955 research outputs found
Comparing Non-invasive Inverse Electrocardiography With Invasive Endocardial and Epicardial Electroanatomical Mapping During Sinus Rhythm
- Author
- Publication venue
- Publication date
- 04/10/2021
- Field of study
This study presents a novel non-invasive equivalent dipole layer (EDL) based inverse electrocardiography (iECG) technique which estimates both endocardial and epicardial ventricular activation sequences. We aimed to quantitatively compare our iECG approach with invasive electro-anatomical mapping (EAM) during sinus rhythm with the objective of enabling functional substrate imaging and sudden cardiac death risk stratification in patients with cardiomyopathy. Thirteen patients (77% males, 48 ± 20 years old) referred for endocardial and epicardial EAM underwent 67-electrode body surface potential mapping and CT imaging. The EDL-based iECG approach was improved by mimicking the effects of the His-Purkinje system on ventricular activation. EAM local activation timing (LAT) maps were compared with iECG-LAT maps using absolute differences and Pearson’s correlation coefficient, reported as mean ± standard deviation [95% confidence interval]. The correlation coefficient between iECG-LAT maps and EAM was 0.54 ± 0.19 [0.49–0.59] for epicardial activation, 0.50 ± 0.27 [0.41–0.58] for right ventricular endocardial activation and 0.44 ± 0.29 [0.32–0.56] for left ventricular endocardial activation. The absolute difference in timing between iECG maps and EAM was 17.4 ± 7.2 ms for epicardial maps, 19.5 ± 7.7 ms for right ventricular endocardial maps, 27.9 ± 8.7 ms for left ventricular endocardial maps. The absolute distance between right ventricular endocardial breakthrough sites was 30 ± 16 mm and 31 ± 17 mm for the left ventricle. The absolute distance for latest epicardial activation was median 12.8 [IQR: 2.9–29.3] mm. This first in-human quantitative comparison of iECG and invasive LAT-maps on both the endocardial and epicardial surface during sinus rhythm showed improved agreement, although with considerable absolute difference and moderate correlation coefficient. Non-invasive iECG requires further refinements to facilitate clinical implementation and risk stratification
Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/07/2018
- Field of study
Brugada syndrome (BrS) is an inherited cardiac arrhythmia commonly associated with SCN5A mutations, yet its ionic mechanisms remain unclear due to a lack of cellular models. Here, we used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from a BrS patient (BrS1) to evaluate the roles of Na+ currents (INa) and transient outward K+ currents (Ito) in BrS induced action potential (AP) changes. To understand the role of these current changes in repolarization we employed dynamic clamp to "electronically express" IK1 and restore normal resting membrane potentials and allow normal recovery of the inactivating currents, INa, ICa and Ito. HiPSC-CMs were generated from BrS1 with a compound SCN5A mutation (p. A226V & p. R1629X) and a healthy sibling control (CON1). Genome edited hiPSC-CMs (BrS2) with a milder p. T1620M mutation and a commercial control (CON2) were