1,223 research outputs found
Essential Functions of the Histone Demethylase Lid
- Author
- A Lagarou
- AG Scibetta
- Asifa Akhtar
- BE Bernstein
- BE Bernstein
- Christina Greer
- D Pasini
- E Guccione
- EL Greer
- G Li
- GG Wang
- H Santos-Rosa
- HH Kavi
- J Christensen
- J Jung
- J Secombe
- JC Eissenberg
- JC Peng
- JJ Gildea
- Julie Secombe
- K Yamane
- L Di Stefano
- LA Johnston
- Ling Li
- LWM Loo
- M Lloret-Llinares
- M Tahiliani
- N Lee
- N Lee
- N Lopez-Bigas
- PV Pena
- R Aasland
- R Liefke
- R Schneider
- RD Kortschak
- RJ Klose
- Robert N. Eisenman
- S Hayami
- S Iwase
- S Zaffran
- SD Taverna
- SJ Tu
- SN Radyuk
- T Rudolph
- XB Shi
- Y Tanaka
- Y Xiang
- YM Moshkin
- ZZ Chen
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Drosophila Little imaginal discs (Lid) is a recently described member of the JmjC domain class of histone demethylases that specifically targets trimethylated histone H3 lysine 4 (H3K4me3). To understand its biological function, we have utilized a series of Lid deletions and point mutations to assess the role that each domain plays in histone demethylation, in animal viability, and in cell growth mediated by the transcription factor dMyc. Strikingly, we find that lid mutants are rescued to adulthood by either wildtype or enzymatically inactive Lid expressed under the control of its endogenous promoter, demonstrating that Lid's demethylase activity is not essential for development. In contrast, ubiquitous expression of UAS-Lid transgenes lacking its JmjN, C-terminal PHD domain, and C5HC2 zinc finger were unable to rescue lid homozygous mutants, indicating that these domains carry out Lid's essential developmental functions. Although Lid-dependent demethylase activity is not essential, dynamic removal of H3K4me3 may still be an important component of development, as we have observed a genetic interaction between lid and another H3K4me3 demethylase, dKDM2. We also show that Lid's essential C-terminal PHD finger binds specifically to di- and trimethylated H3K4 and that this activity is required for Lid to function in dMyc-induced cell growth. Taken together, our findings highlight the importance of Lid function in the regulated removal and recognition of H3K4me3 during development
A Sodium Leak Current Regulates Pacemaker Activity of Adult Central Pattern Generator Neurons in Lymnaea Stagnalis
- Author
- A Reynolds
- AK Tryba
- AL Hodgkin
- B Lu
- B Lu
- B Lu
- BD Bennett
- BE Taylor
- CA Del Negro
- CH Guo
- CS Chan
- E Yeh
- ER Kandel
- F Pena
- G Fei
- GE Spencer
- H Koizumi
- H Onimaru
- HA Nash
- IM Raman
- J Wolfart
- J Zheng
- JC Smith
- JD Jones
- JD Spafford
- JH Lee
- JL Feldman
- JN MacLean
- K Hui
- K Staras
- L Forti
- LA Swayne
- M Jospin
- M Puopolo
- M Thoby-Brisson
- MT Do
- MT van Diepen
- MW Pfaffl
- NE Hallworth
- NI Syed
- NI Syed
- PS Dickinson
- RD Keynes
- RM Harris-Warrick
- S Tazerart
- SA Korneev
- ST Sipila
- TM van den
- Tom Z. Lu
- TZ Lu
- Vladimir Brezina
- W Winlow
- X Coumoul
- Zhong-Ping Feng
- ZP Feng
- ZP Feng
- Publication venue
- Public Library of Science
- Publication date
- 19/04/2011
- Field of study
The resting membrane potential of the pacemaker neurons is one of the essential
mechanisms underlying rhythm generation. In this study, we described the
biophysical properties of an uncharacterized channel (U-type channel) and
investigated the role of the channel in the rhythmic activity of a respiratory
pacemaker neuron and the respiratory behaviour in adult freshwater snail
Lymnaea stagnalis. Our results show that the channel
conducts an inward leak current carried by Na+
(ILeak-Na). The ILeak-Na contributed to the resting
membrane potential and was required for maintaining rhythmic action potential
bursting activity of the identified pacemaker RPeD1 neurons. Partial knockdown
of the U-type channel suppressed the aerial respiratory behaviour of the adult
snail in vivo. These findings identified the
Na+ leak conductance via the U-type channel, likely a
NALCN-like channel, as one of the fundamental mechanisms regulating rhythm
activity of pacemaker neurons and respiratory behaviour in adult animals
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
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- Amelung C
- Amidei D
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- Angelidakis S
- Angerami A
- Anisenkov A
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Nutrição mineral do mangarito num Latossolo Vermelho Amarelo
- Author
- AGUIAR APA.
- ANJOS JT
- ARAÚJO RC.
- Candido A da Costa
- CARNEIRO JGA.
- CHAMINADE R.
- COURSEY DG.
- Daniel S Alves
- DECHEN AR
- ENY BAC.
- Ernane Ronie Martins
- ERNANI PR
- FERNANDES LA
- GODDARD RE
- GOMES JM
- GOMES MAF.
- GRAHAM RD.
- HARIDASAN M.
- JORDAN FL.
- JUNQUEIRA AH
- KLEIN VL
- LOPES AS.
- Luiz Arnaldo Fernandes
- MALAVOLTA E
- MALAVOLTA E.
- MALAVOLTA E.
- MALAVOLTA E.
- MARSCHNER H.
- MELO JW
- MENGEL K
- PENA RS.
- RAIJ BV.
- Regynaldo A Sampaio
- SCHELLER E.
