529 research outputs found
A medieval multiverse?: Mathematical modelling of the thirteenth century universe of Robert Grosseteste
In his treatise on light, written about 1225, Robert Grosseteste describes a cosmological model in which the universe is created in a big-bang-like explosion and subsequent condensation. He postulates that the fundamental coupling of light and matter gives rises to the material body of the entire cosmos. Expansion is arrested when matter reaches a minimum density and subsequent emission of light from the outer region leads to compression and rarefaction of the inner bodily mass so as to create nine celestial spheres, with an imperfect residual core. In this paper, we reformulate the Latin description in terms of a modern mathematical model, teasing out consequences implicit in the text, but which the author would not have had the tools to explore. The equations which describe the coupling of light and matter are solved numerically, subjected to initial conditions and critical criteria consistent with the text. Formation of a universe with a non-infinite number of perfected spheres is extremely sensitive to the initial conditions, the intensity of the light and the transparency of these spheres. In this ‘medieval multiverse’, only a small range of opacity and initial density profiles leads to a stable universe with nine perfected spheres. As in current cosmological thinking, the existence of Grosseteste’s universe relies on a very special combination of fundamental parameters
Wound healing and hyper-hydration - a counter intuitive model
Winters seminal work in the 1960s relating to providing an optimal level of moisture to aid wound healing (granulation and re-epithelialisation) has been the single most effective advance in wound care over many decades. As such the development of advanced wound dressings that manage the fluidic wound environment have provided significant benefits in terms of healing to both patient and clinician. Although moist wound healing provides the guiding management principle confusion may arise between what is deemed to be an adequate level of tissue hydration and the risk of developing maceration. In addition, the counter-intuitive model ‘hyper-hydration’ of tissue appears to frustrate the moist wound healing approach and advocate a course of intervention whereby tissue is hydrated beyond what is a normally acceptable therapeutic level. This paper discusses tissue hydration, the cause and effect of maceration and distinguishes these from hyper-hydration of tissue. The rationale is to provide the clinician with a knowledge base that allows optimisation of treatment and outcomes and explains the reasoning behind wound healing using hyper-hydration
A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase
Simocyclinones are bifunctional antibiotics that inhibit bacterial DNA gyrase by preventing DNA binding to the enzyme. We report the crystal structure of the complex formed between the N-terminal domain of the Escherichia coli gyrase A subunit and simocyclinone D8, revealing two binding pockets that separately accommodate the aminocoumarin and polyketide moieties of the antibiotic. These are close to, but distinct from, the quinolone-binding site, consistent with our observations that several mutations in this region confer resistance to both agents. Biochemical studies show that the individual moieties of simocyclinone D8 are comparatively weak inhibitors of gyrase relative to the parent compound, but their combination generates a more potent inhibitor. Our results should facilitate the design of drug molecules that target these unexploited binding pockets
Dark Matter Direct Detection Signals inferred from a Cosmological N-body Simulation with Baryons
We extract at redshift z=0 a Milky Way sized object including gas, stars and
dark matter (DM) from a recent, high-resolution cosmological N-body simulation
with baryons. Its resolution is sufficient to witness the formation of a
rotating disk and bulge at the center of the halo potential. The phase-space
structure of the central galactic halo reveals the presence of a dark disk
component, that is co-rotating with the stellar disk. At the Earth's location,
it contributes to around 25% of the total DM local density, whose value is
rho_DM ~ 0.37 GeV/cm^3. The velocity distributions also show strong deviations
from pure Gaussian and Maxwellian distributions, with a sharper drop of the
high velocity tail.
We give a detailed study of the impact of these features on the predictions
for DM signals in direct detection experiments. In particular, the question of
whether the modulation signal observed by DAMA is or is not excluded by limits
set by other experiments (CDMS, XENON and CRESST...) is re-analyzed and
compared to the case of a standard Maxwellian halo, in both the elastic and the
inelastic scattering scenarios. We find that the compatibility between DAMA and
the other experiments is improved. In the elastic scenario, the DAMA modulation
signal is slightly enhanced in the so-called channeling region, as a result of
several effects. For the inelastic scenario, the improvement of the fit is
mainly attributable to the departure from a Maxwellian distribution at high
velocity.Comment: 39 page
Optical properties of structurally-relaxed Si/SiO superlattices: the role of bonding at interfaces
We have constructed microscopic, structurally-relaxed atomistic models of
Si/SiO superlattices. The structural distortion and oxidation-state
characteristics of the interface Si atoms are examined in detail. The role
played by the interface Si suboxides in raising the band gap and producing
dispersionless energy bands is established. The suboxide atoms are shown to
generate an abrupt interface layer about 1.60 \AA thick. Bandstructure and
optical-absorption calculations at the Fermi Golden rule level are used to
demonstrate that increasing confinement leads to (a) direct bandgaps (b) a blue
shift in the spectrum, and (c) an enhancement of the absorption intensity in
the threshold-energy region. Some aspects of this behaviour appear not only in
the symmetry direction associated with the superlattice axis, but also in the
orthogonal plane directions. We conclude that, in contrast to Si/Ge, Si/SiO
superlattices show clear optical enhancement and a shift of the optical
spectrum into the region useful for many opto-electronic applications.Comment: 11 pages, 10 figures (submitted to Phys. Rev. B
Low Complexity Regularization of Linear Inverse Problems
Inverse problems and regularization theory is a central theme in contemporary
signal processing, where the goal is to reconstruct an unknown signal from
partial indirect, and possibly noisy, measurements of it. A now standard method
for recovering the unknown signal is to solve a convex optimization problem
that enforces some prior knowledge about its structure. This has proved
efficient in many problems routinely encountered in imaging sciences,
statistics and machine learning. This chapter delivers a review of recent
advances in the field where the regularization prior promotes solutions
conforming to some notion of simplicity/low-complexity. These priors encompass
as popular examples sparsity and group sparsity (to capture the compressibility
of natural signals and images), total variation and analysis sparsity (to
promote piecewise regularity), and low-rank (as natural extension of sparsity
to matrix-valued data). Our aim is to provide a unified treatment of all these
regularizations under a single umbrella, namely the theory of partial
smoothness. This framework is very general and accommodates all low-complexity
regularizers just mentioned, as well as many others. Partial smoothness turns
out to be the canonical way to encode low-dimensional models that can be linear
spaces or more general smooth manifolds. This review is intended to serve as a
one stop shop toward the understanding of the theoretical properties of the
so-regularized solutions. It covers a large spectrum including: (i) recovery
guarantees and stability to noise, both in terms of -stability and
model (manifold) identification; (ii) sensitivity analysis to perturbations of
the parameters involved (in particular the observations), with applications to
unbiased risk estimation ; (iii) convergence properties of the forward-backward
proximal splitting scheme, that is particularly well suited to solve the
corresponding large-scale regularized optimization problem
Does accelerating universe indicates Brans-Dicke theory
The evolution of universe in Brans-Dicke (BD) theory is discussed in this
paper.
Considering a parameterized scenario for BD scalar field
which plays the role of gravitational "constant" ,
we apply the Markov Chain Monte Carlo method to investigate a global
constraints on BD theory with a self-interacting potential according to the
current observational data: Union2 dataset of type supernovae Ia (SNIa),
high-redshift Gamma-Ray Bursts (GRBs) data, observational Hubble data (OHD),
the cluster X-ray gas mass fraction, the baryon acoustic oscillation (BAO), and
the cosmic microwave background (CMB) data. It is shown that an expanded
universe from deceleration to acceleration is given in this theory, and the
constraint results of dimensionless matter density and parameter
are, and
which is consistent with the
result of current experiment exploration, . In
addition, we use the geometrical diagnostic method, jerk parameter , to
distinguish the BD theory and cosmological constant model in Einstein's theory
of general relativity.Comment: 16 pages, 3 figure
Interprofessional Education: An evaluation of a joint learning workshop for podiatry and pharmacy students
"Interprofessional Education occurs when two or more professionals learn with, from and about each other to improve collaboration and the quality of care" (CAIPE 2002). Interprofessional education forms part of the Standards for the Initial Education and Training of Pharmacists. Working with and understanding the role of another profession has been shown to positively impact on the quality of care of the patient. Following positive pharmacy student feedback from visits to podiatry clinics an interprofessional learning workshop with case - based scenarios was developed. These were based on patients with high risk medical conditions that would impact on the work of both professions. Data from the feedback forms was evaluated and analysed to determine whether the workshop increased knowledge of the British National Formulary (BNF), the prescribing process and gave an insight in to the role of other healthcare professionals. We discuss how the student’s learning has been enhanced by the contribution of another professional group. The workshop was positively received. Students were observed working together discussing the patients’ conditions and issues relating to their care. This initially revolved around the students’ area of knowledge; however, as the session progressed it became apparent that the students were learning with, from and about each other for the benefit of patient care
Translating SOD1 gene silencing towards the clinic: A highly efficacious, off-target free and biomarker-supported strategy for familial ALS
Twenty per cent of familial amyotrophic lateral sclerosis (fALS) cases are caused by mutations in
the gene encoding human cytosolic Cu/Zn superoxide dismutase (hSOD1). Efficient translation of
the therapeutic potential of interfering RNA (RNAi) for the treatment of SOD1-ALS patients
requires the development of vectors that are free of significant off-target effects and with reliable
biomarkers to discern sufficient target engagement and correct dosing. Using adeno-associated virus
serotype 9 to deliver RNAi against hSOD1 in the SOD1G93A mouse model, we found that intrathecal
injection of the therapeutic vector via the cisterna magna delayed onset of disease, decreased motor
neuron death at end stage by up to 88% and prolonged the median survival of SOD1G93A mice by up
to 42%. To our knowledge this is the first report to demonstrate no significant off-target effects
linked to hSOD1 silencing, providing further confidence in the specificity of this approach. We also
report the measurement of cerebrospinal fluid (CSF) hSOD1 protein levels as a biomarker of
effective dosing and efficacy of hSOD1 knockdown. Together, these data provide further confidence
in the safety of the clinical therapeutic vector. The CSF biomarker will be a useful measure of
biological activity for translation into human clinical trials
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
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