185 research outputs found
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anh T. Vu
- Anisimov A
- Antillon E
- Antipov P
- Antonelli L
- Anttila E
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arnold B
- Arora S
- Artamonov A
- Asaadi J
- Asghar MI
- Ashby S
- Askew A
- Atac M
- Atramentov O
- Auffray E
- Aurisano A
- Autermann C
- Avery P
- Avetisyan A
- Avila C
- Awan MIM
- Ayan AS
- Ayhan A
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babb J
- Babucci E
- Baccaro S
- Bacchetta N
- Bacchi W
- Bachtis M
- Baden D
- Badgett W
- Baechler J
- Baer H
- Baesso P
- Baffioni S
- Bagby L
- Bagliesi G
- Bahk SY
- Bailleux D
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Baldin B
- Ball G
- Ball H
- Ballin J
- Bally SL
- Ban Y
- Bandurin D
- Banerjee S
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- Banicz K
- Bansal S
- Banzuzi K
- Barashko V
- Barbagli G
- Barberis E
- Barbone L
- Barcala JM
- Barcellan L
- Bard R
- Bargassa P
- Baringer P
- Barnes VE
- Barnett BA
- Barney D
- Barone L
- Bartalini P
- Bartoloni A
- Bartz E
- Basegmez S
- Battilana C
- Baty C
- Baud A
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- Bauer J
- Bauerdick LAT
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- Bazterra VE
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- Beauceron S
- Beaudette F
- Beaumont W
- Bechtel F
- Bedjidian M
- Bedoya CF
- Beetz CP
- Behrens U
- Bejar JC
- Belforte S
- Beliy N
- Bell KW
- Bellan P
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- Bellinger JN
- Belotelov I
- Benaglia A
- Bencze G
- Bendavid J
- Bender W
- Benedetti D
- Benelli G
- Benettoni M
- Beni N
- Benucci L
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- Benvenuti AC
- Berengueres JOL
- Beretvas A
- Bergauer H
- Bergauer T
- Beri SB
- Bernardini J
- Bernet C
- Berntzon L
- Berretta L
- Berry D
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- Berryhill J
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- Bertl W
- Bertoldi M
- Berzano U
- Besancon M
- Besson A
- Betchart B
- Betev B
- Betts RR
- Beuselinck R
- Bhat PC
- Bhatnagar V
- Bhattacharya S
- Bhattacharya S
- Bhatti A
- Biallass P
- Bianchini L
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- Biasini M
- Biasotto M
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- Bilei GM
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- Bitioukov S
- Blaha J
- Blekman F
- Bloch D
- Bloch I
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- Blumenfeld B
- Blyweert S
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- Bocci A
- Bockelman B
- Bodek A
- Bodin D
- Boeriu O
- Boldini M
- Boldizsar L
- Bolla G
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- Bolton T
- Bona M
- Bonacorsi D
- Bonato A
- Bondar N
- Bontenackels M
- Boos E
- Borcherding F
- Borgia MA
- Bornheim A
- Borras K
- Borrello L
- Borsato E
- Bortoletto D
- Bos J
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- Bosi F
- Bostock F
- Botta C
- Boudoul G
- Bouhali O
- Bourgeois N
- Bourilkov D
- Bourrel T
- Boutemeur M
- Boutle S
- Braibant-Giacomelli S
- Branca A
- Branson JG
- Brauer R
- Braunschweig W
- Breedon R
- Brett AM
- Breuker H
- Brew C
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- Briggs R
- Brigljevic V
- Broccolo G
- Brom JM
- Brooke JJ
- Brown RM
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- Bruno G
- Buchmuller O
- Budd H
- Buege V
- Buehler M
- Bunin P
- Bunkowski K
- Bunn J
- Buontempo S
- Burkett K
- Burtovoy V