also studied. CON1, CON2 and BrS2, had unaltered peak INa amplitudes, and normal APs whereas BrS1, with over 75% loss of INa, displayed a loss-of-INa basal AP morphology (at 1.0 Hz) manifested by a reduced maximum upstroke velocity (by ~80%, p < 0.001) and AP amplitude (p < 0.001), and an increased phase-1 repolarization pro-arrhythmic AP morphology (at 0.1 Hz) in ~25% of cells characterized by marked APD shortening (~65% shortening, p < 0.001). Moreover, Ito densities of BrS1 and CON1 were comparable and increased from 1.0 Hz to 0.1 Hz by ~ 100%. These data indicate that a repolarization deficit could be a mechanism underlying BrS
Phenotype Prediction Using Regularized Regression on Genetic Data in the DREAM5 Systems Genetics B Challenge
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2011
- Field of study
A major goal of large-scale genomics projects is to enable the use of data from high-throughput experimental methods to predict complex phenotypes such as disease susceptibility. The DREAM5 Systems Genetics B Challenge solicited algorithms to predict soybean plant resistance to the pathogen Phytophthora sojae from training sets including phenotype, genotype, and gene expression data. The challenge test set was divided into three subcategories, one requiring prediction based on only genotype data, another on only gene expression data, and the third on both genotype and gene expression data. Here we present our approach, primarily using regularized regression, which received the best-performer award for subchallenge B2 (gene expression only). We found that despite the availability of 941 genotype markers and 28,395 gene expression features, optimal models determined by cross-validation experiments typically used fewer than ten predictors, underscoring the importance of strong regularization in noisy datasets with far more features than samples. We also present substantial analysis of the training and test setup of the challenge, identifying high variance in performance on the gold standard test sets.National Science Foundation (U.S.). Graduate Research Fellowship ProgramNational Defense Science and Engineering Graduate Fellowshi
Experiences of treatment decision making for young people diagnosed with depressive disorders: a qualitative study in primary care and specialist mental health settings
- Author
- A Edwards
- A Goossensen
- A Loh
- A Loh
- A Loh
- A Simpson
- A Thompson
- AF Jorm
- AF Jorm
- Anthony F Jorm
- B Brimaher
- BW Van Voorhees
- C Charles
- C Charles
- C Goss
- CE Wills
- D Cicchetti
- D Simon
- Drake
- E Duncan
- E O'Neal
- G Andrews
- G Clarke
- G Elwyn
- J Hamann
- J Hamann
- J Hamann
- J Ryan
- JP Wisdom
- JP Wisdom
- JR Adams
- JR Asarnow
- JR Asarnow
- KJ Gergen
- KJ Gergen
- L Cooper-Patrick
- L Fraenkel
- L Richardson
- LJ Barney
- M Holmes-Rovner
- Magenta B Simmons
- NB Allen
- NICE
- NK Arora
- PM Lewinsohn
- PS Wang
- PS Wang
- RB Deber
- RE Drake
- RE Say
- S Gilbody
- S Hetrick
- Sarah E Hetrick
- SL Clever
- T Hope
- T Whelan
- V Braun
- V Patel
- VA Entwistle
- VA Entwistle
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Clinical guidelines advocate for the inclusion of young people experiencing depression as well as their caregivers in making decisions about their treatment. Little is known, however, about the degree to which these groups are involved, and whether they want to be. This study sought to explore the experiences and desires of young people and their caregivers in relation to being involved in treatment decision making for depressive disorders.</p> <p>Methods</p> <p>Semi-structured interviews were carried out with ten young people and five caregivers from one primary care and one specialist mental health service about their experiences and beliefs about treatment decision making. Interviews were audio taped, transcribed verbatim and analysed using thematic analysis.</p> <p>Results</p> <p>Experiences of involvement for clients varied and were influenced by clients themselves, clinicians and service settings. For caregivers, experiences of involvement were more homogenous. Desire for involvement varied across clients, and within clients over time; however, most clients wanted to be involved at least some of the time. Both clients and caregivers identified barriers to involvement.</p> <p>Conclusions</p> <p>This study supports clinical guidelines that advocate for young people diagnosed with depressive disorders to be involved in treatment decision making. In order to maximise engagement, involvement in treatment decision making should be offered to all clients. Involvement should be negotiated explicitly and repeatedly, as desire for involvement may change over time. Caregiver involvement should be negotiated on an individual basis; however, all caregivers should be supported with information about mental disorders and treatment options.</p
Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinomas
- Author
- A Gazit
- AJ da Silva
- CA Dahl
- CA Heid
- CH Heldin
- D Matesa-Anic
- DG Gilbertson
- E Kebebew
- EK Chow
- GF Del Prete
- H Li
- Hans G Eiken
- Jan E Varhaug
- JL Browning
- Johan R Lillehaug
- JW Lowenthal
- KA Smith
- KC Loh
- KT Chen
- LA Akslen
- Lars A Akslen
- LJ Reigstad
- M Marzec
- M Sobrinho-Simoes
- MP Beckmann
- O Fluge
- O Fluge
- O Ozaki
- Ove Bruland
- P Anatol
- Per M Knappskog
- S Matsubayashi
- T Nishida
- T Takeshita
- VG Tusher
- Y Yano
- Øystein Fluge
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>Members of the PDGF family have been suggested as potential biomarkers for papillary thyroid carcinomas (PTC). However, it is known that both expression and stimulatory effect of PDGF ligands can be affected by inflammatory cytokines. We have performed a microarray study in a collection of PTCs, of which about half the biopsies contained tumour-infiltrating lymphocytes or thyroiditis. To investigate the expression level of PDGF ligands and receptors in PTC we measured the relative mRNA expression of all members of the PDGF family by qRT-PCR in 10 classical PTC, eight clinically aggressive PTC, and five non-neoplastic thyroid specimens, and integrated qRT-PCR data with microarray data to enable us to link PDGF-associated gene expression profiles into networks based on recognized interactions. Finally, we investigated potential influence on PDGF mRNA levels by the presence of tumour-infiltrating lymphocytes.</p> <p>Methods</p> <p>qRT-PCR was performed on <it>PDGFA</it>, <it>PDGFB</it>, <it>PDGFC</it>, <it>PDGFD</it>, <it>PDGFRA PDGFRB </it>and a selection of lymphocyte specific mRNA transcripts. Semiquantitative assessment of tumour-infiltrating lymphocytes was performed on the adjacent part of the biopsy used for RNA extraction for all biopsies, while direct quantitation by qRT-PCR of lymphocyte-specific mRNA transcripts were performed on RNA also subjected to expression analysis. Relative expression values of PDGF family members were combined with a cDNA microarray dataset and analyzed based on clinical findings and PDGF expression patterns. Ingenuity Pathway Analysis (IPA) was used to elucidate potential molecular interactions and networks.</p> <p>Results</p> <p>PDGF family members were differentially regulated at the mRNA level in PTC as compared to normal thyroid specimens. Expression of <it>PDGFA </it>(p = 0.003), <it>PDGFB </it>(p = 0.01) and <it>PDGFC </it>(p = 0.006) were significantly up-regulated in PTCs compared to non-neoplastic thyroid tissue. In addition, expression of <it>PDGFC </it>was significantly up-regulated in classical PTCs as compared to clinically aggressive PTCs (p = 0.006), and <it>PDGFRB </it>were significantly up-regulated in clinically aggressive PTCs (p = 0.01) as compared to non-neoplastic tissue. Semiquantitative assessment of lymphocytes correlated well with quantitation of lymphocyte-specific gene expression. Further more, by combining TaqMan and microarray data we found a strong inverse correlation between <it>PDGFC </it>expression and the expression of lymphocyte specific mRNAs.</p> <p>Conclusion</p> <p>At the mRNA level, several members of the PDGF family are differentially expressed in PTCs as compared to normal thyroid tissue. Of these, only the <it>PDGFC </it>mRNA expression level initially seemed to distinguish classical PTCs from the more aggressive PTCs. However, further investigation showed that <it>PDGFC </it>expression level correlated inversely to the expression of several lymphocyte specific genes, and to the presence of lymphocytes in the biopsies. Thus, we find that <it>PDGFC </it>mRNA expression were down-regulated in biopsies containing infiltrated lymphocytes or thyroiditis. No other PDGF family member could be linked to lymphocyte specific gene expression in our collection of PTCs biopsies.</p
Study of Bc+ decays to the K+K−π+ final state and evidence for the decay Bc+→χc0π+
- Author
- Aaij R
- Adeva B
- Adinolfi M
- Ajaltouni Z
- Akar S
- Albrecht J
- Alessio F
- Alexander M
- Ali S
- Alkhazov G
- Altarelli M Pepe
- Amato S
- Amerio S
- Amhis Y
- An L
- Anderlini L
- Andreassi G
- Andreotti M
- Andrews JE
- Appleby RB
- Archilli F
- Artamonov A
- Artuso M
- Aslanides E
- Auriemma G
- Baalouch M
- Babuschkin I
- Bachmann S
- Back JJ
- Badalov A
- Baesso C
- Baldini W
- Barlow RJ
- Barschel C
- Barsuk S
- Barter W
- Baszczyk M
- Batozskaya V
- Batsukh B
- Battista V
- Bay A
- Beaucourt L
- Beddow J
- Bedeschi F
- Bediaga I
- Bel LJ
- Bellee V
- Belloli N
- Belous K
- Belyaev I
- Ben-Haim E
- Bencivenni G
- Benson S
- Benton J
- Berezhnoy A
- Bernet R
- Bertolin A
- Betti F
- Bettler M-O
- Bezshyiko Ia
- Bifani S
- Billoir P
- Bird T
- Birnkraut A
- Bitadze A
- Bizzeti A
- Blake T
- Blanc F
- Blouw J
- Blusk S
- Bocci V
- Boettcher T
- Bondar A
- Bondar N
- Bonivento W
- Borgheresi A
- Borghi S
- Borisyak M
- Borsato M
- Bossu F
- Boubdir M
- Bowcock TJV
- Bowen E
- Bozzi C
- Braun S
- Britsch M
- Britton T
- Brodzicka J
- Buchanan E
- Burr C
- Bursche A
- Buytaert J
- Cadeddu S
- Calabrese R
- Calvi M
- Calvo Gomez M
- Camboni A
- Campana P
- Capriotti L
- Carbone A
- Carboni G
- Cardinale R
- Cardini A
- Cardoso LA Granado
- Carniti P
- Carson L
- Cartelle P Alvarez
- Carvalho Akiba K
- Casse G
- Cassina L
- Cattaneo M
- Cauet Ch
- Cavallero G
- Cazon BR Gruberg
- Cenci R
- Charles M
- Charpentier Ph
- Chatzikonstantinidis G
- Chefdeville M
- Chen S
- Cheung S-F
- Chobanova V
- Chrzaszcz M
- Cid Vidal X
- Ciezarek G
- Clarke PEL
- Clemencic M
- Cliff HV
- Closier J
- Coco V
- Cogan J
- Cogneras E
- Cogoni V
- Cojocariu L
- Collaboration Lhcb
- Collaboration LHCb
- Collazuol G
- Collins P
- Comerma-Montells A
- Contu A
- Cook A
- Coquereau S
- Corti G
- Corvo M
- Coutinho R Silva
- Couturier B
- Cowan GA
- Craik DC
- Crocombe A
- Cunliffe S
- Currie R
- D'Ambrosio C
- d'Argent P
- Dall'Occo E
- Dalseno J
- David PNY
- Davis A
- De Aguiar Francisco O
- De Bruyn K
- De Capua S
- De Cian M
- De Miranda JM
- De Paula L
- De Serio M
- De Simone P
- de Vries JA
- Dean C-T
- Decamp D
- Deckenhoff M
- Del Buono L
- Deleage N
- Demmer M
- Derkach D
- Deschamps O
- Dettori F
- Dey B
- Di Canto A
- Dijkstra H
- Dordei F
- Dorigo M
- dos Reis AC
- Dosil Suarez A
- Dovbnya A
- Dreimanis K
- Dufour L
- Dujany G
- Dungs K
- Durante P
- Dzhelyadin R
- Dziurda A
- Dzyuba A
- Easo S
- Ebert M
- Egede U
- Egorychev V
- Eidelman S
- Eisenhardt S
- Eitschberger U
- Ekelhof R
- Eklund L
- Elsasser Ch
- Ely S
- Esen S
- Evans HM
- Evans T
- Falabella A
- Farber C
- Farley N
- Farry S
- Fay R
- Fazzini D
- Ferguson D
- Fernandez Albor V
- Fernandez Prieto A
- Ferrari F
- Ferreira Rodrigues F
- Ferro-Luzzi M
- Filippov S
- Fini RA
- Fiore M
- Fiorini M
- Firlej M
- Fitzpatrick C
- Fiutowski T
- Fleuret F
- Fohl K
- Fontana M
- Fontanelli F
- Forshaw DC
- Forty R
- Frank M
- Frei C
- Fu J
- Furfaro E
- Gallas Torreira A
- Galli D
- Gallorini S
- Gambetta S
- Gandara M Grabalosa
- Gandelman M
- Gandini P
- Gao Y
- Garcia Martin LM
- Garcia Pardinas J
- Garcia L Castillo
- Garra Tico J
- Garrido L
- Garsed PJ
- Gascon D
- Gaspar C
- Gavardi L
- Gazzoni G
- Gerick D
- Gersabeck E
- Gersabeck M
- Gershon T
- Ghez Ph
- Giani S
- Gibson V
- Girard OG
- Giubega L
- Gizdov K
- Gligorov VV
- Gobel C
- Golubkov D
- Golutvin A
- Gomes A
- Gomez R Vazquez
- Gorelov IV
- Gotti C
- Graciani Diaz R
- Grauges E
- Graverini E
- Graziani G
- Grecu A
- Griffith P
- Grillo L
- Grunberg O
- Gushchin E
- Guz Yu
- Gys T
- Hadavizadeh T
- Hadjivasiliou C
- Haefeli G
- Haen C
- Haines SC
- Hall S
- Hamilton B
- Han X
- Hansmann-Menzemer S
- Harnew N
- Harnew ST
- Harrison J
- Hatch M
- He J
- Head T
- Heister A
- Hennessy K
- Henrard P
- Henry L
- Hernando Morata JA
- Hess M
- Hicheur A
- Hill D
- Hombach C
