Ontwikkeling methodologie voor berekening broeikasgaseffecten binnen tuinbouwketens : eindrapport fase II

Dit is het eindrapport van fase II van het project 'Ontwikkeling methodologie voor het berekenen van broeikasgaseffecten binnen tuinbouwketens.' Het primaire doel van het project is een systematiek en (demo) tool te ontwikkelen waarmee de Nederlandse teeltsector en handel van tuinbouwproducten broeikasgasemissiescores kunnen berekenen die geschikt zijn voor communicatie met Nederlandse en buitenlandse retail en via de retail naar de consument. Een belangrijke aanleiding voor het ontstaan van dit project is de groeiende druk vanuit de Britse supermarkt sector om van toeleveranciers te eisen dat ze verantwoording af leggen over hun bijdrage aan het mondiaal broeikaseffect

Management of penetrating injuries of the upper extremities

Background: Routine surgical exploration after penetrating upper extremity trauma (PUET) to exclude arterial injury leads to a large number of negative explorations and iatrogenic injuries. Selective non-operative mana

DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway

The DNA damage response (DDR), comprising distinct repair and signalling pathways, safeguards genomic integrity. Protein ubiquitylation is an important regulatory mechanism of the DDR. To study its role in the UV-induced DDR, we characterized changes in protein ubiquitylation following DNA damage using quantitative di-Gly proteomics. Interestingly, we identified multiple sites of histone H1 that are ubiquitylated upon UV-damage. We show that UV-dependent histone H1 ubiquitylation at multiple lysines is mediated by the E3-ligase HUWE1. Recently, it was shown that poly-ubiquitylated histone H1 is an important signalling intermediate in the double strand break response. This poly-ubiquitylation is dependent on RNF8 and Ubc13 which extend pre-existi

Sustainable vegetable chain development in Brazil: Grape tomatoes from Holambra to the higher market segment

Holambra (Brazilie) is een groot tuinbouwcluster nabij Sao Paolo. Het cluster is traditioneel op sierteelt gericht. Een aantal telers zijn gaan experimenteren met bedekte groenteteelt om zo het gebruik van gewasbeschermingsmiddelen te kunnen reduceren en voor een hoger marktsegment te kunnen telen. Wageningen UR kon deze ondernemers helpen bij het verbeteren van hun teeltsystemen door een systematische check op het wortelmilieu, de voedingshuishouding en het teeltklimaat. Daarbij zijn de knelpunten in de supply-chain in kaart gebracht. Op basis van deze analyse konden ondernemers keuzes maken voor investeringen in gerichte verbetering van deze supply chain. Het project is vervolgens aanjager geweest in het gebied voor verdere samenwerking tussen tuinders op R&D en kwaliteitsmanagement. Holambra (Brasil) has a large horticultural cluster for flowers and ornamentals. However, only few growers use protected cultivation for vegetable productions. This study analysed the market and market chain relationships for vegetables in the Sao Paolo region as well as the technology used for cultivation. With the rising middle class the demand for quality vegetables with high food safety standards is rising strongly. The growers supplying this market niche are aware of these quality demands and are able to deliver according to them. The growers had been developing their production systems individually, but were aware of the advantage in closer cooperation on R&D as well as improving supply chain quality (cooled chains). The technological developments were needed in areas of climate control and water and nutrition steering. During the project growers were given tools to improve their systems as well as identify the crucial factors for quality control in the supply chain. The study was conducted by LEI and Wageningen UR Greenhouse Horticultur

Impact of ongoing centralization of acute stroke care from "drip and ship" into "direct-to-mothership" model in a Dutch urban area

