High-Velocity Features: a ubiquitous property of Type Ia SNe

Evidence of high-velocity features such as those seen in the near-maximum spectra of some Type Ia Supernovae (eg SN 2000cx) has been searched for in the available SNIa spectra observed earlier than one week before B maximum. Recent observational efforts have doubled the number of SNeIa with very early spectra. Remarkably, all SNeIa with early data (7 in our RTN sample and 10 from other programmes) show signs of such features, to a greater or lesser degree, in CaII IR, and some also in SiII 6255A line. High-velocity features may be interpreted as abundance or density enhancements. Abundance enhancements would imply an outer region dominated by Si and Ca. Density enhancements may result from the sweeping up of circumstellar material by the highest velocity SN ejecta. In this scenario, the high incidence of HVFs suggests that a thick disc and/or a high-density companion wind surrounds the exploding white dwarf, as may be the case in Single Degenerate systems. Large-scale angular fluctuations in the radial density and abundance distribution may also be responsible: this could originate in the explosion, and would suggest a deflagration as the more likely explosion mechanism. CSM-interaction and surface fluctuations may coexist, possibly leaving different signatures on the spectrum. In some SNe the HVFs are narrowly confined in velocity, suggesting the ejection of blobs of burned material.Comment: 12 pages, 2 figures, ApJ Letters in pres

Shutting down or powering up a (U)LIRG? Merger components in distinctly different evolutionary states in IRAS 19115-2124 (the Bird)

We present new SINFONI near-infrared (NIR) integral field unit (IFU) spectroscopy and Southern African Large Telescope (SALT) optical long-slit spectroscopy characterizing the history of a nearby merging luminous infrared galaxy, dubbed the Bird (IRAS19115-2124). TheNIR line-ratio maps of the IFU data cubes and stellar population fitting of the SALT spectra now allow dating of the star formation (SF) over the triple system uncovered from our previous adaptive optics data. The distinct components separate clearly in line-ratio diagnostic diagrams, both thermal and non-thermal excitation is present. An off-nuclear starburst dominates the current SF of the Bird with 60-70 per cent of the total, with a 4-7 Myr age. The most massive nucleus, in contrast, is quenched with a starburst age of >40 Myr and shows hints of budding active galactic nucleus (AGN) activity. The secondary massive nucleus is at an intermediate stage. The two major components have signs of an older stellar population, consistent with a starburst triggered 1 Gyr ago in a first encounter. The simplest explanation of the history is that of a triple merger, where the strongly star-forming component has joined later. We detect multiple gas flows. The Bird offers an opportunity to witness multiple stages of galaxy evolution in the same system; triggering as well as very recent quenching of SF, and, perhaps, an early appearance of AGN activity. It also serves as a cautionary note on interpretations of observations with lower spatial resolution and/or without infrared data. At high redshift the system would look like a clumpy starburst with crucial pieces of its puzzle hidden in danger of misinterpretations

Airway obstruction, serum vitamin D and mortality in a 33-year follow-up study

Background and objective: Chronic obstructive pulmonary disease and low vitamin D status predict mortality, but their combined effect on mortality remains inconclusive. We aimed to investigate a joint effect of airway obstruction and vitamin D status on mortality in a nationally representative cohort. Methods: We analysed data of 6676 Finnish adults participating between 1978 and 1980 in a national health examination survey, undergoing spirometry and having all necessary data collected. We followed them up in national registers through record linkage until 31 December 2011. We categorised the subjects with obstruction using the lower limit of normal (LLN) and the measured serum 25-hydroxyvitamin-D (s-25(OH)D) into tertiles. Results: Both obstruction and low s-25(OH) D independently predicted mortality in a multivariate model adjusted also for age, sex, smoking, education, leisure physical activity, body mass index, asthma and serum C-reactive protein. However, a statistically significant (p = 0.007) interaction emerged: the adjusted mortality HRs (95% CI's) for s-25(OH)D in tertiles among the subjects without and with obstruction were 1.00 (lowest), 0.96 (0.87-1.05) and 0.89 (0.81-0.98); and 1.00, 0.96 (0.71-1.31) and 0.57 (0.40-0.80), respectively. Conclusions: In conclusion, obstruction and low s-25(OH)D predict mortality independently of each other. Our findings suggest that low vitamin D status might be particularly detrimental among subjects with obstruction.Peer reviewe

Upper limit for circumstellar gas around the Type Ia SN 2000cx

The nature of the companion stars in Type Ia Supernova (SNe) progenitor systems remains unclear. One possible way to discriminate between different scenarios is the presence (or absence) of circumstellar material, the left overs from the progenitor evolution that may be revealed by their interaction with the SN. A new method to probe the circumstellar environment has been exploited for the normal Type Ia SN 2006X, leading for the first time to the direct detection of material which escaped the progenitor system. In this paper we apply the same analysis to the peculiar Type Ia SN 2000cx, with the aim of constraining the properties of its progenitor system. Using multi-epoch, high-resolution spectroscopy we have studied the spectral region where narrow, time-variable NaID absorption features are expected in case circumstellar material is present along the line of sight. No NaID absorption is detected in the rest-frame of the host galaxy to a level of a few mA, setting a stringent upper limit to the column density of the absorbing material (N(NaI)<=2 x 10^10 cm-2). In this respect the peculiar Type Ia SN 2000cx is different from the normal Ia SN 2006X. Whether this is to be attributed to a different progenitor system, to viewing-angle effects or to a low metallicity remains to be clarified.Comment: 6 pages, 3 figures. Accepted for publication in Astronomy and Astrophysic

ULTRA-BRIGHT OPTICAL TRANSIENTS ARE LINKED WITH TYPE Ic SUPERNOVAE

Recent searches by unbiased, wide-field surveys have uncovered a group of extremely luminous optical transients. The initial discoveries of SN 2005ap by the Texas Supernova Search and SCP-06F6 in a deep Hubble pencil beam survey were followed by the Palomar Transient Factory confirmation of host redshifts for other similar transients. The transients share the common properties of high optical luminosities (peak magnitudes ~−21 to −23), blue colors, and a lack of H or He spectral features. The physical mechanism that produces the luminosity is uncertain, with suggestions ranging from jet-driven explosion to pulsational pair instability. Here, we report the most detailed photometric and spectral coverage of an ultra-bright transient (SN 2010gx) detected in the Pan-STARRS 1 sky survey. In common with other transients in this family, early-time spectra show a blue continuum and prominent broad absorption lines of O ii. However, about 25 days after discovery, the spectra developed type Ic supernova features, showing the characteristic broad Fe ii and Si ii absorption lines. Detailed, post-maximum follow-up may show that all SN 2005ap and SCP-06F6 type transients are linked to supernovae Ic. This poses problems in understanding the physics of the explosions: there is no indication from late-time photometry that the luminosity is powered by 56Ni, the broad light curves suggest very large ejected masses, and the slow spectral evolution is quite different from typical Ic timescales. The nature of the progenitor stars and the origin of the luminosity are intriguing and open questions

A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007

We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - September 2007, which coincided with the fifth and first science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed for candidate gravitational-wave signals coincident in time and direction with the neutrino events. No significant coincident events were observed. We place limits on the density of joint high energy neutrino - gravitational wave emission events in the local universe, and compare them with densities of merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access area to figures, tables at https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000

The end of star formation in Chamaeleon I ? A LABOCA census of starless and protostellar cores

Chamaeleon I is the most active region in terms of star formation in the Chamaeleon molecular cloud complex. Its population of prestellar and protostellar cores is not known and a controversy exists concerning its history of star formation. Our goal is to characterize the earliest stages of star formation in this cloud. We used the bolometer array LABOCA at APEX to map the cloud in dust continuum emission at 870 micron. The detected sources are analysed by carefully taking into account the spatial filtering inherent in the data reduction process. A search for associations with YSOs is performed using Spitzer data and the SIMBAD database. Most of the detected 870 micron emission is distributed in 5 filaments. We identify 59 starless cores, one candidate first hydrostatic core, and 21 sources associated with more evolved YSOs. The starless cores are only found above a visual extinction threshold of 5 mag. They are less dense than those detected in other nearby molecular clouds by a factor of a few on average. The core mass distribution is consistent with the IMF at the high-mass end but is overpopulated at the low-mass end. In addition, at most 17% of the cores have a mass larger than the critical Bonnor-Ebert mass. Both results suggest that a large fraction of the starless cores may not be prestellar. Based on the census of prestellar cores, Class 0 protostars, and more evolved YSOs, we conclude that the star formation rate has decreased with time in this cloud. The low fraction of candidate prestellar cores among the population of starless cores, the small number of Class 0 protostars, the high global star formation efficiency, the decrease of the star formation rate with time, and the low mass per unit length of the detected filaments all suggest that we may be witnessing the end of the star formation process in Cha I {abridged}.Comment: Accepted for publication in A&A. 35 pages, 17 figures, 13 tables. A version with high-resolution figures is available on request to the first autho

COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer

Increased expression of COX-2 or VEGF-C has been correlated with progressive disease in certain cancers. Present study utilized several human breast cancer cell lines (MCF-7, T-47D, Hs578T and MDA-MB-231, varying in COX-2 expression) as well as 10 human breast cancer specimens to examine the roles of COX-2 and prostaglandin E (EP) receptors in VEGF-C expression or secretion, and the relationship of COX-2 or VEGF-C expression to lymphangiogenesis. We found a strong correlation between COX-2 mRNA expression and VEGF-C expression or secretion levels in breast cancer cell lines and VEGF-C expression in breast cancer tissues. Expression of LYVE-1, a selective marker for lymphatic endothelium, was also positively correlated with COX-2 or VEGF-C expression in breast cancer tissues. Inhibition of VEGF-C expression and secretion in the presence of COX-1/2 or COX-2 inhibitors or following downregulation of COX-2 with COX-2 siRNA established a stimulatory role COX-2 in VEGF-C synthesis by breast cancer cells. EP1 as well as EP4 receptor antagonists inhibited VEGF-C production indicating the roles of EP1 and EP4 in VEGF-C upregulation by endogenous PGE2. Finally, VEGF-C secretion by MDA-MB-231 cells was inhibited in the presence of kinase inhibitors for Her-2/neu, Src and p38 MAPK, indicating a requirement of these kinases for VEGF-C synthesis. These results, for the first time, demonstrate a regulatory role of COX-2 in VEGF-C synthesis (and thereby lymphangiogenesis) in human breast cancer, which is mediated at least in part by EP1/EP4 receptors

The incidence of unpleasant dreams after sub-anaesthetic ketamine

Ketamine is an N-methyl-D-aspartate (NMDA)receptor antagonist with psychotogenic effects and for whichthere are diverse reports of whether pleasant or unpleasantdreams result during anaesthesia, post-operatively or aftersub-anaesthetic use. The aim was to assess in healthy volunteers the incidence ofunpleasant dreams over the three nights after receiving asub-anaesthetic dose of ketamine, in comparison to placebo,and with retrospective home nightmare frequency as acovariate.Thirty healthy volunteers completed questionnairesabout retrospective home dream recall and were then giveneither ketamine or placebo. Ketamine resulted in significantly more meandream unpleasantness relative to placebo and caused athreefold increase in the odds ratio for the incidence of anunpleasant dream. The number of dreams reported over thethree nights did not differ between the groups. Theincidence of unpleasant dreams after ketamine use waspredicted by retrospectively assessed nightmare frequencyat home.Ketamine causes unpleasant dreams over thethree post-administration nights. This may be evidence of aresidual psychotogenic effect that is not found on standardself-report symptomatology measures or a result of disturbedsleep electrophysiology. The results have theoretical implications for the relationship between nightmares and schizotypy

Combinatorial Mismatch Scan (CMS) for loci associated with dementia in the Amish

BACKGROUND: Population heterogeneity may be a significant confounding factor hampering detection and verification of late onset Alzheimer's disease (LOAD) susceptibility genes. The Amish communities located in Indiana and Ohio are relatively isolated populations that may have increased power to detect disease susceptibility genes. METHODS: We recently performed a genome scan of dementia in this population that detected several potential loci. However, analyses of these data are complicated by the highly consanguineous nature of these Amish pedigrees. Therefore we applied the Combinatorial Mismatch Scanning (CMS) method that compares identity by state (IBS) (under the presumption of identity by descent (IBD)) sharing in distantly related individuals from such populations where standard linkage and association analyses are difficult to implement. CMS compares allele sharing between individuals in affected and unaffected groups from founder populations. Comparisons between cases and controls were done using two Fisher's exact tests, one testing for excess in IBS allele frequency and the other testing for excess in IBS genotype frequency for 407 microsatellite markers. RESULTS: In all, 13 dementia cases and 14 normal controls were identified who were not related at least through the grandparental generation. The examination of allele frequencies identified 24 markers (6%) nominally (p ≤ 0.05) associated with dementia; the most interesting (empiric p ≤ 0.005) markers were D3S1262, D5S211, and D19S1165. The examination of genotype frequencies identified 21 markers (5%) nominally (p ≤ 0.05) associated with dementia; the most significant markers were both located on chromosome 5 (D5S1480 and D5S211). Notably, one of these markers (D5S211) demonstrated differences (empiric p ≤ 0.005) under both tests. CONCLUSION: Our results provide the initial groundwork for identifying genes involved in late-onset Alzheimer's disease within the Amish community. Genes identified within this isolated population will likely play a role in a subset of late-onset AD cases across more general populations. Regions highlighted by markers demonstrating suggestive allelic and/or genotypic differences will be the focus of more detailed examination to characterize their involvement in dementia