- Hopchev H
- Hulsbergen W
- Humair T
- Hushchyn M
- Hussain N
- Hutchcroft D
- Idzik M
- Ilten P
- Jacobsson R
- Jaeger A
- Jalocha J
- Jans E
- Jawahery A
- John M
- Johnson D
- Jones CR
- Joram C
- Jost B
- Jr Alves AA
- Jurik N
- Kandybei S
- Kanso W
- Karacson M
- Kariuki JM
- Karodia S
- Kecke M
- Kelsey M
- Kenyon IR
- Kenzie M
- Ketel T
- Khairullin E
- Khanji B
- Khurewathanakul C
- Kirn T
- Klaver S
- Klimaszewski K
- Koliiev S
- Kolpin M
- Komarov I
- Koopman RF
- Koppenburg P
- Kozachuk A
- Kozeiha M
- Kravchuk L
- Kreplin K
- Kreps M
- Krokovny P
- Kruse F
- Krzemien W
- Kucewicz W
- Kucharczyk M
- Kudryavtsev V
- Kuonen AK
- Kurek K
- Kvaratskheliya T
- Lacarrere D
- Lafferty G
- Lai A
- Lambert D
- Lanfranchi G
- Langenbruch C
- Langhans B
- Latham T
- Lazzeroni C
- Le Gac R
- Lees J-P
- Lefevre R
- Leflat A
- Lefrancois J
- Lemaitre F
- Lemos Cid E
- Leroy O
- Lesiak T
- Leverington B
- Li Y
- Likhomanenko T
- Lima V Franco
- Lindner R
- Linn C
- Lionetto F
- Liu B
- Liu X
- Loh D
- Longstaff I
- Lopes JH
- Lucchesi D
- Lucio Martinez M
- Luo H
- Lupato A
- Luppi E
- Lupton O
- Lusiani A
- Lyu X
- Machefert F
- Maciuc F
- Maev O
- Maguire K
- Malde S
- Malinin A
- Maltsev T
- Manca G
- Mancinelli G
- Manning P
- Maratas J
- Marchand JF
- Marconi U
- Marin Benito C
- Marino P
- Marks J
- Martellotti G
- Martin M
- Martinelli M
- Martinez Santos D
- Martinez Vidal F
- Martins Tostes D
- Massacrier LM
- Massafferri A
- Matev R
- Mathad A
- Mathe Z
- Matteuzzi C
- Mauri A
- Maurin B
- Mazurov A
- McCann M
- McCarthy J
- McNab A
- McNulty R
- Meadows B
- Meier F
- Meissner M
- Melnychuk D
- Merk M
- Merli A
- Michielin E
- Milanes DA
- Minard M-N
- Mitzel DS
- Mogini A
- Molina Rodriguez J
- Monroy IA
- Monteil S
- Morandin M
- Morawski P
- Morda A
- Morello MJ
- Moron J
- Morris AB
- Mountain R
- Muheim F
- Mulder M
- Muller D
- Muller J
- Muller K
- Muller V
- Mussini M
- Naik P
- Nakada T
- Nandakumar R
- Nandi A
- Nasteva I
- Navarro A Puig
- Needham M
- Neri N
- Neubert S
- Neufeld N
- Neuner M
- Nguyen AD
- Nguyen-Mau C
- Nieswand S
- Niet R
- Nikitin N
- Nikodem T
- Novoselov A
- O'Hanlon DP
- Oblakowska-Mucha A
- Obraztsov V
- Ogilvy S
- Oldeman R
- Onderwater CJG
- Otalora Goicochea JM
- Otto A
- Owen P
- Oyanguren A
- Pais PR
- Palano A
- Palombo F
- Palutan M
- Panman J
- Papanestis A
- Pappagallo M
- Pappalardo LL
- Parker W
- Parkes C
- Passaleva G
- Pastore A
- Patel GD
- Patel M
- Patrignani C
- Pearce A
- Pellegrino A
- Penso G
- Perazzini S
- Perez D Campora
- Perez DH Campora
- Perez P Rodriguez
- Perret P
- Pescatore L
- Petridis K
- Petrolini A
- Petrov A
- Petruzzo M
- Picatoste Olloqui E
- Pietrzyk B
- Pikies M
- Pinci D
- Pistone A
- Piucci A
- Playfer S
- Plo Casasus M
- Poikela T
- Polci F
- Poluektov A
- Polyakov I
- Polycarpo E
- Pomery GJ
- Popov A
- Popov D
- Popovici B
- Potterat C
- Price E
- Price JD
- Prisciandaro J
- Pritchard A
- Prouve C
- Pugatch V
- Punzi G
- Qian W
- Quagliani R
- Rachwal B
- Rademacker JH
- Rama M
- Ramos Pernas M
- Rangel MS
- Raniuk I
- Raven G
- Redi F
- Reichert S
- Remon Alepuz C
- Renaudin V
- Ricciardi S
- Richards S
- Rihl M
- Rinnert K
- Rives Molina V
