70 research outputs found

    The Effectiveness of Star Strategy Learning on Gifted Students Mathematical Creative Thinking Ability

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    The purpose of this research is to investigate the mathematics creative thinking skills of gifted students in the International Private School before, during, and after receiving instruction using the STAR method. An analysis of behaviour analysis (ABA) was used as the study approach for the exploration of a certain subject. The sample of the study was selected from International private school in Al-Ain, UAE during the academic year 2020-2021. The investigation focused on two pupils who were both considered to have impressive levels of academic ability. An exercise in description was used as a component of the investigation. According to the findings of this research, subject G1 exhibited a higher ability for mathematically innovative thinking than subject G2 did in baseline condition 2 (A2), with subject G1 attaining 93.33 percent and subject G2 achieving 90 percent. Throughout the whole of this experiment, this was consistently the case for both of the individuals. Subject G1 had a higher percentage of creative thinking ability than subject G2 (83.3% vs. 81.5%), despite the fact that in baseline condition 1 (A1), both individuals creative thinking abilities were at their lowest possible level. Subject G1 had a score of 88.75% in the intervention condition, whereas subject G2 had a score of 86.25% in the intervention condition. This research came to the conclusion that the use of the STAR learning technique, which consists of the phases Search, Translate, Answer, and Review, is beneficial on mathematical creative thinking abilities as measured by Problem Sensitivity, Fluency, Flexibility, Originality, and elaboration

    The Faint End Slopes Of Galaxy Luminosity Functions In The COSMOS 2-Square Degree Field

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    We examine the faint-end slope of the rest-frame V-band luminosity function (LF), with respect to galaxy spectral type, of field galaxies with redshift z<0.5, using a sample of 80,820 galaxies with photometric redshifts in the Cosmic Evolution Survey (COSMOS) field. For all galaxy spectral types combined, the LF slope, alpha, ranges from -1.24 to -1.12, from the lowest redshift bin to the highest. In the lowest redshift bin (0.02<z<0.1), where the magnitude limit is M(V) ~ -13, the slope ranges from ~ -1.1 for galaxies with early-type spectral energy distributions (SEDs), to ~ -1.9 for galaxies with low-extinction starburst SEDs. In each galaxy SED category (Ell, Sbc, Scd/Irr, and starburst), the faint-end slopes grow shallower with increasing redshift; in the highest redshift bin (0.4<z<0.5), the slope is ~ -0.5 and ~ -1.3 for early-types and starbursts respectively. The steepness of alpha at lower redshift could be qualitatively explained by large numbers of faint dwarf galaxies, perhaps of low surface brightness, which are not detected at higher redshifts.Comment: 24 pages including 5 figures, accepted to ApJ

    The faint-end slopes of galaxy luminosity functions in the COSMOS field

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    We examine the faint-end slope of the rest-frame V-band luminosity function (LF), with respect to galaxy spectral type, of field galaxies with redshift z < 0.5, using a sample of 80,820 galaxies with photometric redshifts in the 2 deg^2 Cosmic Evolution Survey (COSMOS) field. For all galaxy spectral types combined, the LF slope ranges from –1.24 to –1.12, from the lowest redshift bin to the highest. In the lowest redshift bin (0.02 < z < 0.1), where the magnitude limit is MV ≾ − 13, the slope ranges from α ~ − 1.1 for galaxies with early-type spectral energy distributions (SEDs) to α ~ − 1.9 for galaxies with low-extinction starburst SEDs. In each galaxy SED category (early-type, Sbc, Scd+Irr, and starburst), the faint-end slopes grow shallower with increasing redshift; in the highest redshift bin (0.4 < z < 0.5), α ~ − 0.5 and –1.3 for early types and starbursts, respectively. The steepness of α at lower redshifts could be qualitatively explained by LF evolution, or by large numbers of faint dwarf galaxies, perhaps of low surface brightness, that are not detected at higher redshifts

    The Drosophila neural lineages: a model system to study brain development and circuitry

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    In Drosophila, neurons of the central nervous system are grouped into units called lineages. Each lineage contains cells derived from a single neuroblast. Due to its clonal nature, the Drosophila brain is a valuable model system to study neuron development and circuit formation. To better understand the mechanisms underlying brain development, genetic manipulation tools can be utilized within lineages to visualize, knock down, or over-express proteins. Here, we will introduce the formation and development of lineages, discuss how one can utilize this model system, offer a comprehensive list of known lineages and their respective markers, and then briefly review studies that have utilized Drosophila neural lineages with a look at how this model system can benefit future endeavors

