Application of numerical modelling to the comprehensive analysis of slope stability

Paper deals with the comprehensive methodology for the numerical simulation of potentially unstable slopes combining engineering geological, hydrological, hydrogeological and geotechnical computational model for the assessment of slope stability. Engineering geological model based on available survey data characterizes the rock environment using individual quasi-homogenous units. Model is defined on the basis of documented lithostratigraphic units in exploration probes and field relief documented by advanced methods, including satellite radar interferometry and laser surface scanning. On the basis of engineering geological model, the hydrological model using MIKE SHE software (Finite Difference Method) was performed. Hydrological model includes simulation of surface runoff, evapotranspiration and flow in unsaturated near-surface zone. The model was calibrated on the basis of available field data. Outputs from this model were used as input initial conditions of the following hydrogeological model. Software FEFLOW based on the Finite Element Method was subsequently used to the creation of hydrogeological model focused on the water flow and distribution of pore pressures of groundwater in individual quasi-homogeneous units in saturated zone. The infiltration condition determined by the hydrological model is considered and a flow model with variable saturation is applied. Finally, the geotechnical stability model of slope following the engineering geological, hydrological and hydrogeological models was performed. The occurrence of plastic and failure zones (assuming elastic-perfectly plastic Mohr-Coulomb constitutive model) inside the slope was simulated by using software MIDAS GTS NX based on the Finite Element Method. Stability factor SSRF (Shear Strength Reduction Factor) is evaluated based on the Shear Strength Reduction Method) as the ratio of actual shear strength and minimum shear strength required to maintain stability. Paper deals also with the comparison of stability factor of natural slope obtained from 3D and 2D numerical model. Generally, in the case of natural slope the condition of plane strain is not fulfil, 2D model is not realistic and 3D model is needed, especially in case of concave morphology of slope

Bcl-2 21 and Ac-DEVD-CHO inhibit death of wheat microspores

Microspore cell death and low green plant production efficiency are an integral obstacle in the development of doubled haploid production in wheat. The aim of the current study was to determine the effect of anti-apoptotic recombinant human B-cell lymphoma-2 (Bcl-2△21) and caspase-3-inhibitor (Ac-DEVD-CHO) in microspore cell death in bread wheat cultivars AC Fielder and AC Andrew. Induction medium containing Bcl-2△21 and Ac-DEVD-CHO yielded a significantly higher number of viable microspores, embryo-like structures and total green plants in wheat cultivars AC Fielder and AC Andrew. Total peroxidase activity was lower in Bcl-2△21 treated microspore cultures at 96 h of treatment compared to control and Ac-DEVD-CHO. Electron paramagnetic resonance study of total microspore protein showed a different scavenging activity for Bcl-2△21 and Ac-DEVD-CHO. Bcl-2△21 scavenged approximately 50% hydroxyl radical (HO•) formed, whereas Ac-DEVD-CHO scavenged approximately 20% of HO•. Conversely, reduced caspase-3-like activities were detected in the presence of Bcl-2△21 and Ac-DEVD-CHO, supporting the involvement of Bcl-2△21 and Ac-DEVD-CHO in increasing microspore viability by reducing oxidative stress and caspase-3-like activity. Our results indicate that Bcl-2△21 and Ac-DEVD-CHO protects cells from cell death following different pathways. Bcl-2△21 prevents cell damage by detoxifying HO• and suppressing caspase-3-like activity, while Ac-DEVD-CHO inhibits the cell death pathways by modulating caspase-like activit

Numerical simulation of heat recovery from asphalt pavement in Finnish climate conditions