- Robbe P
- Rodrigues AB
- Rodrigues E
- Rodriguez Lopez JA
- Rogozhnikov A
- Roiser S
- Romanovskiy V
- Romero Vidal A
- Romeu J Arnau
- Ronayne JW
- Rotondo M
- Rudolph MS
- Ruf T
- Ruiz Valls P
- Saborido Silva JJ
- Sadykhov E
- Sagidova N
- Saitta B
- Salustino Guimaraes V
- Sanchez Mayordomo C
- Sanmartin Sedes B
- Santacesaria R
- Santamarina Rios C
- Santimaria M
- Santovetti E
- Sarti A
- Satriano C
- Satta A
- Saunders DM
- Savrina D
- Schael S
- Schellenberg M
- Schiller M
- Schindler H
- Schlupp M
- Schmelling M
- Schmelzer T
- Schmidt B
- Schneider O
- Schopper A
- Schubert K
- Schubiger M
- Schune M-H
- Schwemmer R
- Sciascia B
- Sciubba A
- Semennikov A
- Sergi A
- Serra N
- Serrano J
- Sestini L
- Seyfert P
- Shapkin M
- Shapoval I
- Shcheglov Y
- Shears T
- Shekhtman L
- Shevchenko V
- Shires A
- Siddi BG
- Silva de Oliveira L
- Simi G
- Simone S
- Sirendi M
- Skidmore N
- Skwarnicki T
- Smith E
- Smith IT
- Smith J
- Smith M
- Snoek H
- Sobral CM Costa
- Sokoloff MD
- Soler FJP
- Souza De Paula B
- Souza D
- Spaan B
- Spradlin P
- Sridharan S
- Stagni F
- Stahl M
- Stahl S
- Stefko P
- Stefkova S
- Steinkamp O
- Stenyakin O
- Stenzel Martins J
- Stevenson S
- Stoica S
- Stone S
- Storaci B
- Stracka S
- Straticiuc M
- Straumann U
- Sun L
- Sutcliffe W
- Swientek K
- Syropoulos V
- Szczekowski M
- Szumlak T
- T'Jampens S
- Tayduganov A
- Tekampe T
- Teklishyn M
- Tellarini G
- Teubert F
- Thomas C
- Thomas E
- Tisserand V
- Tobin M
- Tolk S
- Tomassetti L
- Tonelli D
- Topp-Joergensen S
- Toriello F
- Torres M Cruz
- Tournefier E
- Tourneur S
- Trabelsi K
- Traill M
- Tran MT
- Tresch M
- Trisovic A
- Tsaregorodtsev A
- Tsopelas P
- Tully A
- Tuning N
- Ukleja A
- Ustyuzhanin A
- Uwer U
- Vacca C
- Vagnoni V
- Valassi A
- Valat S
- Valenti G
- Vallier A
- van Beuzekom M
- van Herwijnen E
- van Leerdam J
- van Tilburg J
- van Veghel M
- Vazquez Regueiro P
- Vazquez Sierra C
- Vecchi S
- Velthuis JJ
- Veltri M
- Veneziano G
- Venkateswaran A
- Vernet M
- Vesterinen M
- Viaud B
- Vieira D
- Vieites Diaz M
- Vilasis-Cardona X
- Volkov V
- Vollhardt A
- Voneki B
- Vorobyev A
- Vorobyev V
- Voss C
- Waldi R
- Wallace C
- Wallace R
- Walsh J
- Wang J
- Ward DR
- Wark HM
- Watson NK
- Websdale D
- Weiden A
- Whitehead M
- Wicht J
- Wilkinson G
- Wilkinson M
- Williams M
- Williams M
- Williams MP
- Williams T
- Wilson FF
- Wimberley J
- Wishahi J
- Wislicki W
- Witek M
- Wormser G
- Wotton SA
- Wraight K
- Wright S
- Wyllie K
- Xie Y
- Xing Z
- Xu Z
- Yang Z
- Yin H
- Yu J
- Yuan X
- Yushchenko O
- Zangoli M
- Zarebski KA
- Zavertyaev M
- Zhang L
- Zhang Y
- Zhang Y
- Zhelezov A
- Zheng Y
- Zhokhov A
- Zhu X
- Zhukov V
- Zucchelli S
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2016
- Field of study
A study of Bc+→K+K−π+ decays is performed for the first time
using data corresponding to an integrated luminosity of 3.0 fb−1
collected by the LHCb experiment in pp collisions at centre-of-mass energies
of 7 and 8 TeV. Evidence for the decay Bc+→χc0(→K+K−)π+
is reported with a significance of 4.0 standard deviations, resulting in the
measurement of
σ(B+)σ(Bc+)×B(Bc+→χc0π+) to
be (9.8−3.0+3.4(stat)±0.8(syst))×10−6.