    Intraflagellar Transport (IFT) Protein IFT25 Is a Phosphoprotein Component of IFT Complex B and Physically Interacts with IFT27 in Chlamydomonas

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    BACKGROUND: Intraflagellar transport (IFT) is the bidirectional movement of IFT particles between the cell body and the distal tip of a flagellum. Organized into complexes A and B, IFT particles are composed of at least 18 proteins. The function of IFT proteins in flagellar assembly has been extensively investigated. However, much less is known about the molecular mechanism of how IFT is regulated. METHODOLOGY/PRINCIPAL FINDINGS: We herein report the identification of a novel IFT particle protein, IFT25, in Chlamydomonas. Dephosphorylation assay revealed that IFT25 is a phosphoprotein. Biochemical analysis of temperature sensitive IFT mutants indicated that IFT25 is an IFT complex B subunit. In vitro binding assay confirmed that IFT25 binds to IFT27, a Rab-like small GTPase component of the IFT complex B. Immunofluorescence staining showed that IFT25 has a punctuate flagellar distribution as expected for an IFT protein, but displays a unique distribution pattern at the flagellar base. IFT25 co-localizes with IFT27 at the distal-most portion of basal bodies, probably the transition zones, and concentrates in the basal body region by partially overlapping with other IFT complex B subunits, such as IFT46. Sucrose density gradient centrifugation analysis demonstrated that, in flagella, the majority of IFT27 and IFT25 including both phosphorylated and non-phosphorylated forms are cosedimented with other complex B subunits in the 16S fractions. In contrast, in cell body, only a fraction of IFT25 and IFT27 is integrated into the preassembled complex B, and IFT25 detected in complex B is preferentially phosphorylated. CONCLUSION/SIGNIFICANCE: IFT25 is a phosphoprotein component of IFT particle complex B. IFT25 directly interacts with IFT27, and these two proteins likely form a subcomplex in vivo. We postulate that the association and disassociation between the subcomplex of IFT25 and IFT27 and complex B might be involved in the regulation of IFT

    Genotype and phenotype landscape of MEN2 in 554 medullary thyroid cancer patients: the BrasMEN study

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    Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant genetic disease caused by RET gene germline mutations that is characterized by medullary thyroid carcinoma (MTC) associated with other endocrine tumors. Several reports have demonstrated that the RET mutation profile may vary according to the geographical area. In this study, we collected clinical and molecular data from 554 patients with surgically confirmed MTC from 176 families with MEN2 in 18 different Brazili an centers to compare the type and prevalence of RET mutations with those from other countries. The most frequent mutations, classified by the number of families affected, occur in codon 634, exon 11 (76 families), followed by codon 918, exon 16 (34 families: 26 with M918T and 8 with M918V) and codon 804, exon 14 (22 families: 15 with V804M and 7 with V804L). When compared with other major published series from Europe, there are several similarities and some differences. While the mutations in codons C618, C620, C630, E768 and S891 present a similar prevalence, some mutations have a lower prevalence in Brazil, and others are found mainly in Brazil (G533C and M918V). These results reflect the singular proportion of European, Amerindian and African ancestries in the Brazilian mosaic genome83289298CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO RIO GRANDE DO SUL - FAPERGSSem informaçãoSem informação2006/60402-1; 2010/51547-1; 2013/01476-9; 2014/06570-6; 2009/50575-4; 2010/51546-5; 2012/21942-116/2551-0000482-

    Search for dark matter at √s=13 TeV in final states containing an energetic photon and large missing transverse momentum with the ATLAS detector

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    Results of a search for physics beyond the Standard Model in events containing an energetic photon and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. As the number of events observed in data, corresponding to an integrated luminosity of 36.1 fb−1 of proton–proton collisions at a centre-of-mass energy of 13 TeV, is in agreement with the Standard Model expectations, model-independent limits are set on the fiducial cross section for the production of events in this final state. Exclusion limits are also placed in models where dark-matter candidates are pair-produced. For dark-matter production via an axial-vector or a vector mediator in the s-channel, this search excludes mediator masses below 750–1200 GeV for dark-matter candidate masses below 230–480 GeV at 95% confidence level, depending on the couplings. In an effective theory of dark-matter production, the limits restrict the value of the suppression scale M∗ to be above 790 GeV at 95% confidence level. A limit is also reported on the production of a high-mass scalar resonance by processes beyond the Standard Model, in which the resonance decays to Zγ and the Z boson subsequently decays into neutrinos

    Genotype and phenotype landscape of MEN2 in 554 medullary thyroid cancer patients: the BrasMEN study

