34 research outputs found

    Ten principles of heterochromatin formation and function

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    Multi-messenger observations of a binary neutron star merger

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    On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

    A novel technique for extracting parametric models from MEM resonator test data

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    This paper reports an innovative test and modeling procedure that is well-suited to high-Q resonators and overcomes several shortcomings of FFT-based approaches. The novel technique uses excitation-response data to generate parametric resonator models in the time-domain. The models possess the following advantages: immunity to parasitic coupling, a spectral resolution that is not limited by record length, and the ability to clearly distinguish nearly degenerate and degenerate modes by using multi-input, multi-output data sets. The parametrization readily yields transfer functions, natural frequencies, time constants and insight into mode shapes. © 2014 IEEE

    A subdivision approach to the solution of polynomial constraints over finite domains using the modified Bernstein form

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    This paper discusses an algorithm to solve polynomial constraints over finite domains, namely constraints which are expressed in terms of equalities, inequalities and disequalities of polynomials with integer coefficients whose variables are associated with finite domains. The proposed algorithm starts with a preliminary step intended to rewrite all constraints to a canonical form. Then, the modified Bernstein form of obtained polynomials is used to recursively restrict the domains of variables, which are assumed to be initially approximated by a bounding box. The proposed algorithm proceeds by subdivisions, and it ensures that each variable is eventually associated with the inclusion maximal finite domain in which the set of constraints is satisfiable. If arbitrary precision integer arithmetic is available, no approximation is introduced in the solving process because the coefficients of the modified Bernstein form are integer numbers

    Targeting protein tyrosine phosphatase σ after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias

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    Millions of people suffer a myocardial infarction (MI) every year, and those who survive have increased risk of arrhythmias and sudden cardiac death. Recent clinical studies have identified sympathetic denervation as a predictor of increased arrhythmia susceptibility. Chondroitin sulfate proteoglycans present in the cardiac scar after MI prevent sympathetic reinnervation by binding the neuronal protein tyrosine phosphatase receptor σ (PTPσ). Here we show that the absence of PTPσ, or pharmacologic modulation of PTPσ by the novel intracellular sigma peptide (ISP) beginning 3 days after injury, restores sympathetic innervation to the scar and markedly reduces arrhythmia susceptibility. Using optical mapping we observe increased dispersion of action potential duration, supersensitivity to β-adrenergic receptor stimulation and Ca(2+) mishandling following MI. Sympathetic reinnervation prevents these changes and renders hearts remarkably resistant to induced arrhythmias

    Research of CO 2 and N 2 Adsorption Behavior in K-Illite Slit Pores by GCMC Method

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    Understanding the adsorption mechanisms of CO2 and N2 in illite, one of the main components of clay in shale, is important to improve the precision of the shale gas exploration and development. We investigated the adsorption mechanisms of CO2 and N2 in K-illite with varying pore sizes at the temperature of 333, 363 and 393 K over a broad range of pressures up to 30 MPa using the grand canonical Monte Carlo (GCMC) simulation method. The simulation system is proved to be reasonable and suitable through the discussion of the impact of cation dynamics and pore wall thickness. The simulation results of the excess adsorption amount, expressed per unit surface area of illite, is in general consistency with published experimental results. It is found that the sorption potential overlaps in micropores, leading to a decreasing excess adsorption amount with the increase of pore size at low pressure, and a reverse trend at high pressure. The excess adsorption amount increases with increasing pressure to a maximum and then decreases with further increase in the pressure, and the decreasing amount is found to increase with the increasing pore size. For pores with size greater larger thaN2 nm, the overlap effect disappears
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