Here B denotes a branching fraction while σ(Bc+) and
σ(B+) are the production cross-sections for Bc+ and B+ mesons.
An indication of bˉc weak annihilation is found for the region
m(K−π+)<1.834GeV/c2, with a significance of
2.4 standard deviations.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-022.html,
link to supplemental material inserted in the reference
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
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- Abdinov O
- Aben R
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- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector
- Author
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- De Pedis D
- De Regie JBDV
- de Renstrom PAB
- De Salvo A
- De Sanctis U
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- della Porta GZ
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- Deluca C
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- Demilly A
- Demirkoz B
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- Deviveiros PO
- Dewhurst A
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- Di Ciaccio L
- Di Domenico A
- Di Donato C
- Di Girolamo A
- Di Girolamo B
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- Doglioni C
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- Enari Y
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- Endo M
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- Erdmann J
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- Errede D
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- Errede S
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- Ertel E
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- Escalier M
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- Esch H
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- Escobar C
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- Espinal Curull X
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- Esposito B
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- Etienne F
- Etienne F
- Etienvre AI
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- Etzion E
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- Evans H
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- Fabbri L
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- Facini G
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- Fakhrutdinov RM
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- Falciano S
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- Faltova J
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- Fang Y
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- Fanti M
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- Farbin A
- Farbin A
- Farilla A
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- Farooque T
- Farooque T
- Farrell S
- Farrell S
- Farrington SM
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- Farthouat P
- Farthouat P
- Fassi F
- Fassi F
- Fassnacht P
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- Fassouliotis D
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- Favareto A
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- Fayard L
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- Federic P
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- Fedin OL
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- Fedorko W
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- Fehling-Kaschek M
- Fehling-Kaschek M
- Feigl S
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- Feligioni L
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- Feng C
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- Feng EJ
- Feng EJ
- Feng H
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- Fenyuk AB
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- Fernando W
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- Ferrag S
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- Ferrando BMS
- Ferrando J
- Ferrando J
- Ferrara V
- Ferrara V
- Ferrari A
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- Ferrari P
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- Ferrari R
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- Ferrer A
- Ferrer A
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- Ferrere D
- Ferretti C
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- Fiascaris M
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- Fiedler F
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- Filipcic A
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- Filipuzzi M
- Filipuzzi M
- Filthaut F
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- Fincke-Keeler M
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- Fiolhais MCN
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- Fiorini L
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- Firan A
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- Fisher MJ
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- Fitzgerald EA
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- Fleck I
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- Fleischmann P
- Fleischmann P
- Fleischmann S
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- Fletcher G
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- Floderus A
- Floderus A
- Florez Bustos AC
- Flowerdew MJ
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- Formica A
- Formica A
- Forti A
- Forti A
- Fortin D
- Fortin D
- Fournier D
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- Fox H
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- Francavilla P
- Francavilla P
- Franchini M
- Franchini M
- Franchino S
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- Francis D
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- Franklin M
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- Franz S
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- Fraternali M
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- French ST
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- Gadomski S
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- Gagnon P
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- Galea C
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- Galhardo B
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- Gallas EJ
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- Gallo V
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- Gallop BJ
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- Garelli N
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- Garonne V
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- Garrido MDMC
- Gatti C
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- Gaudio G
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- Gecse Z
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- Gee CNP
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- Geich-Gimbel C
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- Giordani MP
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- Giordano R
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- Goshaw AT
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- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zobernig G
- Zoccoli A
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentre−of−massframeisusedtosuppressthelargemulti−jetbackground.Thecross−sectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
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- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
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- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
- …