The biology of vascular calcification

Vascular calcification (VC), characterized by different mineral deposits (i.e., carbonate apatite, whitlockite and hydroxyapatite) accumulating in blood vessels and valves, represents a relevant pathological process for the aging population and a life-threatening complication in acquired and in genetic diseases. Similarly to bone remodeling, VC is an actively regulated process in which many cells and molecules play a pivotal role. This review aims at: (i) describing the role of resident and circulating cells, of the extracellular environment and of positive and negative factors in driving the mineralization process; (ii) detailing the types of VC (i.e., intimal, medial and cardiac valve calcification); (iii) analyzing rare genetic diseases underlining the importance of altered pyrophosphate-dependent regulatory mechanisms; (iv) providing therapeutic options and perspectives

Search for the Standard Model Higgs boson produced in association with a vector boson and decaying to a b-quark pair with the ATLAS detector

This Letter presents the results of a direct search with the ATLAS detector at the LHC for a Standard Model Higgs boson of mass 110 llbb, WH->lvbb, and ZH->vvbb, where l corresponds to an electron or a muon. No evidence for Higgs boson production is observed in a dataset of 7 TeV pp collisions corresponding to 4.7/fb of integrated luminosity collected by ATLAS in 2011. Exclusion limits on Higgs boson production, at the 95% confidence level, of 2.5 to 5.5 times the Standard Model cross section are obtained in the mass range 110 - 130 GeV. The expected exclusion limits range between 2.5 and 4.9 for the same mass interval