251 research outputs found
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis
- Author
- Angelakopoulou Aspasia
- Baranzini Sergio E.
- Barkhof Frederik
- Caillier Stacy J.
- Cree Bruce A. C.
- Galwey Nicholas
- Gass Achim
- George Michaela F.
- Geurts Jeroen J.G.
- Gibson Rachel A.
- Gomez Refujia
- Goodin Douglas S.
- Green Ari J.
- Guerrero Rosa
- Hall Leslie
- Hauser Stephen L.
- Johnson Michael R.
- Kappos Ludwig
- Kragt Jolijn
- Lincoln Robin R.
- Lindberg Raija L.P.
- Matthews Paul M.
- Mousavi Hourieh
- Naegelin Yvonne
- Oksenberg Jorge R.
- Okuda Darin T.
- Pelletier Daniel
- Polman Chris H.
- Prinjha Rab K.
- Qualley Pamela
- Radue Ernst-Wilhelm
- Richardson Jill C.
- Sombekke Madeleine
- Uitdehaag Bernard M.G.
- Vrenken Hugo
- Wang Joanne
- Waubant Emmanuelle
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Multiple sclerosis (MS), a chronic disorder of the central nervous system and common cause of neurological disability in young adults, is characterized by moderate but complex risk heritability. Here we report the results of a genome-wide association study performed in a 1000 prospective case series of well-characterized individuals with MS and group-matched controls using the Sentrix® HumanHap550 BeadChip platform from Illumina. After stringent quality control data filtering, we compared allele frequencies for 551 642 SNPs in 978 cases and 883 controls and assessed genotypic influences on susceptibility, age of onset, disease severity, as well as brain lesion load and normalized brain volume from magnetic resonance imaging exams. A multi-analytical strategy identified 242 susceptibility SNPs exceeding established thresholds of significance, including 65 within the MHC locus in chromosome 6p21.3. Independent replication confirms a role for GPC5, a heparan sulfate proteoglycan, in disease risk. Gene ontology-based analysis shows a functional dichotomy between genes involved in the susceptibility pathway and those affecting the clinical phenotyp
Participant experiences of mindfulness-based childbirth education: a qualitative study
- Author
- A Hallgren
- A Howarth
- A Premberg
- A Snowden
- A Willcox
- AC Huizink
- BG Glaser
- BG Glaser
- BRH van den Bergh
- C Fisher
- C Snowden Ac Martin
- Colleen Fisher
- D Creedy
- D Dannenbring
- D Walsh
- DA McNeil
- E Namey
- ED Hodnett
- HM Fabian
- J Gibbins
- J Lee
- J Svensson
- J Svensson
- Jean Byrne
- JM Green
- JS Savage
- K Antle-May
- L Chapman
- L Chapman
- LG Duncan
- M Friedewald
- M Nichols
- ML Nolan
- MP Johnson
- NM Talge
- P Simkin
- P Slade
- RA Baer
- S Brown
- S Halldorsdottir
- S Renkert
- Sara Bayes
- SB Merriam
- SG Doering
- SM Tighe
- SS Rising
- T Beardshaw
- T Deave
- T Kabakian-Khasholian
- U WaldenstrÖm
- U WaldenstrÖm
- W Christiaens
- YS Lincoln
- Yvonne Hauck
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Background: Childbirth is an important transitional life event, but one in which many women are dissatisfied stemming in part from a sense that labour is something that happens to them rather than with them. Promoting maternal satisfaction with childbirth means equipping women with communication and decision making skills that will enhance their ability to feel involved in their labour. Additionally, traditional antenatal education does not necessarily prepare expectant mothers and their birth support partner adequately for birth. Mindfulness-based interventions appear to hold promise in addressing these issues. Mindfulness-based Child Birth Education (MBCE) was a pilot intervention combining skills-based antenatal education and Mindfulness Based Stress Reduction. Participant experiences of MBCE, both of expectant mothers and their birth support partners are the focus of this article. Methods: A generic qualitative approach was utilised for this study. Pregnant women between 18 and 28 weeks gestation, over 18 years of age, nulliparous with singleton pregnancies and not taking medication for a diagnosed mental illness or taking illicit drugs were eligible to undertake the MBCE program which was run in a metropolitan city in Australia. Focus groups with 12 mothers and seven birth support partners were undertaken approximately four months after the completion of MBCE. Audio recordings of the groups were