- Sílvio Junio Ramos
- TAIZ L
- VASCONCELOS EFC.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at root s = 8 TeV with the ATLAS detector (vol 75, 299, 2015)
- Author
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- Abbott B
- Abdallah J
- Abdinov O
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- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
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- Castanheira MTD
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- Castillo IS
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- Cattai A
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- Chelkov GA
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- Chernyatin V
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- Chilingarov A
- Chiodini G
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- Zanzi D
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- Zemla A
- Zengel K
- Zenin O
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- Zhemchugov A
- Zhong J
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- Zhu CG
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- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zinonos Z
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- Zivkovic L
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √s=8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT>120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between EmissT>150 GeV and EmissT>700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presented
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at root s = 8 TeV with the ATLAS detector (vol 75, 299, 2015)
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Aloisio A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Anatomy of the sign-problem in heavy-dense QCD
- Author
- Adam E Romero
- Aranda C Padilla
- Arjanovic MM
- Armadans R Caminal
- Astigarraga ME Pozo
- Barajas CA Chavez
- Bechtle P
- Beck HP
- Becker K
- Becker M
- Beckingham M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behr JK
- Belanger-Champagne C
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- Bellerive A
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- Beltramello O
- Belyaev NL
- Benary O
- Benchekroun D
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- Benitez J
- Benjamin DP
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
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- Berger N
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- Beringer J
- Berlendis S
- Berlingen J Montejo
- Bernard NR
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- Zhemchugov A
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- Zimine NI
- Zimmermann C
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- Zobernig G
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- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
QCD at finite densities of heavy quarks is investigated
using the density-of-states method. The phase factor
expectation value of the quark determinant is calculated to
unprecedented precision as a function of the chemical potential.
Results are validated using those from a reweighting
approach where the latter can produce a significant signalto-noise
ratio. We confirm the particle–hole symmetry at low
temperatures, find a strong sign problem at intermediate values
of the chemical potential, and an inverse Silver Blaze
feature for chemical potentials close to the onset value: here,
the phase-quenched theory underestimates the density of the
full theory
Reconstruction of hadronic decay products of tau leptons with the ATLAS experiment
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Affolder AA
- Agatonovic-Jovin T
- Agricola J
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TP
- Akimov AV
- Alberghi GL
- Alberich LC
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Alkire SP
- Allbrooke BMM
- Allport PP
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- Amadio BT
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- Chelkov GA
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- Zhao Z
- Zhemchugov A
- Zhong J
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- Zhu CG
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- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2016
- Field of study
This paper presents a new method of reconstructing the individual charged and neutral hadrons in tau decays with the ATLAS detector. The reconstructed hadrons are used to classify the decay mode and to calculate the visible four-momentum of reconstructed tau candidates, significantly improving the resolution with respect to the calibration in the existing tau reconstruction. The performance of the reconstruction algorithm is optimised and evaluated using simulation and validated using samples of Z→ττ and Z(→μμ)+jets events selected from proton–proton collisions at a centre-of-mass energy √s=8TeV, corresponding to an integrated luminosity of 5 fb−1.- We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, the Canada Council, CANARIE, CRC, Compute Canada, FQRNT, and the Ontario Innovation Trust, Canada; EPLANET, ERC, FP7, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex and Idex, ANR, Region Auvergne and Fondation Partager le Savoir, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF; BSF, GIF and Minerva, Israel; BRF, Norway; the Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN and the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA) and in th
Measurement of the transverse polarization of Λ and Λ¯ hyperons produced in proton-proton collisions at √s=7 TeV using the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexa C
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- Zurzolo G
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/12/2014
- Field of study
The transverse polarization of Λ and Λ¯ hyperons produced in proton-proton collisions at a center-of-mass energy of 7 TeV is measured. The analysis uses 760 μb−1 of minimum bias data collected by the ATLAS detector at the LHC in the year 2010. The measured transverse polarization averaged over Feynman xF from 5×10−5 to 0.01 and transverse momentum pT from 0.8 to 15 GeV is −0.010±0.005(stat)±0.004(syst) for Λ and 0.002±0.006(stat)±0.004(syst) for Λ¯. It is also measured as a function of xF and pT, but no significant dependence on these variables is observed. Prior to this measurement, the polarization was measured at fixed-target experiments with center-of-mass energies up to about 40 GeV. The ATLAS results are compatible with the extrapolation of a fit from previous measurements to the xF range covered by this measurement
Search for anomalous couplings in the W tb vertex from the measurement of double differential angular decay rates of single top quarks produced in the t-channel with the ATLAS detector
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/10/2015
- Field of study
The electroweak production and subsequent decay of single top quarks is determined by the properties of the Wtb vertex. This vertex can be described by the complex parameters of an effective Lagrangian. An analysis of angular distributions of the decay products of single top quarks produced in the t -channel constrains these parameters simultaneously. The analysis described in this paper uses 4.6 fb−1 of proton-proton collision data at √s =7 TeV collected with the ATLAS detector at the LHC. Two parameters are measured simultaneously in this analysis. The fraction f 1 of decays containing transversely polarised W bosons is measured to be 0.37 ± 0.07 (stat.⊕syst.). The phase δ − between amplitudes for transversely and longitudinally polarised W bosons recoiling against left-handed b-quarks is measured to be −0.014π ± 0.036π (stat.⊕syst.). The correlation in the measurement of these parameters is 0.15. These values result in two-dimensional limits at the 95% confidence level on the ratio of the complex coupling parameters g R and V L, yielding Re[g R /V L] ∈ [−0.36, 0.10] and Im[g R /V L] ∈ [−0.17, 0.23] with a correlation of 0.11. The results are in good agreement with the predictions of the Standard Model
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