The properties of the Malin 1 galaxy giant disk: A panchromatic view from the NGVS and GUViCS surveys

Low surface brightness galaxies (LSBGs) represent a significant percentage of local galaxies but their formation and evolution remain elusive. They may hold crucial information for our understanding of many key issues (i.e., census of baryonic and dark matter, star formation in the low density regime, mass function). The most massive examples - the so called giant LSBGs - can be as massive as the Milky Way, but with this mass being distributed in a much larger disk. Malin 1 is an iconic giant LSBG, perhaps the largest disk galaxy known. We attempt to bring new insights on its structure and evolution on the basis of new images covering a wide range in wavelength. We have computed surface brightness profiles (and average surface brightnesses in 16 regions of interest), in six photometric bands (FUV, NUV, u, g, i, z). We compared these data to various models, testing a variety of assumptions concerning the formation and evolution of Malin 1. We find that the surface brightness and color profiles can be reproduced by a long and quiet star-formation history due to the low surface density; no significant event, such as a collision, is necessary. Such quiet star formation across the giant disk is obtained in a disk model calibrated for the Milky Way, but with an angular momentum approximately 20 times larger. Signs of small variations of the star-formation history are indicated by the diversity of ages found when different regions within the galaxy are intercompared.For the first time, panchromatic images of Malin 1 are used to constrain the stellar populations and the history of this iconic example among giant LSBGs. Based on our model, the extreme disk of Malin 1 is found to have a long history of relatively low star formation (about 2 Msun/yr). Our model allows us to make predictions on its stellar mass and metallicity.Comment: Accepted in Astronomy and Astrophysic

Radial distribution of stars, gas and dust in SINGS galaxies. I. Surface photometry and morphology

We present ultraviolet through far-infrared surface brightness profiles for the 75 galaxies in the Spitzer Infrared Nearby Galaxies Survey (SINGS). The imagery used to measure the profiles includes GALEX UV data, optical images from KPNO, CTIO and SDSS, near-IR data from 2MASS, and mid- and far-infrared images from Spitzer. Along with the radial profiles, we also provide multi-wavelength asymptotic magnitudes and several non-parametric indicators of galaxy morphology: the concentration index (C_42), the asymmetry (A), the Gini coefficient (G) and the normalized second-order moment of the brightest 20% of the galaxy's flux (M_20). Our radial profiles show a wide range of morphologies and multiple components (bulges, exponential disks, inner and outer disk truncations, etc.) that vary not only from galaxy to galaxy but also with wavelength for a given object. In the optical and near-IR, the SINGS galaxies occupy the same regions in the C_42-A-G-M_20 parameter space as other normal galaxies in previous studies. However, they appear much less centrally concentrated, more asymmetric and with larger values of G when viewed in the UV (due to star-forming clumps scattered across the disk) and in the mid-IR (due to the emission of Polycyclic Aromatic Hydrocarbons at 8.0 microns and very hot dust at 24 microns).Comment: 66 pages in preprint format, 14 figures, published in ApJ. The definitive publisher authenticated version is available online at http://dx.doi.org/10.1088/0004-637X/703/2/156

Integral Field Spectroscopy and multi-wavelength imaging of the nearby spiral galaxy NGC5668: an unusual flattening in metallicity gradient

We present the analysis of the full bi-dimensional optical spectral cube of the nearby spiral galaxy NGC 5668, observed with the PPAK IFU at the Calar Alto observatory 3.5m telescope. We make use of broad-band imaging to provide further constraints on the evolutionary history of the galaxy. This dataset will allow us to improve our understanding of the mechanisms that drive the evolution of disks. We investigated the properties of 62 H II regions and concentric rings in NGC 5668 and derived maps in ionized-gas attenuation and chemical (oxygen) abundances. We find that, while inwards of r\,$\sim\,36",\sim$\,4.4kpc\,$\sim$\,0.36\,$(\frac {D_{25}}{2})$ the derived O/H ratio follows the radial gradient typical of spiral galaxies, the abundance gradient beyond r$\sim36"$ flattens out. The analysis of the multi-wavelength surface brightness profiles of NGC 5668 is performed by fitting these profiles with those predicted by chemo-spectrophotometric evolutionary models of galaxy disks. From this, we infer a spin and circular velocity of $\lambda$=0.053 and v$_{c}$=167\,km\,s$^{-1}$, respectively. The metallicity gradient and rotation curve predicted by this best-fitting galaxy model nicely match the values derived from the IFU observations, especially within r\,\sim36\arcsec. The same is true for the colors despite of some small offsets and a reddening in the bluest colors beyond that radius. On the other hand, deviations of some of these properties in the outer disk indicate that a secondary mechanism, possibly gas transfer induced by the presence of a young bar, must have played a role in shaping the recent chemical and star formation histories of NGC 5668.Comment: 44 pages, 13 figures, Accepted for publication in ApJ. arXiv admin note: text overlap with arXiv:astro-ph/020649

Outer-Disk Populations in NGC 7793: Evidence for Stellar Radial Migration

We analyzed the radial surface brightness profile of the spiral galaxy NGC 7793 using HST/ACS images from the GHOSTS survey and a new HST/WFC3 image across the disk break. We used the photometry of resolved stars to select distinct populations covering a wide range of stellar ages. We found breaks in the radial profiles of all stellar populations at 280" (~5.1 kpc). Beyond this disk break, the profiles become steeper for younger populations. This same trend is seen in numerical simulations where the outer disk is formed almost entirely by radial migration. We also found that the older stars of NGC 7793 extend significantly farther than the underlying HI disk. They are thus unlikely to have formed entirely at their current radii, unless the gas disk was substantially larger in the past. These observations thus provide evidence for substantial stellar radial migration in late-type disks.Comment: 8 pages, 6 figure. Accepted for publication in Ap

The GALEX Arecibo SDSS survey: III. Evidence for the Inside-Out Formation of Galactic Disks

We analyze a sample of galaxies with stellar masses greater than $10^{10} M_{\odot}$ and with redshifts in the range $0.025<z<0.05$ for which HI mass measurements are available from the GALEX Arecibo SDSS Survey (GASS) or from the Arecibo Legacy Fast ALFA survey (ALFALFA). At a given value of $M_*$, our sample consists primarily of galaxies that are more HI-rich than average. We constructed a series of three control samples for comparison with these HI-rich galaxies. As expected, HI-rich galaxies differ strongly from galaxies of same stellar mass that are selected without regard to HI content. The majority of these differences are attributable to the fact that galaxies with more gas are bluer and more actively star-forming. In order to identify those galaxy properties that are causally connected with HI content, we compare results derived for the HI sample with those derived for galaxies matched in stellar mass, size and NUV-$r$ colour. The only photometric property that is clearly attributable to increasing HI content, is the colour gradient of the galaxy. Galaxies with larger HI fractions have bluer, more actively star-forming outer disks compared to the inner part of the galaxy. HI-rich galaxies also have larger $g$-band radii compared to $i$-band radii. Our results are consistent with the "inside-out" picture of disk galaxy formation, which has commonly served as a basis for semi-analytic models of the formation of disks in the context of Cold Dark Matter cosmologies. The lack of any intrinsic connection between HI fraction and galaxy asymmetry suggests that gas is accreted smoothly onto the outer disk.Comment: 18 pages, 20 figures. Accepted for publication in MNRAS. GASS publications and released data can be found at http://www.mpa-garching.mpg.de/GASS/index.ph

The GALEX Ultraviolet Virgo Cluster Survey (GUViCS). II. Constraints on star formation in ram-pressure stripped gas

Context: Several galaxies in the Virgo cluster are known to have large HI gas tails related to a recent ram-pressure stripping event. The Virgo cluster has been extensively observed at 1539 A in the far-ultraviolet for the GALEX Ultraviolet Virgo Cluster Survey (GUViCS), and in the optical for the Next Generation Virgo Survey (NGVS), allowing a study of the stellar emission potentially associated with the gas tails of 8 cluster members. On the theoretical side, models of ram-pressure stripping events have started to include the physics of star formation. Aim: We aim to provide quantitative constraints on the amount of star formation taking place in the ram-pressure stripped gas, mainly on the basis of the far-UV emission found in the GUViCS images in relation with the gas content of the tails. Methods: We have performed three comparisons of the young stars emission with the gas column density: visual, pixel-by-pixel and global. We have compared our results to other observational and theoretical studies. Results: We find that the level of star formation taking place in the gas stripped from galaxies by ram-pressure is low with respect to the available amount of gas. Star formation is lower by at least a factor 10 compared to the predictions of the Schmidt Law as determined in regular spiral galaxy disks. It is also lower than measured in dwarfs galaxies and the outer regions of spirals, and than predicted by some numerical simulations. We provide constraints on the star formation efficiency in the ram-pressure stripped gas tails, and compare these with current models.Comment: Accepted in A&A, 17 pages (including the appendix and "on-line" figures of the paper

The dynamic use of EGFR mutation analysis in cell-free DNA as a follow-up biomarker during different treatment lines in non-small-cell lung cancer patients

Epidermal growth factor receptor (EGFR) mutational testing in advanced non-small-cell lung cancer (NSCLC) is usually performed in tumor tissue, although cfDNA (cell-free DNA) could be an alternative. We evaluated EGFR mutations in cfDNA as a complementary tool in patients, who had already known EGFR mutations in tumor tissue and were treated with either EGFR-tyrosine kinase inhibitors (TKIs) or chemotherapy. We obtained plasma samples from 21 advanced NSCLC patients with known EGFR tumor mutations, before and during therapy with EGFR-TKIs and/or chemotherapy. cfDNA was isolated and EGFR mutations were analyzed with the multiple targeted cobas EGFR Mutation Test v2. EGFR mutations were detected at baseline in cfDNA from 57% of patients. The semiquantitative index (SQI) significantly decreased from the baseline (median = 11, IQR = 9 5-13) to the best response (median = 0, IQR = 0-0, p < 0 01), followed by a significant increase at progression (median = 11, IQR = 11-15, p < 0 01) in patients treated with either EGFR-TKIs or chemotherapy. The SQI obtained with the cobas EGFR Mutation Test v2 did not correlate with the concentration in copies/mL determined by droplet digital PCR. Resistance mutation p.T790M was observed at progression in patients with either type of treatment. In conclusion, cfDNA multiple targeted EGFR mutation analysis is useful for treatment monitoring in tissue of EGFR-positive NSCLC patients independently of the drug received

