Imaging myocardial carcinoid with T2-STIR CMR

We used T2-STIR (Short Tau Inversion Recovery) cardiovascular magnetic resonance to demonstrate carcinoid tumor metastases to the heart and liver in a 64-year-old woman with a biopsy-proven ileal carcinoid tumor who was referred because of an abnormal echocardiogram

A Retrospective Genomic Landscape of 661 Young Adult Glioblastomas Diagnosed Using 2016 WHO Guidelines for Central Nervous System Tumors

The authors present a cohort of 661 young adult glioblastomas diagnosed using 2016 WHO World Health Organization Classification of Tumors of the Central Nervous System, utilizing comprehensive genomic profiling (CGP) to explore their genomic landscape and assess their relationship to currently defined disease entities. This analysis explored variants with evidence of pathogenic function, common copy number variants (CNVs), and several novel fusion events not described in literature. Tumor mutational burden (TMB) mutational signatures, anatomic location, and tumor recurrence are further explored. Using data collected from CGP, unsupervised machine-learning techniques were leveraged to identify 10 genomic classes in previously assigned young adult glioblastomas. The authors relate these molecular classes to current World Health Organization guidelines and reference current literature to give therapeutic and prognostic descriptions where possible

In vitro synergy testing of anidulafungin with fluconazole, tioconazole, 5-flucytosine and amphotericin B against some Candida spp

In this paper the authors investigated a synergistic antimycotic effect between four antifungal drugs Ampho- tericin B, Fluconazole, Tioconazole, and Flucytosine individually combined with Anidulafungin compound. This latter is considered a drug of choice in the treatment of fungal infections; it has good activity both in vitro and in vivo against yeasts and moulds, as Candida and Aspergillus. The goal of this study was to evaluate the in vitro interaction of Anidula- fungin in the synergic combinations with previous reported drugs against 12 Candida strains according to CLSI M27-A3 protocol. A synergistic interaction was observed against the most antifungal strains; in particular an increasing of the an- timycotic efficacy was obtained from the association between Anidulafungin and Amphotericin B or Fluconazole (Mix- ture 4:6). In contrast the association Tioconazole/Anidulafungin was less effective on fungal species growth. The antimy- cotics MIC reduction values were more evident against some strains as C. glabrata, C. krusei, C. tropicalis and C. parap- silosis

Prospects for a survey of the Galactic plane with the Cherenkov Telescope Array

International audienceApproximately one hundred sources of very-high-energy (VHE) gamma rays are known in the Milky Way. A survey of the entire Galactic Plane in the energy range from a few tens of GeV to a few hundred TeV has been proposed as a Key Science Project for the upcoming Cherenkov Telescope Array Observatory (CTAO). This article presents the status of the studies towards the Galactic Plane Survey (GPS). We build and make publicly available a sky model that combines data from observations of known gamma-ray emitters with state-of-the-art physically-driven models of synthetic populations of the main classes of established Galactic VHE sources, as well as of interstellar emission from cosmic-ray interactions in the Milky Way. We also perform an optimisation of the observation strategy. We use the improved sky model and observation strategy to simulate GPS data that are analysed using the methods and software tools under development for real data. We show that the GPS has the potential to increase the number of known Galactic VHE emitters by almost a factor of five. This corresponds to the detection of more than two hundred pulsar wind nebulae and a few tens of supernova remnants at average integral fluxes one order of magnitude lower than in the existing sample above 1 TeV, therefore opening the possibility to perform unprecedented population studies. The GPS also has the potential to provide new VHE detections of binary systems and pulsars, and to identify any bright PeVatrons. Furthermore, the GPS will constitute a pathfinder for deeper follow-up observations of these source classes. Finally, we show that we can extract from GPS data an estimate of the contribution to diffuse emission from unresolved sources, and that there are good prospects of detecting interstellar emission and statistically distinguishing different scenarios. (Abridged

