52 research outputs found
A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
- Author
- A Alape-Girón
- A Alape-Girón
- A Goldbeter
- A Kauskot
- A Mariano-Oliveira
- A Ménez
- AA Valério
- AF Vitorino-Cardoso
- AK Tashima
- AM Brown
- AM Moura-da-Silva
- AM Moura-da-Silva
- AM Moura-da-Silva
- AP Guércio
- ATC Ching
- B Zhang
- BG Fry
- BG Fry
- C Baudet
- C Correa-Netto
- C Gomez
- C Montecucco
- C Teixeira
- CC Gay
- CC Gay
- CF Teixeira
- CM Kerchove
- CM Kerchove
- D Georgieva
- D Kordis
- D Kordis
- DA Warrell
- DAP Cidade
- DF Cardoso
- DH Souza
- E Fantini
- E Gasparello-Clemente
- E Kochva
- ES Arnér
- ES Arnér
- F Fonseca
- FA Bauab
- FM Pinho
- FOS França
- G Kreil
- GL Zaganelli
- GP Queiroz
- Gustavo GL Costa
- GW Birrell
- H Purtscher
- HC Castro
- HE Nisenbom
- HE Nisenbom
- HE Nisenbom
- HS Selistre-de-Araujo
- IL Junqueira-de-Azevedo
- IL Junqueira-de-Azevedo
- ILM Junqueira-de-Azevedo
- ILM Junqueira-de-Azevedo
- IMB Francischetti
- J Boldrini-França
- J Jurka
- J Pawlak
- J Pawlak
- J Tang
- JA Campbell
- JC Cogo
- JD Thompson
- JG Soto
- JJ Calvete
- JJ Calvete
- JL Durigan
- JM Gutiérrez
- JM Gutiérrez
- JM Gutiérrez
- JM Gutiérrez
- JM Gutiérrez
- JM Gutiérrez
- JM Gutiérrez
- JM Nascimento
- JP Zuliani
- JW Fox
- JW Fox
- JW Fox
- Kiara C Cardoso
- KL Jeffrey
- L Menin
- L Qinghua
- L Sanz
- L Sanz
- L St. Pierre
- L St. Pierre
- LA Ponce-Soto
- LA Ponce-Soto
- LA Ribeiro
- LD Possani
- LI Leão
- Luiz Eduardo V Del Bem
- M Ashburner
- M Gallacci
- M Neiva
- M Ohno
- M Pessatti
- M Öhler
- Marcelo Menossi
- MB Smolka
- ME Peichoto
- MI Estevão-Costa
- Ministerio de Salud
- MR Cominetti
- MR Cominetti
- MR Soares
- Márcio J Da Silva
- N Murayama
- N Yamanouye
- N Yamanouye
- NR Casewell
- OH Ramos
- OH Ramos
- P Escoubas
- P Green
- P Rice
- PBV Sales
- R Apweiler
- RA Borgheresi
- Ramon O Vidal
- RB Zingali
- RG Stábeli
- RH Valente
- RM Ruiz de Torrent
- S Higuchi
- S Kashima
- S Pahari
- SC Wagstaff
- SC Wagstaff
- SD Aird
- SD Aird
- SF Altschul
- SH Andrião-Escarso
- SH Andrião-Escarso
- SH Ferreira
- SM Carneiro
- SM Serrano
- SR Zamunér
- Stephen Hyslop
- Tatiana T Torres
- V Arocas
- V Núñez
- VA Lee
- X Huang
- XY Du
- Y Angulo
- Y Jia
- Y Ogawa
- Y Ogawa
- Y Ogawa
- YF Pung
- YF Pung
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
<p>Abstract</p> <p>Background</p> <p>The genus <it>Bothrops </it>is widespread throughout Central and South America and is the principal cause of snakebite in these regions. Transcriptomic and proteomic studies have examined the venom composition of several species in this genus, but many others remain to be studied. In this work, we used a transcriptomic approach to examine the venom gland genes of <it>Bothrops alternatus</it>, a clinically important species found in southeastern and southern Brazil, Uruguay, northern Argentina and eastern Paraguay.</p> <p>Results</p> <p>A cDNA library of 5,350 expressed sequence tags (ESTs) was produced and assembled into 838 contigs and 4512 singletons. BLAST searches of relevant databases showed 30% hits and 70% no-hits, with toxin-related transcripts accounting for 23% and 78% of the total transcripts and hits, respectively. Gene ontology analysis identified non-toxin genes related to general metabolism, transcription and translation, processing and sorting, (polypeptide) degradation, structural functions and cell regulation. The major groups of toxin transcripts identified were metalloproteinases (81%), bradykinin-potentiating peptides/C-type natriuretic peptides (8.8%), phospholipases A<sub>2 </sub>(5.6%), serine proteinases (1.9%) and C-type lectins (1.5%). Metalloproteinases were almost exclusively type PIII proteins, with few type PII and no type PI proteins. Phospholipases A<sub>2 </sub>were essentially acidic; no basic PLA<sub>2 </sub>were detected. Minor toxin transcripts were related to L-amino acid oxidase, cysteine-rich secretory proteins, dipeptidylpeptidase IV, hyaluronidase, three-finger toxins and ohanin. Two non-toxic proteins, thioredoxin and double-specificity phosphatase Dusp6, showed high sequence identity to similar proteins from other snakes. In addition to the above features, single-nucleotide polymorphisms, microsatellites, transposable elements and inverted repeats that could contribute to toxin diversity were observed.</p> <p>Conclusions</p> <p><it>Bothrops alternatus </it>venom gland contains the major toxin classes described for other <it>Bothrops </it>venoms based on trancriptomic and proteomic studies. The predominance of type PIII metalloproteinases agrees with the well-known hemorrhagic activity of this venom, whereas the lower content of serine proteases and C-type lectins could contribute to less marked coagulopathy following envenoming by this species. The lack of basic PLA<sub>2 </sub>agrees with the lower myotoxicity of this venom compared to other <it>Bothrops </it>species with these toxins. Together, these results contribute to our understanding of the physiopathology of envenoming by this species.</p
A emergência dos "remanescentes": notas para o diálogo entre indígenas e quilombolas
- Author
- AHMAD Aijaz
- ANDERSON Benedict
- ARRUTI José Maurício Andion
- ARRUTI José Maurício Andion
- ARRUTI José Maurício Andion
- ASSUNÇÃO Luiz C.
- BAIOCCHI Mari de N.
- BANDEIRA Maria de Lourdes
- BANTON Michael
- BARRETO FILHO Hênio T.
- BARTH Fredrik
- BATISTA Mércia
- BENJAMIN Walter
- BOURDIEU Pierre
- BRANDÃO C. R.
- CARDOSO DE OLIVEIRA Roberto
- CARDOSO DE OLIVEIRA Roberto
- CARNEIRO DA CUNHA Manuela
- CARNEIRO DA CUNHA Manuela
- CARVALHO José J. de
- CARVALHO Maria Rosário
- COHEN Abner
- DANTAS Beatriz Góes
- DANTAS Beatriz Góes
- DESPRES Leo A.
- FORTES M
- FREEDMAN Maurice
- GALATY John G.
- GALLAGHER Joseph T
- GOMES Flávio dosSantos
- GRUNEWALD Rodrigo
- GUSMÃO Neusa M. M.
- HOBSBAWM Eric
- José Maurício Andion Arruti
- KEYES Charles
- MARTINS Silvia
- MONTEIRO Anita M. Q.
- MONTEIRO John
- OLIVEIRA Claudia Menezes Paes de
- OLIVEIRA FILHO João Pacheco de
- OLIVEIRA FILHO João Pacheco de
- PERES Sidney C.
- QUEIROZ Renato
- REIS João José
- RIBEIRO Darcy
- SADER Eder
- SAID Edward W
- SIDER Gerald M.
- SILVA Dimas S. da
- SILVA Orlando S.
- SOARES L. E.
- SOUZA V. F.
- STOLCKE Verena
- TELLES M. O. da C.
- VALLE Carlos Guilherme do
- VOGT Carlos
- VOGT Carlos
- VOGT Carlos
- VOGT Carlos
- VOGT Carlos
- WEBER Max
- WOLF Eric
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Consistent patterns of common species across tropical tree communities
- Author
- Adu-Bredu Stephen
- Affum-Baffoe Kofi
- Ahuite Reategui Manuel Augusto
- Aiba Shin-Ichiro
- Albuquerque Bianca Weiss
- Alonso Alfonso
- Amani Christian A.
- Andrade Ana
- Angoboy Ilondea B.
- Araujo-Murakami Alejandro
- Arboleda Nicolás Castaño
- Arroyo Luzmila
- Ashton Peter
- Aymard C Gerardo A.
- Baider Cláudia
- Baker Timothy R.
- Balinga Michael Philippe Bessike
- Balslev Henrik
- Banin Lindsay F.
- Baraloto Chris
- Barbier Nicolas
- Barbosa Edelcilio Marques
- Barbosa Flávia Rodrigues
- Barlow Jos
- Bastin Jean-Francois
- Beeckman Hans
- Begne Serge
- Bengone Natacha Nssi
- Berenguer Erika
- Berry Nicholas
- Bitariho Robert
- Boeckx Pascal
- Bogaert Jan
- Bonyoma Bernard
- Boundja Patrick
- Bourland Nils
- Boyemba Bosela Faustin
- Brambach Fabian
- Brienen Roel
- Burslem David F. R. P.
- Bánki Olaf S.
- Camargo José Luís
- Campelo Wegliane
- Cano Angela
- Carrero Márquez Yrma Andreina
- Carvalho Fernanda Antunes
- Casas Luisa Fernanda
- Castellanos Hernán
- Castilho Carolina V.
- Cerón Carlos
- Chapman Colin A.
- Chave Jerome
- Chhang Phourin
- Chutipong Wanlop
- Chuyong George B.
- Cintra Bruno Barçante Ladvocat
- Clark Connie J.
- Coelho de Souza Fernanda
- Comiskey James A.
- Coomes David A.
- Cooper Declan L. M.
- Cornejo Valverde Fernando
- Correa Diego F.
- Costa Flávia R. C.
- Costa Janaina Barbosa Pedrosa
- Couteron Pierre
- Culmsee Heike
- Cuni-Sanchez Aida
- Cárdenas López Dairon
- Cárdenas Sasha
- da Silva Guimarães José Renan
- Dallmeier Francisco
- Damasco Gabriel
- Dauby Gilles
- de Aguiar Daniel P. P.
- De Alban Jose Don T.
- de Almeida Matos Francisca Dionízia
- de Andrade Miranda Ires Paula
- de Assis Rafael L.
- De Canniere Charles
- De Haulleville Thales
- de Jesus Veiga Carim Marcelo
- de Medeiros Marcelo Brilhante
- de Oliveira Edmar Almeida
- de Queiroz Helder Lima
- de Sousa Farias Emanuelle
- de Souza Coelho Luiz
- de Sá Carpanedo Rainiellen
- de Toledo José Julio
- Demarchi Layon O.
- Dexter Kyle G.
- Di Fiore Anthony
- Din Hazimah Haji Mohammad
- Disney Mathias I.
- Djiofack Brice Yannick
- Djuikouo Marie-Noël K.
- do Amaral Dário Dantas
- do Amaral Iêda Leão
- Do Tran Van
- Doucet Jean-Louis
- Draper Freddie C.
- Droissart Vincent
- Duivenvoorden Joost F.
- Dávila Doza Hilda Paulette
- Dávila Nállarett
- Engel Julien
- Estienne Vittoria
- Ewango Corneille E. N.
- Farfan-Rios William
- Fauset Sophie
- Feeley Kenneth J.
- Feitosa Yuri Oliveira
- Feldpausch Ted R.
- Ferreira Cid
- Ferreira Joice
- Ferreira Leandro Valle
- Fletcher Christine D.
- Flores Bernardo Monteiro
- Fofanah Alusine
- Foli Ernest G.
- Fonty Émile
- Fredriksson Gabriella M.
- Fuentes Alfredo
- Galbraith David
- Gallardo Gonzales George Pepe
- Garcia-Cabrera Karina
- García-Villacorta Roosevelt
- Gomes Vitor H. F.
- Gonzales Therany
- Gribel Rogerio
- Guedes Marcelino Carneiro
- Guevara Juan Ernesto
- Gómez Ricardo Zárate
- Hakeem Khalid Rehman
- Hall Jefferson S.
- Hamer Keith C.
- Hamilton Alan C.
- Harris David J.
- Harrison Rhett D.
- Hart Terese B.
- Hector Andy
- Henkel Terry W.
- Herbohn John
- Hockemba Mireille B. N.
- Hoffman Bruce
- Holmgren Milena
- Honorio Coronado Euridice N.
- Huamantupa-Chuquimaco Isau
- Hubau Wannes
- Imai Nobuo
- Irume Mariana Victória
- Jansen Patrick A.
- Jeffery Kathryn J.
- Jimenez Eliana M.
- Jucker Tommaso
- Junqueira André Braga
- Kalamandeen Michelle
- Kamdem Narcisse G.
- Kartawinata Kuswata
- Kasongo Yakusu Emmanuel
- Katembo John M.
- Kearsley Elizabeth
- Kenfack David
- Kessler Michael
- Khaing Thiri Toe
- Killeen Timothy J.
- Kitayama Kanehiro
- Klitgaard Bente
- Labrière Nicolas
- Laumonier Yves
- Laurance Susan G. W.
- Laurance William F.
- Laurent Félix
- Le Tinh Cong
- Le Trai Trong
- Leal Miguel E.
- Levesley Aurora
- Lewis Simon L.
- Leão de Moraes Novo Evlyn Márcia
- Libalah Moses B.
- Licona Juan Carlos
- Lima Filho Diógenes de Andrade
- Lindsell Jeremy A.
- Lopes Aline
- Lopes Maria Aparecida
- Lovett Jon C.
- Lowe Richard
- Lozada José Rafael
- Lu Xinghui
- Luambua Nestor K.
- Luize Bruno Garcia
- Maas Paul
- Magalhães José Leonardo Lima
- Magnusson William E.
- Mahayani Ni Putu Diana
- Makana Jean-Remy
- Malhi Yadvinder
- Maniguaje Rincón Lorena
- Mansor Asyraf
- Manzatto Angelo Gilberto
- Marimon Beatriz S.
- Marimon-Junior Ben Hur
- Marshall Andrew R
- Martins Maria Pires
- Mbayu Faustin M.
- Mesones Italo
- Metali Faizah
- Mihindou Vianet
- Millet Jerome
- Milliken William
- Mogollón Hugo F.
- Mohd. Said Mohd. Nizam
- Molino Jean-François
- Monteagudo Mendoza Abel
- Montero Juan Carlos
- Moore Sam
- Mostacedo Bonifacio
- Mozombite Pinto Linder Felipe
- Mukul Sharif Ahmed
- Munishi Pantaleo K. T.
- Nagamasu Hidetoshi
- Nascimento Henrique Eduardo Mendonça
- Nascimento Marcelo Trindade
- Neill David
- Nilus Reuben
- Noronha Janaína Costa
- Nsenga Laurent
- Núñez Vargas Percy
- Ojo Lucas
- Oliveira Alexandre A.
- Ondo Fidèle Evouna
- Palacios Cuenca Walter
- Pansini Susamar
- Pansonato Marcelo Petratti
- Paredes Marcos Ríos
- Paudel Ekananda
- Pauletto Daniela
- Pearson Richard G.
- Pena José Luis Marcelo
- Pennington R. Toby
- Peres Carlos A.
- Permana Andrea
- Petronelli Pascal
- Peñuela Mora Maria Cristina
- Phillips Juan Fernando
- Phillips Oliver L.
- Pickavance Georgia
- Piedade Maria Teresa Fernandez
- Pitman Nigel C. A.
- Ploton Pierre
- Popelier Andreas
- Poulsen John R.
- Prado Paulo I.
- Prieto Adriana
- Primack Richard B.
- Priyadi Hari
- Qie Lan
- Quaresma Adriano Costa
- Ramirez-Angulo Hirma
- Ramos José Ferreira
- Reis Neidiane Farias Costa
- Reitsma Jan
- Revilla Juan David Cardenas
- Riutta Terhi
- Rivas-Torres Gonzalo
- Robiansyah Iyan
- Rocha Maira
- Rodrigues Domingos de Jesus
- Rodriguez-Ronderos M. Elizabeth
- Rovero Francesco
- Rozak Andes H.
- Rudas Agustín
- Rutishauser Ervan
- Sabatier Daniel
- Sagang Le Bienfaiteur
- Sampaio Adeilza Felipe
- Samsoedin Ismayadi
- Satdichanh Manichanh
- Schietti Juliana
- Schöngart Jochen
- Scudeller Veridiana Vizoni
- Seuaturien Naret
- Sheil Douglas
- Sierra Rodrigo
- Silman Miles R.
- Silva Thiago Sanna Freire
- Simo-Droissart Murielle
- Simon Marcelo Fragomeni
- Sist Plinio
- Slik Ferry
- Sonké Bonaventure
- Sousa Thaiane R.
- Spracklen Dominick V.
- Stas Suzanne M.
- Steinmetz Robert
- Stevenson Pablo R.
- Stropp Juliana
- Sukri Rahayu S.
- Sullivan Martin J. P.
- Sunderland Terry C. H.
- Suzuki Eizi
- Swaine Michael D.
- Tang Jianwei
- Taplin James
- Taylor David M.
- Tello J. Sebastián
- ter Steege Hans
- Terborgh John
- Texier Nicolas
- Theilade Ida
- Thomas Duncan W.
- Thomas Raquel
- Thomas Sean C.
- Tirado Milton
- Toirambe Benjamin
- Tomlinson Kyle W.
- Torres-Lezama Armando
- Tran Hieu Dang
- Tshibamba Mukendi John
- Tumaneng Roven D.
- Umaña Maria Natalia
- Umunay Peter M.
- Urrego Giraldo Ligia Estela
- Valderrama Sandoval Elvis H.
- Valenzuela Gamarra Luis
- Van Andel Tinde R.
- van de Bult Martin
- van de Pol Jaqueline
- van der Heijden Geertje
- Vasquez Rodolfo
- Vela César I. A.
- Venticinque Eduardo Martins
- Verbeeck Hans
- Veridiano Rizza Karen A.
- Vicentini Alberto
- Vieira Ima Célia Guimarães
- Vilanova Torre Emilio
- Villa Zegarra Boris Eduardo
- Villarroel Daniel
- Vleminckx Jason
- von Hildebrand Patricio
- Vos Vincent Antoine
- Vriesendorp Corine
- Webb Edward L.
- White Lee J. T.
- Wich Serge
- Wittmann Florian
- Zagt Roderick
- Zang Runguo
- Zartman Charles Eugene
- Zemagho Lise
- Zent Egleé L.
- Zent Stanford
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Trees structure the Earth’s most biodiverse ecosystem, tropical forests. The vast number of tree species presents a formidable challenge to understanding these forests, including their response to environmental change, as very little is known about most tropical tree species. A focus on the common species may circumvent this challenge. Here we investigate abundance patterns of common tree species using inventory data on 1,003,805 trees with trunk diameters of at least 10 cm across 1,568 locations1,2,3,4,5,6 in closed-canopy, structurally intact old-growth tropical forests in Africa, Amazonia and Southeast Asia. We estimate that 2.2%, 2.2% and 2.3% of species comprise 50% of the tropical trees in these regions, respectively. Extrapolating across all closed-canopy tropical forests, we estimate that just 1,053 species comprise half of Earth’s 800 billion tropical trees with trunk diameters of at least 10 cm. Despite differing biogeographic, climatic and anthropogenic histories7, we find notably consistent patterns of common species and species abundance distributions across the continents. This suggests that fundamental mechanisms of tree community assembly may apply to all tropical forests. Resampling analyses show that the most common species are likely to belong to a manageable list of known species, enabling targeted efforts to understand their ecology. Although they do not detract from the importance of rare species, our results open new opportunities to understand the world’s most diverse forests, including modelling their response to environmental change, by focusing on the common species that constitute the majority of their trees.Publisher PDFPeer reviewe
Uma utopia brasileira: Vargas e a construção do estado de bem-estar numa sociedade estruturalmente desigual
- Author
- Adalberto Cardoso
- ALVIM Rosilene
- BARROS Ricardo P.
- BARROS Ricardo P. de
- BÉRTOLA Luis
- CARDOSO Adalberto M.
- CARDOSO Adalberto M.
- CARDOSO Adalberto M.
- CARDOSO Adalberto M.
- CARDOSO Adalberto M.
- CARDOSO Fernando H.
- CASTEL Robert
- COSTA SOBRINHO Pedro V.
- COUTINHO Ronaldo do L.
- DEAN Warren
- DURHAM Eunice R.
- DÁVILLA Jerry
- ERICKSON Kenneth P.
- FERNANDES Florestan
- FERREIRA Jorge
- FISCHER Brodwyn
- FONTES Paulo
- FRENCH John D
- FRENCH John D
- GARCIA Afrânio
- GOMES Angela de C.
- GOMES Angela de C.
- GOMES Flávio dos S.
- GUIMARÃES Nadya A.
- GUIMARÃES Nadya A.
- GUIMARÃES Nadya A.
- HASENBALG Carlos A.
- HUTCHINSON Bertrand
- LEVINE Robert M.
- LINHARES Maria Yedda L.
- LOPES José Sergio L.
- LOPES Juarez B.
- LOPES Juarez B.
- LOWENSTEIN Karl
- MARAM Sheldom L.
- MARTINELLO Pedro
- MARTINS RODRIGUES Leôncio
- MARTINS RODRIGUES Leôncio
- MARTINS RODRIGUES Leôncio
- MERRICK Thomas W.
- MONTALI Lilia T.
- MORAES FILHO Evaristo de
- MOURA Margarida M.
- NEGRO Antonio. L.
- OLIVEIRA Francisco de
- OLIVEIRA VIANNA Francisco J.
- OLIVEIRA VIANNA Francisco J.
- OLIVEIRA VIANNA Francisco J.
- OLIVEIRA VIANNA Francisco J.
- OLIVEIRA VIANNA Francisco J.
- PAOLI Maria C.
- PAOLI Maria C.
- PERLMAN Janice E.
- QUEIROZ Maria Isaura P.
- RIOS Ana L.
- ROSANVALLON Pierre
- SALES Teresa
- SANTANA Marco A.
- SANTOS Wanderley G. dos
- SANTOS Wanderley G. dos
- SCHÜHLY Gunther F.
- SIGAUD Lygia
- SILVA Adalberto F.
- SIMÃO Azis
- SKIDMORE Thomas
- SOUZA Alberto de M
- SOUZA Jessé
- SUPIOT Alain
- TAVARES DE ALMEIDA Maria H.
- THOMPSON Edward P
- TITMUSS Richard M
- TOURAINE Alain
- ULYSSEA Gabriel
- VARGAS Getúlio D
- VARGAS Getúlio D
- VILLELA Annibal V
- WEFFORT Francisco
- WEINSTEIN Barbara
- WERNECK VIANNA Luiz J
- WILLEMS Emilio
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2010
- Field of study
Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).
- Author
- A'Court C.
- Aaroe H.
- Abd El-Aziz A.
- Abdalla Saad J.
- Abdel-Qader M.
- Abdelrahman H.
- Abdul A.
- Abe M. (Masahiko)
- Abe M. (Masatake)
- Abe M. (Mitsunori)
- Abe S.
- Abe Y.
- Abhayaratna W.
- Abou Seif S. K.
- Abraham S.
- Abu-Mahfouz M.
- Abushal S.
- Accetta Gabriele
- Accogli M.
- Adachi S.
- Adachi S. (Sen)
- Adachi S. (Susumu)
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- Adriaansen H.
- Agakhanyan A.
- Agata J.
- Ageta M.
- Aggarwala A.
- Agliardi P.
- Agnelli G.
- Agnelli Giancarlo
- Agrawal A.
- Aguilar J.
- Ahbeck E.
- Ahlmark H.
- Ahmad K.
- Ahmad N.
- Ahmad S.
- Ahmed F.
- Ahmed W.
- Ahn J. J.
- Ahuad Guerrero R. A.
- Ainsworth P.
- Airaksinen J.
- Akahane K.
- Akiyama M.
- Aktas O.
- Akutsu M.
- Al Mahmeed W.
- Al Mahmeed Wael
- Al Mulla A.
- Al Naeemi A.
- Al Omairi M.
- Al-Khalili F.
- Alaguibe E. D.
- Alban F.
- Alberts M.
- Alborough E.
- Aldegather J.
- Aleksandrova E.
- Alfaro T. A. A.
- Alfieri A.
- Ali A.
- Alkan D. Uzun
- Allasia B.
- Almeida Fernandez C. A.
- Alonso C. (Carmela)
- Alonso C. (Concepcion)
- Alpay D.
- Altamirano Bellorin S.
- Altun A.
- Alunni M.
- Alvarez D'Amelio A.
- Alvarez Garcia P.
- Alvarez Lopez H.
- Alvarez D.
- Alvarez M.
- Alves da Costa F. A.
- Alves de Oliveira Gomes J.
- Alzand B.
- Amano T.
- Amarenco P.
- Amaro M.
- Ambicka M.
- Ambrosino P.
- Ambrosio Giuseppe
- Amstutz D.
- An H. J.
- Andere N.
- Andersson A.
- Andersson L. (Lars)
- Andersson L. (Lisbeth)
- Ando H.
- Ando S.
- Andrzejewski D.
- Angaran P.
- Angchaisuksiri P.
- Angchaisuksiri Pantep
- Angel G.
- Ann W.
- Antonova P.
- Antonsen H.
- Aoki K.
- Aoyama T.
- Arabetti C.
- Aracil Villar J.
- Arai H.
- Araminowicz J.
- Aranha Rosito G. B.
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- Arasaki O.
- Araujo G. R.
- Araujo V
- Arcocha Torres M. F.
- Argena A.
- Arias L.
- Arima S.
- Arino T.
- Armaganijan D.
- Armitano Ochoa R.
- Aro L.
- Arola O.
- Arriaga Nava R.
- Arriagada G.
- Arruda Nakazone M.
- Arstall M.
- Asafu-Adjaye N.
- Asano H.
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
- Author
- A. Abd El-Aziz
- A. Abdul
- A. Agakhanyan
- A. Aggarwala
- A. Agrawal
- A. Al Mulla
- A. Al Naeemi
- A. Alfieri
- A. Ali
- A. Altun
- A. Alvarez D'Amelio
- A. Andersson
- A. Argena
- A. Austria
- A. Aydinlar
- A. Babyesiza
- A. Barai
- A. Barreau
- A. Barszcz
- A. Bartes
- A. Bazzoni Ruiz
- A. Beattie
- A. Bianchi
- A. Biernacka
- A. Black
- A. Blenkhorn
- A. Branjovich Tijuan
- A. Bremmelgaard
- A. Brown
- A. Browne
- A. Capucci
- A. Caspar
- A. Catanchin
- A. Chmielowski
- A. Choi
- A. Cieszynska
- A. Conde Y Bolado
- A. Connelly
- A. Cortada Cabrera
- A. Davids
- A. De Blasio
- A. De Wolf
- A. Dickerson
- A. Domenech Borras
- A. Dumikyan
- A. Edin
- A. Egilsson
- A. El-Etreby
- A. Elbahry
- A. Elorriaga Madariaga
- A. Espallargas
- A. Ewert
- A. Fearon
- A. Fedorowsky
- A. Ferreira-Jardim
- A. Ferrer
- A. Filippi
- A. Fleck
- A. Flynn
- A. Forero
- A. Frankiewicz
- A. Fujisawa
- A. Gallagher
- A. Ganatra
- A. Gegenhuber
- A. Gieroba
- A. Gilliland
- A. Giombolini
- A. Gonzales Segovia
- A. Grande Ruiz
- A. Grau
- A. Grytzmann
- A. Gubanov
- A. Guerrero Molina
- A. Guinand
- A. Haideri
- A. Hajimirsadeghi
- A. Hallaråker
- A. Halpin
- A. Hay
- A. Heer
- A. Heyse
- A. Horak
- A. Hot-Bjelac
- A. Howitt
- A. Iglesias Garcia
- A. Ishihara
- A. Ivanov
- A. Iñiguez Romo
- A. Jackun-Podlesna
- A. Jaremczuk-Kaczmarczyk
- A. Jarzebowski
- A. Jefferies
- A. Jekthammer
- A. Jerzewski
- A. John Camm
- A. John Camm
- A. John Camm
- A. Jones
- A. Kaczmarzyk-Radka
- A. Karczmarczyk
- A. Katta
- A. Kemmel
- A. Khan
- A. Khokhlov
- A. Koch
- A. Kolesnikova
- A. Kolodzinska
- A. Komlo
- A. Konopka
- A. Kopf
- A. Krueger
- A. Krzesiak-Lodyga
- A. Lavoie
- A. Lawande
- A. Lee
- A. Lettenström
- A. Leyva Rendón
- A. Lindberg
- A. Lindh
- A. Lindourkova
- A. Lischka-Lindner
- A. Lo Buglio
- A. Lopes
- A. Lopez
- A. Lucassen
- A. Ludkova
- A. Lysek-Jozefowicz
- A. Mannermyr
- A. Manzanal Rey
- A. Mariani
- A. Markiewicz
- A. Marquand
- A. Martin Vila
- A. Martinelli
- A. Maselli
- A. Matoltsy
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- A. Merliss
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- A. Murray
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- A. Nakata
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- A. Pedersen
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- A. Sasaki
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- A. Soliman
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- A. Steffens
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- A. Svilaas
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- A. Szulowska
- A. Taguchi
- A. Talkenberger
- A. Tangsirira
- A. Tetlak
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- A. Therkelsen
- A. Thomson
- A. Tomasello
- A. Ushakov
- A. Vandorpe
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- A. Vishnevsky
- A. Vonbank
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- A.J. Kleiban
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- A.L. Baek
- A.L. Cappi
- A.L. Tufare
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- A.P. Drummond Wainstein
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- Ajay K. Kakkar
- Ajay K. Kakkar
- Alex Parkhomenko
- Alex Spyropoulos
- Alexander G.G. Turpie
- Ali Oto
- Antonio Carlos Pereira Barretto
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- B. Liu
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- B.Y. Sayin
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- Bernard J. Gersh
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- David Fitzmaurice
- Dayi Hu
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- I.-A. Jung
- I.K. Noh
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- I.N. De Urquiza
- I.U. Haq
- J. Abdalla Saad
- J. Agata
- J. Aguilar
- J. Airaksinen
- J. Aldegather
- J. Alves de Oliveira Gomes
- J. Aracil Villar
- J. Araminowicz
- J. Ayers
- J. Azuma
- J. Bartnik
- J. Baszak
- J. Bayat
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- J. Bennett
- J. Berg-Johansen
- J. Berlingieri
- J. Bigcanoe
- J. Bisatt
- J. Boerger
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- J. Boys
- J. Bruegger
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- J. Cabeza Ramirez
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- J. Cameron-Watts
- J. Cha
- J. Chen
- J. Chlumsky
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- J. de Graauw
- J. Debrunner
- J. DePauw
- J. Doiuchi
- J. Dshabrailov
- J. Dunnigan
- J. Eden
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- Y. Wakasa
- Y. Ye
- Y. Yokoyama
- Y. Zhang
- Y.-I. Kim
- Y.H. Li
- Y.H. Sun
- Y.H. Yin
- Y.J. Yang
- Y.J. Yang
- Y.K. On
- Y.M. Chen
- Y.M. Lee
- Y.M. Sohn
- Y.R. Jeon
- Y.S. Oh
- Y.S. Son
- Y.S. Zhao
- Y.Y. Liu
- Ying Wang
- Yoichi Nakamura
- Yong Wang
- Yoshihisa Fujiura
- Yoshitake Fujiura
- Yuhei Shiga
- Yuichiro Nakamura
- Yukihiro Koretsune
- Yukio Shiga
- Z. Babjakova
- Z. Boda
- Z. Djaidani
- Z. Lajkowski
- Z. Laszlo
- Z. May
- Z. Monhart
- Z. Ongen
- Z. Radics
- Z.C. Lu
- Z.H. Zhou
- Z.M. Yang
- Publication venue
- Indian Heart J
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A.
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmadizar Fariba
- Ahmed Soheir H.
- Ahrens Wolfgang
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Aly Eman
- Amarapurkar Deepak N.
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A.
- Andre Moura-dos-Santos Marcos
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
- Assuncao Maria Cecilia F.
- Auvinen Juha
- Avdicova Maria
- Azevedo Ana
- Azimi-Nezhad Mohsen
- Azizi Fereidoun
- Azmin Mehrdad
- Babu Bontha V.
- Bahijri Suhad
- Balakrishna Nagalla
- Balanova Yulia
- Balanova Yulia
- Bamoshmoosh Mohamed
- Banach Maciej
- Banadinovic Maja
- Bandosz Piotr
- Banegas Jose R.
- Baran Joanna
- Barbagallo Carlo M.
- Barcelo Alberto
- Barkat Amina
- Barreto Marta
- Barros Aluisio J. D.
- Bartosiewicz Anna
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- Tang Xun
- Tanser Frank
- Tao Yong
- Tarawneh Mohammed Rasoul
- Tarqui-Mamani Carolina B.
- Taylor Anne
- Taylor Julie
- Tebar William R.
- Tell Grethe S.
- Tello Tania
- Tham Yih Chung
- Thankappan K. R.
- Theobald Holger
- Theodoridis Xenophon
- Thijs Lutgarde
- Thinggaard Mikael
- Thomas Nihal
- Thorand Barbara
- Thuesen Betina H.
- Timmermans Erik J.
- Tjandrarini Dwi H.
- Tjonneland Anne
- Toft Ulla
- Tolonen Hanna K.
- Tolstrup Janne S.
- Topbas Murat
- Topor-Madry Roman
- Tornaritis Michael J.
- Torrent Maties
- Torres-Collado Laura
- Touloumi Giota
- Traissac Pierre
- Tran Quoc Bao Tran Quoc Bao
- Triantafyllou Areti
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Trinh Oanh T. H.
- Trivedi Atul
- Tshepo Lechaba
- Tsugane Shoichiro
- Tuliakova Azaliia M.
- Tulloch-Reid Marshall K.
- Tullu Fikru
- Tuomainen Tomi-Pekka
- Tuomilehto Jaakko
- Turley Maria L.
- Twig Gilad
- Tynelius Per
- Tzourio Christophe
- Ueda Peter
- Ugel Eunice
- Ulmer Hanno
- Uusitalo Hannu M. T.
- Valdivia Gonzalo
- Valvi Damaskini
- van Dam Rob M.
- van den Born Bert-Jan
- Van der Heyden Johan
- van der Schouw Yvonne T.
- Van Herck Koen
- Van Schoor Natasja M.
- van Valkengoed Irene G. M.
- van Zutphen Elisabeth M.
- Vanderschueren Dirk
- Vanuzzo Diego
- Varbo Anette
- Varghese Cherian
- Vasan Senthil K.
- Vega Tomas
- Veidebaum Toomas
- Velasquez-Melendez Gustavo
- Veronesi Giovanni
- Verschuren W. M. Monique
- Verstraeten Roosmarijn
- Victora Cesar G.
- Viet Lucie
- Villalpando Salvador
- Vineis Paolo
- Vioque Jesus
- Virtanen Jyrki K.
- Visvikis-Siest Sophie
- Viswanathan Bharathi
- Vlasoff Tiina
- Vollenweider Peter
- Voutilainen Ari
- Vrkic Tajana Zeljkovic
- Wade Alisha N.
- Walton Janette
- Wambiya Elvis O. A.
- Wanderley Junior Rildo de Souza
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S. Goya
- Wareham Nicholas
- Wei Wenbin
- Weres Aneta
- Werner Bo
- Whincup Peter H.
- Widhalm Kurt
- Widyahening Indah S.
- Widyahening Indah S.
- Wiecek Andrzej
- Wilks Rainford J.
- Willeit Johann
- Willeit Peter
- Williams Emmanuel A.
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Andrew
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Woodward Mark
- Wu Frederick C.
- Wu Shouling
- Wyszynska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yoosefi Moein
- Yoshihara Akihiro
- You San-Lin
- Younger-Coleman Novie O.
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zainuddin Ahmad A.
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhen Shiqi
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuniga Cisneros Julio
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. FINDINGS: The number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. INTERPRETATION: Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings. FUNDING: WHO
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A.
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmadizar Fariba
- Ahmed Soheir H.
- Ahrens Wolfgang
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Aly Eman
- Amarapurkar Deepak N.
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A.
- Andre Moura-dos-Santos Marcos
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
- Assuncao Maria Cecilia F.
- Auvinen Juha
- Avdicova Maria
- Azevedo Ana
- Azimi-Nezhad Mohsen
- Azizi Fereidoun
- Azmin Mehrdad
- Babu Bontha V.
- Bahijri Suhad
- Balakrishna Nagalla
- Balanova Yulia
- Balanova Yulia
- Bamoshmoosh Mohamed
- Banach Maciej
- Banadinovic Maja
- Bandosz Piotr
- Banegas Jose R.
- Bao Khanh Le Nguyen
- Bao Tran Quoc
- Baran Joanna
- Barbagallo Carlo M.
- Barcelo Alberto
- Barkat Amina
- Barreto Marta
- Barros Aluisio J. D.
- Bartosiewicz Anna
- Basit Abdul
- Bastos Joao Luiz D.
- Bata Iqbal
- Batieha Anwar M.
- Batyrbek Assembekov
- Baur Louise A.
- Beaglehole Robert
- Bebakar Wan Mohamad Wan
- Belavendra Antonisamy
- Ben Romdhane Habiba
- Benchekor Sounnia Mediene
- Benet Mikhail
- Bennett James E.
- Bennett James E.
- Benson Lowell S.
- Berkinbayev Salim
- Bernabe-Ortiz Antonio
- Bettiol Heloisa
- Bezerra Jorge
- Bhagyalaxmi Aroor
- Bhargava Santosh K.
- Bia Daniel
- Biasch Katia
- Bikbov Mukharram M.
- Bista Bihungum
- Bjerregaard Peter
- Bjertness Espen
- Bjertness Marius B.
- Bjorkelund Cecilia
- Bloch Katia V.
- Blokstra Anneke
- Bo Simona
- Bobak Martin
- Boeing Heiner
- Boggia Jose G.
- Boissonnet Carlos P.
- Bojesen Stig E.
- Boker Lital Keinan
- Bonet Gorbea Mariano
- Bongard Vanina
- Bonilla-Vargas Alice
- Bopp Matthias
- Borghs Herman
- Bovet Pascal
- Boyer Christopher B.
- Braeckman Lutgart
- Brajkovich Imperia
- Branca Francesco
- Breckenkamp Juergen
- Brenner Hermann
- Brewster Lizzy M.
- Briceno Yajaira
- Brito Miguel
- Bruno Graziella
- Bueno Gloria
- Bueno-de-Mesquita H. Bas
- Bugge Anna
- Burns Con
- Bursztyn Michael
- Cabrera de Leon Antonio
- Cacciottolo Joseph
- Cadena Leticia Hernandez
- Cameron Christine
- Can Gunay
- Candido Ana Paula C.
- Capanzana Mario V.
- Capkova Nadezda
- Capuano Eduardo
- Capuano Vincenzo
- Cardoso Viviane C.
- Carlsson Axel C.
- Carrillo-Larco Rodrigo M.
- Carvalho Joana
- Casanueva Felipe F.
- Censi Laura
- Cervantes-Loaiza Marvin
- Chadjigeorgiou Charalambos A.
- Chamukuttan Snehalatha
- Chan Angelique W.
- Chan Queenie
- Chaturvedi Himanshu K.
- Chaturvedi Nish
- Chee Miao Li
- Chen Chien-Jen
- Chen Fangfang
- Chen Huashuai
- Chen Shuohua
- Chen Zhengming
- Cheng Ching-Yu
- Cheraghian Bahman
- Chetrit Angela
- Chien Kuo-Liong
- Chiolero Arnaud
- Chiou Shu-Ti
- Chirita-Emandi Adela
- Chirlaque Maria-Dolores
- Cho Belong
- Christensen Kaare
- Christofaro Diego G.
- Chudek Jerzy
- Cifkova Renata
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- Claessens Frank
- Clarke Janine
- Clays Els
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- Cordeiro da Silva Bruna Goncalves
- Costanzo Simona
- Cottel Dominique
- Cowan Melanie J.
- Cowell Chris
- Craig Cora L.
- Crampin Amelia C.
- Crujeiras Ana B.
- Cruz Juan J.
- Csilla Semanova
- Cui Liufu
- Cureau Felipe V.
- Cuschieri Sarah
- D'Arrigo Graziella
- d'Orsi Eleonora
- Dallongeville Jean
- Damasceno Albertino
- Damasceno Albertino
- Danaei Goodarz
- Danaei Goodarz
- Dankner Rachel
- Dantoft Thomas M.
- Dauchet Luc
- Davletov Kairat
- De Backer Guy
- De Bacquer Dirk
- De Curtis Amalia
- de Gaetano Giovanni
- De Henauw Stefaan
- de Moura Silva Caroline Ramos
- de Oliveira Paula Duarte
- de Paiva Karina Mary
- De Ridder David
- De Smedt Delphine
- de Wit Tobias F. Rinke
- Deepa Mohan
- Deev Alexander D.
- DeGennaro Vincent Jr
- Dekkaki Imane Cherkaoui
- del Cristo Rodriguez-Perez Maria
- Delisle Helene
- Demarest Stefaan
- Dennison Elaine
- Deschamps Valerie
- Dhimal Meghnath
- Di Castelnuovo Augusto F.
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Dickerson Ty T.
- Dika Zivka
- Dinc Gonul Horasan
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- Doering Angela
- Doerr Marcus
- Donfrancesco Chiara
- Donoso Silvana P.
- Dorobantu Maria
- Doua Kouamelan
- Dragano Nico
- Drygas Wojciech
- Duante Charmaine A.
