THE ANKLE-HIP TRANSVERSE PLANE COUPLING DURING THE STANCE PHASE OF NORMAL WALKING

The aim of this study was to investigate the strength and features of a possibly existent ankle-hip transverse plane coupling during the stance of walking. Fifteen healthy volunteers walked on a 10m walkway in their natural speed using sandals. Kinematic data were obtained with a 3-dimensional motion analysis system. Calculation of the cross-correlation (r=-0.78) indicated a strong ankle-hip coupling, with ankle external rotation (foot pronation) coupled with hip internal rotation, and ankle internal rotation (foot supination) coupled with hip external rotation. Vector coding technique (Φ=41.01°) showed that ankle and hip joints present similar displacement magnitudes. The results agree with suggestions of ankle-hip transverse plane interdependency and an important kinetic energy transmission between the shank and thigh in this plane of movement

EFFECTS OF SIMULATING FOREFOOT VARISM INCREASES ON LOWER EXTREMITY KINEMATICS DURING THE STANCE PHASE OF WALKING

This study investigates the effects of simulating forefoot varism increases on lower extremity kinematics during the stance phase. Sixteen volunteers walked on a walkway in three conditions: wearing flat sandals; wearing a 5º and a 10º laterally wedged sandal. Data were obtained with a 3-D motion analysis system. The variables analyzed were: subtalar eversion/inversion; shank internal/external rotation; knee internal/external rotation; hip internal/external rotation. The simulations of 5º and 10º increases in forefoot varism increased subtalar pronation (P≤.007) and the simulation of 10º increased internal rotation of the shank in relation to the pelvis and of the hip (P=.001). The results suggest that forefoot varism can lead to kinematic patterns related to the occurrence of overuse injuries

Interaction of 8He with 208Pb at near-barrier energies: 4He and 6He production

Angular distributions for the inclusive 4He and 6He production cross sections in the 8He+208Pb system at incident energies of 16 and 22 MeV measured at the SPIRAL facility of the GANIL laboratory are presented. Using a combination of kinematical arguments and distorted wave Born approximation (DWBA) calculations, neutron transfer reactions were inferred to be the dominant contributors to both inclusive cross sections. Model-dependent values for the ratios of two- to one-neutron stripping, s2n/s1n, were derived and compared with previous results for 8He and 6He projectiles incident on other heavy targets. Three- and four-neutron stripping were inferred to be the main processes leading to 4He production, although the exact mechanism remains to be elucidated.The authors would like to thank the staff of the GANIL accelerator facility for providing the high-quality 8He beam. This work was supported in part by Grants No. FPA-2010-22131-CO2-01 (FINURA) and No. FPA2013-47327-C2-1-R from the Spanish Ministry of Economy and Competitiveness, UNAM-PAPIIT IA103218 (Mexico); Grant No. N202 033637 from the Ministry of Science and Higher Education of Poland; the National Science Centre of Poland under Contracts No. 2013/08/M/ST2/00257 (LEA-COPIGAL) and No. 2014/14/M/ST2/00738 (COPIN-INFN Collaboration); and Grant No. EUI2009-04163432 (EUROGENESIS) from the European Science Foundation

Perfil dos adolescentes que realizaram o teste anti-HIV no COAS de Porto Alegre

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Maximal oxygen uptake is underestimated during incremental testing in hypertensive older adults: findings from the HAEL study

Purpose: The present cross-sectional study aimed to investigate whether a maximal oxygen uptake (VO2max) verification phase (VER) could improve the accuracy of a previous graded exercise test (GXT) to assess individual VO2max in hypertensive individuals. Methods: Thirtythree older adults with hypertension (24 women) taking part in the Hypertension Approaches in the Elderly Study (NCT03264443) were recruited. Briefly, after performing a treadmill GXT to exhaustion, participants rested for 10 min and underwent a multistage VER to confirm GXT results. Individual VO2max, respiratory exchange ratio (RER), maximal heart rate (HRmax), and rating of perceived exertion (RPE) were measured during both GXT and VER tests. Mean values were compared between bouts using paired sample t-tests and VO2max was also compared between GXT and VER on an individual basis. Results: Testing was well tolerated by all participants. Both absolute (p=0.011) and relative (p=0.014) VO2max values were higher in VER than in GXT. RER (p<0.001) and RPE (p=0.002) were lower in VER, whereas HRmax (p=0.286) was not different between the two trials. Individual VO2max comparisons revealed that 54.6% of the participants (18/33) achieved a VO2max value that was ≥3% during VER (mean: 13.5%, range: from +3% to +22.1%, ES=0.062), whereas 87.9% (29/33) of the tests would have been validated as a maximal effort if the classic criteria were employed (i.e. VO2 plateau or at least two secondary criteria). Conclusion: In sedentary older individuals with hypertension, GXT to exhaustion underestimated VO2max in more than half of tested participants, even when established but criticized criteria were used to confirm whether a maximal effort was attained. Employing VER after GXT is a quick approach to assist with the verification of an individual’s VO2max

ARIA 2016 : Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease.Peer reviewe

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.info:eu-repo/semantics/publishedVersio

Open X-Embodiment:Robotic learning datasets and RT-X models

Large, high-capacity models trained on diverse datasets have shown remarkable successes on efficiently tackling downstream applications. In domains from NLP to Computer Vision, this has led to a consolidation of pretrained models, with general pretrained backbones serving as a starting point for many applications. Can such a consolidation happen in robotics? Conventionally, robotic learning methods train a separate model for every application, every robot, and even every environment. Can we instead train "generalist" X-robot policy that can be adapted efficiently to new robots, tasks, and environments? In this paper, we provide datasets in standardized data formats and models to make it possible to explore this possibility in the context of robotic manipulation, alongside experimental results that provide an example of effective X-robot policies. We assemble a dataset from 22 different robots collected through a collaboration between 21 institutions, demonstrating 527 skills (160266 tasks). We show that a high-capacity model trained on this data, which we call RT-X, exhibits positive transfer and improves the capabilities of multiple robots by leveraging experience from other platforms. The project website is robotics-transformer-x.github.io