transcribed verbatim and analysed thematically using the method of constant comparison by all four authors independently and consensus on analysis and interpretation arrived at through team meetings.Results: A sense of both ‘empowerment’ and ‘community’ were the essences of the experiences of MBCE both for mothers and their birth support partner and permeated the themes of ‘awakening my existing potential’ and ‘being in a community of like-minded parents’. Participants suggested that mindfulness techniques learned during MBCE facilitated their sense of control during birth, and the content and pedagogical approach of MBCE enabled them to be involved in decision making during the birth. The pedagogical approach also fostered a sense of community among participants which extended into the postnatal period. Conclusions: MBCE has the potential to empower women to become active participants in the birthing process, thus addressing common concerns regarding lack of control and satisfaction with labour and facilitate peer support into the postnatal period. Further education of health professionals may be needed to ensure that they respond positively to those women and birth support partners who remain active in decision making during birth
Valid and reliable instruments for arm-hand assessment at ICF activity level in persons with hemiplegia: a systematic review
- Author
- A Barghout
- A Cusick
- A Eliasson
- A Harvey
- A Heller
- A Henderson
- A Houwink
- A Karabegovic
- A Reeuwijk
- A Siebers
- A Sterr
- A Sunderland
- A Sunderland
- A Sunderland
- A Thilmann
- A Van de Winckel
- A van Straten
- A Vega-Gonzalez
- A Vega-Gonzalez
- A Yelnik
- AA Timmermans
- AC Eliasson
- AE Van Heest
- AG Fisher
- AI Spooren
- AJ Turton
- AK Welmer
- AM Gordon
- Annick AA Timmermans
- B Brorsson
- B Kopp
- B Steenbergen
- B Steenbergen
- BH Dobkin
- BS Tur
- C Arnould
- C Arnould
- C Brogardh
- C DeMatteo
- C Van Heugten
- CA Tucker
- CA Tucker
- CA Unsworth
- CA Unsworth
- CA Van Bennekom
- CA van Bennekom
- CA van Bennekom
- CD Wolfe
- CK English
- CM Walker
- D Barnes
- D de Groot-Driessen
- D Steenbeek
- DJ Wilson
- DM Breslin
- DS Nichols-Larsen
- DT Wade
- E Blair
- E Pagliano
- E Taub
- E Taub
- E Yoo
- EH Cup
- ER Skidmore
- ET Kruitwagen-van Reenen
- F Jelles
- F Malouin
- FJ Carod-Artal
- FM Nouri
- G Alon
- G Alon
- G Kwakkel
- G Uswatte
- G Uswatte
- GL Almeida
- H Bourke-Taylor
- H van Dijk
- H Woldag
- H Yagura
- Henk AM Seelen
- I Autti-Ramo
- I Sung
- IC Eyssen
- J Desrosiers
- J Desrosiers
- J Fletcher-Smith
- J Hurn
- J Kinghorn
- J Kinghorn
- J Lin
- JA Beebe
- JE Lewin
- JE Sullivan
- JG Broeks
- JG Broeks
- JH Burridge
- JH Carr
- JH van der Lee
- JH van der Lee
- JH van der Lee
- JL Alberts
- JM Blennerhassett
- JR Charles
- JR Davids
- JR de Kroon
- JW Varni
- K Hiraoka
- K Sheikh
- KA Wesdock
- KE Halsaa
- KH Asberg
- KJ Ottenbacher
- KM Sodring
- L Krumlinde-Sundholm
- L Krumlinde-Sundholm
- L Sheppard
- LA van de Ven-Stevens
- M Arner
- M de Niet
- M Duff
- M Holbrook
- M Huber
- M Ietswaart
- M Law
- M Penta
- M Penta
- M Randall
- M Santos
- M Suzuki
- M van Eck
- M Wallen
- MD Crocker
- ME Msall
- ME Stoykov
- MH Bowman
- MJ Watson
- MK Chan
- ML Talbot
- MW Post
- N Byl
- N Dursun
- N Gebruers
- N Lincoln
- N Sezer
- N Smania
- N Smania
- N Yozbatiran
- N Yozbatiran
- NB Lincoln
- P Ertzgaard
- P Staubli
- PA Burtner
- PB Aarts
- PB Aarts
- PM Waters
- PW Duncan
- PW Duncan
- R Blank
- R Boian
- R Nakamura
- RA Keith
- RH Jebsen
- Rob JEM Smeets
- Ryanne JM Lemmens
- S Ashford
- S Barreca
- S Greaves
- S Miyamoto
- S Tyson
- SE McEwen
- SE McEwen
- SJ Spaulding
- SK Shah
- SL Wolf
- SL Wolf
- SM Cope
- SM Haley
- SM Waller
- SR Barreca
- TA Dodds
- TA Thrasher
- TB Wyller
- TF Yang
- TJH Bovend'Eerdt
- TM Wolf
- U Radell
- VW Mark
- Y Kurtais
- Yvonne JM Janssen-Potten
- Publication venue
- BioMed Central
- Publication date
- 01/01/2012
- Field of study
Contains fulltext :