- Duboz Priscilla
- Duda Rosemary B.
- Dulskiene Virginija
- Dushpanova Anar
- Dzakula Aleksandar
- Dzerve Vilnis
- Dziankowska-Zaborszczyk Elzbieta
- Eddie Ricky
- Eftekhar Ebrahim
- Eggertsen Robert
- Eghtesad Sareh
- Eiben Gabriele
- Ekelund Ulf
- El Ati Jalila
- El-Khateeb Mohammad
- Eldemire-Shearer Denise
- Eliasen Marie
- Elisa Zapata Maria
- Elliott Paul
- Elliott Paul
- Elosua Roberto
- Erasmus Rajiv T.
- Erbel Raimund
- Erem Cihangir
- Eriksen Louise
- Eriksson Johan G.
- Escobedo-de la Pena Jorge
- Eslami Saeid
- Esmaeili Ali
- Evans Alun
- Ezzati Majid
- Faeh David
- Fakhretdinova Albina A.
- Fall Caroline H.
- Faramarzi Elnaz
- Farjam Mojtaba
- Farzadfar Farshad
- Farzadfar Farshad
- Fattahi Mohammad Reza
- Fawwad Asher
- Felix Stephan B.
- Felix-Redondo Francisco J.
- Ferguson Trevor S.
- Fernandes Romulo A.
- Fernandez-Berges Daniel
- Ferrante Daniel
- Ferrao Thomas
- Ferrari Marika
- Ferrario Marco M.
- Ferreccio Catterina
- Ferreira Haroldo S.
- Ferrer Eldridge
- Ferrieres Jean
- Figueiro Thamara Hubler
- Fink Gunther
- Fischer Krista
- Foo Leng Huat
- Forsner Maria
- Fouad Heba M.
- Francis Damian K.
- Franco Maria do Carmo
- Frikke-Schmidt Ruth
- Frontera Guillermo
- Fuchs Flavio D.
- Fuchs Sandra C.
- Fujita Yuki
- Fumihiko Matsuda
- Furdela Viktoriya
- Furer Ariel
- Furusawa Takuro
- Gaciong Zbigniew
- Galbarczyk Andrzej
- Galenkamp Henrike
- Galvano Fabio
- Gao Jingli
- Gao Pei
- Garcia Pablo
- Garcia-de-la-Hera Manoli
- Gareta Dickman
- Garnett Sarah P.
- Gaspoz Jean-Michel
- Gasull Magda
- Gazzinelli Andrea
- Gehring Ulrike
- Geleijnse Johanna M.
- George Ronnie
- Ghanbari Ali
- Ghasemi Erfan
- Gheorghe-Fronea Oana-Florentina
- Ghimire Anup
- Gialluisi Alessandro
- Giampaoli Simona
- Gieger Christian
- Gill Tiffany K.
- Giovannelli Jonathan
- Gironella Glen
- Giwercman Aleksander
- Gkiouras Konstantinos
- Glavic Mihalea Marinovic
- Goldberg Marcel
- Goldsmith Rebecca A.
- Gomes Barros Mauro Virgilio
- Gomez Luis F.
- Gomula Aleksandra
- Goncalves Helen
- Goncalves Mauer
- Gonzalez Angel R.
- Gonzalez-Chica David A.
- Gonzalez-Gross Marcela
- Gonzalez-Rivas Juan P.
- Gonzalez-Villalpando Clicerio
- Gonzalez-Villalpando Maria-Elena
- Gottrand Frederic
- Graff-Iversen Sidsel
- Grafnetter Dusan
- Grajda Aneta
- Grammatikopoulou Maria G.
- Gregg Edward W.
- Gregor Ronald D.
- Grodzicki Tomasz
- Grosso Giuseppe
- Gruden Gabriella
- Gu Dongfeng
- Guan Ong Peng
- Gudmundsson Elias F.
- Gudnason Vilmundur
- Guerrero Ramiro
- Guessous Idris
- Guimaraes Andre L.
- Gulliford Martin C.
- Gunnlaugsdottir Johanna
- Gunter Marc J.
- Gupta Prakash C.
- Gupta Rajeev
- Gureje Oye
- Gurzkowska Beata
- Gutierrez Laura
- Gutzwiller Felix
- Ha Seongjun
- Hadaegh Farzad
- Haghshenas Rosa
- Hakimi Hamid
- Halkjaer Jytte
- Hambleton Ian R.
- Hamzeh Behrooz
- Hange Dominique
- Hanif Abu A. M.
- Hantunen Sari
- Hao Jie
- Hardman Carla Meneses
- Hashemi-Shahri Seyed Mohammad
- Hata Jun
- Haugsgjerd Teresa
- Hayes Alison J.
- He Jiang
- He Jiang
- He Yuna
- Heier Margit
- Hendriks Marleen Elisabeth
- Henrique Rafael dos Santos
- Henriques Ana
- Herrala Sauli
- Heshmat Ramin
- Hill Allan G.
- Ho Sai Yin
- Ho Suzanne C.
- Hobbs Michael
- Holdsworth Michelle
- Homayounfar Reza
- Horimoto Andrea R. V. R.
- Hormiga Claudia M.
- Horta Bernardo L.
- Houti Leila
- Howitt Christina
- Htay Thein Thein
- Htet Aung Soe
- Htike Maung Maung Than
- Hu Yonghua
- Huerta Jose Maria
- Huhtaniemi Ilpo Tapani
- Huiart Laetitia
- Huisman Martijn
- Husseini Abdullatif S.
- Huybrechts Inge
- Hwalla Nahla
- Iacoviello Licia
- Iannone Anna G.
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- Jamrozik Konrad
- Janszky Imre
- Janus Edward
- Jarvelin Marjo-Riitta
- Jasienska Grazyna
- Jelakovic Ana
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- Jennings Garry
- Jerome Charles Sossa
- Jha Anjani Kumar
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- Joeckel Karl-Heinz
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- Khaw Kay-Tee
- Kheiri Bahareh
- Kheradmand Motahareh
- Khosravi Alireza
- Kiechl Stefan
- Kiechl-Kohlendorfer Ursula
- Killewo Japhet
- Kim Dong Wook
- Kim Hyeon Chang
- Kim Hyeon Chang
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- Klakk Heidi
- Klimek Magdalena
- Klumbiene Jurate
- Knoflach Michael
- Kolle Elin
- Kolsteren Patrick
- Kontto Jukka P.
- Korpelainen Raija
- Korrovits Paul
- Kos Jelena
- Koskinen Seppo
- Kouda Katsuyasu
- Kowlessur Sudhir
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- Kriaucioniene Vilma
- Kristensen Peter Lund
- Krokstad Steiner
- Kromhout Daan
- Kruger Herculina S.
- Kubinova Ruzena
- Kuciene Renata
- Kujala Urho M.
- Kulaga Zbigniew
- Kumar R. Krishna
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- Kuulasmaa Kari
- Kyobutungi Catherine
- Laatikainen Tiina
- Lachat Carl
- Laid Youcef
- Lam Tai Hing
- Landrove Orlando
- Lanska Vera
- Lappas Georg
- Larijani Bagher
- Latt Tint Swe
- Laxmaiah Avula
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- Lee Jeannette
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- Litwin Mieczyslaw
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- Meisinger Christa
- Mendoza Montano Carlos
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- Menon Geetha R.
