The State's Management of New Religious Movements in Singapore: A Case Study of ISKCON.

Master'sMASTER OF SOCIAL SCIENCE

Proteomic and metabolomic characterisation of novel wine yeasts: towards the evaluation and improvements of their ability to produce aromatic sauvignon blanc wines

Philosophiae Doctor - PhD (Biotechnology)Wine yeast Saccharomyces cerevisiae and wild yeasts e.g. Torulaspora delbrueckii forms an integral part of wine production by converting relatively 'neutral' flavoured Sauvignon blanc grape must into varietal aromatic wines. Yeast derived and mediated metabolites which contribute to Sauvignon blanc wine aroma and flavour, are regulated by yeast proteins (enzymes) that are differentially expressed during the course of fermentation. Inoculation with an appropriate yeast strain can, therefore, increase commercial wines sales as resultant wines will have sought-after aromas and flavours. Likewise, inoculation with the incorrect strain can have an undesirable effect on wine quality. Subsequently, the development of yeasts for the production of varietal aromatic Sauvignon blanc with lower volatile acidity (VA) was also identified as a South African industry priority. Although genetic modification can address this, the use of genetically modified organisms (GMO) is illegal

Construction of the Literature Graph in Semantic Scholar

We describe a deployed scalable system for organizing published scientific literature into a heterogeneous graph to facilitate algorithmic manipulation and discovery. The resulting literature graph consists of more than 280M nodes, representing papers, authors, entities and various interactions between them (e.g., authorships, citations, entity mentions). We reduce literature graph construction into familiar NLP tasks (e.g., entity extraction and linking), point out research challenges due to differences from standard formulations of these tasks, and report empirical results for each task. The methods described in this paper are used to enable semantic features in www.semanticscholar.orgComment: To appear in NAACL 2018 industry trac

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

The Discursive Legitimation of Political Regimes: A Network Perspective

In this working paper, we treat legitimacy and legitimation as interactive, discursive and relational concepts: Legitimacy is socially constructed in the public spheres of (democratic) political regimes, that is, in discursive exchanges of political elites and citizens about the acceptability of these regimes. Legitimacy claims and assessments establish a link between regimes and their institutions on the one hand, and normative benchmarks on the other. Hence they may be examined with the help of discourse network analysis - a novel application of network analysis whose rationale and potential are illustrated on the basis of a corpus of legitimation statements gleaned from German and US quality newspapers. Our method enables us to discover and visualize the structures of legitimation discourses - prominent speaker types, privileged legitimation criteria and discourse coalitions - and to offer some conjectures on the link between discourses and the institutional arrangements of the German and US polities.Dieses Arbeitspapier behandelt Legitimität und Legitimation als interaktive, diskursive und relationale Konzepte: Legitimität wird in den Öffentlichkeiten (demokratischer) politischer Regimes, also in einem diskursiven Austausch von politischen Eliten und Bürgern über die Akzeptabilität politischer Herrschaft, sozial konstruiert. In Legitimitätsbehauptungen und -bewertungen wird eine Verbindung zwischen Regimes und ihren Institutionen auf der einen und normativen Kriterien auf der anderen Seite hergestellt. Diese können mit Hilfe der Diskursnetzwerkanalyse untersucht werden; Logik und Potential dieser neuen Anwendung der Netzwerkanalyse werden auf der Basis eines Korpus von Legitimationsstatements aus deutschen und US-amerikanischen Qualitätszeitungen illustriert. Unsere Methode erlaubt es, die Strukturen von Legitimationsdiskursen - etwa prominente Sprechertypen, privilegierte Legitimationskriterien und Diskurskoalitionen - aufzudecken und zu visualisieren; daraus lassen sich schließlich auch Erkenntnisse über die Verbindung zwischen Diskursen und politischen Institutionenarrangements in Deutschland und den USA ableiten

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Abstract: Background: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. Methods: Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results were scaled to a one mmol/L lower LDL-C concentration. Results: The PCSK9 GS (comprising 4 SNPs) associations with plasma lipid and apolipoprotein levels were consistent in direction with treatment effects. The GS odds ratio (OR) for myocardial infarction (MI) was 0.53 (95% CI 0.42; 0.68), compared to a PCSK9 inhibitor effect of 0.90 (95% CI 0.86; 0.93). For ischemic stroke ORs were 0.84 (95% CI 0.57; 1.22) for the GS, compared to 0.85 (95% CI 0.78; 0.93) in the drug trials. ORs with type 2 diabetes mellitus (T2DM) were 1.29 (95% CI 1.11; 1.50) for the GS, as compared to 1.00 (95% CI 0.96; 1.04) for incident T2DM in PCSK9 inhibitor trials. No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer’s disease – outcomes for which large-scale trial data were unavailable. Conclusions: Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate

Формирование эмоциональной культуры как компонента инновационной культуры студентов

Homozygosity has long been associated with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity, ROH), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power3,4. Here we use ROH to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts and find statistically significant associations between summed runs of homozygosity (SROH) and four complex traits: height, forced expiratory lung volume in 1 second (FEV1), general cognitive ability (g) and educational attainment (nominal p<1 × 10−300, 2.1 × 10−6, 2.5 × 10−10, 1.8 × 10−10). In each case increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing convincing evidence for the first time that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples5,6, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein (LDL) cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection7, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been