When acute stroke care is organised using a "drip-and-ship" model, patients receive immediate treatment at the nearest primary stroke centre followed by transfer to a comprehensive stroke centre (CSC). When stroke care is further centralised into the "direct-to-mothership" model, patients with stroke symptoms are immediately brought to a CSC to further reduce treatment times and enhance stroke outcomes. We investigated the effects of the ongoing centralization in a Dutch urban setting on treatment times of patients with confirmed ischemic stroke in a 4-year period. Next, in a non-randomized controlled trial, we assessed treatment times of patients with suspected ischemic stroke, and treatment times of patients with neurologic disorders other than suspected ischemic stroke, before and after the intervention in the CSC and the decentralized hospitals, the intervention being the change from "drip and ship" into "direct-to-mothership". Our findings provide support for the ongoing centralization of acute stroke care in urban areas. Treatment times for patients with ischemic stroke decreased significantly, potentially improving functional outcomes. Improvements in treatment times for patients with suspected ischemic stroke were achieved without negative side effects for self-referrals with stroke symptoms and patients with other neurological disorders. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )Paroxysmal Cerebral Disorder

Correlations between the peak flux density and the position angle of inner-jet in three blazars

We aim to investigate the relation between the long-term flux density and the position angle (PA) evolution of inner-jet in blazars. We have carried out the elliptic Gaussian model-fit to the `core' of 50 blazars from 15 GHz VLBA data, and analyzed the variability properties of three blazars from the model-fit results. Diverse correlations between the long-term peak flux density and the PA evolution of the major axis of the `core' have been found in $\sim$ 20% of the 50 sources. Of them, three typical blazars have been analyzed, which also show quasi-periodic flux variations of a few years (T). The correlation between the peak flux density and the PA of inner-jet is positive for S5~0716+714, and negative for S4~1807+698. The two sources cannot be explained with the ballistic jet models, the non-ballistic models have been analyzed to explain the two sub-luminal blazars. A correlation between the peak flux density and the PA (with a T/4 time lag) of inner-jet is found in [HB89]~1823+568, this correlation can be explained with a ballistic precession jet model. All the explanations are based mainly on the geometric beaming effect; physical flux density variations from the jet base would be considered for more complicated situations in future, which could account for the no or less significance of the correlation between the peak flux density and the PA of inner-jet in the majority blazars of our sample.Comment: 6 pages, 7 figures, accepted for publication in Astrophysics and Space Scienc

Prospective analysis of circulating metabolites and endometrial cancer risk

Background: Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: A total of 129 metabolites (acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexoses, and sphingolipids) were measured by liquid chromatography-mass spectrometry. Conditional logistic regression estimated the associations of metabolites with endometrial cancer risk. An analysis focusing on clusters of metabolites using the bootstrap lasso method was also employed. Results: After adjustment for body mass index, sphingomyelin [SM] C18:0 was positively (OR1SD: 1.18, 95% CI: 1.05-1.33), and glycine, serine, and free carnitine (C0) were inversely (OR1SD: 0.89, 95% CI: 0.80-0.99; OR1SD: 0.89, 95% CI: 0.79-1.00 and OR1SD: 0.91, 95% CI: 0.81-1.00, respectively) associated with endometrial cancer risk. Serine, C0 and two sphingomyelins were selected by the lasso method in >90% of the bootstrap samples. The ratio of esterified to free carnitine (OR1SD: 1.14, 95% CI: 1.02-1.28) and that of short chain to free acylcarnitines (OR1SD: 1.12, 95% CI: 1.00-1.25) were positively associated with endometrial cancer risk. Further adjustment for C-peptide or other endometrial cancer risk factors only minimally altered the results. Conclusion: These findings suggest that variation in levels of glycine, serine, SM C18:0 and free carnitine may represent specific pathways linked to endometrial cancer development. If causal, these pathways may offer novel targets for endometrial cancer prevention

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio

Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS

The chi_b(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb^-1, these states are reconstructed through their radiative decays to Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes. This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table, corrected author list, matches final version in Physical Review Letter

Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS

We present the results of a search for new, heavy particles that decay at a significant distance from their production point into a final state containing charged hadrons in association with a high-momentum muon. The search is conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS detector operating at the Large Hadron Collider. Production of such particles is expected in various scenarios of physics beyond the standard model. We observe no signal and place limits on the production cross-section of supersymmetric particles in an R-parity-violating scenario as a function of the neutralino lifetime. Limits are presented for different squark and neutralino masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final version to appear in Physics Letters