Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression.

Obesity and depression are major public health concerns, and there is increasing evidence that they share etiological mechanisms. CREB-regulated transcription coactivator 1 (CRTC1) participates in neurobiological pathways involved in both mood and energy balance regulation. Crtc1 -/- mice rapidly develop a depressive-like and obese phenotype in early adulthood, and are therefore a relevant animal model to explore possible common mechanisms underlying mood disorders and obesity. Here, the obese phenotype of male and female Crtc1 -/- mice was further characterized by investigating CRTC1's role in the homeostatic and hedonic regulation of food intake, as well as its influence on daily locomotor activity. Crtc1 -/- mice showed a strong gender difference in the homeostatic regulation of energy balance. Mutant males were hyperphagic and rapidly developed obesity on normal chow diet, whereas Crtc1 -/- females exhibited mild late-onset obesity without hyperphagia. Overeating of mutant males was accompanied by alterations in the expression of several orexigenic and anorexigenic hypothalamic genes, thus confirming a key role of CRTC1 in the central regulation of food intake. No alteration in preference and conditioned response for saccharine was observed in Crtc1 -/- mice, suggesting that mutant males' hyperphagia was not due to an altered hedonic regulation of food intake. Intriguingly, mutant males exhibited a hyperphagic behavior only during the resting (diurnal) phase of the light cycle. This abnormal feeding behavior was associated with a higher diurnal locomotor activity indicating that the lack of CRTC1 may affect circadian rhythmicity. Collectively, these findings highlight the male-specific involvement of CRTC1 in the central control of energy balance and circadian locomotor activity

Holocene regional gradients of dust provenance and flux between Talos Dome and Dome C, East Antarctica.

Aeolian sequences from Central East Antarctic ice cores provide climate and environmental information of hemispheric significance. Close to the margins of the ice sheet, high-elevation ice-free terrains protruding above the ice sheet surface can provide an additional input of fine dust particles to the atmosphere, making peripheral locations particularly interesting for the study of the regional climate evolution. In the Talos Dome area of East Antarctica, entrainment and transport of local mineral particles is merely influenced by local wind direction and strength, which in turn is tuned by regional climate changes. We investigate the spatial variability of modern and Holocene dust flux, grain size and isotopic (Sr-Nd) composition along a hypothetic transect from Talos Dome all through the interior of the ice sheet (Dome C/Vostok area), and compare the geochemical fingerprint of dust extracted from firn and ice cores to the equivalent size fraction of regolith and glacial deposits from high altitude Victoria Land sources. This study aims to better understand the environmental gradients of dust flux and provenance from the marginal Talos Dome site to the higher Dome C drainage area, with implications for the regional atmospheric circulation, while documenting the isotopic composition of local exposed sediments

Spectropolarimetry of the Deep Impact target comet 9P/Tempel 1 with HiVIS

High resolution spectropolarimetry of the Deep Impact target, comet 9P/ Tempel 1, was performed during the impact event on July 4th, 2005 with the HiVIS Spectropolarimeter and the AEOS 3.67m telescope on Haleakala, Maui. We observed atypical polarization spectra that changed significantly in the few hours after the impact. The polarization of scattered light as a function of wavelength is very sensitive to the size and composition (complex refractive index) of the scattering particles as well as the scattering geometry. As opposed to most observations of cometary dust, which show an increase in the linear polarization with the wavelength (at least in the visible domain and for phase angles greater than about 30%, a red polarization spectrum) observations of 9P/Tempel 1 at a phase angle of 41 degrees beginning 8 minutes after impact and centered at 6:30UT showed a polarization of 4% at 650 nm falling to 3% at 950 nm. The next observation, centered an hour later showed a polarization of 7% at 650 nm falling to 2% at 950nm. This corresponds to a spectropolarimetric gradient, or slope, of -0.9% per 1000 Angstroms 40 minutes after impact, decreasing to a slope of -2.3% per 1000 Angstroms an hour and a half after impact. This is an atypical blue polarization slope, which became more blue 1 hour after impact. The polarization values of 4% and 7% at 650nm are typical for comets at this scattering angle, whereas the low polarization of 2% and 3% at 950nm is not. We compare observations of comet 9P/Tempel 1 to that of a typical comet, C/2004 Machholz, at a phase angle of 30 degrees which showed a typical red slope, rising from 2% at 650nm to 3% at 950nm in two different observations (+1.0 and +0.9% per 1000 Angstroms).Comment: Icarus Deep Impact special issue, accepted Aug 28 200

Strong rejuvenation in a chiral-glass superconductor

The glassy paramagnetic Meissner phase of a Bi$_2$Sr$_2$CaCu$_2$O$_x$ superconductor ($x$ = 8.18) is investigated by squid magnetometry, using ``dc-memory'' experiments employed earlier to study spin glasses. The temperature dependence of the zero-field-cooled and thermo-remanent magnetization is recorded on re-heating after specific cooling protocols, in which single or multiple halts are performed at constant temperatures. The 'spin' states equilibrated during the halts are retrieved on re-heating. The observed memory and rejuvenation effects are similar to those observed in Heisenberg-like spin glasses.Comment: REVTeX 4 style; 5 pages, 5 figure

Periodic Orbits and Escapes in Dynamical Systems

We study the periodic orbits and the escapes in two different dynamical systems, namely (1) a classical system of two coupled oscillators, and (2) the Manko-Novikov metric (1992) which is a perturbation of the Kerr metric (a general relativistic system). We find their simple periodic orbits, their characteristics and their stability. Then we find their ordered and chaotic domains. As the energy goes beyond the escape energy, most chaotic orbits escape. In the first case we consider escapes to infinity, while in the second case we emphasize escapes to the central "bumpy" black hole. When the energy reaches its escape value a particular family of periodic orbits reaches an infinite period and then the family disappears (the orbit escapes). As this family approaches termination it undergoes an infinity of equal period and double period bifurcations at transitions from stability to instability and vice versa. The bifurcating families continue to exist beyond the escape energy. We study the forms of the phase space for various energies, and the statistics of the chaotic and escaping orbits. The proportion of these orbits increases abruptly as the energy goes beyond the escape energy.Comment: 28 pages, 23 figures, accepted in "Celestial Mechanics and Dynamical Astronomy

Dispersion of Ordered Stripe Phases in the Cuprates

A phase separation model is presented for the stripe phase of the cuprates, which allows the doping dependence of the photoemission spectra to be calculated. The idealized limit of a well-ordered array of magnetic and charged stripes is analyzed, including effects of long-range Coulomb repulsion. Remarkably, down to the limit of two-cell wide stripes, the dispersion can be interpreted as essentially a superposition of the two end-phase dispersions, with superposed minigaps associated with the lattice periodicity. The largest minigap falls near the Fermi level; it can be enhanced by proximity to a (bulk) Van Hove singularity. The calculated spectra are dominated by two features -- this charge stripe minigap plus the magnetic stripe Hubbard gap. There is a strong correlation between these two features and the experimental photoemission results of a two-peak dispersion in La$_{2-x}$Sr$_x$CuO$_4$, and the peak-dip-hump spectra in Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$. The differences are suggestive of the role of increasing stripe fluctuations. The 1/8 anomaly is associated with a quantum critical point, here expressed as a percolation-like crossover. A model is proposed for the limiting minority magnetic phase as an isolated two-leg ladder.Comment: 24 pages, 26 PS figure

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02