Radial distribution of stars, gas and dust in SINGS galaxies. II. Derived dust properties

We present a detailed analysis of the radial distribution of dust properties in the SINGS sample, performed on a set of UV, IR and HI surface brightness profiles, combined with published molecular gas profiles and metallicity gradients. The internal extinction, derived from the TIR-to-FUV luminosity ratio, decreases with radius, and is larger in Sb-Sbc galaxies. The TIR-to-FUV ratio correlates with the UV spectral slope beta, following a sequence shifted to redder UV colors with respect to that of starbursts. The star formation history (SFH) is identified as the main driver of this departure. We have also derived radial profiles of the total dust mass surface density, the fraction of the dust mass contributed by PAHs, the fraction of the dust mass heated by very intense starlight and the intensity of the radiation field heating the grains. The dust profiles are exponential, their radial scale-length being constant from Sb to Sd galaxies (only ~10% larger than the stellar scale-length). Many S0/a-Sab galaxies have central depressions in their dust radial distributions. The PAH abundance increases with metallicity for 12+\log(O/H)<9, and at larger metallicities the trend flattens and even reverses, with the SFH being a plausible underlying driver for this behavior. The dust-to-gas ratio is also well correlated with metallicity and therefore decreases with galactocentric radius.Comment: 73 pages in preprint format, 21 figures, published in ApJ. The definitive publisher authenticated version is available online at http://dx.doi.org/10.1088/0004-637X/701/2/196

The Spanish biology/disease initiative within the human proteome project: Application to rheumatic diseases

The Spanish Chromosome 16 consortium is integrated in the global initiative Human Proteome Project, which aims to develop an entire map of the proteins encoded following a gene-centric strategy (C-HPP) in order to make progress in the understanding of human biology in health and disease (B/D-HPP). Chromosome 16 contains many genes encoding proteins involved in the development of a broad range of diseases, which have a significant impact on the health care system. The Spanish HPP consortium has developed a B/D platform with five programs focused on selected medical areas: cancer, obesity, cardiovascular, infectious and rheumatic diseases. Each of these areas has a clinical leader associated to a proteomic investigator with the responsibility to get a comprehensive understanding of the proteins encoded by Chromosome 16 genes. Proteomics strategies have enabled great advances in the area of rheumatic diseases, particularly in osteoarthritis, with studies performed on joint cells, tissues and fluids. BIOLOGICAL SIGNIFICANCE: In this manuscript we describe how the Spanish HPP-16 consortium has developed a B/D platform with five programs focused on selected medical areas: cancer, obesity, cardiovascular, infectious and rheumatic diseases. Each of these areas has a clinical leader associated to a proteomic investigator with the responsibility to get a comprehensive understanding of the proteins encoded by Chromosome 16 genes. We show how the Proteomic strategy has enabled great advances in the area of rheumatic diseases, particularly in osteoarthritis, with studies performed on joint cells, tissues and fluids. This article is part of a Special Issue entitled: HUPO 2014

DustPedia: Multiwavelength photometry and imagery of 875 nearby galaxies in 42 ultraviolet-microwave bands

Aims. The DustPedia project is capitalising on the legacy of the Herschel Space Observatory, using cutting-edge modelling techniques to study dust in the 875 DustPedia galaxies – representing the vast majority of extended galaxies within 3000 km s-1 that were observed by Herschel. This work requires a database of multiwavelength imagery and photometry that greatly exceeds the scope (in terms of wavelength coverage and number of galaxies) of any previous local-Universe survey. Methods. We constructed a database containing our own custom Herschel reductions, along with standardised archival observations from GALEX, SDSS, DSS, 2MASS, WISE, Spitzer, and Planck. Using these data, we performed consistent aperture-matched photometry, which we combined with external supplementary photometry from IRAS and Planck. Results. We present our multiwavelength imagery and photometry across 42 UV-microwave bands for the 875 DustPedia galaxies. Our aperture-matched photometry, combined with the external supplementary photometry, represents a total of 21 857 photometric measurements. A typical DustPedia galaxy has multiwavelength photometry spanning 25 bands. We also present the Comprehensive & Adaptable Aperture Photometry Routine (CAAPR), the pipeline we developed to carry out our aperture-matched photometry. CAAPR is designed to produce consistent photometry for the enormous range of galaxy and observation types in our data. In particular, CAAPR is able to determine robust cross-compatible uncertainties, thanks to a novel method for reliably extrapolating the aperture noise for observations that cover a very limited amount of background. Our rich database of imagery and photometry is being made available to the community