Propuesta estratégica de mejora en la implementación de los estándares mínimos del Sistema de Gestión de la Seguridad y Salud en el Trabajo (SG-SST) en confiar Cooperativa Financiera para el segundo semestre del 2019 y principios del 2020.

La presente propuesta integral para la implementación de los estándares mínimos del SG-SST según parámetros legales en la Cooperativa Confiar a nivel nacional, es el interés académico y profesional que parte de la adquisición y profundización de los conocimientos adquiridos y se resume en la identificación de los problemas por medio de la matriz de riesgos y la resolución de los mismos mediante estrategias específicas que Implican la aplicación de herramientas idóneas que facilitan la mejora contínua, es decir; la comprensión de los sistemas estructurados que permiten la correcta toma de decisiones basadas en métodos lógicos.The present integral proposal for the implementation of the minimum standards of the SG-SST according to legal parameters at the "Cooperativa Confiar" at national level, is the academic and professional interest that starts from the acquisition and deepening of the knowledge acquired and is summarized in the identification of the problems through the risk matrix and their resolution through specific strategies that imply the application of suitable tools that facilitate continuous improvement, that is; the understanding of structured systems that allow the correct decision making through logical methods

Adenylyl Cyclase α and cAMP Signaling Mediate Plasmodium Sporozoite Apical Regulated Exocytosis and Hepatocyte Infection

Malaria starts with the infection of the liver of the host by Plasmodium sporozoites, the parasite form transmitted by infected mosquitoes. Sporozoites migrate through several hepatocytes by breaching their plasma membranes before finally infecting one with the formation of an internalization vacuole. Migration through host cells induces apical regulated exocytosis in sporozoites. Here we show that apical regulated exocytosis is induced by increases in cAMP in sporozoites of rodent (P. yoelii and P. berghei) and human (P. falciparum) Plasmodium species. We have generated P. berghei parasites deficient in adenylyl cyclase α (ACα), a gene containing regions with high homology to adenylyl cyclases. PbACα-deficient sporozoites do not exocytose in response to migration through host cells and present more than 50% impaired hepatocyte infectivity in vivo. These effects are specific to ACα, as re-introduction of ACα in deficient parasites resulted in complete recovery of exocytosis and infection. Our findings indicate that ACα and increases in cAMP levels are required for sporozoite apical regulated exocytosis, which is involved in sporozoite infection of hepatocytes

Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018) : Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.Peer reviewe

Morphological and molecular assessment of <i>Sargassum</i> (Fucales, Phaeophyceae) from Caribbean Colombia, including the proposal of <i>Sargassum giganteum</i> sp. nov., <i>Sargassum schnetteri</i> comb. nov. and <i>Sargassum</i> section <i>Cladophyllum</i> sect. nov.

<div><p>The use of molecular markers to evaluate species delineation in the genus <i>Sargasssum</i> is of critical importance given the large variability of morphological traits among and within taxa. To date, most molecular studies of this group have focused on the central Indo-Pacific region, even though the genus is also well represented in the Atlantic Ocean. In the present study, we re-assessed the diversity and taxonomy of <i>Sargassum</i> and the monospecific genus <i>Cladophyllum</i> from Caribbean Colombia (especially from the Santa Marta-Tayrona National Natural Park) and extended to the western tropical Atlantic towards a comprehensive revision of the genus in this basin based on morphological and molecular analyses (ITS-2, <i>rbc</i>LS, <i>cox</i>3 and <i>mtsp</i>) on new and existing collections from the region. Sequences obtained from the genus <i>Cladophyllum</i> revealed its nesting inside <i>Sargassum</i> subgenus <i>Sargassum</i> as a close relative of <i>S. pteropleuron</i>, a broadly distributed species in the Caribbean. Analysis of molecular divergence in this newly identified clade demonstrated a similar range of variation as that present in existing sections leading to the description of a new section, <i>Sargassum</i> sect. <i>Cladophyllum</i> (Bula-Meyer) Camacho, Mattio & Diaz-Pulido, sect. nov., that includes the two sister species mentioned above. Based on these results, we also merged <i>Cladophyllum</i> within <i>Sargassum</i> and renamed its unique species <i>S. schnetteri</i> (Bula-Meyer) Camacho, Mattio & Diaz-Pulido, comb. nov. The remaining <i>Sargassum</i> spp. included in the analyses clustered in a polytomy within the worldwide-distributed <i>S</i>. section <i>Sargassum</i>, thus providing no support for the other eight morphological species currently recognized in the Caribbean Colombia and other western tropical Atlantic areas. Based on the morphological analysis we further described a new species, <i>S. giganteum</i> Camacho & Diaz-Pulido sp. nov., endemic from TNNP. Detailed morphological descriptions and illustrations, as well as an identification key, are provided for all studied taxa.</p></div

Impact of late presentation of HIV infection on short-, mid- and long-term mortality and causes of death in a multicenter national cohort : 2004-2013

To analyze the impact of late presentation (LP) on overall mortality and causes of death and describe LP trends and risk factors (2004-2013). Cox models and logistic regression were used to analyze data from a nation-wide cohort in Spain. LP is defined as being diagnosed when CD4 < 350 cells/ml or AIDS. Of 7165 new HIV diagnoses, 46.9% (CI:45.7-48.0) were LP, 240 patients died.First-year mortality was the highest (aHR = 10.3[CI:5.5-19.3]); between 1 and 4 years post-diagnosis, aHR = 1.9(1.2-3.0); an

Volumen II. Tomo II. Catálogo de biodiversidad de las regiones andina, pacífica y piedemonte amazónico. Nivel Local. Volumen 2 Tomo 2. Serie Planeación ambiental para la conservación de la biodiversidad en áreas operativas de Ecopetrol

Bogotá, D. C.Instituto de Investigación de Recursos Biológicos Alexander von Humbold