in Aotearoa/New Zealand universities by exploring Māori perceptions of the scope, influence and challenges of their senior leadership roles. These perceptions are described by five participants in the study and supported by literature predominantly authored by Māori academics. The qualitative study is underpinned by Political Race Theory, linking race and power at the individual level as well as at the institutional level. Findings give voice to senior leaders’ answers to the critical question: how can Indigenous leadership secure sustainable, transformative change in Aotearoa/New Zealand universities. The response to this question is underscored by the notion of shifting leadership positioning from the back-foot reactive politics to a front-foot status of strategic and transformative leadership. Reporting on Stage Five of an Australian project–Walan Mayiny: Indigenous Leadership in Higher Education, this study is the second in a series of three international case studies investigating Indigenous leadership in higher education

Paying-it-forward : Indigenous leadership in American higher education

This study focuses on Native American experiences of senior leadership in higher education, presenting a paradigm of Indigenous leadership based on the principle of paying-it-forward. The qualitative study, underpinned by Indigenist methodology, centers the responses of four Native American senior leaders in mainland America and Hawai´i who have strategically designed community-building policies and practices to counter ongoing isolation in higher education. Findings detail place-based leadership paradigms and practical strategies derived from Native American leadership rationales, showing the power of Native American leadership to challenge systemically biased perceptions, policies and practices that endeavor to isolate Indigenous peoples from each other, culture, language, and ways of being knowing and doing. The study is part of the international phase of an Australian-based project not only gives insight into higher education internationally, but also creates opportunity for consideration of what we can learn to our advantage in other colonized contexts

A multi-national European cross-sectional study of feline calicivirus epidemiology, diversity and vaccine cross-reactivity

Background Feline calicivirus (FCV) is an important pathogen of cats for which vaccination is regularly practised. Long-term use of established vaccine antigens raises the theoretical possibility that field viruses could become resistant. This study aimed to assess the current ability of the FCV-F9 vaccine strain to neutralise a randomly collected contemporary panel of FCV field strains collected prospectively in six European countries. Methods Veterinary practices (64) were randomly selected from six countries (UK, Sweden, Netherlands, Germany, France and Italy). Oropharyngeal swabs were requested from 30 (UK) and 40 (other countries) cats attending each practice. Presence of FCV was determined by virus isolation, and risk factors for FCV shedding assessed by multivariable logistic regression. Phylogenetic analyses were used to describe the FCV population structure. In vitro virus neutralisation assays were performed to evaluate FCV-F9 cross-reactivity using plasma from four vaccinated cats. Results The overall prevalence of FCV was 9.2%. Risk factors positively associated with FCV shedding included multi-cat households, chronic gingivostomatitis, younger age, not being neutered, as well as residing in certain countries. Phylogenetic analysis showed extensive variability and no countrywide clusters. Despite being first isolated in the 1950s, FCV-F9 clustered with contemporary field isolates. Plasma raised to FCV-F9 neutralized 97% of tested isolates (titres 1:4 to 1:5792), with 26.5%, 35.7% and 50% of isolates being neutralized by 5, 10 and 20 antibody units respectively. Conclusions This study represents the largest prospective analysis of FCV diversity and antigenic cross-reactivity at a European level. The scale and random nature of sampling used gives confidence that the FCV isolates used are broadly representative of FCVs that cats are exposed to in these countries. The in vitro neutralisation results suggest that antibodies raised to FCV-F9 remain broadly cross-reactive to contemporary FCV isolates across the European countries sampled

Practical whole-system provenance capture

Data provenance describes how data came to be in its present form. It includes data sources and the transformations that have been applied to them. Data provenance has many uses, from forensics and security to aiding the reproducibility of scientific experiments. We present CamFlow, a whole-system provenance capture mechanism that integrates easily into a PaaS offering. While there have been several prior whole-system provenance systems that captured a comprehensive, systemic and ubiquitous record of a system’s behavior, none have been widely adopted. They either A) impose too much overhead, B) are designed for long-outdated kernel releases and are hard to port to current systems, C) generate too much data, or D) are designed for a single system. CamFlow addresses these shortcoming by: 1) leveraging the latest kernel design advances to achieve efficiency; 2) using a self-contained, easily maintainable implementation relying on a Linux Security Module, NetFilter, and other existing kernel facilities; 3) providing a mechanism to tailor the captured provenance data to the needs of the application; and 4) making it easy to integrate provenance across distributed systems. The provenance we capture is streamed and consumed by tenant-built auditor applications. We illustrate the usability of our implementation by describing three such applications: demonstrating compliance with data regulations; performing fault/intrusion detection; and implementing data loss prevention. We also show how CamFlow can be leveraged to capture meaningful provenance without modifying existing applications.Engineering and Applied Science

Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (SNP) content of genome-wide arrays. The UK10K Cohorts project has generated a data set of 3,781 whole genomes sequenced at low depth (average 7x), aiming to exhaustively characterize genetic variation down to 0.1% minor allele frequency in the British population. Here we demonstrate the value of this resource for improving imputation accuracy at rare and low-frequency variants in both a UK and an Italian population. We show that large increases in imputation accuracy can be achieved by re-phasing WGS reference panels after initial genotype calling. We also present a method for combining WGS panels to improve variant coverage and downstream imputation accuracy, which we illustrate by integrating 7,562 WGS haplotypes from the UK10K project with 2,184 haplotypes from the 1000 Genomes Project. Finally, we introduce a novel approximation that maintains speed without sacrificing imputation accuracy for rare variants

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Hidden in plain view : Indigenous early career researchers' experiences and perceptions of racism in Australian universities

Despite extensive impact studies over the past two decades documenting the insipid and debilitating health, social, and emotional impacts of racism on Indigenous peoples in Australia, racism remains a key factor impacting negatively on the lives of Indigenous Australians at all levels of education. Racism experienced by Indigenous early career researchers is much-neglected area of research to date: the aim of this paper is to force a conversation about the prevalence of institutional racism in the higher education sector through an examination of the impact of racism on the experiences and career trajectories of Indigenous early career researchers in Australian universities. We challenge the day-to-day perceptions of normalcy where the Whiteness of the institution goes unnoticed and make clear that claiming ignorance does not absolve the individual or the institution of accountability. Although grounded in Australian experiences of institutional racism in higher education, the study has global significance to other relationally-like colonised nations. International literature highlights racism is imbricated across the Pan-Pacific nations; this is laid bared by the recounting of Australian Indigenous experiences and perceptions

[In Press] Where we're going, not where we've been : Indigenous leadership in Canadian higher education

Despite increasing calls for systemic change in the Canadian higher education sector, Indigenous leaders continue to be underrepresented, under-funded, and overworked. This qualitative study investigates the purview of senior Indigenous leaders within Canadian higher education, drawing on interviews conducted with four senior Indigenous leaders at Canadian universities. The study, underpinned by emancipatory Indigenist research, draws on the literature predominantly written by Canadian Indigenous scholars. Reporting on Stage Five of a qualitative Australian project – Walan Mayiny: Indigenous Leadership in Higher Education, this paper is the first of four international aspects of the larger project. Findings suggest these Indigenous senior leaders overcome significant barriers to gain senior roles, while the weight of systemic change is carried by individual Indigenous leaders. The question addressed is how senior Indigenous leaders can unsettle systemic barriers so that universities are facing in the direction of where they need to be going, and not where they’ve been