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- Busza W
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- Butler PH
- Butt J
- Butz E
- Bylsma B
- Caballero IG
- Cabrillo IJ
- Cafaro VD
- Cai J
- Caiazza SS
- Cakir A
- Cakir I. Turk
- Calderon A
- Cali IA
- Callner J
- Calloni M
- Calvo E
- Calzolari F
- Camanzi B
- Caminada L
- Campagnari C
- Campbell A
- Campderros JD
- Campi D
- Camporesi T
- Cankocak K
- Cano E
- Capiluppi P
- Caponeri B
- Cardaci M
- Carleton M
- Carlin R
- Carlsmith D
- Carroll R
- Cartiglia N
- Carvalho W
- Case M
- Cassel D
- Castaldi R
- Castellani L
- Castello R
- Castro A
- Castro E
- Castro MA
- Cattai A
- Caudron J
- Cavallari F
- Cavallo FR
- Cavallo N
- Cavanaugh R
- Ceballos GG
- Cebra D
- Cepeda M
- Cerati GB
- Cerci S
- Cerizza G
- Cerminara G
- Ceron C
- Cerrada M
- Chabert EC
- Chan M
- Chandra A
- Chang P
- Chang S
- Chang YH
- Chanon N
- Chao Y
- Charaf O
- Charlot C
- Chatelain JP
- Chatrchyan S
- Chatterjee A
- Chauhan S
- Chauvey M
- Checchia P
- Checcucci B
- Chekhovsky V
- Chen EA
- Chen GM
- Chen HS
- Chen J
- Chen KF
- Chen M
- Chen WT
- Chen Z
- Cheng TL
- Chertok M
- Chetluru V
- Cheung HWK
- Chien CY
- Chierici R
- Chiochia V
- Chiorboli M
- Chipaux R
- Chiumarulo F
- Chlebana F
- Choi M
- Choi S
- Choi Y
- Chou JP
- Choudhary BC
- Choudhury RK
- Christian G
- Christiansen T
- Chtchipounov L
- Chuang SH
- Chung J
- Chung K
- Chung YS
- Churin I
- Chwalek T
- Cihangir S
- Cimmino A
- Cirino G
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clarida W
- Clemente A
- Clemente F
- Clerbaux B
- Cline D
- Cockerill DJA
- Codispoti G
- Colafranceschi S
- Colaleo A
- Cole JE
- Colino N
- Colling D
- Colonna D
- Conetti S
- Contardo D
- Conte E
- Conti E
- Conway J
- Cooper SI
- Cordonnier AM
- Cortabitarte RV
- Cossutti F
- Costa M
- Costa S
- Coughlan JA
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- Crawford M
- Creanza D
- Cremaldi LM
- Cripps N
- Crotty I
- Cuevas J
- Cuffiani M
- Cumalat JP
- Cuplov V
- Cure B
- Cuscela G
- Cushman P
- Cussans D
- Cutts D
- Cwiok M
- Czellar S
- D'Alessandro R
- D'Alfonso M
- D'Angelo P
- D'Antone I
- D'Enterria D
- D'Hondt J
- Dabrowski R
- Dafinei I
- Dagenhart W
- Dahmes B
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- Dallavalle GM
- Dambach S
- Damgov J
- Damiao DD
- Dammann D
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- Danielson T
- Darmenov N
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- Daskalakis G
- Dasu S
- Dattola D
- Daubie E
- David A
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- de Abril IM
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- De Boer W
- de Cassagnac RG
- de Fatis TT
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- De Guio F
- De La Cruz B
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- De Robertis G
- De Roeck A
- De Souza SF
- de Troconiz JF
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- De Weirdt S
- De Wolf EA
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- Deiters K
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- del Arbol PMR
- Del Re D
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- Deliomeroglu M
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- Della Negra M
- Della Ricca G
- Dellacasa G
- Delmeire E
- Demaria N
- Demarteau M
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- Denegri D
- Denisov A
- Deniz M
- Depasse P
- Dermenev A
- Dero V
- Derylo G
- Descamps J
- Devroede O
- Deyrail D
- Dharmaratna WGD
- Di Calafiori DRDS