110141.pdf (publisher's version ) (Open Access)BACKGROUND: Loss of arm-hand performance due to a hemiparesis as a result of stroke or cerebral palsy (CP), leads to large problems in daily life of these patients. Assessment of arm-hand performance is important in both clinical practice and research. To gain more insight in e.g. effectiveness of common therapies for different patient populations with similar clinical characteristics, consensus regarding the choice and use of outcome measures is paramount. To guide this choice, an overview of available instruments is necessary. The aim of this systematic review is to identify, evaluate and categorize instruments, reported to be valid and reliable, assessing arm-hand performance at the ICF activity level in patients with stroke or cerebral palsy. METHODS: A systematic literature search was performed to identify articles containing instruments assessing arm-hand skilled performance in patients with stroke or cerebral palsy. Instruments were identified and divided into the categories capacity, perceived performance and actual performance. A second search was performed to obtain information on their content and psychometrics. RESULTS: Regarding capacity, perceived performance and actual performance, 18, 9 and 3 instruments were included respectively. Only 3 of all included instruments were used and tested in both patient populations. The content of the instruments differed widely regarding the ICF levels measured, assessment of the amount of use versus the quality of use, the inclusion of unimanual and/or bimanual tasks and the inclusion of basic and/or extended tasks. CONCLUSIONS: Although many instruments assess capacity and perceived performance, a dearth exists of instruments assessing actual performance. In addition, instruments appropriate for more than one patient population are sparse. For actual performance, new instruments have to be developed, with specific focus on the usability in different patient populations and the assessment of quality of use as well as amount of use. Also, consensus about the choice and use of instruments within and across populations is needed
Alignment of the CMS tracker with LHC and cosmic ray data
- Author
- Abbaneo D.
- Abbiendi G.
- Abbrescia M.
- Abdelalim A. A.
- Abdullin S.
- Abdulsalam A.
- Acosta D.
- Acosta J. G.
- Adair A.
- Adam W.
- Adams M. R.
- Adams T.
- Adiguzel A.
- Adler V.
- Adzic P.
- Afer C. Sch
- Agram J.-L.
- Aguilar-Benitez M.
- Ahmad M.
- Ahmed I.
- Ahuja S.
- Akchurin N.
- Akgun B.
- Akgun U.
- Akin I. V.
- Alagoz E.
- Albajar C.
- Albayrak E. A.
- Albergo S.
- Albert E.
- Albrow M.
- Alcaraz Maestre J.
- Aldaya Martin M.
- Alderweireldt S.
- Aldá jr. W. L.
- Alexander J.
- Aliev T.
- Alimena J.
- Alverson G.
- Alves G. A.
- Amapane N.
- Amsler C.
- Anagnostou G.
- Anastassov A.
- Anderson I.
- Anderson J.
- Andrea J.
- Andreev V.
- Andreev V.
- Andreev Yu.
- Andrews W.
- Androsov K.
- Antonelli L.
- Antunovic Z.
- Apanasevich L.
- Apollinari G.
- Appelt E.
- Apresyan A.
- Apyan A.
- Arcidiacono R.
- Arenton M. W.
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- Argiro S.
- Arndt K.
- Arneodo M.
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- Asavapibhop B.
- Asawatangtrakuldee C.
- Asghar M. I.
- Asin I.
- Askew A.
- Aslanoglou X.
- Assran Y.
- Ata Metin
- Attikis A.
- Auffray E.
- Autermann Christian Tobias
- Auzinger G.
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
© CERN 2014 for the benefit of the CMS collaboration, published under the terms of the Creative Commons Attribution 3.0 License by IOP Publishing Ltd and Sissa Medialab srl. Any further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation and DOI.The central component of the CMS detector is the largest silicon tracker ever built. The precise alignment of this complex device is a formidable challenge, and only achievable with a significant extension of the technologies routinely used for tracking detectors in the past. This article describes the full-scale alignment procedure as it is used during LHC operations. Among the specific features of the method are the simultaneous determination of up to 200 000 alignment parameters with tracks, the measurement of individual sensor curvature parameters, the control of systematic misalignment effects, and the implementation of the whole procedure in a multi-processor environment for high execution speed. Overall, the achieved statistical accuracy on the module alignment is found to be significantly better than 10μm
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1
- Author
- Abecasis Gonçalo R.
- Absher Devin
- Adrienne Cupples L.
- Aherrahrou Zouhair
- Allayee Hooman
- Allione Alessandra
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Angelica Merlini Pier
- Ardissino Diego
- Ardlie Kristin
- Assimes Themistocles L.
- Aulchenko Yurii S.
- Baas Annette F.
- Badger Stephen A.
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Bandinelli Stefania
- Barbalic Maja
- Barnes Timothy A.
- Barroso Inês
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Benediktsson Rafn
- Bengtsson Boström Kristina
- Bennett Amanda J.
- Berger Klaus
- Berglund Göran
- Bergman Richard N.
- Bingham Sheila A.
- Bis Joshua C.
- Blagieva Roza
- Blair Ross D.
- Blankenberg Stefan
- Blankensteijn Jan D.
- Bochud Murielle
- Boehm Bernhard O.
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Bots Michiel L.
- Bown Matthew J.
- Bradley Declan T.
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris
- Bumpstead Suzannah
- Burnand Kevin
- Burton Paul R.
- Burtt Noël P.
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Chambers John C.
- Charpentier Guillaume
- Chen Li
- Child Anne H.
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Clough Rachel E.
- Cockerill Gillian
- Codd Veryan
- Coin Lachlan
- Connell John M.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Crawford Gabriel J.
- Daly Mark J.
- Davies Robert W.
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- Matthijs Boekholdt S.
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- McCarroll Steve A.
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- Rathmann Wolfgang
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- Schrezenmeir Jürgen
- Schunkert Heribert
- Schwartz Stephen M.
- Schäfer Arne
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- Scott Laura J.
- Scuteri Angelo
- Seedorf Udo
- Segrè Ayellet V.
- Shields Beverley M.
- Shrader Peter
- Sigurdsson Gunnar
- Sijbrands Eric
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Smith Alberto
- Smith Andrew J.
- Smith Tamara B.
- Snieder Harold
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- Sohrabi Soroush
- Song Kijoung
- Soranzo Nicole
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- Spector Tim D.
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- Stefansson Kari
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- Steinthorsdottir Valgerdur
- Stewart Alexandre F. R.
- Stirrups Kathy
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- Strassburger Klaus
- Stringham Heather M.
- Subirana Isaac
- Sun Qi
- Susan Burnett Mary
- Swift Amy J.
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- Syvänen Ann-Christine
- Tanaka Toshiko
- Teijink Joep A. W.
- Tennstedt Stephanie
- Teumer Alexander
- Thompson John R.
- Thompson Matthew M.
- Thomson Ian A.
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Tobin Martin D.
- Tognoni Giovanni
- Tomaszewski Maciej
- Topless Ruth
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tybjærg-Hansen Anne
- Uda Manuela
- Uiterwaal Cuno S.
- Uitterlinden Andre
- Uitterlinden Andre G.
- Valle Timo T.
- van Bockxmeer Frank M.
- van Dam Rob M.
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Rij Andre
- van Rij Andre M.
- van Vliet-Ostaptchouk Jana V.
- Vasudevan Thodur M.
- Vicky Phillips L.
- Vineis Paolo
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Waeber Gerard
- Wain Louise V.
- Walker Mark
- Wallace Chris
- Waltham Matthew
- Wareham Nicholas J.
- Watanabe Richard M.
- Waterworth Dawn M.
- Watkins Hugh
- Webster John
- Weedon Michael N.
- Welch Ryan P.
- Wells George A.
- Wichmann H-Erich
- Wijmenga Cisca
- Wild John B.
- Wild Philipp S.
- Willenborg Christina
- Willer Cristen J.
- William Rayner N.
- Williams Frances M.
- Wilson Tang W. H.
- Wilson James F.
- Witteman Jaqueline C. M.
- Wouter Jukema J.
- Wright Benjamin J.
- Wu Guanming
- Ye Shu
- Yu Grace
- Yuan Xin
- Zeggini Eleftheria
- Zelenika Diana
- Zeller Tanja
- Zhai Guangju
- Zhang Feng
- Ziegler Andreas
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10-5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1 × 10-5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 × 10-10, odds ratio 1.15 [1.10-1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04-1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression
Search for stop and higgsino production using diphoton Higgs boson decays
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Alimena Juliette
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Androsov Konstantin
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Asin Ivan
- Askew Andrew
- Aslanoglou Xenofon
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M
- Babb John
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahtiyar Hüseyin
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Monika
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Barbone Lucia
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barlas Esra
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Bartalini Paolo
- Barth Christian
- Bartosik Nazar
- Basegmez Suzan
- Battilana Carlo
- Bauer Gerry
- Bauerdick Lothar AT
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
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- Beaupere Nicolas
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- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W
- Bellan Riccardo
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
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- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benitez Jose F
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
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- Bergholz Matthias
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- Bethani Agni
- Betts Russell Richard
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
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- Cerci Salim
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- Cerrada Marcos
- Chabert Eric Christian
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Kwok Ming
- Chan Matthew
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chanon Nicolas
- Chao Yuan
- Chaparro Sierra Luisa Fernanda
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan S.
- Chatterjee Avishek
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chauhan Sushil
- Checchia Paolo
- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
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- Chen Mingshui
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- Cherepanov Vladimir
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- Chinellato Jose
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Choi Minkyoo
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- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C
- Choudhury Somnath
- Christiansen Tim
- Christopher Grant
- Chuang Shan-Huei
- Chwalek Thorsten
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Ciocci Maria Agnese
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R
- Clare Robert
- Clarida Warren
- Clement Emyr
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- CMS Collaboration
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- Cockerill David JA
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
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- Colino Nicanor
- Collard Caroline
- Colling David
- Contardo Didier
- Conte Eric
- Contreras-Campana Christian
- Contreras-Campana Emmanuel
- Conway John
- Conway Rylan
- Cooper Seth
- Cornelis Tom
- Correa Martins Junior Marcos
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
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- Costanza Francesco
- Couderc Fabrice
- Coughlan John A
- Cousins Robert
- Covarelli Roberto
- Cowden Christopher
- Cox Bradley
- Cox Peter Timothy
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- Cussans David
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- Cutajar Michael
- Cutts David
- Cwiok Mikolaj
- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
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- D'Hondt Jorgen
- Da Costa Eliza Melo
- Da Silveira Gustavo Gil
- Dabrowski Anne
- Daci Nadir
- Dahmes Bryan
- Dahms Torsten
- Dalchenko Mykhailo
- Dallavalle Gaetano-Marco
- Damgov Jordan
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- Das Souvik
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- Daubie Evelyne
- Dauncey Paul
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- De Almeida Dias Flavia
- de Barbaro Pawel
- De Benedetti Abraham
- De Boer Wim
- De Cosa Annapaola
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F
- De Visscher Simon
- De Wolf Eddi A
- Degano Alessandro
- Deisher Amanda
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delannoy Andrés G
- Delgado Peris Antonio
- Dell'Orso Roberto
- Della Negra Michel
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- Hatakeyama Kenichi
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- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xie Si
- Xie Wei
- Xu Lingshan
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Yücel Mete
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zeise Manuel
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zheng Yu
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zielinski Marek
- Zito Giuseppe
- Zou Wei
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- American Physical Society
- Publication date
- 01/01/2013
- Field of study
Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass
Severe early onset preeclampsia: short and long term clinical, psychosocial and biochemical aspects
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Alimena Juliette
- Almeida Nuno
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Androsov Konstantin
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Asin Ivan
- Askew Andrew
- Aslanoglou Xenofon
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M
- Babb John
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahtiyar Hüseyin
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Monika
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barlas Esra
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Bartalini Paolo
- Barth Christian
- Bartosik Nazar
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Bauer Gerry
- Bauerdick Lothar AT
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Beernaert Kelly
- Behr Joerg
- Behrenhoff Wolf
- Behrens Ulf
- Beirão Da Cruz E Silva Cristóvão
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W
- Bellan Riccardo
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benitez Jose F
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Bergholz Matthias
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- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialkowska Helena
- Bian Jian-Guo
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- Bornheim Adolf
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- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Boutle Sarah
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G
- Breedon Richard
- Breto Guillermo
- Breuker Horst
- Brew Christopher
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brochet Sébastien
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Brown Robert M
- Brownson Eric
- Brun Hugues
- Bruno Giacomo
- Buchmann Marco-Andrea
- Buchmuller Oliver
- Bucinskaite Inga
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- Bunn Julian
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- Burgmeier Armin
- Burkett Kevin
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- Busza Wit
- Butler Joel Nathan
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- Butt Jamila
- Butz Erik
- Bylsma Ben
- Bäni Lukas
- Böser Christian
- Cabrillo Iban Jose
- Caebergs Thierry
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- Chabert Eric Christian
- Chadwick Matthew
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Kwok Ming
- Chan Matthew
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chanon Nicolas
- Chao Yuan
- Chaparro Sierra Luisa Fernanda
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan S.