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    Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant genetic disease caused by RET gene germline mutations that is characterized by medullary thyroid carcinoma (MTC) associated with other endocrine tumors. Several reports have demonstrated that the RET mutation profile may vary according to the geographical area. In this study, we collected clinical and molecular data from 554 patients with surgically confirmed MTC from 176 families with MEN2 in 18 different Brazilian centers to compare the type and prevalence of RET mutations with those from other countries. The most frequent mutations, classified by the number of families affected, occur in codon 634, exon 11 (76 families), followed by codon 918, exon 16 (34 families: 26 with M918T and 8 with M918V) and codon 804, exon 14 (22 families: 15 with V804M and 7 with V804L). When compared with other major published series from Europe, there are several similarities and some differences. While the mutations in codons C618, C620, C630, E768 and S891 present a similar prevalence, some mutations have a lower prevalence in Brazil, and others are found mainly in Brazil (G533C and M918V). These results reflect the singular proportion of European, Amerindian and African ancestries in the Brazilian mosaic genome

    Características psicológicas dos pacientes submetidos à intervenção coronária percutânea Psychological characteristics of patients undergoing percutaneous coronary interventions

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    FUNDAMENTO: Há poucos dados sobre análises da prevalência e da influência de características psicológicas adversas no prognóstico dos indivíduos submetidos a intervenções coronárias percutâneas. Nenhum estudo abordou essa questão no Brasil. OBJETIVO: Investigar a prevalência de depressão, ansiedade, estresse psicológico e personalidade tipo D, bem como sua associação com eventos cardiovasculares em pacientes submetidos à intervenção coronária percutânea (ICP). MÉTODOS: As características psicológicas foram avaliadas por escalas: inventário de depressão de Beck (IDB), inventário de ansiedade de Beck (IAB), inventário de sintomas de estresse de Lipp para adultos (ISSL) e escala de personalidade tipo D. A meta do estudo foi a ocorrência de eventos cardiovasculares maiores em um seguimento de um ano. RESULTADOS: Durante março e maio de 2006, 137 pacientes foram incluídos. A personalidade tipo D foi identificada em 34% dos casos; 29% apresentaram ansiedade, 25% apresentaram depressão, e 70% dos pacientes apresentaram estresse. Em relação à frequência de características psicológicas de acordo com a ocorrência de eventos cardiovasculares adversos maiores, não houve diferença estatística entre os dois grupos de pacientes no que se refere à depressão (29% vs. 26% p = 0,8), ansiedade (33% vs. 23% p = 0,3), estresse (76% vs. 65% p = 0,3) e personalidade tipo D (33% vs. 32% p = 0,9). No entanto, encontrou-se um escore de afetividade negativa significativamente maior no grupo de pacientes que apresentaram eventos (13,9 vs. 9,8 p = 0,01). CONCLUSÃO: Em pacientes submetidos à intervenção coronária percutânea, a prevalência de efeitos adversos psicológicos característicos foi alta. Eventos adversos cardiovasculares maiores em um ano foram associados à afetividade negativa basal, mas não a outras características psicológicas estudadas.BACKGROUND: There is few data evaluating the prevalence and influence of adverse psychological characteristics on the prognosis of individuals submitted to percutaneous coronary interventions. No study has addressed this issue in Brazil. OBJECTIVE: To investigate the prevalence of depression, anxiety, psychological stress, and Type D personality and its association with cardiovascular events in patients undergoing percutaneous coronary interventions. METHODS: Psychological characteristics were evaluated by scales: Beck Depression Inventory, Beck Anxiety Inventory, Lipp Inventory for Stress Symptoms for Adults and Type D Personality Scale. The end-point of this study was the occurrence of major cardiovascular events in one-year follow-up. RESULTS: During March and May 2006, 137 patients were included. Type D personality was identified in 34% of the cases, 29% presented anxiety, 25% presented depression and 70% of the patients presented stress. In relation to the frequency of psychological characteristics according to the occurrence of major adverse cardiovascular events, there was no statistical difference between both groups of patients regarding depression (29% vs. 26% p = 0.8), anxiety (33% vs. 23% p = 0.3), stress (76% vs. 65% p = 0.3), and Type D personality (33% vs. 32% p = 0.9). However, the negative affectivity score was significantly higher in the group of patients presenting events (13.9 vs. 9.8 p = 0.01). CONCLUSION: In patients submitted to percutaneous coronary interventions, the prevalence of adverse psychological characteristics was high. One-year major cardiovascular adverse events were associated with baseline negative affectivity, but not with the other psychological characteristics studie
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