- Di Giovanni GP
- Di Marco E
- Di Vincenzo S
- Dias MAF
- Diemoz M
- Dierlamm A
- Dimitrov A
- Dimitrov L
- Dinardo ME
- Dinu N
- Dirkes G
- Dissertori G
- Dittmar M
- Djaoshvili N
- Djordjevic M
- Do Amaral SMS
- Dobrzynski L
- Dobur D
- Dolen J
- Dolgopolov A
- Dominguez A
- Dominik W
- Donckt MV
- Donvito G
- Dorigo T
- Doroba K
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- Draeger J
- Dragicevic M
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- Dremin I
- Drouhin F
- Drozdetskiy A
- Druzhkin D
- Dubinin M
- Duda M
- Dudero PR
- Dudko L
- Dugad S
- Dughera G
- Dumanoglu I
- Dumitrache F
- Dupasquier T
- Dupont T
- Duric S
- Durkin LS
- Duru F
- Dusinberre E
- Dutta D
- Dutta S
- Dvornikov O
- Dykstra D
- Dyulendarova M
- Dzelalija M
- Eads M
- Eartly DP
- Eckerlin G
- Ecklund KM
- Eckstein D
- Edelhoff M
- Edera LM
- Efron J
- Egeland R
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- Erdmann M
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- Eskut E
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- Eugster J
- Eulisse G
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- Fabbricatore P
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- Fabozzi F
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- Fasanella D
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- Fernandez M
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- Filozova I
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- Gentit FX
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
- Author
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- Solomon R
- Song W
- Sood V
- Soto Gonzalez A
- Soto Mb
- Sowinski D
- Sprague A
- Spry L
- Sreedhar R
- Sreelatha M
- Starzec A
- Steele A
- Stella A
- Stephens J
- Strzelecka A
- Suchinda P
- Sudhakar B
- Sultan S
- Sun J
- Sun L
- Surampudi P
- Sussman S
- Svyshchenko Y
- Symonds R
- Takacs R
- Takai M
- Tamayo Y Orozco JA
- Tan A
- Tan G
- Tangri N
- Tellez Chavez E
- Temelkova M
- Terns Riera M
- Terrelonge A
- Terront Lozano Ma
- Tesar V
- Thervet E
- Thimmaiah R
- Thom\ue9 F
- Thompson M
- Tibes Hachmann Jc
- Tinahones Madueno Fj
- Toarba C
- Tolentino M
- Tomashkevych H
- Tomonaga O
- Topchii I
- Torshizi A
- Travis K
- Trespalacios F
- Trevisan R
- Trippe B
- Trueba P
- Tryshchuk N
- Tsang V
- Tseluyko V
- Tsujimoto M
- Tu P
- Turchin A
- Turcios Juarez E
- Turner W
- Twahirwa M
- Ulla Mr
- Updegrove J
- Urbanaviciene E
- Uriasyev O
- Valderrama Cometa L
- Valdes Depeda A
- Valdez M
- Valenzuela A
- Valis M
- Vallejos A
- Van Buren P
- Vangel S
- Vannorsdall M
- Vargas Alonso Rd
- Varghese F
- Vasas S
- Vazelov E
- Vejar M
- Velasquez-Mieyer P
- Velichkova E
- Venegas Carrillo L
- Vengadasalam P
- Ventrapragada S
- Veronelli Am
- Villagordoa Mesa J
- Villarino A
- Villegas I
- Visco Ve
- Vizir V
- Vlasenko M
- von Ingersleben G
- Vorobyev S
- Vukotic G
- Vyasam Rc
- Wada T
- Wadud K
- Wahba M
- Wakasugi M
- Wakeling J
- Wakida Y
- Walker R
- Wang G
- Wang H
- Warren M
- Wassermann A
- Watanabe T
- Watson E
- Watson H
- Watts R
- Weiner D
- Weiner P
- Welker J
- Welsh J
- Wheeler D
- Wheeler David C
- Wheeler Dc
- Williams M
- Williams S
- Winocour P
- Wong Ac
- Woo V
- Yakov A
- Yamada M
- Yamada S
- Yanagida K
- Yanase T
- Yang J
- Yao C
- Yap Ye
- Yavin Yshai
- Ygpuara Mdl
- Yin A
- Yoiti Hayashida C
- Yoon Kh
- Yost L
- Young S
- Yu X
- Yumita W
- Yupanqui H
- Zaidman Cj
- Zalunardo N
- Zamarripa Escobedo R
- Zanata Petry Tb
- Zanella Mt
- Zaniewski-Singh M.