- Chatterjee Avishek
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chauhan Sushil
- Checchia Paolo
- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
- Chen Kai-Feng
- Chen Kuan-Hsin
- Chen Mingshui
- Chen Yi
- Cheng Tongguang
- Cherepanov Vladimir
- Chertok Maxwell
- Chetluru Vasundhara
- Cheung Harry
- Chhibra Simranjit Singh
- Chierici Roberto
- Chinellato Jose
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Choi Minkyoo
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- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C
- Choudhury Somnath
- Christiansen Tim
- Christopher Grant
- Chuang Shan-Huei
- Chwalek Thorsten
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- Cline David
- CMS Collaboration
- Coarasa Perez Jose Antonio
- Cockerill David JA
- Codispoti Giuseppe
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- Cole Joanne
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- de Barbaro Pawel
- De Benedetti Abraham
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- De Gruttola Michele
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- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F
- De Visscher Simon
- De Wolf Eddi A
- Deisher Amanda
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delannoy Andrés G
- Delgado Peris Antonio
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
- Demina Regina
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- Demortier Luc
- Denegri Daniel
- Deniz Muhammed
- Depasse Pierre
- Dermenev Alexander
- Descroix Alexis
- Dhingra Nitish
- Di Giovanni Gian Piero
- Di Guida Salvatore
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- Di Matteo Leonardo
- Diamond Brendan
- Diemoz Marcella
- Dierlamm Alexander
- Dietz Charles
- Dietz-Laursonn Erik
- Diez Pardos Carmen
- Dildick Sven
- Dilsiz Kamuran
- Dimitrov Anton
- Dinardo Mauro Emanuele
- Dissertori Günther
- Dittmann Jay
- Dittmar Michael
- Djordjevic Milos
- Dobrzynski Ludwik
- Dobson Marc
- Dobur Didar
- Doesburg Robert
- Dolen James
- Dominguez Aaron
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- Domínguez Vázquez Daniel
- Donegà Mauro
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- Doroba Krzysztof
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- Dozen Candan
- Dragicevic Marko
- Dragoiu Cosmin
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- Drozdetskiy Alexey
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- Dubinin Mikhail
- Duchardt Deborah
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- Dudko Lev
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- Duric Senka
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- Wu Weimin
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
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- Würthwein Frank
- Xiao Hong
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- Xu Ming
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- Yelton John
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- Yohay Rachel
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- Yun Jae Chul
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- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zeise Manuel
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zheng Yu
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zielinski Marek
- Zito Giuseppe
- Zotto Pierluigi
- Zou Wei
- Zsigmond Anna Julia
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance. This thesis opens with a review of the literature on identifiable risk factors of preeclampsia.
- Publication date
- 01/01/2011
- Field of study
Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension
and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions
available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression
to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity
in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia
by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids
to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh
the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance.
This thesis opens with a review of the literature on identifiable risk factors of preeclampsia
A genome-wide association search for type 2 diabetes genes in African Americans.
- Author
- Abecasis Goncalo R
- Adeyemo Adebowale
- Altshuler David
- Amin Najaf
- An Ping
- An S Sandy
- Ardlie Kristin
- Ariyurek Yavuz
- Aulchenko Yurii S
- Balkau Beverley
- Barroso Inês
- Barter Philip
- Beilby John P
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J
- Bergman Richard N
- Bergmann Sven
- Blagieva Roza
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Bonnefond Amélie
- Bonnycastle Lori L
- Boomsma Dorret I
- Borch-Johnsen Knut
- Borecki Ingrid B
- Bornstein Stefan R
- Bostrom Meredith A
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowden Donald W
- Bravenboer Bert
- Brunner Eric
- Buchanan Thomas A
- Bumpstead Suzannah
- Bumpstead Suzannah J
- Burtt Noël P
- Böttcher Yvonne
- Campbell Harry
- Cao Antonio
- Cauchi Stephane
- Cavalcanti-Proença Christine
- Charpentier Guillaume
- Chen Yii-Der Ida
- Chines Peter
- Chines Peter S
- Clarke Robert
- Coin Lachlan JM
- Collins Francis S
- Cooke Jessica N
- Cooper Cyrus
- Cooper Matthew N
- Cornelis Marilyn
- Couper David J
- Crawford Gabe
- Crisponi Laura
- Daly Mark J
- Day Ian NM
- de Geus Eco JC
- Dedoussis George V
- Dehghan Abbas
- Deloukas Panos
- Delplanque Jerome
- DIAGRAM Consortium
- Dina Christian
- Divers Jasmin
- Doney Alex
- Doney Alex SF
- Dupuis Josée
- Ebrahim Shah
- Egan Josephine M
- Elliott Amanda
- Elliott Amanda L
- Elliott Katherine S
- Elliott Paul
- Erdos Michael R
- Fedson Annette C
- Ferrara Assiamira
- Ferreira Teresa
- Ferrucci Luigi
- Fischer-Rosinsky Antje
- Florez Jose C
- Forouhi Nita G
- Fox Caroline S
- Franklin Christopher S
- Franks Paul W
- Frants Rune
- Franzosi Maria Grazia
- Frayling Timothy M
- Freedman Barry I
- Froguel Philippe
- Galan Pilar
- Ganser Martha
- Gieger Christian
- Glazer Nicole L
- Gloyn Anna L
- Goel Anuj
- Goodarzi Mark O
- Graessler Jürgen
- Grallert Harald
- Grarup Niels
- Green Todd
- Griffin Simon
- Groop Leif
- Groves Christopher J
- Grundy Scott
- Guiducci Candace
- Gwilliam Rhian
- Gyllensten Ulf
- Hadjadj Samy
- Hallmans Göran
- Hammond Naomi
- Hamsten Anders
- Han Xijing
- Hansen Torben
- Hartikainen Anna-Liisa
- Hassanali Neelam
- Hattersley Andrew T
- Hayward Caroline
- Heath Simon C
- Henneman Peter
- Hercberg Serge
- Herder Christian
- Hester Jessica M
- Hicks Andrew A
- Hicks Pamela J
- Hide Winston A
- Hillman David R
- Hingorani Aroon D
- Hitman Graham A
- Hofman Albert
- Hofmann Oliver M
- Hottenga Jouke Jan
- Hu Frank B
- Hui Jennie
- Hung Joe
- Hunter David J
- Huth Cornelia
- Hveem Kristian
- Illig Thomas
- Ingelsson Erik
- Isomaa Bo
- Jackson Anne U
- Jarvelin Marjo-Riitta
- Johnson Paul RV
- Johnson Toby
- Jula Antti
- Jørgensen Torben
- Kaakinen Marika
- Kanoni Stavroula
- Kao Wen HL
- Kao WH Linda
- Kaprio Jaakko
- Karpe Fredrik
- Kesaniemi Y Antero
- Kivimaki Mika
- Klopp Norman
- Knight Beatrice
- Kong Augustine
- Koskinen Seppo
- Kovacs Peter
- Kraft Peter
- Kumari Meena
- Kuusisto Johanna
- Kyvik Kirsten Ohm
- Laakso Markku
- Lajunen Taina
- Langefeld Carl D
- Langenberg Claudia
- Lathrop G Mark
- Lauritzen Torsten
- Lawlor Debbie A
- Le Bacquer Olivier
- Lecoeur Cécile
- Lewis Joshua P
- Li Man
- Li Yun
- Lieverse Aloysius
- Lind Lars
- Lindgren Cecilia M
- Loos Ruth JF
- Lu Lingyi
- Luan Jian'an
- Lyssenko Valeriya
- MAGIC Investigators
- Magnusson Patrik KE
- Mahley Robert
- Mangino Massimo
- Manning Alisa K
- Marmot Michael
- Marre Michel
- Martínez-Larrad María Teresa
- McAteer Jarred B
- McCarroll Steve A
- McCarroll Steven A
- McCarthy Mark I
- McCulloch Laura J
- McDonough Caitrin W
- McPherson Ruth
- Meigs James B
- Meisinger Christa
- Meitinger Thomas
- Melzer David
- Meneton Pierre
- Meyre David
- Midthjell Kristian
- Mitchell Braxton D
- Mohlke Karen L
- Mooser Vincent
- Morken Mario A
- Morris Andrew D
- Morris Andrew P
- Mukherjee Sutapa
- Mägi Reedik
- Naitza Silvia
- Narisu Narisu
- Nathan David M
- Navarro Pau
- Neville Matthew J
- Ng Maggie CY
- Nilsson Peter
- O'Connell Jeffrey
- Oostra Ben A
- Orrù Marco
- Owen Katharine R
- Pakyz Ruth
- Palmer Colin NA
- Palmer Lyle J
- Palmer Nicholette D
- Pankow James S
- Paolisso Giuseppe
- Pattaro Cristian
- Pattou François
- Payne Felicity
- Pearson Daniel
- Peden John F
- Pedersen Nancy L
- Pedersen Oluf
- Peltonen Leena
- Penninx Brenda WJH
- Perola Markus
- Perry John RB
- Petersen Ann-Kristin
- Pfeiffer Andreas FH
- Pichler Irene
- Platou Carl
- Polasek Ozren
- Posthuma Danielle
- Potter Simon C
- Pouta Anneli
- Pramstaller Peter P
- Pramstaller Peter Paul
- Proença Christine
- Prokopenko Inga
- Province Michael A
- Psaty Bruce M
- Qi Lu
- Randall Joshua
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Rayner N William
- Rayner Nigel W
- Rice Kenneth
- Ripatti Samuli
- Rivadeneira Fernando
- Robertson Neil R
- Roccasecca Rosa Maria
- Rocheleau Ghislain
- Roden Michael
- Roh Bong H
- Rolandsson Olov
- Rotimi Charles N
- Rotter Jerome I
- Rudan Igor
- Rudock Megan E
- Ruokonen Aimo
- Rybin Denis
- Sale Michele M
- Salomaa Veikko
- Sampson Michael J
- Sandbaek Annelli
- Sandhu Manjinder
- Sanna Serena
- Saxena Richa
- Sayer Avan Aihie
- Scheet Paul
- Schlessinger David
- Schwarz Peter
- Scott Laura J
- Scuteri Angelo
- Seedorf Udo
- Segrè Ayellet V
- Serrano-Ríos Manuel
- Sethupathy Praveen
- Sharp Stephen J
- Shields Beverley
- Shields Beverley M
- Shrader Peter
- Shriner Daniel
- Shuldiner Alan R
- Sigurdsson Gunnar
- Sijbrands Eric
- Sijbrands Eric JG
- Silander Kaisa
- Silveira Angela
- Simpson Laila
- Singleton Andrew
- Siscovick David S
- Sladek Rob
- Sladek Robert
- Smith George Davey
- Smith Nicholas L
- Song Kijoung
- Soranzo Nicole
- Sovio Ulla
- Sparsø Thomas
- Spector Timothy D
- Spranger Joachim
- Stefansson Kari
- Stein Lincoln D
- Steinthorsdottir Valgerdur
- Strassburger Klaus
- Stringham Heather M
- Stumvoll Michael
- Sun Qi
- Swift Amy
- Swift Amy J
- Syddall Holly
- Syvänen Ann-Christine
- Talbert Matthew E
- Tanaka Toshiko
- Thorand Barbara
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Timpson Nicholas J
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tönjes Anke
- Uda Manuela
- Uitterlinden Andre
- Uitterlinden André G
- Valle Timo T
- van Dam Rob M
- van Dijk Ko Willems
- van Duijn Cornelia M
- van Haeften Timon W
- van Herpt Thijs
- van Hoek Mandy
- van Vliet-Ostaptchouk Jana V
- Varma Dhiraj
- Visvikis-Siest Sophie
- Vitart Veronique
- Vogelzangs Nicole
- Voight Benjamin F
- Vollenweider Peter
- Waeber Gérard
- Wagner Peter J
- Walker Mark
- Walley Andrew
- Walters G Bragi
- Ward Kim L
- Wareham Nicholas J
- Watanabe Richard M
- Waterworth Dawn M
- Watkins Hugh
- Weedon Michael N
- Welch Ryan P
- Wheeler Eleanor
- Wichmann H-Erich
- Wijmenga Cisca
- Wild Sarah H
- Willemsen Gonneke
- Willer Cristen J
- Williams Gordon H
- Wilson James F
- Wing Maria R
- Witteman Jacqueline
- Witteman Jaqueline CM
- Wright Alan F
- Wu Guanming
- Yarnell John WG
- Zabena Carina
- Zeggini Eleftheria
- Zelenika Diana
- Zethelius Björn
- Zhai Guangju
- Zhao Jing Hua
- Ziegler Julie T
- Zillikens M Carola
- Publication venue
- PLoS One
- Publication date
- 22/11/2011
- Field of study
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A
- Bedognetti Davide
- Bedognetti Davide
- Bedognetti Davide
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- Bell Charles J M
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- Berzofsky Jay A
- Bhardwaj Nina
- Bian Zhen
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- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M
- Bischoff Helge
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- Blazar Bruce R
- Blogowski Wojciech
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- Bokovanov Vladimir
- Bommareddy Praveen K
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- Brockstedt Dirk G
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- Dhupkar Pooja
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- Ding Yueyun
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- Fesenkova Valentyna
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- Gajewski Thomas F
- Gajewski Thomas F
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- Gajewski Thomas F
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- Gameiro Sofia
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- Grossenbacher Steven K
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- Milenova Ioanna
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- Zeng Xue
- Zha Yuanyuan
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- Zhang Jing
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- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
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