- Mereke Alibek
- Meshram Indrapal I.
- Metspalu Andres
- Meyer Haakon E.
- Mi Jie
- Michels Nathalie
- Mikkel Kairit
- Milanovic Sanja Music
- Milkowska Karolina
- Miller Jody C.
- Minderico Claudia S.
- Minh Hoang Van
- Mini G. K.
- Miranda J. Jaime
- Miranda J. Jaime
- Mirjalili Mohammad Reza
- Mirrakhimov Erkin
- Misigoj-Durakovic Marjeta
- Modesti Pietro A.
- Moghaddam Sahar Saeedi
- Mohajer Bahram
- Mohamed Mostafa K.
- Mohamed Shukri F.
- Mohammad Kazem
- Mohammadi Mohammad Reza
- Mohammadi Zahra
- Mohammadifard Noushin
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- Viswanathan Bharathi
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- Wambiya Elvis O. A.
- Wanderley Junior Rildo de Souza
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S. Goya
- Wareham Nicholas
- Wei Wenbin
- Weres Aneta
- Werner Bo
- Whincup Peter H.
- Widhalm Kurt
- Widyahening Indah S.
- Widyahening Indah S.
- Wiecek Andrzej
- Wilks Rainford J.
- Willeit Johann
- Willeit Peter
- Williams Emmanuel A.
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Andrew
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Woodward Mark
- Wu Frederick C.
- Wu Shouling
- Wyszynska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yoosefi Moein
- Yoshihara Akihiro
- You San-Lin
- Younger-Coleman Novie O.
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zainuddin Ahmad A.
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhen Shiqi
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuniga Cisneros Julio
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 01/01/2021
- Field of study
Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings The number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings. Copyright (C) 2021 World Health Organization; licensee Elsevier
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A.
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmadizar Fariba
- Ahmed Soheir H.
- Ahrens Wolfgang
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Aly Eman
- Amarapurkar Deepak N.
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A.
- Andre Moura-dos-Santos Marcos
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
- Assuncao Maria Cecilia F.
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- Azevedo Ana
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- Balakrishna Nagalla
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- Bamoshmoosh Mohamed
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- Banegas Jose R.
- Baran Joanna
- Barbagallo Carlo M.
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- Widyahening Indah S.
- Widyahening Indah S.
- Wiecek Andrzej
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- Willeit Johann
- Willeit Peter
- Williams Emmanuel A.
- Wilsgaard Tom
- Wojtyniak Bogdan
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- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Woodward Mark
- Wu Frederick C.
- Wu Shouling
- Wyszynska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yoosefi Moein
- Yoshihara Akihiro
- You San-Lin
- Younger-Coleman Novie O.
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zainuddin Ahmad A.
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhen Shiqi
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuniga Cisneros Julio
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background
Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories.
Methods
We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age.
Findings
The number of people aged 30–79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306–359) million women and 317 (292–344) million men in 1990 to 626 (584–668) million women and 652 (604–698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55–62) of women and 49% (46–52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43–51) of women and 38% (35–41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20–27) for women and 18% (16–21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran.
Interpretation
Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
- Author
- Abarca-Gómez Leandra
- Abdeen Ziad A
- Abdul Rahim Hanan F
- Abu-Rmeileh Niveen M
- Acosta-Cazares Benjamin
- Adams Robert J
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmadizar Fariba
- Ahmed Soheir H
- Ahrens Wolfgang
- Ajlouni Kamel
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Aly Eman
- Amarapurkar Deepak N
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araújo Joana
- Ariansen Inger
- Aris Tahir
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- Theodoridis Xenophon
- Thijs Lutgarde
- Thinggaard Mikael
- Thomas Nihal
- Thorand Barbara
- Thuesen Betina H
- Timmermans Erik J
- Tjandrarini Dwi H
- Tjonneland Anne
- Toft Ulla
- Tolonen Hanna K
- Tolstrup Janne S
- Topbas Murat
- Topór-Madry Roman
- Tormo María José
- Tornaritis Michael J
- Torrent Maties
- Torres-Collado Laura
- Touloumi Giota
- Traissac Pierre
- Triantafyllou Areti
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Trinh Oanh TH
- Trivedi Atul
- Tshepo Lechaba
- Tsugane Shoichiro
- Tuliakova Azaliia M
- Tulloch-Reid Marshall K
- Tullu Fikru
- Tuomainen Tomi-Pekka
- Tuomilehto Jaakko
- Turley Maria L
- Twig Gilad
- Tynelius Per
- Tzourio Christophe
- Ueda Peter
- Ugel Eunice
- Ulmer Hanno
- Uusitalo Hannu MT
- Valdivia Gonzalo
- Valvi Damaskini
- van Dam Rob M
- van den Born Bert-Jan
- Van der Heyden Johan
- van der Schouw Yvonne T
- Van Herck Koen
- Van Minh Hoang
- Van Schoor Natasja M
- van Valkengoed Irene GM
- van Zutphen Elisabeth M
- Vanderschueren Dirk
- Vanuzzo Diego
- Varbo Anette
- Varghese Cherian
- Vasan Senthil K
- Vega Tomas
- Veidebaum Toomas
- Velasquez-Melendez Gustavo
- Veronesi Giovanni
- Verschuren WM Monique
- Verstraeten Roosmarijn
- Victora Cesar G
- Viet Lucie
- Villalpando Salvador
- Vineis Paolo
- Vioque Jesus
- Virtanen Jyrki K
- Visvikis-Siest Sophie
- Viswanathan Bharathi
- Vlasoff Tiina
- Vollenweider Peter
- Voutilainen Ari
- Wade Alisha N
- Walton Janette
- Wambiya Elvis OA
- Wan Bebakar Wan Mohamad
- Wan Mohamud Wan Nazaimoon
- Wanderley Júnior Rildo de Souza
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S Goya
- Wareham Nicholas
- Wei Wenbin
- Weres Aneta
- Werner Bo
- Whincup Peter H
- Widhalm Kurt
- Widyahening Indah S
- Wiecek Andrzej
- Wilks Rainford J
- Willeit Johann
- Willeit Peter
- Williams Emmanuel A
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Andrew
- Wong Tien Yin
- Wong-McClure Roy A
- Woo Jean
- Woodward Mark
- Wu Frederick C
- Wu Shouling
- Wyszynska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K
- Yoosefi Moein
- Yoshihara Akihiro
- You San-Lin
- Younger-Coleman Novie O
- Yusoff Ahmad Faudzi
- Zainuddin Ahmad A
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zapata Maria Elisa
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeljkovic Vrkic Tajana
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhen Shiqi
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuñiga Cisneros Julio
- Čapková Naděžda
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/09/2021
- Field of study
Background
Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories.
Methods
We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age.
Findings
The number of people aged 30–79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306–359) million women and 317 (292–344) million men in 1990 to 626 (584–668) million women and 652 (604–698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55–62) of women and 49% (46–52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43–51) of women and 38% (35–41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20–27) for women and 18% (16–21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran.
Interpretation
Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings
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