Prospects for a survey of the Galactic plane with the Cherenkov Telescope Array

International audienceApproximately one hundred sources of very-high-energy (VHE) gamma rays are known in the Milky Way. A survey of the entire Galactic Plane in the energy range from a few tens of GeV to a few hundred TeV has been proposed as a Key Science Project for the upcoming Cherenkov Telescope Array Observatory (CTAO). This article presents the status of the studies towards the Galactic Plane Survey (GPS). We build and make publicly available a sky model that combines data from observations of known gamma-ray emitters with state-of-the-art physically-driven models of synthetic populations of the main classes of established Galactic VHE sources, as well as of interstellar emission from cosmic-ray interactions in the Milky Way. We also perform an optimisation of the observation strategy. We use the improved sky model and observation strategy to simulate GPS data that are analysed using the methods and software tools under development for real data. We show that the GPS has the potential to increase the number of known Galactic VHE emitters by almost a factor of five. This corresponds to the detection of more than two hundred pulsar wind nebulae and a few tens of supernova remnants at average integral fluxes one order of magnitude lower than in the existing sample above 1 TeV, therefore opening the possibility to perform unprecedented population studies. The GPS also has the potential to provide new VHE detections of binary systems and pulsars, and to identify any bright PeVatrons. Furthermore, the GPS will constitute a pathfinder for deeper follow-up observations of these source classes. Finally, we show that we can extract from GPS data an estimate of the contribution to diffuse emission from unresolved sources, and that there are good prospects of detecting interstellar emission and statistically distinguishing different scenarios. (Abridged

Prospects for a survey of the Galactic plane with the Cherenkov Telescope Array

International audienceApproximately one hundred sources of very-high-energy (VHE) gamma rays are known in the Milky Way. A survey of the entire Galactic Plane in the energy range from a few tens of GeV to a few hundred TeV has been proposed as a Key Science Project for the upcoming Cherenkov Telescope Array Observatory (CTAO). This article presents the status of the studies towards the Galactic Plane Survey (GPS). We build and make publicly available a sky model that combines data from observations of known gamma-ray emitters with state-of-the-art physically-driven models of synthetic populations of the main classes of established Galactic VHE sources, as well as of interstellar emission from cosmic-ray interactions in the Milky Way. We also perform an optimisation of the observation strategy. We use the improved sky model and observation strategy to simulate GPS data that are analysed using the methods and software tools under development for real data. We show that the GPS has the potential to increase the number of known Galactic VHE emitters by almost a factor of five. This corresponds to the detection of more than two hundred pulsar wind nebulae and a few tens of supernova remnants at average integral fluxes one order of magnitude lower than in the existing sample above 1 TeV, therefore opening the possibility to perform unprecedented population studies. The GPS also has the potential to provide new VHE detections of binary systems and pulsars, and to identify any bright PeVatrons. Furthermore, the GPS will constitute a pathfinder for deeper follow-up observations of these source classes. Finally, we show that we can extract from GPS data an estimate of the contribution to diffuse emission from unresolved sources, and that there are good prospects of detecting interstellar emission and statistically distinguishing different scenarios. (Abridged

Prospects for a survey of the Galactic plane with the Cherenkov Telescope Array

International audienceApproximately one hundred sources of very-high-energy (VHE) gamma rays are known in the Milky Way. A survey of the entire Galactic Plane in the energy range from a few tens of GeV to a few hundred TeV has been proposed as a Key Science Project for the upcoming Cherenkov Telescope Array Observatory (CTAO). This article presents the status of the studies towards the Galactic Plane Survey (GPS). We build and make publicly available a sky model that combines data from observations of known gamma-ray emitters with state-of-the-art physically-driven models of synthetic populations of the main classes of established Galactic VHE sources, as well as of interstellar emission from cosmic-ray interactions in the Milky Way. We also perform an optimisation of the observation strategy. We use the improved sky model and observation strategy to simulate GPS data that are analysed using the methods and software tools under development for real data. We show that the GPS has the potential to increase the number of known Galactic VHE emitters by almost a factor of five. This corresponds to the detection of more than two hundred pulsar wind nebulae and a few tens of supernova remnants at average integral fluxes one order of magnitude lower than in the existing sample above 1 TeV, therefore opening the possibility to perform unprecedented population studies. The GPS also has the potential to provide new VHE detections of binary systems and pulsars, and to identify any bright PeVatrons. Furthermore, the GPS will constitute a pathfinder for deeper follow-up observations of these source classes. Finally, we show that we can extract from GPS data an estimate of the contribution to diffuse emission from unresolved sources, and that there are good prospects of detecting interstellar emission and statistically distinguishing different scenarios. (Abridged