On the origin and pathway of the saline inflow to the Nordic Seas: insights from models

The behaviours of three high-resolution ocean circulation models of the North Atlantic, differing chiefly in their description of the vertical coordinate, are investigated in order to elucidate the routes and mechanisms by which saline water masses of southern origin provide inflows to the Nordic Seas. An existing hypothesis is that Mediterranean Overflow Water (MOW) is carried polewards in an eastern boundary undercurrent, and provides a deep source for these inflows. This study, however, provides an alternative view that the inflows are derived from shallow sources, and are comprised of water masses of western origin, carried by branches of the North Atlantic Current (NAC), and also more saline Eastern North Atlantic Water (ENAW), transported northwards from the Bay of Biscay region via a ‘Shelf Edge Current’ (SEC) flowing around the continental margins. In two of the models, the MOW flows northwards, but reaches only as far as the Porcupine Bank (53°N). In third model, the MOW also invades the Rockall Trough (extending to 60°N). However, none of the models allows the MOW to flow northwards into the Nordic Seas. Instead, they all support the hypothesis of there being shallow pathways, and that the saline inflows to the Nordic Seas result from NAC-derived and ENAW water masses, which meet and partially mix in the Rockall Trough. Volume and salinity transports into the southern Rockall Trough via the SEC are, in the various models, between 25 and 100% of those imported by the NAC, and are also a similarly significant proportion (20–75%) of the transports into the Nordic Seas. Moreover, the highest salinities are carried northwards by the SEC (these being between 0.13 and 0.19 psu more saline at the southern entrance to the Trough than those in the NAC-derived waters). This reveals for the first time the importance of the SEC in carrying saline water masses through the RockallTrough and into the Nordic Seas. Furthermore, the high salinities found on density surfaces appropriate to the MOW in the Nordic Seas are shown to result from the wintertime mixing of the saline near-surface waters advected northwards by the SEC/NAC system. Throughout, we have attempted to demonstrate the extent to which the models agree or disagree with interpretations derived from observations, so that the study also contributes to an ongoing community effort to assess the realism of our current generation of ocean models

Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies

Three different tetraazamacrocyclic ligands containing four amide substituents that feature groups (namely allyl, styryl and propargyl groups) suitable for polymerisation have been synthesised. Gadolinium(III) complexes of these three ligands have been prepared as potential monomers for the synthesis of polymeric MRI contrast agents. To assess the potential of these monomers as MRI contrast agents, their relaxation enhancement properties and cytotoxicity have been determined. A europium(III) complex of one of these ligands (with propargyl substituents) is also presented together with its PARACEST properties. In addition, to gain further insight into the coordination chemistry of the tetra-propargyl substituted ligand, the corresponding zinc(II) and cadmium(II) complexes have been prepared. The X-ray crystal structures of the tetra-propargyl ligand and its corresponding gadolinium(III), zinc(II) and cadmium(II) complexes are also presented

A process-based model of conifer forest structure and function with special emphasis on leaf lifespan

We describe the University of Sheffield Conifer Model (USCM), a process-based approach for simulating conifer forest carbon, nitrogen, and water fluxes by up-scaling widely applicable relationships between leaf lifespan and function. The USCM is designed to predict and analyze the biogeochemistry and biophysics of conifer forests that dominated the ice-free high-latitude regions under the high pCO2 “greenhouse” world 290–50 Myr ago. It will be of use in future research investigating controls on the contrasting distribution of ancient evergreen and deciduous forests between hemispheres, and their differential feedbacks on polar climate through the exchange of energy and materials with the atmosphere. Emphasis is placed on leaf lifespan because this trait can be determined from the anatomical characteristics of fossil conifer woods and influences a range of ecosystem processes. Extensive testing of simulated net primary production and partitioning, leaf area index, evapotranspiration, nitrogen uptake, and land surface energy partitioning showed close agreement with observations from sites across a wide climatic gradient. This indicates the generic utility of our model, and adequate representation of the key processes involved in forest function using only information on leaf lifespan, climate, and soils

Barriers and opportunities for evidence-based health service planning: the example of developing a Decision Analytic Model to plan services for sexually transmitted infections in the UK

Decision Analytic Models (DAMs) are established means of evidence-synthesis to differentiate between health interventions. They have mainly been used to inform clinical decisions and health technology assessment at the national level, yet could also inform local health service planning. For this, a DAM must take into account the needs of the local population, but also the needs of those planning its services. Drawing on our experiences from stakeholder consultations, where we presented the potential utility of a DAM for planning local health services for sexually transmitted infections (STIs) in the UK, and the evidence it could use to inform decisions regarding different combinations of service provision, in terms of their costs, cost-effectiveness, and public health outcomes, we discuss the barriers perceived by stakeholders to the use of DAMs to inform service planning for local populations, including (1) a tension between individual and population perspectives; (2) reductionism; and (3) a lack of transparency regarding models, their assumptions, and the motivations of those generating models