- Zanoli L
- Zaoui P
- Zateyshchikova A
- Zateyshshikov D
- Zaviriukha V
- Zemek S
- Zhang H
- Zhang Hong
- Zhao M
- Zheng H
- Zinman B
- Zinman Bernard
- Zlova T
- Zsom M
- Zub L
- Zykova T
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodiumâglucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with reninâangiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
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- Aarsland D
- Abramzon Y
- Adams DJ
- Adeleye A
- Aguilar M
- Ahmed S
- Al-Chalabi A
- Al-Sarraj S
- Al-Sarraj S
- Alba C
- Alba C
- Albani D
- Albert MS
- Altschuler S
- Alvarez I
- Amar K
- Ambrose JC
- Archibald N
- Arcila-Londono X
- Arepalli S
- Aronica E
- Arumugam P
- Asress S
- Atassi N
- Attems J
- Auluck P
- Baas F
- Baas F
- Babu S
- Bacikova D
- Bacikova D
- Baloh RH
- Baloh RH
- Bandmann O
- Baple EL
- Barrett MJ
- Beach TG
- Bekris LM
- Bennett DA
- Benussi L
- Berry JD
- Bertolin C
- Besser LM
- Bigio EH
- Binetti G
- Black SE
- Blair IP
- Bleda M
- Boada M
- Boardman-Pretty F
- Boeve BF
- Bohannan RC
- Boissiere JM
- Borroni B
- Boustred CR
- Bowser R
- Bowser R
- Boylan KB
- Brady CB
- Brett F
- Brice A
- Brice A
- Brittain H
- Broach J
- Broach JR
- Broce I
- Brown RH
- Brunetti M
- Bruni A
- Butovsky O
- Calini D
- Calvo A
- Camu W
- Canosa A
- Capps E
- Caraway CA
- Caroppo P
- Castellotti B
- Caulfield MJ
- Cereda C
- Ceroni M
- Chan GC
- Chandran S
- Chia R
- Chiang H-H
- Chiò A
- Chiò A
- Church A
- Clarimon J
- Clarimon J
- Coebergh J
- Colombrita C
- Comi GP
- Cooper-Knock J
- Corcia P
- Corrado L
- Corti S
- Costantini A
- Cox GA
- Craig CEH
- Crary J
- Critchley P
- Dalgard CL
- Danek A
- Danielson EW
- Dardiotis E
- Daugherty LC
- De Belleroche J
- De Burca A
- Del Bo R
- Devereau A
- Dewan R
- Dickson D
- Diehl-Schimd J
- Diekstra FP
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- Ding J
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- Drepper C
- Drory V
- Drory VE
- Dubnau J
- Duga S
- Dunckley TL
- Duyckaerts C
- DâAlfonso S
- Elgar G
- Esteban-PĂŠrez J
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- Fallini C
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- Feldman E
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- Ferrucci L
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- Flanagan ME
- Floeter MK
- Floris G
- Foroud TM
- Fortea J
- Foulger RE
- Fowler T
- Fraenkel E
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- Galimberti D
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- GarcĂa-Redondo A
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- Gentleman S
- Gerhard G
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- Ghosh BCP
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- Gibbs JR
- Gibson SB
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- Glass JD
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- Goldstein D
- GonzĂĄlez-Aramburu I
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- Goutman SA
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- Graff-Radford NR
- Hackett JM
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- Hammell MG
- Hardiman O
- Hardy JA
- Harms M
- Harms MB
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- HernĂĄndez I
- Hickman RA
- Hjermind LE
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- Holman JE
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- Infante J
- Iranzo A
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- Kamel F
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- Kaufmann H
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- Keith J
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- Khoshnood B
- Kim RC
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- Kobylecki C
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- Kowall NW
- KrĂźger R
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- Morris HR
- Morris HR
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- Ostrow LW
- Padovani A
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- Sapp PC
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- Schlachetzki JC
- Scholz SW
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- Serrano GE
- Shakkottai V
- Shalem O
- Shankaracharya FNU
- Sharma J
- Shaw CE
- Shaw PJ
- Shaw PJ
- Shneider NA
- Siddiq A
- Sidle KC
- Sidransky E
- Sieghart A
- Silani V
- Simmons Z
- Simmons Z
- Singleton AB
- Smedley D
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- Smith KR
- Soltis AR
- SorarĂš G
- Sorbi S
- Sosinsky A
- Spooner W
- Stefanis L
- Stein TD
- Stevens HE
- Stevic Z
- Stone DJ
- Stuckey A
- Sukumar G
- Sultana R
- Tagliavini F
- Talbot K
- Tanaka T
- Taroni F
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- Ten Asbroek ALMA
- Thomas AJ
- Thomas ERA
- Thompson LM
- Thompson SR
- Ticozzi N
- Tienari PJ
- Tilley BS
- Tiloca C
- Topp SD
- Torkamani A
- Traynor BJ
- Tregidgo C
- Troakes C
- Troakes C
- Trojanowski JQ
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- Troncoso JC
- Tucci A
- Tuck M
- Turner MR
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- Van Blitterswijk M
- Van Damme P
- Van Deerlin V
- Van den Berg LH
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- Van Rheenen W
- Vance C
- Vaughan J
- Veldink JH
- Viollet C
- Vonsattel JP
- Waldo ML
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- Walton RL
- Watters SA
- Welland MJ
- Wilkerson MD
- Williams E
- Williams KL
- Witkowska K
- Woltjer R
- Wood SM
- Wszolek ZK
- Wu L
- Wu Z
- Xiromerisiou G
- Zaitlen N
- Zarowiecki M
- Zecca C
- Zhang B
- Zhang X
- Zinman L
- Ăijerstedt L
- Publication venue
- Neuron
- Publication date
- 01/01/2020
- Field of study
We examined the role of repeat expansions in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) by analyzing whole-genome sequence data from 2,442 FTD/ALS patients, 2,599 Lewy body dementia (LBD) patients, and 3,158 neurologically healthy subjects. Pathogenic expansions (range, 40-64 CAG repeats) in the huntingtin (HTT) gene were found in three (0.12%) patients diagnosed with pure FTD/ALS syndromes but were not present in the LBD or healthy cohorts. We replicated our findings in an independent collection of 3,674 FTD/ALS patients. Postmortem evaluations of two patients revealed the classical TDP-43 pathology of FTD/ALS, as well as huntingtin-positive, ubiquitin-positive aggregates in the frontal cortex. The neostriatal atrophy that pathologically defines Huntington's disease was absent in both cases. Our findings reveal an etiological relationship between HTT repeat expansions and FTD/ALS syndromes and indicate that genetic screening of FTD/ALS patients for HTT repeat expansions should be considered
Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study
- Author
- Abad RD
- Abe T
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
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- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Ă
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlaf G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- AntĂ´nio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Araujo AM
- Arizmendi A
- Arnal JM
- Artiga MJD
- Artigas A
- Ascoli A
- Au SM
- Avila LE
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- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
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- Balkhi H
- Baltus T
- Banner-Goodspeed VM
- Barberet G
- Baron RM
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- Barratt-Due A
- Barros FM
- Barros NC
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- Battle CE
- Bauer PR
- Beck E
- Beck O
- Bedreag OH
- Beegle SH
- Beitler JR
- Bellani G
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- Beloncle F
- Ben Souissi A
- Benslama A
- Beraldo DO
- Berghe C
- Berkelmans F
- Besset SL
- Bettini LR
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- Bhardwaj VK
- Bhowmick K
- Biehler J
- Bigot C
- Bihari S
- Biondi RS
- Biscione RR
- Bisso MC
- Black CS
- Blakeman TC
- Blanco J
- Bolon S
- Borello SA
- Borotto EE
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- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2019
- Field of study
OBJECTIVES: To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity. DESIGN: Planned secondary analysis of a prospective, observational, multicentre cohort study. SETTING: International sample of 459 ICUs from 50 countries. PATIENTS: Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days. INTERVENTIONS: Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilation and by actual respiratory rate compared with set respiratory rate during the first 48 hours of mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Spontaneous breathing was present in 67% of patients with mild acute respiratory distress syndrome, 58% of patients with moderate acute respiratory distress syndrome, and 46% of patients with severe acute respiratory distress syndrome. Patients with spontaneous breathing were older and had lower acute respiratory distress syndrome severity, Sequential Organ Failure Assessment scores, ICU and hospital mortality, and were less likely to be diagnosed with acute respiratory distress syndrome by clinicians. In adjusted analysis, spontaneous breathing during the first 2 days was not associated with an effect on ICU or hospital mortality (33% vs 37%; odds ratio, 1.18 [0.92-1.51]; p = 0.19 and 37% vs 41%; odds ratio, 1.18 [0.93-1.50]; p = 0.196, respectively ). Spontaneous breathing was associated with increased ventilator-free days (13 [0-22] vs 8 [0-20]; p = 0.014) and shorter duration of ICU stay (11 [6-20] vs 12 [7-22]; p = 0.04). CONCLUSIONS: Spontaneous breathing is common in patients with acute respiratory distress syndrome during the first 48 hours of mechanical ventilation. Spontaneous breathing is not associated with worse outcomes and may hasten liberation from the ventilator and from ICU. Although these results support the use of spontaneous breathing in patients with acute respiratory distress syndrome independent of acute respiratory distress syndrome severity, the use of controlled ventilation indicates a bias toward use in patients with higher disease severity. In addition, because the lack of reliable data on inspiratory effort in our study, prospective studies incorporating the magnitude of inspiratory effort and adjusting for all potential severity confounders are required
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
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- Ramirez-Alfaro Cm
- Ramirez-Gutierrez A
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- Strauch U
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- Tulaimat A
- Twohey L
- Uchiyama A
- Ueda T
- Ueno K
- Umbrello M
- Unnikrishnan R
- Uppalapati A
- Van Haren F
- Van Wezel Hm
- Vargas Mp
- Vascotto Er
- Vasquez Dn
- Vega Ld
- Veljovic M.
- Venti A
- Vercueil A
- Vermassen J
- Verstraete R
- Villagomez A
- Villagomez Aj
- Villamagua Bg
- Villar V
- Virgilio Cg
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- Zheng R
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- Zogheib Eh
- Ăamendys-Silva Sa
- Ănal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013
Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries
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- Abad RD
- Abe T
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- Adams JC
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- Aguirre JS
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- Aisiku I
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- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
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- Algaba Ă
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- Zhu BH
- Zhu WH
- Zogheib EH
- Ăamendys-Silva SA
- Ănal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteristics, management and outcomes of patients that received tracheostomy, in the cohort of patients that developed ARDS on day 1-2 of acute hypoxemic respiratory failure, and in a subsequent propensity-matched cohort. Results: Of the 2377 patients with ARDS that fulfilled the inclusion criteria, 309 (13.0%) underwent tracheostomy during their ICU stay. Patients from high-income European countries (n = 198/1263) more frequently underwent tracheostomy compared to patients from non-European high-income countries (n = 63/649) or patients from middle-income countries (n = 48/465). Only 86/309 (27.8%) underwent tracheostomy on or before day 7, while the median timing of tracheostomy was 14 (Q1-Q3, 7-21) days after onset of ARDS. In the subsample matched by propensity score, ICU and hospital stay were longer in patients with tracheostomy. While patients with tracheostomy had the highest survival probability, there was no difference in 60-day or 90-day mortality in either the patient subgroup that survived for at least 5 days in ICU, or in the propensity-matched subsample. Conclusions: Most patients that receive tracheostomy do so after the first week of critical illness. Tracheostomy may prolong patient survival but does not reduce 60-day or 90-day mortality. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
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- Author
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- Zhang Y
- Zhang Z
- Zheng Y
- Zhiltsov V
- Zhokin A
- Zhu B
- Zhu K
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Zielinski M
- Zilizi G
- Zinonos Z
- Zito G
- Zoeller MH
- Zotto P
- Zub S
- Zumerle G
- Zuranski A
- Zuyeuski R
- Zych P
- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anh T. Vu
- Anisimov A
- Antillon E
- Antipov P
- Antonelli L
- Anttila E
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arnold B
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- Artamonov A
- Asaadi J
- Asghar MI
- Ashby S
- Askew A
- Atac M
- Atramentov O
- Auffray E
- Aurisano A
- Autermann C
- Avery P
- Avetisyan A
- Avila C
- Awan MIM
- Ayan AS
- Ayhan A
- Azhgirey I
- Aziz T
- Azzi P
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- Publication venue
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adhyapak S
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aimsâ The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisinâkexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (âĽ1.8âmmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and resultsâ Median follow-up was 2.8âyears. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (nâ=â2) or Type 5 (nâ=â5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77â0.95; Pâ=â0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77â0.99; Pâ=â0.032) and Type 2 (0.77, 0.61â0.97; Pâ=â0.025), but not Type 4 MI. Conclusionâ After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Measurement of the Pseudorapidity and Centrality Dependence of the Transverse Energy Density in Pb-Pb Collisions at âsNN=2.76ââTeV
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The transverse energy (E-T) in Pb-Pb collisions at 2.76 TeV nucleon-nucleon center-of-mass energy (root s(NN)) has been measured over a broad range of pseudorapidity (eta) and collision centrality by using the CMS detector at the LHC. The transverse energy density per unit pseudorapidity (dE(T)/d eta) increases faster with collision energy than the charged particle multiplicity. This implies that the mean energy per particle is increasing with collision energy. At all pseudorapidities, the transverse energy per participating nucleon increases with the centrality of the collision. The ratio of transverse energy per unit pseudorapidity in peripheral to central collisions varies significantly as the pseudorapidity increases from eta = 0 to vertical bar eta vertical bar = 5.0. For the 5% most central collisions, the energy density per unit volume is estimated to be about 14 GeV/fm(3) at a time of 1 fm/c after the collision. This is about 100 times larger than normal nuclear matter density and a factor of 2.6 times higher than the energy density reported at root s(NN) = 200 GeV at the Relativistic Heavy Ion Collider
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