Die Untersuchung von VeA Phosphorylierungsstellen in der Lichtantwort in Aspergillus nidulans

Organisms like Aspergillus nidulans have to adapt to certain environmental conditions. VeA is a central regulator and is connected to light reception. This work investigates the role of VeA phosphorylation sites and their function concerning development, secondary metabolism and gene transcription. Finally a VeA population modell is postulated

Regulatory aspects of nanotechnology in the agri/feed/food sector in EU and non-EU countries

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The influence of driver’s mood on car following and glance behaviour: Using cognitive load as an intervention

Driving safety relies on a driver’s ability to maintain their attentional focus and that mood is one of the factors which influences this ability. This driving simulator study used mind wandering theory to understand the changes in car following behaviour and driver glance patterns when affected by neutral, happy, sad and angry moods during car following. Two types of cognitive load were used to investigate ways of disengaging drivers from the mind wandering state. The moods were induced via music and mental imagery and assessed via self-reports and physiological measures. The results show that mood valence and arousal have different effects on driving safety, with negative moods resulting in the most dangerous driving, regardless of arousal. The cognitive load, in some cases, disengaged drivers from mood-related mind wandering. However, more detailed research is needed to understand the amount of load necessary for this disengagement in different moods. The importance of using driving-related measures together with glance patterns in mood research was highlighted to overcome ambiguities resulting from conclusions based on single measurements

Endothelial Progenitor Cells, Cardiovascular Risk Factors, Cytokine Levels and Atherosclerosis – Results from a Large Population-Based Study

EPC number and functionality are assumed to reflect the endogenous vascular repair capacity with the EPC pool declining in higher ages and being exhausted by unfavorable life-style and risk factors. This intriguing and clinically highly relevant concept, however, has so far been derived from small case-control studies and patient series.In the population-based Bruneck Study EPC number and EPC-colony forming units (EPC-CFU) were assessed as part of the fourth follow-up evaluation (2005) in 571 and 542 subjects, respectively. EPC number declined with age (p = 0.013), was significantly lower in women (p = 0.006) and higher in subjects on statin, hormone replacement or ACE inhibitor/angiotensin-receptor blockers, and correlated positively with moderate alcohol consumption. Unexpectedly, a positive relation between EPC number and several vascular risk factors emerged. In a step forward multivariate linear regression analysis EPC number was independently related with SDF1alpha, MMP-9, triglycerides, alcohol consumption, and Hba1c. EPC-CFU in turn was related to SDF1alpha and diastolic blood pressure. Moreover, EPC number showed a significant positive association with the Framingham risk score (P = 0.001). Finally, there was an inverse association between EPC number and common carotid artery intima-media thickness (p = 0.02) and the carotid artery atherosclerosis score (p = 0.059).Our population-based data confirm the decline of EPC number with advancing age and lend first epidemiological support to a role of SDF-1alpha and MMP9 in EPC differentiation, mobilization and homing, but are conflict with the view that EPC number is unfavorably affected by cardiovascular risk factors. EPC number increases with the cardiovascular risk estimated by the Framingham risk score (FRS), which in the absence of similar changes for EPC-CFU. Finally, we demonstrate a significant inverse association between EPC number and extent of carotid atherosclerosis even though this association was only of moderate strength and not entirely consistent in other vascular territories

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements