732 research outputs found
The Far-Infrared Surveyor (FIS) for AKARI
- Author
- Baba Hajime
- Barthel Peter D.
- Clements David
- Cohen Martin
- Doi Yasuo
- Figueredo Elysandra
- Fujiwara Mikio
- Goto Tomotsugu
- Hasegawa Sunao
- Hibi Yasunori
- Hirao Takanori
- Hiromoto Norihisa
- Jeong Woong-Seob
- Kaneda Hidehiro
- Kawada Mitsunobu
- Kawai Toshihide
- Kawamura Akiko
- Kester Do
- Kii Tsuneo
- Kobayashi Hisato
- Kwon Suk Minn
- Lee Hyung Mok
- Makiuti Sin'itirou
- Matsuo Hiroshi
- Matsuura Shuji
- Murakami Noriko
- Müller Thomas G.
- Nagata Hirohisa
- Nakagawa Takao
- Narita Masanao
- Noda Manabu
- Oh Sang Hoon
- Okada Yoko
- Okuda Haruyuki
- Oliver Sebastian
- Ootsubo Takafumi
- Pak Soojong
- Park Yong-Sun
- Pearson Chris P.
- Rowan-Robinson Michael
- Saito Toshinobu
- Salama Alberto
- Sato Shinji
- Savage Richard S.
- Serjeant Stephen
- Shibai Hiroshi
- Shirahata Mai
- Sohn Jungjoo
- Suzuki Toyoaki
- Takagi Toshinobu
- Takahashi Hidenori
- Thomson Matthew
- Usui Fumihiko
- Verdugo Eva
- Wang Lingyu
- Watabe Toyoki
- White Glenn J.
- Yamamuchi Chisato
- Yamamura Issei
- Yasuda Akiko
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2007
- Field of study
The Far-Infrared Surveyor (FIS) is one of two focal plane instruments on the
AKARI satellite. FIS has four photometric bands at 65, 90, 140, and 160 um, and
uses two kinds of array detectors. The FIS arrays and optics are designed to
sweep the sky with high spatial resolution and redundancy. The actual scan
width is more than eight arcmin, and the pixel pitch is matches the diffraction
limit of the telescope. Derived point spread functions (PSFs) from observations
of asteroids are similar to the optical model. Significant excesses, however,
are clearly seen around tails of the PSFs, whose contributions are about 30% of
the total power. All FIS functions are operating well in orbit, and its
performance meets the laboratory characterizations, except for the two longer
wavelength bands, which are not performing as well as characterized.
Furthermore, the FIS has a spectroscopic capability using a Fourier transform
spectrometer (FTS). Because the FTS takes advantage of the optics and detectors
of the photometer, it can simultaneously make a spectral map. This paper
summarizes the in-flight technical and operational performance of the FIS.Comment: 23 pages, 10 figures, and 2 tables. Accepted for publication in the
AKARI special issue of the Publications of the Astronomical Society of Japa
Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus
- Author
- A Ahmadian
- A Doreau
- AC Grammer
- AL Price
- AL Sestak
- Alexander Moon Ho Leung
- AM Jacobi
- C Du
- CC Mok
- Chak Sing Lau
- Chi Chiu Mok
- Chun-Ming Wong
- CK Wong
- CK Wong
- CO Jacob
- CW Garvie
- D Wang
- Dingge Ying
- Dong-Qing Ye
- DS Cunninghame Graham
- E Bettelli
- EF Remmers
- F Ramos-Niembro
- FC Arnett
- G Hom
- H Maier
- Hai-Feng Pan
- HC Hsu
- HO Siu
- I Kim
- Irene Oi Lin Ng
- J Chen
- J Dittmer
- J Moisan
- J Yang
- JB Harley
- JC Barrett
- JC Bories
- JC Edberg
- Jonathan Flint
- JW Han
- K Liu
- Ka Wing Lee
- KH Sun
- Lu Zhang
- MA Pufall
- Marco Hok Kung Ho
- MC Hochberg
- Mo Yin Mok
- Nan Shen
- Nattiya Hirankarn
- NK Bhat
- Pak Chung Sham
- Pamela Pui Wah Lee
- Philip H. Li
- Qiji Liu
- R Ettinger
- R Webb
- Raymond Woon Sing Wong
- RR Graham
- Ruo-Jie Li
- S Purcell
- S Xu
- SA John
- Sik Nin Wong
- SK Nath
- SL Musone
- SN Wong
- SV Kozyrev
- Tak Mao Chan
- Tsz Leung Lee
- V Gateva
- W Yang
- W Yang
- Wanling Yang
- Wilfred Hing Sang Wong
- Xiang-Pei Li
- Xiao-Xia Qian
- Y Tang
- Yan Zhang
- Yingyos Avihingsanon
- YK Chang
- Yu Lung Lau
- Yuk Kwan Chang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Systemic lupus erythematosus is a complex and potentially fatal autoimmune disease, characterized by autoantibody production and multi-organ damage. By a genome-wide association study (320 patients and 1,500 controls) and subsequent replication altogether involving a total of 3,300 Asian SLE patients from Hong Kong, Mainland China, and Thailand, as well as 4,200 ethnically and geographically matched controls, genetic variants in ETS1 and WDFY4 were found to be associated with SLE (ETS1: rs1128334, P = 2.33×10−11, OR = 1.29; WDFY4: rs7097397, P = 8.15×10−12, OR = 1.30). ETS1 encodes for a transcription factor known to be involved in a wide range of immune functions, including Th17 cell development and terminal differentiation of B lymphocytes. SNP rs1128334 is located in the 3′-UTR of ETS1, and allelic expression analysis from peripheral blood mononuclear cells showed significantly lower expression level from the risk allele. WDFY4 is a conserved protein with unknown function, but is predominantly expressed in primary and secondary immune tissues, and rs7097397 in WDFY4 changes an arginine residue to glutamine (R1816Q) in this protein. Our study also confirmed association of the HLA locus, STAT4, TNFSF4, BLK, BANK1, IRF5, and TNFAIP3 with SLE in Asians. These new genetic findings may help us to gain a better understanding of the disease and the functions of the genes involved
Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians
- Author
- Avihingsanon Yingyos
- Chan Tak Mao
- Chen Xiang
- Cheng Hui
- Cherny Stacey S.
- Chong Chun Yin
- Chung Brian Hon-Yin
- Cui Hongzhou
- Cui Yong
- Deekajorndej Thavatchai
- Diao Qingchun
- Fang Hong
- Fung Samuel Ka Shun
- Gao Fei
- Gao Jinping
- Garcia-Barceló Maria-Mercè
- Guo Qing
- Hao Fei
- Hirankarn Nattiya
- Ho Marco Hok Kung
- Hui Yan
- Kang Xiaojing
- Lai Wai Ming
- Lau Chak Sing
- Lau Yu Lung
- Lee Ka Wing
- Lee Pamela Pui Wah
- Lee Tsz Leung
- Leung Alexander Moon Ho
- Li Xiang-Pei
- Li Yang
- Liang Bo
- Liu Qiji
- Lu Qianjin
- Mok Chi Chiu
- Mok Mo Yin
- Ng Irene Oi Lin
- Pan Hai-Feng
- Pu Xiongming
- Rianthavorn Pornpimol
- Sham Pak Chung
- Shen Nan
- Sheng Yujun
- Shi Bingjun
- Shotelersuk Vorasuk
- Sun Liangdan
- Sun Yonghu
- Suphapeetiporn Kanya
- Tam Paul Kwong-Hang
- Tang Huayang
- Tang Xianfa
- Tong Kwok Lung
- Tse Niko Kei Chiu
- Wong Chun-Ming
- Wong Raymond Woon Sing
- Wong Sik Nin
- Wong Wilfred Hing Sang
- Xie Hongfu
- Yang Jing
- Yang Sen
- Yang Wanling
- Ye Dong-Qing
- Yin Xianyong
- Ying Dingge
- Ying Shirley King Yee
- Zeng Fanqin
- Zhai Zhifang
- Zhang Change
- Zhang Jing
- Zhang Lijuan
- Zhang Lu
- Zhang Xiaoguang
- Zhang Xuejun
- Zhang Yan
- Zhou Fusheng
- Zhu Dingxian
- Zuo Xianbo
- Publication venue
- The American Society of Human Genetics. Published by Elsevier Inc.
- Publication date
- 10/01/2013
- Field of study
Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong genetic involvement and ethnic differences. Susceptibility genes identified so far only explain a small portion of the genetic heritability of SLE, suggesting that many more loci are yet to be uncovered for this disease. In this study, we performed a meta-analysis of genome-wide association studies on SLE in Chinese Han populations and followed up the findings by replication in four additional Asian cohorts with a total of 5,365 cases and 10,054 corresponding controls. We identified genetic variants in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with the disease. These findings point to potential roles of cell-cycle regulation, autophagy, and DNA demethylation in SLE pathogenesis. For the region involving TET3 and that involving CDKN1B, multiple independent SNPs were identified, highlighting a phenomenon that might partially explain the missing heritability of complex diseases
Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).
- Author
- A'Court C.
- Aaroe H.
- Abd El-Aziz A.
- Abdalla Saad J.
- Abdel-Qader M.
- Abdelrahman H.
- Abdul A.
- Abe M. (Masahiko)
- Abe M. (Masatake)
- Abe M. (Mitsunori)
- Abe S.
- Abe Y.
- Abhayaratna W.
- Abou Seif S. K.
- Abraham S.
- Abu-Mahfouz M.
- Abushal S.
- Accetta Gabriele
- Accogli M.
- Adachi S.
- Adachi S. (Sen)
- Adachi S. (Susumu)
- Adachi T.
- Adak D.
- Adriaansen H.
- Agakhanyan A.
- Agata J.
- Ageta M.
- Aggarwala A.
- Agliardi P.
- Agnelli G.
- Agnelli Giancarlo
- Agrawal A.
- Aguilar J.
- Ahbeck E.
- Ahlmark H.
- Ahmad K.
- Ahmad N.
- Ahmad S.
- Ahmed F.
- Ahmed W.
- Ahn J. J.
- Ahuad Guerrero R. A.
- Ainsworth P.
- Airaksinen J.
- Akahane K.
- Akiyama M.
- Aktas O.
- Akutsu M.
- Al Mahmeed W.
- Al Mahmeed Wael
- Al Mulla A.
- Al Naeemi A.
- Al Omairi M.
- Al-Khalili F.
- Alaguibe E. D.
- Alban F.
- Alberts M.
- Alborough E.
- Aldegather J.
- Aleksandrova E.
- Alfaro T. A. A.
- Alfieri A.
- Ali A.
- Alkan D. Uzun
- Allasia B.
- Almeida Fernandez C. A.
- Alonso C. (Carmela)
- Alonso C. (Concepcion)
- Alpay D.
- Altamirano Bellorin S.
- Altun A.
- Alunni M.
- Alvarez D'Amelio A.
- Alvarez Garcia P.
- Alvarez Lopez H.
- Alvarez D.
- Alvarez M.
- Alves da Costa F. A.
- Alves de Oliveira Gomes J.
- Alzand B.
- Amano T.
- Amarenco P.
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- Andersson A.
- Andersson L. (Lars)
- Andersson L. (Lisbeth)
- Ando H.
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- Angaran P.
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- Angel G.
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- Yoshimura A.
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- Yu H. Y.
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- Yuksekdag V
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- Zhan Q.
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- Zhang Q.
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- Zheng W. Y.
- Zhirov I
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- Zhurba S.
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
- Author
- A. Abd El-Aziz
- A. Abdul
- A. Agakhanyan
- A. Aggarwala
- A. Agrawal
- A. Al Mulla
- A. Al Naeemi
- A. Alfieri
- A. Ali
- A. Altun
- A. Alvarez D'Amelio
- A. Andersson
- A. Argena
- A. Austria
- A. Aydinlar
- A. Babyesiza
- A. Barai
- A. Barreau
- A. Barszcz
- A. Bartes
- A. Bazzoni Ruiz
- A. Beattie
- A. Bianchi
- A. Biernacka
- A. Black
- A. Blenkhorn
- A. Branjovich Tijuan
- A. Bremmelgaard
- A. Brown
- A. Browne
- A. Capucci
- A. Caspar
- A. Catanchin
- A. Chmielowski
- A. Choi
- A. Cieszynska
- A. Conde Y Bolado
- A. Connelly
- A. Cortada Cabrera
- A. Davids
- A. De Blasio
- A. De Wolf
- A. Dickerson
- A. Domenech Borras
- A. Dumikyan
- A. Edin
- A. Egilsson
- A. El-Etreby
- A. Elbahry
- A. Elorriaga Madariaga
- A. Espallargas
- A. Ewert
- A. Fearon
- A. Fedorowsky
- A. Ferreira-Jardim
- A. Ferrer
- A. Filippi
- A. Fleck
- A. Flynn
- A. Forero
- A. Frankiewicz
- A. Fujisawa
- A. Gallagher
- A. Ganatra
- A. Gegenhuber
- A. Gieroba
- A. Gilliland
- A. Giombolini
- A. Gonzales Segovia
- A. Grande Ruiz
- A. Grau
- A. Grytzmann
- A. Gubanov
- A. Guerrero Molina
- A. Guinand
- A. Haideri
- A. Hajimirsadeghi
- A. Hallaråker
- A. Halpin
- A. Hay
- A. Heer
- A. Heyse
- A. Horak
- A. Hot-Bjelac
- A. Howitt
- A. Iglesias Garcia
- A. Ishihara
- A. Ivanov
- A. Iñiguez Romo
- A. Jackun-Podlesna
- A. Jaremczuk-Kaczmarczyk
- A. Jarzebowski
- A. Jefferies
- A. Jekthammer
- A. Jerzewski
- A. John Camm
- A. John Camm
- A. John Camm
- A. Jones
- A. Kaczmarzyk-Radka
- A. Karczmarczyk
- A. Katta
- A. Kemmel
- A. Khan
- A. Khokhlov
- A. Koch
- A. Kolesnikova
- A. Kolodzinska
- A. Komlo
- A. Konopka
- A. Kopf
- A. Krueger
- A. Krzesiak-Lodyga
- A. Lavoie
- A. Lawande
- A. Lee
- A. Lettenström
- A. Leyva Rendón
- A. Lindberg
- A. Lindh
- A. Lindourkova
- A. Lischka-Lindner
- A. Lo Buglio
- A. Lopes
- A. Lopez
- A. Lucassen
- A. Ludkova
- A. Lysek-Jozefowicz
- A. Mannermyr
- A. Manzanal Rey
- A. Mariani
- A. Markiewicz
- A. Marquand
- A. Martin Vila
- A. Martinelli
- A. Maselli
- A. Matoltsy
- A. Mauric
- A. Meirino
- A. Menezes Lorga Filho
- A. Merliss
- A. Metzgier-Gumiela
- A. Mielot
- A. Mirtl
- A. Miyashita
- A. Mizuno
- A. Mowafy
- A. Murray
- A. Naguib
- A. Nagy
- A. Nakagomi
- A. Nakata
- A. Navarro
- A. Negrete Palma
- A. Negri
- A. Niemirycz-Makurat
- A. Nowak
- A. Nygaard
- A. Ohanissian
- A. Ohlsson
- A. Olofsson
- A. Ortiz
- A. Osberg
- A. Ota
- A. Oto
- A. Ovsannikova
- A. Page
- A. Papp
- A. Parkhomenko
- A. Pawelska-Buczen
- A. Pedersen
- A. Phrommintikul
- A. Pinter
- A. Pizzini
- A. Plauskat
- A. Podczeck-Schweighofer
- A. Postolache
- A. Pronk
- A. Pustelnik
- A. Quick
- A. Quietzsch
- A. Quisi
- A. Raczynska
- A. Raisaro
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- A. Scaccianoce
- A. Seoane Blanco
- A. Sidor
- A. Singal
- A. Skein
- A. Soliman
- A. Soma
- A. Sossich
- A. Spyropoulos
- A. Srinivas
- A. Sriwichian
- A. Stallinga-de Vos
- A. Steffens
- A. Suissa
- A. Sulc
- A. Svilaas
- A. Sword
- A. Szczepanska
- A. Szilagyi
- A. Szulowska
- A. Taguchi
- A. Talkenberger
- A. Tangsirira
- A. Tetlak
- A. Thatcher
- A. Therkelsen
- A. Thomson
- A. Tomasello
- A. Ushakov
- A. Vandorpe
- A. Vertes
- A. Vishnevsky
- A. Vonbank
- A. Wakeman
- A. Waldman
- A. Warke
- A. Wassef
- A. Wierzbicka
- A. Williams
- A. Wilson
- A. Wirdby
- A. Wutthimanop
- A. Yagensky
- A. Yoshimura
- A. Zateyshchikova
- A. Østrem
- A.-B. Ekstrand
- A.-K. Ascoop
- A.-M. Barbuto
- A.-M. Ohlin
- A.A. Damonte
- A.A. Fernandez
- A.B. Lensebraaten
- A.C. Billiaux
- A.C. Ingaramo
- A.C. Rothwell
- A.C. Tovar Castaneda
- A.C.P. Barretto
- A.D. Hrabar
- A.G. Ravi Shankar
- A.J. Kleiban
- A.J. McLeod
- A.L. Baek
- A.L. Cappi
- A.L. Tufare
- A.M. Jackson
- A.P. Drummond Wainstein
- A.P. Macagnan
- A.R. Kelsall
- A.R. Park
- A.S. Pandey
- Ajay K. Kakkar
- Ajay K. Kakkar
- Alex Parkhomenko
- Alex Spyropoulos
- Alexander G.G. Turpie
- Ali Oto
- Antonio Carlos Pereira Barretto
- B. Allasia
- B. Alzand
- B. Ayres
- B. Chatlaong
- B. Clarke
- B. Conway
- B. Coutu
- B. Crousillat
- B. Curyllo
- B. Deshpande
- B. Dolecka
- B. Doucet
- B. Dubois
- B. Dudzik-Richter
- B. Eriksson
- B. Fox
- B. Gaszner
- B. Ghezai
- B. Gosciniecka
- B. Hawkins
- B. Herrero Maeso
- B. Hoffmann
- B. Ikitimur
- B. Jacobson
- B. Jacobson
- B. Jansson
- B. Jimeno Besa
- B. Kurylo
- B. Kurylo
- B. Li
- B. Liu
- B. Lokesh
- B. Martinsson
- B. Mautner
- B. Merkely
- B. Mooso
- B. Naratreekoon
- B. Okopien
- B. Opielowska-Nowak
- B. Ostrowska-Pomian
- B. Racz
- B. Raghuraman
- B. Ramjattan
- B. Rzyczkowska
- B. Sarai
- B. Schaefer
- B. Schneeweiß
- B. Schweitzer
- B. Sievers
- B. Silaruks
- B. Singh
- B. Sinha
- B. Stephanie
- B. Strohmer
- B. Subbaraman
- B. Unterkircher
- B. Uppelschoten
- B. Vandrus
- B. Vanhauwaert
- B. Vishwanathan
- B. Vogel
- B. Voigts
- B. Ward
- B. Wollaert
- B. Wozakowska-Kaplon
- B. Zhou
- B.-T. Kellner
- B.A.J. Stockins Fernandez
- B.C. Jung
- B.E. Groenemeijer
- B.R. Park
- B.Y. Sayin
- Barry Jacobson
- Bernard J. Gersh
- C. A'Court
- C. Arabetti
- C. Astudillo
- C. Axthelm
- C. Batta
- C. Beltra
- C. Bergeron
- C. Bergeron
- C. Bester
- C. Boshoff
- C. Bothin
- C. Bouvy
- C. Bradshaw
- C. Brike
- C. Brotons Cuixart
- C. Bugueño Gutiérrez
- C. Buiks
- C. Bulla
- C. Buzzetti
- C. Cannon
- C. Cantú Brito
- C. Chami
- C. Chigbo
- C. Ciabatta
- C. Conejeros
- C. Correa
- C. Corros Vicente
- C. Costantini Ortiz
- C. D'Arienzo
- C. Dias
- C. Dooldeniya
- C. Díaz de la Vega
- C. Ellervik
- C. Femiano
- C. Fonseca
- C. Fritz
- C. Funosas
- C. Giles
- C. Gines Garcia
- C. Gomez
- C. Grässjö
- C. Guldener
- C. Gómez Pajuelo
- C. Hagn
- C. Hawkins
- C. Hernández Herrera
- C. Herrick
- C. Hines
- C. Houzvic
- C. Hutton
- C. Jacobs
- C. Jean
- C. Juergens
- C. Kongsin
- C. Lara
- C. Latella
- C. Lewis
- C. Liley
- C. Lodigiani
- C. Martinelli
- C. Mazzone
- C. McCarthy
- C. McIntosh
- C. Moncada
- C. Moro Serrano
- C. Mulholland
- C. Munhoz da Fontoura Tavares
- C. Mussap
- C. Nanzer Vital
- C. Nilsson
- C. Ogurusu
- C. Ormundo
- C. Orosco
- C. Ortiz Cortes
- C. Paul
- C. Pisani
- C. Queirantes
- C. Ramesh
- C. Ravenhorst
- C. Reichelt
- C. Reimer
- C. Rey
- C. Richard
- C. Ricotti
- C. Rivera Ramos
- C. Robertson
- C. Roca Saumell
- C. Rodrigo
- C. Santolaya
- C. Scarone
- C. Scheurwegs
- C. Schubert
- C. Schwencke
- C. Seamark
- C. Simon Valero
- C. Singh
- C. Singleton
- C. Smessaert
- C. Stoll
- C. Stöcklöcker
- C. Sugimoto
- C. Takanaka
- C. Thorsen
- C. Tondo
- C. Torres
- C. Treasure
- C. Vantomme
- C. Verdi
- C. Vicente
- C. Villan
- C. Wöhrer
- C. Yeo
- C. Zecca
- C.-J. Kim
- C.-J. Lindholm
- C.A. Almeida Fernández
- C.A. Neden
- C.C. Broilo França
- C.G. Foo
- C.H. Del Carlo
- C.H. Gimenez
- C.J. Sánchez Díaz
- C.K. Ching
- C.L. Bai
- C.L. Gonzalez Garcia
- C.M. Diaz Lopez
- C.P. Jones
- C.R. Costantini Frack
- C.R. Frack Costantini
- C.S. Lee
- Carlos Jerjes Sánchez Díaz
- Carmela Alonso
- Concepcion Alonso
- D. Adak
- D. Alpay
- D. Alvarez
- D. Amstutz
- D. Andrzejewski
- D. Aras
- D. Armaganijan
- D. Atar
- D. Belenky
- D. Bertolim Precoma
- D. Blaszczyk
- D. Buckert
- D. Cassidy
- D. Castro Fernandez
- D. Chemello
- D. Cholsaringkarl
- D. Colquhoun
- D. Conde
- D. Coulshed
- D. Cresp
- D. Crimmins
- D. Davies
- D. De Cleen
- D. Denie
- D. Diercks
- D. Eccleston
- D. Edwards
- D. Faes
- D. Farquhar
- D. Fielder
- D. Fitzmaurice
- D. Fitzpatrick
- D. Flores Martínez
- D. Fournier
- D. Galley
- D. Geatch
- D. Genc
- D. Glatzel
- D. Goodwin
- D. Gray
- D. Greyling
- D. Guanaes
- D. Guedj-Meynier
- D. Gulyas
- D. Ikeda
- D. Jackson
- D. Jain
- D. Kernick
- D. Kettles
- D. Kociolek
- D. Komar
- D. Konyushenko
- D. Kroll
- D. Kruczyk
- D. Kusiak
- D. Kustrzycka-Kratochwil
- D. Lesniewska-Krynska
- D. Leung
- D. Lopes
- D. López Villezca
- D. Martinez Vasquez
- D. Merritt
- D. Michalik
- D. Montes
- D. Moreira
- D. Naik
- D. Nicolaus
- D. Nishijima
- D. O'Donnell
- D. Obadia
- D. Otero Tomera
- D. Platonov
- D. Plevak
- D. Poli
- D. Redpath
- D. Reimer
- D. Roy
- D. Rozewska-Furmanek
- D. Russell
- D. Sanchez
- D. Santos
- D. Seamark
- D. Shah
- D. Shah
- D. Shepherd
- D. Theodoro
- D. Tragen
- D. Uzun Alkan
- D. Van Lier
- D. Vandenbroeck
- D. Wright
- D. Zanolin
- D. Zateyshchikov
- D.-G. Shin
- D.-K. Kim
- D.B. Kim
- D.C. Esteves
- D.C. Sobral Filho
- D.D. Chen
- D.F. Cumberlidge
- D.H. Kim
- D.J. Choi
- D.R. Ryu
- D.W. Wang
- D.Y. Hu
- Dan Atar
- David A. Fitzmaurice
- David Fitzmaurice
- Dayi Hu
- E. Ahbeck
- E. Alborough
- E. Aleksandrova
- E. Banfi
- E. Barraquer Feu
- E. Bearez
- E. Bekieszczuk
- E. Belisario Falchetto
- E. Berge
- E. Blumberg
- E. Broton
- E. Buckley
- E. Burke
- E. Calvo Martinez
- E. Cardona Muñoz
- E. Chuquiure Valenzuela
- E. Corrihons
- E. Daros
- E. Davies
- E. Deweerd
- E. Domanska
- E. Ducasse
- E. Eißfeller
- E. Ellie
- E. Eriksen
- E. Escrivá Montserrat
- E. Fernandes
- E. Fernandez Escobar
- E. Fernandez Mas
- E. Feys
- E. Fisher
- E. Fulop
- E. Gasior
- E. Gjertsen
- E. Gorbunova
- E. Hartranft
- E. Hettwer Magedanz
- E. Hevia Rodriguez
- E. Jaskulska-Niedziela
- E. Kamenska
- E. Kiralyhazine Gyorke
- E. Kis
- E. Kochanska
- E. Korczowska
- E. Kowal
- E. Krcova
- E. Kremis
- E. Kropacheva
- E. Lanna Figueiredo
- E. Lewicka
- E. Lichota
- E. Lileeva
- E. Loyd
- E. Lustosa
- E. López Rosas
- E. Malone
- E. Mazur
- E. Mesolella
- E. Miedlar
- E. Molina
- E. Mollica Poeta
- E. Márquez Contreras
- E. Nagata
- E. Noori
- E. Novikova
- E. Okuyan
- E. Otaki
- E. Ozcelik
- E. Palmegiani
- E. Panchenko
- E. Pawlik-Rak
- E. Pena Garcia
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- T. Koyanagi
- T. Kozuka
- T. Kumazaki
- T. Kupriyanova
- T. Kusumoto
- T. Kuwahata
- T. Laksomya
- T. Lincoln
- T. Loekkegaard
- T. Läßig
- T. Mark
- T. Medvedeva
- T. Minagawa
- T. Mita
- T. Mito
- T. Mori
- T. Mueller
- T. Murayama
- T. Myhill
- T. Nagatomo
- T. Nagoshi
- T. Nakayama
- T. Nanke
- T. Novikova
- T. Ogawa
- T. Ono
- T. Ovdiienko
- T. Parrott
- T. Patching
- T. Phan
- T. Pillay
- T. Purcell
- T. Railton
- T. Richardson
- T. Ripoll Vera
- T. Ruaro Reichert
- T. Rusicka-Piekarz
- T. Saito
- T. Sanghera
- T. Sasaki
- T. Sayin
- T. Scarponi
- T. Schatzberger
- T. Schwarz
- T. Schäfer
- T. Seker
- T. Seo
- T. Seto
- T. Shindo
- T. Shinozuka
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- T. Shiraiwa
- T. Stephenson
- T. Suetsugu
- T. Suga
- T. Suttana
- T. Tabuchi
- T. Taguchi
- T. Takagi
- T. Tana
- T. Taniguchi
- T. Tau
- T. Toennishoff
- T. Traczyk
- T. Trahey
- T. Tripti
- T. Tsuji
- T. Ueda
- T. Ueda
- T. Unoki
- T. van der Kley
- T. Vargas
- T. Vasankari
- T. Viana
- T. Vydt
- T. Wakiyama
- T. Washizuka
- T. Weyn
- T. Wisaratapong
- T. Wolf
- T. Wong
- T. Yamada
- T. Yamagishi
- T. Yamamoto
- T. Yu
- T. Øien
- T.-J. Cha
- T.A.A. Alfaro
- T.G. Wu
- T.J. Hong
- T.M. Caimi
- T.T. Liu
- T.W. Lim
- T.Y. Ma
- Tadashi Nakamura
- Tetsuro Yoshida
- Tomoki Yoshida
- Toon Wei Lim
- Tsugihiro Nakamura
- U. Börjesson
- U. Dichristin
- U. Gerbaulet
- U. Hintze
- U. Horstmeier
- U. Kitmapawanont
- U. Weiser
- U.M. Nagamalesh
- V. Araujo
- V. Becerra Munoz
- V. Biagioli
- V. Bisne
- V. Campisi
- V. Dedek
- V. Dhyani
- V. Durdil
- V. Eissing
- V. Eltishcheva
- V. Fernandez Caputi
- V. Garcia Millan
- V. Hansen
- V. Hubacova
- V. Jain
- V. Klein
- V. Korley
- V. Kostenko
- V. Lawlor
- V. Lilienweiß
- V. Machova
- V. Mitrovic
- V. Mochonyi
- V. Nagalingam
- V. Navarre
- V. Nemtsova
- V. Nilsen
- V. Novas
- V. O'May
- V. Olguin
- V. Oriana
- V. Palumbo
- V. Pannacci
- V. Paul
- V. Pengo
- V. Piamonte
- V. Quintern
- V. Rasanen
- V. Rios
- V. Roa Castro
- V. St Joseph
- V. Thyssen
- V. Tseluyko
- V. Ueckermann
- V. Vanajakshamma
- V. Varenov
- V. Wilson
- V. Worthy
- V. Yuksekdag
- V.A. Kothiwale
- V.A. Sinisi
- V.L. Pereira
- V.M. Ortega
- V.M. Vijan
- Veerappa A. Kothiwale
- Velam Vanajakshamma
- Vikas Bisne
- W. Abhayaratna
- W. Ahmed
- W. Al Mahmeed
- W. Anné
- W. Boonyapisit
- W. Brzozowski
- W. Coulson
- W. Dorsch
- W. Eder
- W. Erdle
- W. Faron
- W. Furumoto
- W. Gadzinski
- W. Gulliver
- W. Haverkamp
- W. Hermans
- W. Jetten
- W. Kunz Sebba Barroso de Souza
- W. Kurdzielewicz
- W. Lang
- W. Lumb
- W. Murdoch
- W. Myszka
- W. Oosthuysen
- W. Rogowski
- W. Smolders
- W. Suebjaksing
- W. Supinski
- W. Szkrobka
- W. Terpstra
- W. Tiyanon
- W. Van Gaal
- W. Wieczorek
- W. Wildenauer
- W. Willcock
- W. Wongcharoen
- W. Wongtheptien
- W.H. Li
- W.J. Chi
- W.L. Liu
- W.M. Kutayli
- W.N. Guo
- W.S. Son
- W.T. Lim
- W.Y. Lee
- W.Y. Zheng
- Wael Al Mahmeed
- Werner Hacke
- X. Chen
- X. Giry
- X. Li
- X. Robiro Robiro
- X. Sheng
- X. Vandamme
- X. Viñolas
- X.A. He
- X.F. Huang
- X.J. Gao
- X.J. Shi
- X.L. Luo
- X.S. Cheng
- X.S. Hu
- X.W. Yan
- X.Y. Zhu
- Xavier Viñolas
- Y. Abe
- Y. Atsuchi
- Y. Balthazar
- Y. Belenkova
- Y. Campisto
- Y. Emura
- Y. Fujii
- Y. Fujisawa
- Y. Go
- Y. Gomez Perez
- Y. Gottwalles
- Y. Guo
- Y. Haraguchi
- Y. Hata
- Y. Hatori
- Y. Hayashi
- Y. Ivanova
- Y. Jiao
- Y. Kamogawa
- Y. Kato
- Y. Katsube
- Y. Katsuda
- Y. Kawada
- Y. Kelfkens
- Y. Kitami
- Y. Koretsune
- Y. Koshibu
- Y. Kumai
- Y. Maruyama
- Y. Matsuura
- Y. Mizuno
- Y. Moiseeva
- Y. Mostovoy
- Y. Niijima
- Y. Nishida
- Y. Nishihata
- Y. Oba
- Y. Onuki Pearce
- Y. Orlov
- Y. Osmolovskaya
- Y. Park
- Y. Saito
- Y. Sakamoto
- Y. Samejima
- Y. Santanakorn
- Y. Sasagawa
- Y. Sekine
- Y. Seta
- Y. Shapovalova
- Y. Shiina
- Y. Shimoyama
- Y. Shozawa
- Y. Stipp
- Y. Suzuki
- Y. Svyshchenko
- Y. Takagi
- Y. Tsuchiya
- Y. Ueyama
- Y. Vandekerckhove
- Y. Vorasettakarnkij
- Y. Wakasa
- Y. Ye
- Y. Yokoyama
- Y. Zhang
- Y.-I. Kim
- Y.H. Li
- Y.H. Sun
- Y.H. Yin
- Y.J. Yang
- Y.J. Yang
- Y.K. On
- Y.M. Chen
- Y.M. Lee
- Y.M. Sohn
- Y.R. Jeon
- Y.S. Oh
- Y.S. Son
- Y.S. Zhao
- Y.Y. Liu
- Ying Wang
- Yoichi Nakamura
- Yong Wang
- Yoshihisa Fujiura
- Yoshitake Fujiura
- Yuhei Shiga
- Yuichiro Nakamura
- Yukihiro Koretsune
- Yukio Shiga
- Z. Babjakova
- Z. Boda
- Z. Djaidani
- Z. Lajkowski
- Z. Laszlo
- Z. May
- Z. Monhart
- Z. Ongen
- Z. Radics
- Z.C. Lu
- Z.H. Zhou
- Z.M. Yang
- Publication venue
- Indian Heart J
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
Age at first birth in women is genetically associated with increased risk of schizophrenia
- Author
- Adolfsson R.
- Agartz I. (Ingrid)
- Agerbo E. (Esben)
- Albus M. (Margot)
- Alexander M. (Madeline)
- Amin F. (Farooq)
- Andreassen O.A. (Ole)
- Bacanu S.A. (Silviu)
- Begemann M. (Martin)
- Belliveau R.A. (Richard A.)
- Bene J. (Judit)
- Bergen S.E. (Sarah)
- Bevilacqua E. (Elizabeth)
- Bigdeli T.B. (Tim B.)
- Black D.W. (Donald)
- Blackwood D.H.R. (Douglas)
- Borglum A.D. (Anders)
- Bramon E. (Elvira)
- Bruggeman R. (Richard)
- Buccola N.G. (Nancy G)
- Buckner M.
- Bulik-Sullivan B.K. (Brendan)
- Buxbaum J.D. (Joseph D.)
- Byerley W.F. (William F)
- Cahn W. (Wiepke)
- Cai G. (Guiqing)
- Campion D. (Dominique)
- Cantor R.M.
- Carr V.J. (Vaughan J.)
- Carrera N. (Noa)
- Catts S.V. (Stanley)
- Chambert K. (Kimberly)
- Chan R.C.K. (Raymond C. K.)
- Chen E.Y.H. (Eric Y. H.)
- Chen R.Y.L. (Ronald Y.)
- Cheng W. (Wei)
- Cheung E.F.C. (Eric F. C.)
- Chong S.A. (Siow Ann)
- Cichon S. (Sven)
- Clair D.S.
- Cloninger C.R. (C Robert)
- Cohen D.J. (David J.)
- Cohen N. (Nadine)
- Collier D.A. (David)
- Cormican P. (Paul)
- Corvin A. (Aiden)
- Craddock N.J. (Nick)
- Crowley J.J. (James)
- Curtis D. (David)
- Daly M.J. (Mark J.)
- Darvasi A. (Ariel)
- Davidson M.W. (Michael )
- Davis K.L. (Kenneth)
- Degenhardt F.
- Del-Favero J. (Jurgen)
- Demontis D. (Ditte)
- Dikeos D. (Dimitris)
- Dinan T. (Timothy)
- Djurovic S. (Srdjan)
- Domenici E. (Enrico)
- Donohoe D.J. (Dennis)
- Drapeau E. (Elodie)
- Duan J. (Jubao)
- Dudbridge F. (Frank)
- Durmishi N. (Naser)
- Ehrenreich H. (Hannelore)
- Eichhammer P. (Peter)
- Escott-Price V. (Valentina)
- Esko T. (Tõnu)
- Essioux L. (Laurent)
- Fanous A.H. (Ayman H.)
- Farh K.-H. (Kai-How)
- Farrell M.S. (Martilias)
- Frank J. (Josef)
- Franke L. (Lude)
- Freedman R. (Robert)
- Freimer N.B. (Nelson)
- Friedl M.
- Friedman J.I. (Joseph)
- Fromer M. (Menachem)
- Gejman P.V. (Pablo)
- Genovese G. (Giulio)
- Georgieva I. (Irina)
- Giegling I. (Ina)
- Gill M. (Michael)
- Giusti-Rodríguez P. (Paola)
- Godard S. (Stephanie)
- Goldstein J.I. (Jacqueline)
- Golimbet V. (Vera)
- Gopal R. (Robin)
- Gratten J. (Jacob)
- Gurling H. (Hugh)
- Haan L. (Lieuwe) de
- Hagen K. (Knut)
- Hammer C. (Christian)
- Hamshere M.L. (Marian)
- Hansen M. (Mark)
- Hansen T. (Thomas)
- Haroutunian V. (Vahram)
- Hartmann A.M. (Annette M.)
- Henskens F.A. (Frans)
- Herms S. (Stefan)
- Hirschhorn J.N. (Joel)
- Hoffmann P. (Per)
- Hofman A. (Andrea)
- Hollegaard M.V. (Mads V)
- Holmans P.A. (Peter A.)
- Hougaard D.M. (David)
- Huang H. (Hailiang)
- Hultman C.M. (Christina)
- Ikeda M. (Masashi)
- Iwata N. (Nakao)
- Jablensky A. (Assen)
- Joa I. (Inge)
- Juliá A. (Antonio)
- Jönsson E.G. (Erik)
- Kahn R. (René)
- Kalaydjieva L. (Luba)
- Karachanak-Yankova S. (Sena)
- Karjalainen J. (Juha)
- Kavanagh D. (David)
- Keller M.C. (Matthew C)
- Kendler K. (K.)
- Kennedy J.L.
- Keong J.L.C. (Jimmy Lee Chee)
- Khrunin A. (Andrey)
- Kim Y. (Yunjung)
- Kirov G. (George)
- Klovins J. (Janis)
- Knight J. (Jo)
- Knowles J.A. (James A)
- Konte B. (Bettina)
- Kucinskiene Z.A. (Zita Ausrele)
- Kuzelova-Ptackova H. (Hana)
- Kučinskas V. (Vaidutis)
- Kähler J. (Jan)
- Laurent C. (Camille)
- Lee P.H. (Phil H.)
- Lee S.H. (Sang Hong)
- Legge S.E. (Sophie)
- Lencz T. (Todd)
- Lerer B. (Bernard)
- Levinson D.F. (Douglas F.)
- Li M. (Miaoxin)
- Li Q.S. (Qingqin S.)
- Li T. (Tao)
- Liang K.-Y. (Kung-Yee)
- Lieberman A.P. (Andrew)
- Limborska S. (Svetlana)
- Liu J. (Jianjun)
- Loughland C.M. (Carmel)
- Lubinski J. (Jan)
- Lönnqvist J. (Jouko)
- Macek M. (Milan MI)
- Magnusson P.K. (Patrik)
- Maher B.S. (Brion)
- Maier W. (Wolfgang)
- Malhotra A.K. (Anil K)
- Mallet V. (Vincent)
- Marsal S. (Sara)
- Mattheisen M. (Manuel)
- Mattingsdal M. (Morten)
- McCarley R.W. (Robert)
- McCarroll S.A. (Steve)
- McDonald C. (Colm)
- McIntosh A.M. (Andrew)
- McQuillin A. (Andrew)
- Meier S.
- Meijer C. (Carin)
- Melegh B. (Bela)
- Melle I. (Ingrid)
- Mesholam-Gately R.I. (Raquelle)
- Metspalu A. (Andres)
- Michie P.T. (Patricia)
- Milani L. (Lili)
- Milanova V. (Vihra)
- Mokrab Y. (Younes)
- Moran J.L. (Jennifer L.)
- Morris D.W. (Derek W.)
- Mors O.
- Mortensen P.B.
- Mowry B.J. (Bryan J)
- Murphy K.C. (Kieran)
- Murray R. (Robin)
- Myin-Germeys I. (Inez)
- Müller-Myhsok B. (B.)
- Neale B.M. (Benjamin)
- Nelis M. (Mari)
- Nenadic I. (Igor)
- Nertney D.A. (Deborah)
- Nestadt G. (Gerald)
- Ni G. (Guiyan)
- Nicodemus K.K. (Kristin)
- Nikitina-Zake L. (Liene)
- Nisenbaum L. (Laura)
- Nordin A. (Annelie)
- Nöthen M.M. (Markus)
- O'Callaghan E. (Eadbhard)
- O'donovan M.C. (Michael)
- O'Dushlaine C. (Colm)
- O'neill F.A. (F. Anthony)
- Oh S.-Y. (Sang-Yun)
- Olincy A. (Ann)
- Olsen L. (Line)
- Ophoff R.A. (Roel)
- Os J.V. (Jim Van)
- Owen M.J. (Michael)
- Palotie A. (Aarno)
- Pantelis C. (Christos)
- Papadimitriou G.N. (George)
- Papiol S. (Sergi)
- Parkhomenko E. (Elena)
- Pato C. (Carlos)
- Pato C. (Carlos)
- Paunio T. (Tiina)
- Pejovic-Milovancevic M. (Milica)
- Perkins D.O. (Diana O.)
- Pers T.H. (Tune)
- Petryshen T.L. (Tracey L.)
- Pietiläinen O.P.H. (Olli)
- Pimm J. (Jonathan)
- Pocklington A.J. (Andrew)
- Posthuma D. (Danielle)
- Powell J. (John)
- Price A. (Alkes)
- Pulver A.E. (Ann)
- Purcell S.M. (Shaun M.)
- Quested D.J. (Digby J)
- Rasmussen H.B. (Henrik B)
- Reichenberg A. (Abraham)
- Reimers B. (Bernhard)
- Richards A. (Alex)
- Rietschel M. (Marcella)
- Riley B.P. (Brien P.)
- Ripke S. (Stephan)
- Roffman J.L. (Joshua)
- Roussos A. (Alexandra)
- Ruderfer D. (Douglas)
- Rujescu D. (Dan)
- Salomaa V. (Veikko)
- Sanders A.R. (Alan)
- Schall J.D. (Jeffrey)
- Schubert C.R. (Christian R.)
- Schulze T.G. (Thomas)
- Schwab S.G. (Sibylle G.)
- Scolnick E. (Edward)
- Scott R.J. (Rodney J.)
- Seidman L.J. (Larry)
- Sham P.C. (Pak C.)
- Shi J. (Jianxin)
- Sigurdsson E. (Engilbert)
- Silagadze T. (Teimuraz)
- Silverman J.M. (Jeremy M.)
- Sim K. (Kang)
- Sklar P. (Pamela)
- Slominsky P. (Petr)
- Smoller J.W.
- So H.-C. (Hon-Cheong)
- Spencer C.C.A. (Chris C.)
- Stahl E.A. (Eli A.)
- Stefansson H. (Hreinn)
- Steinberg S. (Stacy)
- Stogmann E. (Elisabeth)
- Straub R.E. (Richard)
- Strengman E. (Eric)
- Strohmaier J. (Jana)
- Stroup T.S. (T. Scott)
- Subramaniam V. (Venkat)
- Sullivan P.F. (Patrick)
- Suvisaari J. (Jaana)
- Svrakic D.M. (Dragan)
- Szatkiewicz J.P. (Jin P.)
- Söderman E. (Erik)
- Thirumalai S. (Srinivasa)
- Toncheva D. (Draga)
- Tosato S. (Sarah)
- Veijola J. (Juha)
- Visscher P.M. (Peter)
- Waddington J. (John)
- Walsh D. (Dermot)
- Walters J.T. (James)
- Wang D. (Dai)
- Wang Q. (Qiang)
- Webb B.T. (Bradley T.)
- Weinberger D.R. (Daniel)
- Weiser M. (Mark)
- Wendland A. (Annika)
- Werge T.M. (Thomas)
- Wildenauer D.B. (Dieter)
- Williams N.M. (Nigel M.)
- Williams S. (Stephanie)
- Witt S.H. (Stephanie H)
- Wolen A.R. (Aaron)
- Wong E.H.M. (Emily H.M.)
- Wormley B.K. (Brandon K.)
- Wray N.R. (Naomi R.)
- Xi H.S. (Hualin Simon)
- Zai C.C. (Clement C.)
- Zheng X. (Xuebin)
- Zimprich F. (Fritz)
- Zwart J-A. (John-Anker)
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Prof. Paunio on PGC:n jäsenPrevious studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.Peer reviewe
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
- Author
- Abdellaoui Abdel
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Albus Margot
- Alexander Madeline
- Amin Farooq
- Andreassen Ole A.
- Anthony O'Neill
- Bacanu Silviu A.
- Begemann Martin
- Belliveau Richard A.
- Bene Judit
- Bergen Sarah E.
- Bevilacqua Elizabeth
- Bigdeli Tim B.
- Bjelland Douglas W.
- Black Donald W.
- Blackwood Douglas H. R.
- Borglum Anders
- Bramon Elvira
- Breen Gerome
- Bruggeman Richard
- Buccola Nancy G.
- Buckner Randy L.
- Bulik-Sullivan Brendan
- Buxbaum Joseph D.
- Byerley William
- Børglum Anders D.
- Cahn Wiepke
- Cai Guiqing
- Campion Dominique
- Cantor Rita M.
- Carr Vaughan J.
- Carrera Noa
- Catts Stanley V.
- Chambert Kimberly D.
- Chan Raymond C.K.
- Chee Keong Jimmy Lee
- Chen Eric Y.H.
- Chen Ronald Y.L.
- Cheng Wei
- Cheung Eric F.C.
- Chong Siow Ann
- Cichon Sven
- Clair David S.
- Cohen David
- Cohen Nadine
- Collier David A.
- Cormican Paul
- Corvin Aiden
- Craddock Nick
- Crowley James J.
- Curtis David
- Daly Mark J.
- Darvasi Ariel
- Davidson Michael
- Davis Kenneth L.
- de Haan Lieuwe
- Degenhardt Franziska
- Del Favero Jurgen
- Demontis Ditte
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Domenici Enrico
- Donohoe Gary
- Drapeau Elodie
- Duan Jubao
- Dudbridge Frank
- Durmishi Naser
- Ehrenreich Hannelore
- Eichhammer Peter
- Eriksson Johan
- Escott-Price Valentina
- Esko Tõnu
- Essioux Laurent
- Fanous Ayman H.
- Farh Kai-How
- Farrell Martilias S.
- Forstner Andreas J.
- Frank Josef
- Franke Lude
- Freedman Robert
- Freimer Nelson B.
- Friedl Marion
- Friedman Joseph I.
- Fromer Menachem
- Gejman Pablo V.
- Genovese Giulio
- Georgieva Lyudmila
- Giegling Ina
- Gill Michael
- Giusti-Rodríguez Paola
- Godard Stephanie
- Goldstein Jacqueline I.
- Golimbet Vera
- Gopal Srihari
- Gratten Jacob
- Gurling Hugh
- Hammer Christian
- Hamshere Marian L.
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Hartmann Annette M.
- Heilmann-Heimbach Stefanie
- Henskens Frans A.
- Herms Stefan
- Hirschhorn Joel N.
- Hoffman Per
- Hoffmann Per
- Hofman Andrea
- Hollegaard Mads V.
- Holmans Peter A.
- Hong Lee
- Hougaard David M.
- Howrigan Daniel P.
- Huang Hailiang
- Hultman Christina M.
- Ikeda Masashi
- Iwata Nakao
- Jablensky Assen V.
- Joa Inge
- Johnson Emma C.
- Julià Antonio
- Jönsson Erik G.
- Kahn René S.
- Kalaydjieva Luba
- Karachanak-Yankova Sena
- Karjalainen Juha
- Kavanagh David
- Keller Matthew C.
- Keller Matthew C.
- Kendler Kenneth S.
- Kennedy James L.
- Khrunin Andrey
- Kim Yunjung
- Kirov George
- Klovins Janis
- Knight Jo
- Knowles James A.
- Konte Bettina
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kuzelova-Ptackova Hana
- Kähler Anna K.
- Laurent Claudine
- Lee Phil
- Legge Sophie E.
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F.
- Li Miaoxin
- Li Qingqin S.
- Li Tao
- Liang Kung-Yee
- Lieberman Jeffrey
- Limborska Svetlana
- Liu Jianjun
- Loughland Carmel M.
- Lubinski Jan
- Lönnqvist Jouko
- Macek Milan
- Magnusson Patrik K.E.
- Maher Brion S.
- Maier Wolfgang
- Malhotra Anil K.
- Mallet Jacques
- Marsal Sara
- Mattheisen Manuel
- Mattingsdal Morten
- McCarley Robert W.
- McCarroll Steven A.
- McDonald Colm
- McIntosh Andrew M.
- McQuillin Andrew
- Meier Sandra
- Meijer Carin J.
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihra
- Mokrab Younes
- Moran Jennifer L.
- Morris Derek W.
- Mors Ole
- Mortensen Preben B.
- Mowry Bryan
- Mowry Bryan J.
- Murphy Kieran C.
- Murray Robin M.
- Myin-Germeys Inez
- Müller-Mhysok Betram
- Müller-Myhsok Bertram
- Neale Benjamin
- Neale Benjamin M.
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A.
- Nestadt Gerald
- Nicodemus Kristin K.
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nordin Annelie
- Nöthen Markus M.
- Nöthen Markus M.
- O'Callaghan Eadbhard
- O'Donovan Michael C.
- O'Dushlaine Colm
- Oh Sang-Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A.
- Owen Michael J.
- O’Dushlaine Colm
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N.
- Papiol Sergi
- Parkhomenko Elena
- Pato Carlos N.
- Pato Michele T.
- Paunio Tiina
- Pejovic-Milovancevic Milica
- Perkins Diana O.
- Pers Tune H.
- Petryshen Tracey L.
- Pietiläinen Olli
- Pimm Jonathan
- Pocklington Andrew J.
- Posthuma Danielle
- Powell John
- Price Alkes
- Pulver Ann E.
- Purcell Shaun M.
- Quested Digby
- Rasmussen Henrik B.
- Reichenberg Abraham
- Reimers Mark A.
- Richards Alexander L.
- Rietschel Marcella
- Riley Brien P.
- Ripke Stephan
- Robert Cloninger
- Roffman Joshua L.
- Roussos Panos
- Ruderfer Douglas M.
- Rujescu Dan
- Salomaa Veikko
- Sanders Alan R.
- Schall Ulrich
- Schubert Christian R.
- Schulze Thomas G.
- Schwab Sibylle G.
- Scolnick Edward M.
- Scott Stroup
- Scott Rodney J.
- Seidman Larry J.
- Sham Pak C.
- Shi Jianxin
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M.
- Sim Kang
- Simonson Matthew A.
- Sklar Pamela
- Slominsky Petr
- Smoller Jordan W.
- So Hon-Cheong
- Spencer Chris C.A.
- Stahl Eli
- Stahl Eli A.
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Stogmann Elisabeth
- Straub Richard E.
- Strengman Eric
- Strohmaier Jana
- Subramaniam Mythily
- Sullivan Patrick F.
- Suvisaari Jaana
- Svrakic Dragan M.
- Szatkiewicz Jin P.
- Söderman Erik
- Thirumalai Srinivas
- Toncheva Draga
- Tosato Sarah
- Van Os Jim
- Veijola Juha
- Visscher Peter M.
- Waddington John
- Walsh Dermot
- Walters James T.R.
- Wang Dai
- Wang Qiang
- Webb Bradley T.
- Weinberger Daniel R.
- Weiser Mark
- Wendland Jens R.
- Werge Thomas
- Wildenauer Dieter B.
- Williams Nigel M.
- Williams Stephanie
- Witt Stephanie H.
- Wolen Aaron R.
- Wong Emily H. M.
- Wormley Brandon K.
- Wray Naomi R.
- Xi Hualin Simon
- Zai Clement C.
- Zheng Xuebin
- Zimprich Fritz
- Publication venue
- Publication date
- 01/01/2016
- Field of study
It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is to examine the association between disease diagnosis and genome-wide autozygosity estimated using runs of homozygosity (ROH) in genome-wide single nucleotide polymorphism arrays. Using data for schizophrenia from the Psychiatric Genomics Consortium (n = 21,868), Keller et al. (2012) estimated that the odds of developing schizophrenia increased by approximately 17% for every additional percent of the genome that is autozygous (β = 16.1, CI(β) = [6.93, 25.7], Z = 3.44, p = 0.0006). Here we describe replication results from 22 independent schizophrenia case-control datasets from the Psychiatric Genomics Consortium (n = 39,830). Using the same ROH calling thresholds and procedures as Keller et al. (2012), we were unable to replicate the significant association between ROH burden and schizophrenia in the independent PGC phase II data, although the effect was in the predicted direction, and the combined (original + replication) dataset yielded an attenuated but significant relationship between Froh and schizophrenia (β = 4.86,CI(β) = [0.90,8.83],Z = 2.40,p = 0.02). Since Keller et al. (2012), several studies reported inconsistent association of ROH burden with complex traits, particularly in case-control data. These conflicting results might suggest that the effects of autozygosity are confounded by various factors, such as socioeconomic status, education, urbanicity, and religiosity, which may be associated with both real inbreeding and the outcome measures of interest
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
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- Bouatia-Naji Nabila
- Bouchard Claude
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- Chen Wei
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- Cheng Iona
- Cheng Sulin
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- Cho Yoon Shin
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- Ernst Florian
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- Eury Elodie
- Evangelou Evangelos
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- Fagerholm Emma
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- Goessling Wolfram
- Golay Alain
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- González-Macías Jesús
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- Grobbee Diederick E
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- Gustafsson Stefan
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- Gyllensten Ulf B
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- Hayward Caroline
- Hazen Stanley L
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- Hedblad Bo
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- Heikkilä Kauko
- Heikkilä Outi
- Heiss Gerardo
- Heliövaara Markku
- Helmer Catherine
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- Henders Anjali K
- Henderson Brian
- Hengstenberg Christian
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- Herrera Lizbeth
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- Imboden Medea
- Ingelsson Erik
- Ingle Catherine
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- Wichmann H-Erich
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- Wiggins Kerri L
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- Wijnands-van Gent Colette J M
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- Wild Sarah H
- Wilk Alicja
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- Willemsen Gonneke
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- Willenborg Christina
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- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
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- Wilson James G
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- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
- Author
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Albus Margot
- Alexander Madeline
- Als Thomas D.
- Amin Farooq
- Andreassen Ole A.
- Bacanu Silviu A.
- Baekvad-Hansen Marie
- Begemann Martin
- Belliveau Richard A.
- Bene Judit
- Bergen Sarah E.
- Bevilacqua Elizabeth
- Bigdeli Tim B.
- Black Donald W.
- Blackwood Douglas H. R.
- Boocock James
- Borglum Anders D.
- Borglum Anders D.
- Bramon Elvira
- Bruggeman Richard
- Buccola Nancy G.
- Buckner Randy L.
- Bulik-Sullivan Brendan
- Buxbaum Joseph D.
- Buxbaum Joseph D.
- Bybjerg-Grauholm Jonas
- Byerley William
- Cahn Wiepke
- Cai Guiqing
- Campion Dominique
- Cantor Rita M.
- Carr Vaughan J.
- Carrera Noa
- Catts Stanley
- Chambert Kimberly D.
- Chan Raymond C. K.
- Chen Eric Y. H.
- Chen Ronald Y. L.
- Cheng Wei
- Cheung Eric F. C.
- Chong Siow Ann
- Cichon Sven
- Cloninger C. Robert
- Cohen David
- Cohen Nadine
- Collier David A.
- Cormican Paul
- Corvin Aiden
- Cox Nancy J.
- Craddock Nick
- Crowley James J.
- Curtis David
- Daly Mark J.
- Dang Kristen K.
- Darvasi Ariel
- Davidson Michael
- Davis Kenneth L.
- de Haan Lieuwe
- Degenhardt Franziska
- Del Favero Jurgen
- Demontis Ditte
- Devlin Bernie
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Dobbyn Amanda
- Domenici Enrico
- Domenici Enrico
- Donohoe Gary
- Drapeau Elodie
- Duan Jubao
- Dudbridge Frank
- Durmishi Naser
- Ehrenreich Hannelore
- Eichhammer Peter
- Eriksson Johan
- Escott-Price Valentina
- Esko Tonu
- Essioux Laurent
- Essioux Laurent
- Fanous Ayman H.
- Farh Kai-How
- Farrell Martilias S.
- Frank Josef
- Franke Lude
- Freedman Robert
- Freimer Nelson B.
- Friedl Marion
- Friedman Joseph
- Fromer Menachem
- Fromer Menachem
- Gamazon Eric R.
- Gejman Pablo
- Genovese Giulio
- Georgieva Lyudmila
- Giegling Ina
- Gill Michael
- Girdhar Kiran
- Giusti-Rodriguez Paola
- Godard Stephanie
- Goldstein Jacqueline
- Golimbet Vera
- Gopal Srihari
- Gratten Jacob
- Grove Jakob
- Gur Raquel E.
- Gurling Hugh
- Hahn Chang-Gyu
- Hammer Christian
- Hamshere Marian L.
- Hansen Christine Soholm
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Haroutunian Vahram
- Hartmann Annette M.
- Henskens Frans A.
- Herms Stefan
- Hirai Keisuke
- Hirschhorn Joel N.
- Hoffman Gabriel
- Hoffmann Per
- Hofman Andrea
- Hollegaard Mads
- Holmans Peter A.
- Hougaard David M.
- Huang Hailiang
- Huckins Laura M.
- Hultman Christina M.
- Ikeda Masashi
- Im Hae Kyung
- Iwata Nakao
- Jablensky Assen
- Joa Inge
- Johnson Jessica S.
- Jonsson Erik G.
- Julia Antonio
- Kahler Anna K.
- Kahn Rene S.
- Kalaydjieva Luba
- Karachanak-Yankova Sena
- Karjalainen Juha
- Kavanagh David
- Keller Matthew C.
- Kendler Kenneth S.
- Kennedy James L.
- Keong Jimmy Lee Chee
- Khrunin Andrey
- Kim Yunjung
- Kirov George
- Klein Lambertus L.
- Klovins Janis
- Knight Jo
- Knowles James A.
- Konte Bettina
- Kramer Robin
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kuzelova-Ptackova Hana
- Laurent Claudine
- Lee Phil
- Lee S. Hong
- Legge Sophie E.
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F.
- Lewis David A.
- Li Miaoxin
- Li Qingqin S.
- Li Tao
- Liang Kung-Yee
- Lieberman Jeffrey
- Limborska Svetlana
- Lipska Barbara K.
- Liu Jianjun
- Logsdon Benjamin A.
- Lonnqvist Jouko
- Loughland Carmel M.
- Lubinski Jan
- Macek Milan
- Magnusson Patrik K. E.
- Mahajan Milind C.
- Maher Brion S.
- Maier Wolfgang
- Malhotra Anil K.
- Mallet Jacques
- Mangravite Lara M.
- Marsal Sara
- Mattheisen Manuel
- Mattingsdal Morten
- McCarley Robert W.
- McCarroll Steven A.
- McDonald Colm
- McIntosh Andrew M.
- McQuillin Andrew
- Meier Sandra
- Meijer Carin J.
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihra
- Mokrab Younes
- Moran Jennifer L.
- Morris Derek W.
- Mors Ole
- Mors Ole
- Mortensen Preben B.
- Mortensen Preben Bo
- Mowry Bryan J.
- Muller-Myhsok Bertram
- Murphy Kieran C.
- Murray Robin M.
- Myin-Germeys Inez
- Neale Benjamin M.
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A.
- Nestadt Gerald
- Nguyen Hoang T.
- Nicodemus Kristin K.
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nordentoft Merete
- Nordin Annelie
- Nothen Markus M.
- O'Callaghan Eadbhard
- O'Donovan Michael C.
- O'Dushlaine Colm
- O'Neill F. Anthony
- Oh Sang-Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A.
- Owen Michael J.
- Owen Michael J.
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N.
- Papiol Sergi
- Pardinas Antonio F.
- Parkhomenko Elena
- Pato Carlos N.
- Pato Michele T.
- Paunio Tiina
- Pedersen Carsten Bocker
- Pedersen Marianne Giortz
- Pejovic-Milovancevic Milica
- Perkins Diana O.
- Pers Tune H.
- Perumal Thanneer M.
- Peters Mette A.
- Petryshen Tracey L.
- Pietilainen Olli
- Pimm Jonathan
- Pocklington Andrew J.
- Posthuma Danielle
- Powell John
- Price Alkes
- Pulver Ann E.
- Purcell Shaun
- Purcell Shaun M.
- Quested Digby
- Rajagopal Veera M.
- Rajagopal Veera Manikandan
- Rasmussen Henrik B.
- Reichenberg Abraham
- Reimers Mark A.
- Richards Alexander L.
- Rietschel Marcella
- Riley Brien P.
- Ripke Stephan
- Roffman Joshua L.
- Roussos Panos
- Ruderfer Douglas M.
- Ruderfer Douglas M.
- Rujescu Dan
- Salomaa Veikko
- Sanders Alan R.
- Schadt Eric
- Schall Ulrich
- Schubert Christian R.
- Schulze Thomas G.
- Schwab Sibylle G.
- Scolnick Edward M.
- Scott Rodney J.
- Seidman Larry J.
- Shah Hardik R.
- Sham Pak C.
- Shi Jianxin
- Sieberts Solveig K.
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M.
- Sim Kang
- Sklar Pamela
- Slominsky Petr
- Smoller Jordan W.
- So Hon-Cheong
- Soderman Erik
- Spencer Chris C. A.
- St Clair David
- Stahl Eli A.
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Stogmann Elisabeth
- Straub Richard E.
- Strengman Eric
- Strohmaier Jana
- Stroup T. Scott
- Subramaniam Mythily
- Sullivan Patrick
- Sullivan Patrick F.
- Suvisaari Jaana
- Svrakic Dragan M.
- Szatkiewicz Jin P.
- Thirumalai Srinivas
- Toncheva Draga
- Tosato Sarah
- Toyoshiba Hiroyoshi
- Van Os Jim
- Veijola Juha
- Visscher Peter M.
- Waddington John
- Walsh Dermot
- Walters James T. R.
- Wang Dai
- Wang Qiang
- Wang Weiqing
- Webb Bradley T.
- Weinberger Daniel R.
- Weiser Mark
- Wendland Jens R.
- Werge Thomas
- Werge Thomas
- Wildenauer Dieter B.
- Williams Nigel M.
- Williams Stephanie
- Witt Stephanie H.
- Wolen Aaron R.
- Wong Emily H. M.
- Wormley Brandon K.
- Wray Naomi R.
- Xi Hualin Simon
- Zai Clement C.
- Zheng Xuebin
- Zimprich Fritz
- Publication venue
- Ludwig-Maximilians-Universität München
- Publication date
- 01/04/2019
- Field of study
Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression
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