Measurement invariance of cognitive and affective job insecurity: A cross-national study

Empirical evidence of established measurement invariance of job insecurity measures may enhance the practical utility of job insecurity as a valid predictor when utilised over different cross-national samples. This study investigated the measurement invariance of the nine-item versions of the Job Security Index (a measure of cognitive job insecurity) and the Job Security Satisfaction Scale (a measure of affective job insecurity), across four countries (i.e. the United States, N = 486; China, N = 629; Italy, N = 482 and South Africa, N = 345). Based on a novel bifactor-(S-1) model approach we found evidence for partial metric, partial scalar and partial strict invariance of our substantive bifactor-(S-1) structure. The results extend measurement invariance research on job insecurity with obvious pragmatic implications (e.g. scaling units, measurement bias over cross-national interpretations). Contribution: This research provides evidence to support the applied use of cross-national comparisons of job insecurity scores across the nationalities included in this study. Theoretically, this research advances the debate about the nature of the relationship between cognitive and affective job insecurity, suggesting that in this cross-national dataset, a model where cognitive job insecurity is specified as the reference domain outperforms a model where affective job insecurity is assigned this status. Practically, it demonstrates that it is sensible and necessary to differentiate between cognitive and affective job insecurity and include measures of both constructs in future research on the construct

Therapeutic targeting of cathepsin C::from pathophysiology to treatment

Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl aminopeptidase. The best characterized physiological function of CatC is the activation of pro-inflammatory granule-associated serine proteases. These proteases are synthesized as inactive zymogens containing an N-terminal pro-dipeptide, which maintains the zymogen in its inactive conformation and prevents premature activation, which is potentially toxic to the cell. The activation of serine protease zymogens occurs through cleavage of the N-terminal dipeptide by CatC during cell maturation in the bone marrow. In vivo data suggest that pharmacological inhibition of pro-inflammatory serine proteases would suppress or attenuate deleterious effects of inflammatory/auto-immune disorders mediated by these proteases. The pathological deficiency in CatC is associated with Papillon-Lefèvre syndrome. The patients however do not present marked immunodeficiency despite the absence of active serine proteases in immune defense cells. Hence, the transitory pharmacological blockade of CatC activity in the precursor cells of the bone marrow may represent an attractive therapeutic strategy to regulate activity of serine proteases in inflammatory and immunologic conditions. A variety of CatC inhibitors have been developed both by pharmaceutical companies and academic investigators, some of which are currently being employed and evaluated in preclinical/clinical trials

Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics

Cartilage destruction is a key characteristic of arthritic disease, a process now widely established to be mediated by metzincins such as MMPs. Despite showing promise in preclinical trials during the 1990s, MMP inhibitors for the blockade of extracellular matrix turnover in the treatment of cancer and arthritis failed clinically, primarily due to poor selectivity for target MMPs. In recent years, roles for serine proteinases in the proteolytic cascades leading to cartilage destruction have become increasingly apparent, renewing interest in the potential for new therapeutic strategies that utilize pharmacological inhibitors against this class of proteinases. Herein, we describe key serine proteinases with likely importance in arthritic disease and highlight recent advances in this field