Change and Continuity in the Role of State Attorneys General in the Obama and Trump Administrations

During the Trump Administration, state attorneys general (AGs) have become entrenched as integral policymaking actors in the United States. Their expanding policymaking role fits broader patterns of polarized politics, as partisan coalitions of AGs are increasingly willing to sue the federal government, a trend that gathered steam in the Obama Administration and has reached a crescendo in Trump’s first year. However, state AGs do cooperate, particularly in corporate litigation to address allegedly widespread, illegal behavior. Utilizing a comprehensive dataset of multi-state lawsuits and Supreme Court amicus briefs, we identify continuity and change in how AGs have employed their powers, by examining their activities during the first year of the Trump presidency and placing these activities in the context of previous administrations. This analysis is accompanied by a pair of case studies, one on conflictual AG environmental litigation and another on bipartisan efforts to address the opioid epidemic. Both demonstrate AG’s prominent policymaking power, a power unlikely to abate anytime soon

Global asteroseismic properties of solar-like oscillations observed by Kepler : A comparison of complementary analysis methods

We present the asteroseismic analysis of 1948 F-, G- and K-type main-sequence and subgiant stars observed by the NASA {\em Kepler Mission}. We detect and characterise solar-like oscillations in 642 of these stars. This represents the largest cohort of main-sequence and subgiant solar-like oscillators observed to date. The photometric observations are analysed using the methods developed by nine independent research teams. The results are combined to validate the determined global asteroseismic parameters and calculate the relative precision by which the parameters can be obtained. We correlate the relative number of detected solar-like oscillators with stellar parameters from the {\em Kepler Input Catalog} and find a deficiency for stars with effective temperatures in the range $5300 \lesssim T_\mathrm{eff} \lesssim 5700$\,K and a drop-off in detected oscillations in stars approaching the red edge of the classical instability strip. We compare the power-law relationships between the frequency of peak power, $\nu_\mathrm{max}$, the mean large frequency separation, $\Delta\nu$, and the maximum mode amplitude, $A_\mathrm{max}$, and show that there are significant method-dependent differences in the results obtained. This illustrates the need for multiple complementary analysis methods to be used to assess the robustness and reproducibility of results derived from global asteroseismic parameters.Comment: 14 pages, 9 figures, accepted for publication in Monthly Notices of the Royal Astronomical Societ

Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination.

Abstract OBJECTIVE: We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination. METHODS: We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients. RESULTS: The most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurred exclusively in children. ON was the dominant phenotype (UON 35%, BON 19%) of all clinical episodes. 109/226 (48%) MRIs had no brain lesions. Patients were steroid responsive, but 70% of episodes treated with oral prednisone relapsed, particularly at doses <10\u2009mg daily or within 2 months of cessation. Immunotherapy, including maintenance prednisone (P=0.0004), intravenous immunoglobulin, rituximab and mycophenolate, all reduced median ARRs on-treatment. Treatment failure rates were lower in patients on maintenance steroids (5%) compared with non-steroidal maintenance immunotherapy (38%) (P=0.016). 58% of patients experienced residual disability (average follow-up 61 months, visual loss in 24%). Patients with ON were less likely to have sustained disability defined by a final EDSS of 652 (OR 0.15, P=0.032), while those who had any myelitis were more likely to have sustained residual deficits (OR 3.56, P=0.077). CONCLUSION: Relapsing MOG antibody-associated demyelination is strongly associated with ON across all age groups and ADEM in children. Patients are highly responsive to steroids, but vulnerable to relapse on steroid reduction and cessation

A precise asteroseismic age and radius for the evolved Sun-like star KIC 11026764

The primary science goal of the Kepler Mission is to provide a census of exoplanets in the solar neighborhood, including the identification and characterization of habitable Earth-like planets. The asteroseismic capabilities of the mission are being used to determine precise radii and ages for the target stars from their solar-like oscillations. Chaplin et al. (2010) published observations of three bright G-type stars, which were monitored during the first 33.5 days of science operations. One of these stars, the subgiant KIC 11026764, exhibits a characteristic pattern of oscillation frequencies suggesting that it has evolved significantly. We have derived asteroseismic estimates of the properties of KIC 11026764 from Kepler photometry combined with ground-based spectroscopic data. We present the results of detailed modeling for this star, employing a variety of independent codes and analyses that attempt to match the asteroseismic and spectroscopic constraints simultaneously. We determine both the radius and the age of KIC 11026764 with a precision near 1%, and an accuracy near 2% for the radius and 15% for the age. Continued observations of this star promise to reveal additional oscillation frequencies that will further improve the determination of its fundamental properties.Comment: 16 pages, 6 figures, 4 tables, ApJ in pres