A 3-dimensional mathematical model of asphalt pavement system was developed, based on the fundamental energy balance, to calculate temperatures beneath asphalt surface using hourly measured solar radiation, air temperature and wind velocity data. The modelling was conducted to predict the heat retention under the asphalt surface to seek an optimum position of pipe tubing to maximise the heat extraction considering the Nordic winter conditions for future infrastructure projects. The model results show good agreement with the experimental results conducted in a span of three months (June–Sept) notwithstanding the simplification of the model i.e. thermal properties unaffected by changing moisture content, perfect contact between different layers and homogeneous and isotropic thermal properties of materials (asphalt, sand and gravel). The findings indicated that the positioning of the heat extraction tubes under the asphalt layer will be dictated by the application. For heat extraction, pipes closer to the surface are ideal for maximal heat absorption during summer, however, in winter the outer temperature may effect properties the pipes. Parameters including pipe diameter, positioning of the pipes and flow rate were analysed. Temperature increase of up to 10 °C gain was observed for piping closer to the asphalt layer and 6 °C for pipes position at deeper from the asphalt layer. This model could be used in future to optimise critical variables for successful implementation of asphalt heating concepts.© 2023 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).fi=vertaisarvioitu|en=peerReviewed

A combined approach to data mining of textual and structured data to identify cancer-related targets

BACKGROUND: We present an effective, rapid, systematic data mining approach for identifying genes or proteins related to a particular interest. A selected combination of programs exploring PubMed abstracts, universal gene/protein databases (UniProt, InterPro, NCBI Entrez), and state-of-the-art pathway knowledge bases (LSGraph and Ingenuity Pathway Analysis) was assembled to distinguish enzymes with hydrolytic activities that are expressed in the extracellular space of cancer cells. Proteins were identified with respect to six types of cancer occurring in the prostate, breast, lung, colon, ovary, and pancreas. RESULTS: The data mining method identified previously undetected targets. Our combined strategy applied to each cancer type identified a minimum of 375 proteins expressed within the extracellular space and/or attached to the plasma membrane. The method led to the recognition of human cancer-related hydrolases (on average, ~35 per cancer type), among which were prostatic acid phosphatase, prostate-specific antigen, and sulfatase 1. CONCLUSION: The combined data mining of several databases overcame many of the limitations of querying a single database and enabled the facile identification of gene products. In the case of cancer-related targets, it produced a list of putative extracellular, hydrolytic enzymes that merit additional study as candidates for cancer radioimaging and radiotherapy. The proposed data mining strategy is of a general nature and can be applied to other biological databases for understanding biological functions and diseases

Unilateral hippocampal sparing during whole brain radiotherapy for multiple brain metastases: narrative and critical review

BackgroundThe landscape of brain metastases radiotherapy is evolving, with a shift away from whole-brain radiotherapy (WBRT) toward targeted stereotactic approaches aimed at preserving neurocognitive functions and maintaining overall quality of life. For patients with multiple metastases, especially in cases where targeted radiotherapy is no longer feasible due to widespread dissemination, the concept of hippocampal sparing radiotherapy (HA_WBRT) gains prominence.MethodsIn this narrative review we explore the role of the hippocampi in memory formation and the implications of their postradiotherapy lateral damage. We also consider the potential advantages of selectively sparing one hippocampus during whole-brain radiotherapy (WBRT). Additionally, by systematic evaluation of relevant papers published on PubMed database over last 20 years, we provide a comprehensive overview of the various changes that can occur in the left or right hippocampus as a consequence of radiotherapy.ResultsWhile it is important to note that various neurocognitive functions are interconnected throughout the brain, we can discern certain specialized roles of the hippocampi. The left hippocampus appears to play a predominant role in verbal memory, whereas the right hippocampus is associated more with visuospatial memory. Additionally, the anterior part of the hippocampus is more involved in episodic memory and emotional processing, while the posterior part is primarily responsible for spatial memory and pattern separation. Notably, a substantial body of evidence demonstrates a significant correlation between post-radiotherapy changes in the left hippocampus and subsequent cognitive decline in patients.ConclusionIn the context of individualized palliative radiotherapy, sparing the unilateral (specifically, the left, which is dominant in most individuals) hippocampus could expand the repertoire of strategies available for adapted WBRT in cases involving multiple brain metastases where stereotactic radiotherapy is not a viable option. Prospective ongoing studies assessing various memory-sparing radiotherapy techniques will define new standard of radiotherapy care of patients with multiple brain metastases

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements