52 research outputs found
Lobomycosis in Offshore Bottlenose Dolphins (Tursiops truncatus), North Carolina
- Author
- Publication venue
- Centers for Disease Control and Prevention
- Publication date
- Field of study
Lacazia loboi, a cutaneous fungus, is found in humans and dolphins from transitional tropical (Florida) and tropical (South America) regions. We report 2 cases of lobomycosis in stranded bottlenose dolphins (Tursiops truncatus) and 1 case of lobomycosis-like disease in 1 free-swimming, pelagic, offshore bottlenose dolphin from North Carolina, where no cases have previously been observed
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
- Brown Andrew A
- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Bryan N
- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
- Cannon Andrea
- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
- Carter Charles J M
- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Angus
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Conti David V
- Cook Audrey
- Cook Margaret
- Cooke Peter
- Cooksey Graeme
- Coombs L
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P A
- Corolis [Unknown]
- Corr John
- Costello C B
- Coull Mrs N
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crew Jeremy
- Crisp John C
- Cross W
- Cruger Dorthe
- Crundwell Malcolm
- Cummings [Unknown]
- Cybulski Cezary
- Dadaev Tokhir
- Dahar Nazeer
- Daniel Francis N
- Darrad J
- Daruwala Pallon
- Das Gautam
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H Jane
- Doble A
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dooldeniya M
- Douglas S Fiona
- Down Liz
- Drake [Unknown]
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W D
- Durkan Garrett
- Durrani Sajid K
- Easton Douglas
- Eaton Alan C
- Eccles Diane
- Eckert Allison
- Eddy B
- Eden C D
- Edwards J
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Elliott P Tony
- Ellis B W
- Ellis R
- Elves Andrew W S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- England Roland C D
- Errington R D
- Evans D Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
- Featherstone Carolyn J
- Feggetter Jeremy
- Ferguson C
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel
- Fitzgerlad Liesel M
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Foster Paul W
- Franks Kevin N
- Freedman Mathew
- Frim Olivera
- Gale Joanna
- Gallegos Christopher
- Gelister James S
- George Anne
- Ghana [Unknown]
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E M
- Govindasami Koveela
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R L
- Gronberg Henrik
- Gujral Sandy
- Gupta Nishi
- Gurun Riza Murat
- Gustafsson Sven
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Haldar Neil
- Halder N
- Haley James
- Hamdy F C
- Hamdy Freddie
- Hamilton C
- Hammonds John
- Hampson S J
- Hanbury Damien C
- Hardman P D John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harris D
- Harris Sarah
- Harrison G S M
- Harriss D R
- Harvey-Hills N
- Hawkyard Simon
- Hazel Steve
- Hazelett Dennis J
- Heath Catherine M
- Heathcote Peter
- Hehir Michael
- Hellawell Giles O
- Henderson Brian E
- Hendry David
- Henley Mike
- Henrique Rui
- Henry Ann
- Herbert Pippa
- Herkommer Kathleen
- Hetherington John
- Hickish Tamas
- Hicks James A
- Hilman Serena
- Hindley Richard
- Hindmarsh John R
- Hines John
- Hingorani M
- Ho Edwin T S
- Hodgson Shirley
- Hoffman U
- Holden David
- Holding Peter
- Hollingdale A
- Hollins Graham W
- Holmes Simon A V
- Holt Sarah
- Hopper John L
- Horan Gail
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Iversen Peter
- Izatt Louise
- Izegbu Victor
- Jameel Basharat
- James Michael J
- James N
- James R Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Johansson Jan-Erik
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joseph J
- Joss Shelagh
- Jugurnauth-Little Sara
- Kachakova Darina
- Kaisary Amir
- Kaliski Alexandre L
- Kaneva Radka
- Kapur G
- Karim O
- Karlsson Ami
- Karp Stephen J
- Kedda Mary-Anne
- Keeley F X
- Kelkar Anand R
- Kelleher J P
- Kelly John
- Kenwrick Sue
- Kerr Kris
- Key Tim J
- Khan F
- Khaw Kay-Tee
- Khoo Vincent
- Kibel Adam S
- Kierzek Andrzej
- Kimber Rachel M
- Kinder R
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Klarskov Peter
- Kluzniak Wojciech
- Kockelbergh Roger
- Koenig Philip C W C
- Kooiman Gordon G
- Koreich O
- Kote-Jarai Zsofia
- Koupparis Anthony
- Kourah Mohamed
- Kraus Sigurd
- Kujala Paula
- Kujawa Magda L
- Kulkarni Ravi
- Kumar M
- Kumar Rajeev
- Kunkler Ian H
- Kynaston H
- Kynaston Howard
- Lachlan Katherine L
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lane Athene
- Langley Stephen E M
- Laniado Marc
- Larner T R
- Lau Maurice W
- Lawrence W T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J O
- Lee L
- Lemburger R John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel
- Lester Jason
- Leung Hing
- Lewis D Christopher
- Lewis J
- Li Qiuyan
- Lim Hui-Yi
- Lin Hui-Yi
- Liston Thomas
- Livni Naomi
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lophatonanon Artitaya
- Lubinski Jan
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C J
- Lydon Anna
- Lynch Michael
- Lynn Naing N K
- Lyons Norma
- MacDermott James P A
- Macdonagh Ruaraidh P
- Macdonald [Unknown]
- Madaan Sanjeev
- Madhava Kudingila R
- Maeaettaenen Liisa
- Maguire Joseph
- Maher E R
- Mahmood Rana
- Maia Sofia
- Maier Christiane
- Mair Graeme H M
- Malone Greg
- Malone Peter R
- Mangar Stephen A
- Mantle Mark
- Mark I
- Marsden Gemma
- Mason M D
- Mason Malcolm
- Mason Robert
- Matanhelia [Unknown]
- Matenhelia Shyam
- Matthews Philip N
- McAleese J
- McBride Donna
- Mcdonnell Shannon K
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath [Unknown]
- McIlhenny Craig
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McLarty Esther
- McMenemin Rhona
- McNeill Alan
- McNicholas T A
- Meddings Robert N
- Mee A David
- Melcher Lucinda
- Memon [Unknown]
- Menzes Pravin
- Michael Agnieszka
- Miller Marek
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E F
- Mokete [Unknown]
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Moody Martin P
- Morgan Angela
- Morley Roland
- Morris Sean B
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Murtola Teemu
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki [Unknown]
- Neal David E
- Neilson Donald
- Nethersell A
- Newby Jacqueline C
- Newman Hugh
- Newton R
- Nielsen Sune F
- Nordestgaard Børge G
- O'Boyle P J
- O'Brien J
- O'Brien Tim S
- O'Donnell H
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J S
- O'Sullivan Joe
- O'Sullivan Patricia
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Omara Tracy
- Ong Eng K
- Osborn David
- Ostler Peter
- Owen J
- Palfrey Edward
- Panades Miguel
- Panakis Niki
- Pancharatnam M
- Pandha Hardev
- Pantelides Michalakis L
- Panwar U
- Parikh Omi
- Park Hyun
- Park Jong Y
- Parker Chris
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Pashayan Nora
- Patel Anup
- Paterson Joan
- Pathack S
- Pati Jhumur
- Patterson Helen
- Pattu [Unknown]
- Paul A
- Paul Alan
- Paulo Paula
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha Amjad M
- Perry Matthew
- Persad Raj
- Peters John
- Pharoah Paul
- Philp N H
- Philp T
- Pickering Lisa M
- Pigott Katharine
- Pinto Pedro
- Plail R
- Plowman P Nicholas
- Pocock Richard D
- Pope A J
- Popert Rick
- Popov Elenko
- Porter Tim
- Potter John M
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Powles Thomas B
- Prasad Krishna
- Prasad Seshadri Sri
- Prejbisz J W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Raby Nigel
- Radlein Selina
- Ragavan Narasimhan
- Raju Palaniappa G S
- Ramachandra Prakash B
- Raman R
- Rane Abhay
- Rankin Julia
- Rao Y
- Ratan Hari L
- Ravi Ramachandran
- Ravishankar K
- Read [Unknown]
- Reddy Paul J
- Rimington Peter R
- Rinckleb Antje
- Rincon Maria
- Riska Shaun
- Ritchie Peter A
- Roberts J Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rochester Mark A
- Roder Andreas
- Rogers P B
- Rosario Derek
- Rosenbaum Tomas P
- Rothwell Neil
- Rowbotham Carl
- Rowe [Unknown]
- Rowley Kathryn
- Ruddy Deborah
- Rundle John
- Russell John M
- Ryan P G
- Sabharwal A
- Saggar Anand K
- Samanci Ali
- Sangar Vijay K
- Santos Joana
- Saunders Edward J
- Saunders Pamela
- Sawyer Emma J
- Saxby M F
- Schaid Daniel J
- Schleutker Johanna
- Schumacher Fredrick
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Selim [Unknown]
- Sellers Thomas
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shackley David C
- Shaffer [Unknown]
- Shah Nihil
- Shakespeare D
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum Poh Lin
- Side Lucy
- Sidek Norma
- Signorello Lisa B
- Sikora Karol
- Simcock R
- Sinclair Andrew M
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
- Spiers Alexander
- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan [Unknown]
- Sriram Rajagopalan
- Staffurth John N
- Stanford Janet L
- Stattin Paer
- Stegmaier Christa
- Stephens Sarah
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M J
- Strachan John R
- Stuart Nicholas S A
- Sugden Elaine
- Summerton Duncan
- Sundar Santhanam
- Sundaram S K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Symons Stephanie J
- Syndikus Isabel
- Taari Kimmo
- Tahir Saad
- Tammela Teuvo L
- Tammela Teuvo L J
- Tanquay J
- Taylor J W
- Taylor John W
- Teixeira Manuel R
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
- Tidball Sarah
- Tillmans Lori
- Tilsley Owen
- Tindall Stuart F
- Tipples K
- Tong [Unknown]
- Toussi Hamid
- Toy Elizabeth W
- Travis Ruth C
- Trembath Richard C
- Tulloch David N
- Turner Kevin J
- Turner Megan
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C J
- Umez-Eronini N
- Urwin Graeme H
- Vale Justin A
- Van As [Unknown]
- Van As Nicholas
- Vasanthan Subramaniam
- Vesey Sean
- Vilarino-Varela Maria
- Violet John
- Virdi Jaspal
- Viñuela Ana
- Vlahova Aleksandrina
- Vogel Walther
- Wade Robert
- Wahlfors Tiina
- Waite Katherine
- Walker E M
- Walker Roger
- Wallace David M A
- Wallinder Hans
- Wang Liang
- Watkin Nicholas A
- Watson M E
- Waxman J H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Wedderburn Andrew
- Weischer Maren
- Wells Paula
- Wemyss-Holden G D
- Weston P M T
- Wheatley Duncan
- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
- Wilde Adam D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary
- Williams John H
- Williams Simon
- Willis Michael
- Wills Michael I
- Wilson J R
- Wilson Richard
- Winkler Mathias H
- Wise Marcus
- Wokozorczyk Dominika
- Wokołorczyk Dominika
- Wood Glenn
- Woodhams Simon
- Woodhouse C
- Woodward Cathryn
- Woolf [Unknown]
- Woolfenden K A
- Worlding Jane
- Wright Mark
- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
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- Tolonen Nina
- Tomaschitz Andreas
- Tomaszewski Maciej
- Toniolo Daniela
- Townsend Raymond R
- Tracy Russell P
- Travers Mary E
- Tregouet David-Alexandre
- Treloar Susan A
- Tremblay Angelo
- Tremoli Elena
- Tripathy Vikal
- Troffa Chiara
- Trompet Stella
- Trummer Olivia
- Tryggvadottir Laufey
- Tryggvason Karl
- Trégouët David-Alexandre
- Tsaprouni Loukia
- Tsoka Sophia
- Tsui Kim
- Tukiainen Taru
- Tuomilehto Jaakko
- Turner Stephen T
- Tylavsky Frances A
- Tyrer Jonathon
- Tzoulaki Ioanna
- Tönjes Anke
- Uda Manuela
- Ueshima Hirotsugu
- Uh Hae-Won
- Uiterwaal Cuno S P M
- Uitterlinden Andre G
- Uitterlinden André G
- Ulivi Sheila
- Ulivi Shelia
- Umans Jason
- Umemura Satoshi
- Urreizti Roser
- Uusitupa Matti
- Vallejo Edgar E
- van Dam Rob M
- Van den Herik Evita G
- van der Harst Pim
- van der Klauw Melanie M
- van der Schoot C Ellen
- van der Schouw Yvonne T
- van Duijn Cornelia
- Van Duijn Cornelia
- van Gils Carla H
- van Gilst Wiek H
- van Heemst Diana
- Van Hul Wim
- van Meurs Joyce B J
- van Meurs Joyve B J
- van Nierop Peter
- van Oort Floor V A
- van Pelt L Joost
- van Schoor Natasja M
- Van Vliet-Ostaptchouk Jana V
- van Wingerden Sophie
- van Wingerden Sophie W
- Van Zuydam Natalie
- Vandenput Liesbeth
- Varga Tibor V
- Vartiainen Erkki
- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
- Veronesi Giovanni
- Verweij Niek
- Verwoert Germaine
- Verwoert Germaine C
- Viigimaa Margus
- Viikari Jorma
- Vinay D G
- Vineis Paolo
- Vink Jacqueline M
- Virtamo Jarmo
- Visscher Peter M
- Visser Jenny A
- Vitart Veronique
- Vohl Marie-Claude
- Voight Benjamin F
- Volcik Kelly A
- Vollenweider Peter
- Vonk Judith M
- Voorhuis Marlies
- Völker Uwe
- Völzke Henry
- Wadén Johan
- Waeber Gerard
- Waeber Gérard
- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
- Wain Louise V
- Wainwright Nicholas
- Waite Lindsay L
- Walker Mark
- Wallace Leanne
- Wallaschofski Henri
- Wallentin Lars
- Wang Hansong
- Wang Jie Jin
- Wang Thomas J
- Wang Xiaoling
- Wareham Nicholas
- Wareham Nick J
- Warrington Nicole M
- Watanabe Richard M
- Waterworth Dawn
- Watkins Hugh
- Weder Alan B
- Weedon Michael N
- Welch Ryan P
- Wells George A
- Wennauer Roman
- Westra Harm-Jan
- Wheeler Eleanor
- Wheeler Heather E
- Whincup Peter H
- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
- Wild Philipp S
- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease
- Author
- Aad van der Lugt
- Aaron Isaacs
- Aaron Isaacs
- Aaron R. Folsom
- Abbas Dehghan
- Abbas Dehghan
- Abbas Dehghan
- Adebowale Adeyemo
- Afshin Parsa
- Afshin Parsa
- Alan B. Weder
- Alan F. Wright
- Alan R. Shuldiner
- Alan R. Shuldiner
- Alanna C. Morrison
- Albert Hofman
- Albert Hofman
- Albert Hofman
- Albert V. Smith
- Albert V. Smith
- Albert W. Dreisbach
- Aldi T. Kraja
- Alena Stančáková
- Alex N. Parker
- Alexander Teumer
- Alison H. Goodall
- Amy J. Swift
- Anders Franco‐Cereceda
- Anders Hamsten
- Anders Hamsten
- Andre G. Uitterlinden
- Andre G. Uitterlinden
- Andre G. Uitterlinden
- Andre Uitterlinden
- Andreas Ziegler
- Andrew A. Hicks
- Andrew D. Johnson
- Andrew D. Johnson
- Andrew D. Johnson
- Andrew Plump
- Andrew Singleton
- Andrew Taylor
- Andrew Wong
- Angela M. Carter
- Angela Silveira
- Angelo Scuteri
- Angelo Scuteri
- Anna F. Dominiczak
- Anna Köttgen
- Anna Maria Corsi
- Anna‐Liisa Hartikainen
- Anne B. Newman
- Anne U. Jackson
- Annette Peters
- Annika Rosengren
- Ann‐Christine Syvänen
- Antti J. Kangas
- Anuj Goel
- Anuj Goel
- Aravinda Chakravarti
- Arne Schillert
- Aroon D. Hingorani
- Asif Rasheed
- Ayo Doumatey
- Ayse Demirkan
- Bamidele Tayo
- Barbara Ludwig
- Barbara McKnight
- Ben A. Oostra
- Ben Oostra
- Bengt Sennblad
- Benjamin F. Voight
- Benjamin F. Voight
- Bernhard O. Boehm
- Bernhard R. Winkelmann
- Bo Hedblad
- Bok‐Ghee Han
- Bolli Thorsson
- Braxton D. Mitchell
- Bruce M. Psaty
- Bruce M. Psaty
- Bruce M. Psaty
- Carl D. Langefeld
- Carl G. P. Platou
- Caroline Hayward
- Caroline Hayward
- Caroline S. Fox
- Charles C. White
- Charles Rotimi
- Charles S. Janipalli
- Chittaranjan S. Yajnik
- Christa Meisinger
- Christa Meisinger
- Christian Gieger
- Christie Ballantyne
- Christopher J. O'Donnell
- Christopher Newton‐Cheh
- Ci Song
- Colin A. McKenzie
- Cornelia M. van Duijn
- Cornelia van Duijn
- Cristian Pattaro
- Cristiano Fava
- Cuno S. P. M. Uiterwaal
- D. G. Vinay
- Dabeeru C. Rao
- Dag S. Thelle
- Dan E. Arking
- Daniel H. O'Leary
- Daniel I. Chasman
- Daniel Levy
- Daniel Shriner
- Danish Saleheen
- Danish Saleheen
- David Altshuler
- David Altshuler
- David Hadley
- David J. Couper
- David M. Herrington
- David P. Strachan
- David S. Siscovick
- David Tregouet
- Debbie A. Lawlor
- Dena Hernandez
- Diana Kuh
- Diana Zelenika
- Diane M. Becker
- Diederick E. Grobbee
- Dorairaj Prabhakaran
- E. Shyong Tai
- Edward G. Lakatta
- Edward G. Lakatta
- Elin Org
- Elisabeth M. C. Schrijvers
- Eran Halperin
- Eric Boerwinkle
- Eric Boerwinkle
- Eric J. G. Sijbrands
- Erkki Vartiainen
- Ervin R. Fox
- Eva Brand
- Eva‐Maria Stoegerer
- Ewa Zukowska‐Szczechowska
- F. Gerald R. Fowkes
- Fadi J. Charchar
- Feng Zhang
- Fernando Rivadeneira
- Fernando Rivadeneira
- Florian Ernst
- Folkert W. Asselbergs
- Frances M. K. Williams
- Francesco U. S. Mattace‐Raso
- Francis S. Collins
- Francois Cambien
- Fredrik Nyberg
- Fulvio Ricceri
- Gabriel P. Krestin
- Gang Shi
- Gavin Lucas
- Geoffrey H. Tofler
- Georg B. Ehret
- Georg Homuth
- George Davey Smith
- Gerardo Heiss
- Gerjan J. Navis
- Gerjan Navis
- Germaine C. Verwoert
- Gianluca Usala
- Gina Hilton
- Giriraj R. Chandak
- Giuseppe Matullo
- Gonçalo R. Abecasis
- Gonçalo R. Abecasis
- Guangju Zhai
- Gudny Eiriksdottir
- Gudrun Veldre
- Günther Silbernagel
- H. Erich Wichmann
- H.‐Erich Wichmann
- Haidong Zhu
- Haiqing Shen
- Halit Ongen
- Hans L. Hillege
- Harold Snieder
- Harry Campbell
- Heather M. Stringham
- Helena Schmidt
- Henry Völzke
- Henry Völzke
- Heyo K. Kroemer
- Hirotsugu Ueshima
- Hugh S. Markus
- Hugh Watkins
- Hugh Watkins
- Hyung‐Lae Kim
- Ian N. M. Day
- Igor Rudan
- Inga Prokopenko
- Ingrid B. Borecki
- Inês Barroso
- Ioanna Tzoulaki
- J. Hunter Young
- Jaakko Tuomilehto
- Jaana Laitinen
- Jackie A. Cooper
- Jacqueline C. M. Witteman
- Jacqueline Witteman
- Jacques S. Beckmann
- James B. Meigs
- James F. Meschia
- James F. Wilson
- James F. Wilson
- James Scott
- Jan A. Staessen
- Jan Lüdemann
- Janos Terzic
- Jason H. Moore
- Jaspal S. Kooner
- Jaspal S. Kooner
- Jeanette Erdmann
- Jeffrey R. O'Connell
- Jeffrey R. O'Connell
- Jemma C. Hopewell
- Jemma C. Hopewell
- Jennifer E. Huffman
- Jennifer L. Bragg‐Gresham
- Jens Baumert
- Jens Baumert
- Jerome I. Rotter
- Jerome I. Rotter
- Jian'an Luan
- Jie Huang
- Jie Yao
- Jing Hua Zhao
- Jingzhong Ding
- Joachim Thiery
- Joanne M. Murabito
- Joban S. Sehmi
- Jochen Seissler
- Johanna Kuusisto
- Johannes Kettunen
- John C. Chambers
- John C. Chambers
- John D. Eicher
- John Danesh
- John Danesh
- John F. Peden
- John F. Peden
- John M. Connell
- John P. Beilby
- John Öhrvik
- Jong‐Young Lee
- Jorma Viikari
- Jorma Viikari
- Josef Coresh
- Joseph F. Polak
- Joseph M. Massaro
- Joshua C. Bis
- Joshua C. Bis
- Joshua C. Bis
- Josyf C. Mychaleckyj
- Juan P. Casas
- Judith A. Hoffman Bolton
- Julie Cunningham
- Jutta Palmen
- Jürgen Grässler
- K. Radha Mani
- Karen L. Mohlke
- Kari North
- Katja E. Petrovic
- Kay‐Tee Khaw
- Kenneth M. Rice
- Kenneth Rice
- Kent Taylor
- Kent Taylor
- Kerri L. Wiggins
- Khanh‐Dung Hoang Nguyen
- Kristian Hveem
- Kurt K. Lohman
- Kurt Lohman
- L. Adrienne Cupples
- Lasse Folkersen
- Laura J. Scott
- Lawrence F. Bielak
- Leena Peltonen
- Leena Peltonen
- Leif Groop
- Lenore J. Launer
- Lenore Launer
- Leo‐Pekka Lyytikäinen
- Leslie J. Raffel
- Lewis C. Becker
- Linda S. Adair
- Lisa R. Yanek
- Lori L. Bonnycastle
- Louise V. Wain
- Luigi Ferrucci
- Lyle J. Palmer
- Lynne E. Wagenknecht
- M. Arfan Ikram
- M. V. Kranthi Kumar
- Maciej Tomaszewski
- Mahir Karakas
- Manuela Uda
- Manuela Uda
- Marco Orru
- Marco Orru
- Marcus Dörr
- Marcus Dörr
- Marcus E. Kleber
- Margus Viigimaa
- Maria Grazia Franzosi
- Maria Sabater‐Lleal
- Maria Soler Artigas
- Mario A. Morken
- Maris Laan
- Mariza de Andrade
- Marjo‐Riitta Järvelin
- Mark J. Caulfield
- Mark Lathrop
- Mark Seielstad
- Marketa Sjögren
- Markku Laakso
- Markus Perola
- Martin D. Tobin
- Martin Farrall
- Martin G. Larson
- Martina Müller‐Nurasyid
- Mary Cushman
- Mary F. Feitosa
- Maryam Kavousi
- Massimo Mangino
- Matthew Denniff
- Matthew N. Cooper
- Matthias Olden
- Matthias Sitzer
- Matthijs Oudkerk
- Meena Kumari
- Megan E. Rudock
- Melissa Garcia
- Michael A. Nalls
- Michael A. Province
- Michael Boehnke
- Michael G. Marmot
- Michael Nalls
- Michiel L. Bots
- Mika Ala‐Korpela
- Mika Kivimaki
- Mika Kähönen
- Mika Kähönen
- Min Jin Go
- Ming‐Huei Chen
- Ming‐Huei Chen
- Mohammad A. Ikram
- Morris J. Brown
- Muhammad Islam
- Muredach P. Reilly
- Muredach P. Reilly
- Murielle Bochud
- Myriam Alexander
- N. Charlotte Onland‐Moret
- Najaf Amin
- Nanette I. Steinle
- Nanette R. Lee
- Naoharu Iwai
- Narisu Narisu
- Nena Matijevic
- Nicholas J. Wareham
- Nicholas L. Smith
- Nicholas L. Smith
- Nicholette D. Palmer
- Nick R. G. Shrine
- Nicole L. Glazer
- Nicole L. Glazer
- Nicole Soranzo
- Nicole Soranzo
- Nilesh J. Samani
- Nish Chaturvedi
- Nora Franceschini
- Norman Klopp
- Norman Klopp
- null null
- null null
- Olle Melander
- Olli Raitakari
- Olli Raitakari
- Ozren Polasek
- Paavo Zitting
- Pankaj Arora
- Pankaj Sharma
- Panos Deloukas
- Paolo Vineis
- Pasi Soininen
- Patricia A. Peyser
- Patricia B. Munroe
- Paul Elliott
- Paul F. O'Reilly
- Paul M. Ridker
- Paul R. Burton
- Per Eriksson
- Per Lundmark
- Peter E. H. Schwarz
- Peter H. Whincup
- Peter J. Grant
- Peter Nilsson
- Peter P. Pramstaller
- Peter S. Braund
- Peter Vollenweider
- Peter Würtz
- Philip A. Wolf
- Philip Howard
- Philipp S. Wild
- Philippa J. Talmud
- Pierre Meneton
- Pierre‐Emmanuel Morange
- Pilar Galan
- Pim van der Harst
- Pim van der Harst
- Qiong Yang
- Qunyuan Zhang
- Rainer Rettig
- Ralph B. D'Agostino
- Ramachandran S. Vasan
- Ravi Kumar Chilukoti
- Rebecca Hardy
- Reinhold Schmidt
- Renate B. Schnabel
- Renate B. Schnabel
- Richard N. Bergman
- Richard S. Cooper
- Richard W. Morris
- Rick Twee‐Hee Ong
- Robert Clarke
- Robert Clarke
- Robert W. Lawrence
- Roberto Elosua
- Roberto Elosua
- Rona J. Strawbridge
- Rory Collins
- Russell P. Tracy
- Ruth J. F. Loos
- Samer Najjar
- Sanjay Kinra
- Santhi K. Ganesh
- Santosh Dahgam
- Saonli Basu
- Sarah H. Wild
- Satoshi Umemura
- Scott M. Williams
- Sekar Kathiresan
- Sekar Kathiresan
- Sekar Kathiresan
- Serena Sanna
- Serge Hercberg
- Serkalem Demissie
- Sharon L. Kardia
- Sharon L. R. Kardia
- Shelly Smith
- Shih‐Jen Hwang
- Shih‐Jen Hwang
- Sigurdur Sigurdsson
- Siim Sõber
- Simon Heath
- Simonetta Guarrera
- Smita R. Kulkarni
- So‐Youn Shin
- Stefan Blankenberg
- Stefan R. Bornstein
- Stefania Bandinelli
- Stefan‐Martin Brand
- Stephan J. L. Bakker
- Stephen Burgess
- Stephen M. Schwartz
- Stephen M. Schwartz
- Steve Bevan
- Steve E. Humphries
- Steven C. Hunt
- Sudha Seshadri
- Sue Shaw‐Hawkins
- Susan R. Heckbert
- Susan R. Heckbert
- Susana Eyheramendy
- Suzette E. Elias‐Smale
- Sven Bergmann
- Takayoshi Ohkubo
- Tamara B. Harris
- Tamara B. Harris
- Tamara B. Harris
- Tanja Zeller
- Taru Tukiainen
- Tatiana Kuznetsova
- Tazeen H. Jafar
- Terho Lehtimäki
- Terho Lehtimäki
- Terrence Forrester
- Tetsuro Miki
- Thomas H. Mosley
- Thomas Illig
- Thomas J. Wang
- Thomas Meitinger
- Thomas Münzel
- Thor Aspelund
- Thor Aspelund
- Tien Y. Wong
- Tim D. Spector
- Timothy D. Howard
- Timothy D. Spector
- Timothy M. Frayling
- Tiphaine Oudot‐Mellakh
- Toby Johnson
- Tom R. Gaunt
- Tomonori Okamura
- Toshiko Tanaka
- Toshio Ogihara
- Tunde Salako
- Udo Hoffmann
- Udo Seedorf
- Ulf B. Gyllensten
- Ulf Schminke
- Uwe Völker
- Valur Emilsson
- Vasyl Pihur
- Veikko Salomaa
- Veikko Salomaa
- Veronique Vitart
- Vijay Nambi
- Vikal Tripathy
- Vilmundur Gudnason
- Vilmundur Gudnason
- Vincent Mooser
- Vinh Truong
- W. T. Longstreth
- Walter Palmas
- Weihong Tang
- Weihua Zhang
- Wen Hong Linda Kao
- Wendy L. McArdle
- Wendy S. Post
- Wiek H. van Gilst
- Wiek H. van Gilst
- Wilmar Igl
- Winfried März
- Wolfgang Koenig
- Wolfgang Koenig
- Wolfgang Rathmann
- Xia Li
- Xiaofeng Zhu
- Xiaoling Wang
- Xiuqing Guo
- Xueling Sim
- Yali Li
- Yan V. Sun
- Yan V. Sun
- Yanbin Dong
- Yasuharu Tabara
- Yen‐Pei C. Chang
- Ying Wu
- Yongmei Liu
- Yongmei Liu
- Yongmei Liu
- Yoon Shin Cho
- Yoshikuni Kita
- Yuri Milaneschi
- Yurii Aulchenko
- Yu‐Ching Cheng
- Yvonne T. van der Schouw
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2017
- Field of study
Background--Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of coronary heart disease (CHD). However, it is unclear whether the association reflects a causal influence of PAI-1 on CHD risk. Methods and Results--To evaluate the association between PAI-1 and CHD, we applied a 3-step strategy. First, we investigated the observational association between PAI-1 and CHD incidence using a systematic review based on a literature search for PAI-1 and CHD studies. Second, we explored the causal association between PAI-1 and CHD using a Mendelian randomization approach using summary statistics from large genome-wide association studies. Finally, we explored the causal effect of PAI-1 on cardiovascular risk factors including metabolic and subclinical atherosclerosis measures. In the systematic meta-analysis, the highest quantile of blood PAI-1 level was associated with higher CHD risk comparing with the lowest quantile (odds ratio=2.17; 95% CI: 1.53, 3.07) in an age- and sex-adjusted model. The effect size was reduced in studies using a multivariable-adjusted model (odds ratio=1.46; 95% CI: 1.13, 1.88). The Mendelian randomization analyses suggested a causal effect of increased PAI-1 level on CHD risk (odds ratio=1.22 per unit increase of log-transformed PAI-1; 95% CI: 1.01, 1.47). In addition, we also detected a causal effect of PAI-1 on elevating blood glucose and high-density lipoprotein cholesterol. Conclusions--Our study indicates a causal effect of elevated PAI-1 level on CHD risk, which may be mediated by glucose dysfunction
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- Bülow Robin
- Bülow Robin
- Bürger Christian
- Bÿchel Christian
- Cabrera Yuliana
- Cahn Wiepke
- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
- Carmichael Owen
- Carr Vaughan J
- Carrillo Maria
- Carroll Maria
- Carson Richard E
- Carter Raina
- Casaceli Cynthia
- Casalin Paola
- Caseras Xavier
- Caspell Chelsea
- Caspers Svenja
- Catafau Ana
- Cavalleri Gianpiero L
- Cedarbaum Jesse
- Cellar Janet S
- Celmins Dzintra
- Cendes Fernando
- Chahine Lama
- Chakravarty Mallar
- Chalker Alison
- Chao Steven
- Chen Kewei
- Chen Qiang
- Chertkow Howard
- Cheung Joshua W
- Chiang Gloria
- Ching Christopher R K
- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde Lucía
- Comery Thomas
- Conrad Gary
- Conrod Patricia
- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
- Consortium EPIGEN
- Consortium IMAGEN
- Consortium SYS
- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crawford Karen
- Creech Mary L
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- Ittermann Bernd
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- van Eijk Liza
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- Völker Uwe
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- Walter Henrik
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- Wang Yunpeng
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- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
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- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
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- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
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- Bonnett Ralph
- Bonnin David
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- Borzym Katja
- Boukhgalter Boris
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- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
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- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
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- Brokstein Peter
- Brook Jonathan
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- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
- Bryant Nathaniel P.
- Brüls Thomas
- Buatsi Delali
- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
- Butler Adam
- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
- Canning Bruno
- Cao Ting
- Cao Yuzhu
- Caoile Chenier
- Cardenas Faviola
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- Chi Cheng
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- De Anda Claudia
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- Garcia Ricardo M, III
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- Gardner Alison
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- Jacob Leni Susan
- Jaeger Sara
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- Jeffery Grant
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- Jia Jia
- Jia Jia
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- Jin Jian
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- Jones Steven
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- Keenan Stephen
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- Kershaw Joanna
- Kettleborough Ross
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- Khurama Divya
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- Marquis-Homeyer Catherine
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- Mauceli Evan
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- McMurray Des
- McMurray Kimberly
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- McNinch Jenny
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- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images
- Author
- Adam Fleisher
- Adam Fleisher
- Adam Schwartz
- Adrian Preda
- Adrian Preda
- Adrian Preda
- Alan Lerner
- Alexander Norbash
- Alice D. Brown
- Allan I. Levey
- Allyson Rosen
- Amanda Smith
- Andrew E. Budson
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew Kertesz
- Andrew Kertesz
- Angela Oliver
- Ann Marie Hake
- Ann Marie Milliken
- Anna Burke
- Ansgar J. Furst
- Antero Sarrael
- Anton P. Porsteinsson
- Anton P. Porsteinsson
- Archana B. Balasubramanian
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Balebail Ashok Raj
- Barton Lane
- Beau Ances
- Becerra Mauricio
- Benita Mudge
- Betty Lind
- Bojana Stefanovic
- Bonnie Goldstein
- Bonnie S. Goldstein
- Borna Bonakdarpour
- Brandy R. Matthews
- Brendan Kelley
- Bret Borowski
- Bret Borowski
- Brian R. Ott
- Brigid Reynolds
- Brigid Reynolds
- Bruce L. Miller
- Bryan M. Spann
- Carl Sadowsky
- Carl Sadowsky
- Chad Ward
- Charles Bernick
- Charles D. Smith
- Charles DeCArli
- Charles DeCarli
- Chet Mathis
- Chiadi Onyike
- Chris Hosein
- Christine M. Belden
- Christopher H. van Dyck
- Christopher M. Clark
- Chuang-Kuo Wu
- Chunren Lai
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Colleen S. Albers
- Congling Wu
- Connie Brand
- Crawford Karen
- Curtis Caldwell
- Curtis Tatsuoka
- Cynthia M. Carlsson
- Dana Mathews
- Dana Nguyen
- Dana Nguyen
- Dana Nguyen
- Daniel D'Agostino
- Daniel H.S. Silverman
- Daniel Marson
- Daniel Varon
- Danielle Harvey
- Danielle Harvey
- Danielle Harvey
- David A. Wolk
- David Bachman
- David Clark
- David Geldmacher
- David Holtzman
- David Jones
- David Knopman
- David Perry
- David Perry
- Davis Melissa
- Debra Fleischman
- Devon Gessert
- Diana Kerwin
- Dick Drost
- Dick Trost
- Dino Massoglia
- Donna M. Simpson
- Donna Munic
- Douglas W. Scharre
- Dzintra Celmins
- Earl A. Zimmerman
- Edward Coleman
- Effie Mitsis
- Elaine R. Peskind
- Elizabeth Finger
- Elizabeth Finger
- Elizabeth Oates
- Ellen Woo
- Emily Rogalski
- Eric C. Petrie
- Eric M. Reiman
- Eric M. Reiman
- Erik Roberson
- Erin Franklin
- Erin Franklin
- Erin Householder
- Evan Fletcher
- Finley Shannon
- Francine Parfitt
- Franklin Watkins
- Franz Hefti
- Friedl Karl
- Gad Marshall
- Gad Marshall
- Gaikwad Mrunalini
- Gail Li
- Gary Conrad
- Geoffrey Tremont
- George Bartzokis
- Gessert Devon
- Ging-Yuek Robin Hsiung
- Gloria Chiang
- Gloria Chiang
- Godfrey D. Pearlson
- Gordineer Leslie
- Greg Jicha
- Greg Sorensen
- Guiyin Cen
- Gus Jiminez
- Gus Jiminez
- Hayes Jacqueline
- Helen Vanderswag
- Helen Vanderswag
- Hillel Grossman
- Horacio Capote
- Howard Bergman
- Howard Chertkow
- Howard Feldman
- Howard Fillit
- Howard J. Rosen
- Howard Rosen
- Hristina Koleva
- Hyungsub Shim
- Irina Rachinsky
- Irina Rachisky
- Iris Sim
- J. Jay Fruehling
- Jacobo Mintzer
- Jacobo Mintzer
- James Brewer
- James Brewer
- James J. Lah
- Janet S. Cellar
- Jared R. Brosch
- Jared Tinklenberg
- Jason H. Karlawish
- Javier Villanueva-Meyer
- Jeff D. Williamson
- Jeff Gunter
- Jeff Gunter
- Jeffrey Kaye
- Jeffrey M. Burns
- Jeffrey R. Petrella
- Jeffrey R. Petrella
- Jennifer Mason
- Jerome A. Yesavage
- Jerome Yesavage
- Joanne Allard
- Joanne Allard
- Joanne L. Lord
- John Brockington
- John C. Morris
- John C. Morris
- John C. Morris
- John C. Morris
- John Hsiao
- John Morris
- John Olichney
- John Q. Trojanowki
- John Q. Trojanowki
- John Q. Trojanowki
- John Q. Trojanowki
- John Rogers
- Jordan Grafman
- Joseph Quinn
- Joy L. Taylor
- Joy L. Taylor
- Judith L. Heidebrink
- Kantarci Kejal
- Karen Anderson
- Karen Blank
- Karen Crawford
- Karen Ekstam Smith
- Karen L. Bell
- Karen L. Bell
- Kathleen Johnson
- Kathleen Tingus
- Kaycee M. Sink
- Keith A. Johnson
- Keith A. Johnson
- Kejal Kantarci
- Kelley Faber
- Kelley Faber
- Kelly Behan
- Kelly M. Makino
- Kenneth Spicer
- Kewei Chen
- Kewei Chen
- Ki Won Nam
- Kim Martin
- Kim Poki-Walker
- Kimberly S. Martin
- Konstantinos Arfanakis
- Kris Johnson
- Kristin Fargher
- Kristine Lipowski
- Kwangsik Nho
- Kwangsik Nho
- Kyle Womack
- Laura A. Flashman
- Laurel Beckett
- Laurel Beckett
- Lawrence S. Honig
- Lawrence S. Honig
- Lean Thal
- Leon Thal
- Leslie M. Shaw
- Leslie M. Shaw
- Leslie M. Shaw
- Leslie M. Shaw
- Lew Kuller
- Leyla deToledo-Morrell
- Li Shen
- Li Shen
- Liana Apostolova
- Liberty Teodoro
- Lisa Ravdin
- Lisa Ravdin
- Lisa Silbert
- Lisa Taylor-Reinwald
- Lon S. Schneider
- Lon S. Schneider
- Lori A. Daiello
- M. Marcel Mesulam
- M. Saleem Ismail
- Magdalena Korecka
- Magdalena Korecka
- Marc Raichle
- Marc Seltzer
- Marek-Marsel Mesulam
- Maria Carrillo
- Maria Carroll
- Maria Kataki
- Maria T Greig
- Maria T. Greig-Custo
- Marilyn Albert
- Marilyn Albert
- Marissa Natelson Love
- Mark A. Mintun
- Martha G. MacAvoy
- Martin R. Farlow
- Martin Sadowski
- Marwan N. Sabbagh
- Marwan N. Sabbagh
- Mary L. Creech
- Mary L. Hynes
- Mary Quiceno
- MaryAnn Oakley
- Matt Senjem
- Matt Senjem
- Matthew Bernstein
- Matthew Bernstein
- Mauricio Becerra
- Michael Borrie
- Michael Donohue
- Michael Donohue
- Michael Donohue
- Michael Donohue
- Michael Lin
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael Weiner
- Michael Weiner
- Michael Weiner
- Michal Figurski
- Michal Figurski
- Michele Assaly
- Michelle Rainka
- Mimi Dang
- Mohammed O. Sheikh
- Munir Chowdhury
- Nadira Trncic
- Nancy Johnson
- Neil Buckholtz
- Neil Kowall
- Neill R Graff-Radford
- Neu Scott
- Nick Fox
- Nigel J. Cairns
- Nigel J. Cairns
- Norbert Schuff
- Norm Foster
- Norm Foster
- Norman Relkin
- Norman Relkin
- Nunzio Pomara
- Olga Brawman-Mintzer
- Olga James
- Oscar L. Lopez
- Owen Carmichael
- P. Murali Doraiswamy
- P. Murali Doraiswamy
- Parianne Fatica
- Partha Sinha
- Patricia Lynn Johnson
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Malloy
- Paul Thompson
- Paula Ogrocki
- Pauline Maillard
- Peter Davies
- Peter Hardy
- Peter J. Snyder
- Peter Snyder
- Pierre Tariot
- Po H. Lu
- Pradeep Garg
- Pradeep Varma
- Prashanthi Vemuri
- Rachelle S. Doody
- Raina Carter
- Raj C. Shah
- Raj C. Shah
- Randall Griffith
- Ranjan Duara
- Ranjan Duara
- Raymond Scott Turner
- Raymond Scott Turner
- Raymundo Hernando
- Reisa A. Sperling
- Reisa A. Sperling
- Richard E. Carson
- Richard Frank
- Rob Bartha
- Robert A. Koeppe
- Robert A. Koeppe
- Robert B. Santulli
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Ronald G. Thomas
- Ronald G. Thomas
- Ronald Killiany
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Rosemary Morrison
- Russell H. Swerdlow
- Saba Wolday
- Saba Wolday
- Salvador Borges-Neto
- Sandra A. Jacobson
- Sandra A. Jacobson
- Sandra Black
- Sandra Harding
- Sandra Weintraub
- Sanjay Asthana
- Sara Dolen
- Sara S. Mason
- Sarah Walter
- Scott Herring
- Scott Neu
- Shengwen Guo
- Sherye A. Sirrel
- Sherye A. Sirrel
- Smita Kittur
- Sonia Pawluczyk
- Sonia Pawluczyk
- Stacy Schneider
- Stephanie Kielb
- Stephanie Reeder
- Stephen Correia
- Stephen Pasternack
- Stephen Pasternak
- Stephen Salloway
- Sterling C. Johnson
- Sterling Johnson
- Steven Chao
- Steven E. Arnold
- Steven G. Potkin
- Steven G. Potkin
- Steven G. Potkin
- Steven Paul
- Steven Paul
- Steven Potkin
- Steven Potkin
- Sungeun Kim
- Sungeun Kim
- Susan K. Schultz
- Susan Landau
- Susan Landau
- Susan Landau
- Susan Rountree
- T-Y Lee
- Tamie Sather
- Tamie Sather
- Tatiana M. Foroud
- Tatiana M. Foroud
- Terence Z. Wong
- Teresa Villena
- Teresa Villena
- The Alzheimer's Disease Neuroimaging Initiative
- Thomas Neylan
- Thomas Neylan
- Thomas O. Obisesan
- Thomas O. Obisesan
- Tom Montine
- Tom Montine
- Ulysse Anaztasia
- Valory Pavlik
- Vernice Bates
- Vesna Sossi
- Victoria Shibley
- Virginia Lee
- Virginia Lee
- Walter Martinez
- Ward Chad
- Warren Barker
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William M. Brooks
- William Potter
- William Potter
- Yaakov Stern
- Yaakov Stern
- Zaven Khachaturian
- Zaven Khachaturian
- Zaven Khachaturian
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/05/2017
- Field of study
Neuroimaging measurements derived from magnetic resonance imaging provide important information required for detecting changes related to the progression of mild cognitive impairment (MCI). Cortical features and changes play a crucial role in revealing unique anatomical patterns of brain regions, and further differentiate MCI patients from normal states. Four cortical features, namely, gray matter volume, cortical thickness, surface area, and mean curvature, were explored for discriminative analysis among three groups including the stable MCI (sMCI), the converted MCI (cMCI), and the normal control (NC) groups. In this study, 158 subjects (72 NC, 46 sMCI, and 40 cMCI) were selected from the Alzheimer's Disease Neuroimaging Initiative. A sparse-constrained regression model based on the l2-1-norm was introduced to reduce the feature dimensionality and retrieve essential features for the discrimination of the three groups by using a support vector machine (SVM). An optimized strategy of feature addition based on the weight of each feature was adopted for the SVM classifier in order to achieve the best classification performance. The baseline cortical features combined with the longitudinal measurements for 2 years of follow-up data yielded prominent classification results. In particular, the cortical thickness produced a classification with 98.84% accuracy, 97.5% sensitivity, and 100% specificity for the sMCI–cMCI comparison; 92.37% accuracy, 84.78% sensitivity, and 97.22% specificity for the cMCI–NC comparison; and 93.75% accuracy, 92.5% sensitivity, and 94.44% specificity for the sMCI–NC comparison. The best performances obtained by the SVM classifier using the essential features were 5–40% more than those using all of the retained features. The feasibility of the cortical features for the recognition of anatomical patterns was certified; thus, the proposed method has the potential to improve the clinical diagnosis of sub-types of MCI and predict the risk of its conversion to Alzheimer's disease
Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients
- Author
- Adam Fleisher
- Adam Fleisher
- Adam Schwartz
- Adrian Preda
- Adrian Preda
- Adrian Preda
- Alan Lerner
- Alexander Norbash
- Alice D. Brown
- Allan I. Levey
- Allyson Rosen
- Alzheimer's Disease Neuroimaging Initiative
- Amanda Smith
- Andrew E. Budson
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew Kertesz
- Andrew Kertesz
- Angela Oliver
- Ann Marie Hake
- Ann Marie Milliken
- Anna Burke
- Ansgar J. Furst
- Antero Sarrael
- Anton P. Porsteinsson
- Anton P. Porsteinsson
- Archana B. Balasubramanian
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Balebail Ashok Raj
- Barton Lane
- Beau Ances
- Becerra Mauricio
- Benita Mudge
- Betty Lind
- Bojana Stefanovic
- Bonnie Goldstein
- Bonnie S. Goldstein
- Borna Bonakdarpour
- Brandy R. Matthews
- Brendan Kelley
- Bret Borowski
- Bret Borowski
- Bret Borowski
- Brian R. Ott
- Brigid Reynolds
- Brigid Reynolds
- Bruce L. Miller
- Bryan M. Spann
- Carl Sadowsky
- Carl Sadowsky
- Chad Ward
- Chad Ward
- Charles Bernick
- Charles D. Smith
- Charles DeCArli
- Charles DeCarli
- Charles DeCarli
- Chet Mathis
- Chiadi Onyike
- Chris Hosein
- Christine M. Belden
- Christopher H. van Dyck
- Christopher M. Clark
- Chuang-Kuo Wu
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Colleen S. Albers
- Connie Brand
- Craig Nelson
- Craig Nelson
- Crawford Karen
- Curtis Caldwell
- Curtis Tatsuoka
- Cynthia M. Carlsson
- Dana Mathews
- Dana Nguyen
- Dana Nguyen
- Dana Nguyen
- Daniel Catalinotto
- Daniel D'Agostino
- Daniel H.S. Silverman
- Daniel Marson
- Daniel Varon
- Danielle Harvey
- Danielle Harvey
- Danielle Harvey
- Dariella Fernandez
- David A. Wolk
- David Bachman
- David Bickford
- David Bickford
- David Clark
- David Geldmacher
- David Holtzman
- David Jones
- David Knopman
- David Perry
- David Perry
- Davis Melissa
- Debra Fleischman
- Denise Reyes
- Devon Gessert
- Devon Gessert
- Diana Kerwin
- Dick Drost
- Dick Trost
- Dino Massoglia
- Donna M. Simpson
- Donna M. Simpson
- Donna Munic
- Douglas W. Scharre
- Dzintra Celmins
- Earl A. Zimmerman
- Edward Coleman
- Effie Mitsis
- Elaine R. Peskind
- Elise Ong
- Elizabeth Finger
- Elizabeth Finger
- Elizabeth Oates
- Elizabeth Shaffer
- Ellen Woo
- Emily Rogalski
- Eric C. Petrie
- Eric M. Reiman
- Eric M. Reiman
- Erik Roberson
- Erin Drake
- Erin Franklin
- Erin Franklin
- Erin Householder
- Evan Fletcher
- Finley Shannon
- Francine Parfitt
- Franklin Watkins
- Franz Hefti
- Friedl Karl
- Gad Marshall
- Gad Marshall
- Gaikwad Mrunalini
- Gail Li
- Gary Conrad
- Geoffrey Tremont
- George Bartzokis
- Gessert Devon
- Ging-Yuek Robin Hsiung
- Gloria Chiang
- Gloria Chiang
- Godfrey D. Pearlson
- Gordineer Leslie
- Greg Jicha
- Greg Sorensen
- Gus Jiminez
- Gus Jiminez
- Gustavo Jimenez
- Hayes Jacqueline
- Helen Vanderswag
- Helen Vanderswag
- Hillel Grossman
- Horacio Capote
- Howard Bergman
- Howard Chertkow
- Howard Feldman
- Howard Fillit
- Howard J. Rosen
- Howard Rosen
- Howard Rosen
- Hristina Koleva
- Hyungsub Shim
- Irina Rachinsky
- Irina Rachisky
- Iris Sim
- J. Jay Fruehling
- Jacobo Mintzer
- Jacobo Mintzer
- James Brewer
- James Brewer
- James J. Lah
- Janet S. Cellar
- Jared R. Brosch
- Jared Tinklenberg
- Jason H. Karlawish
- Javier Villanueva-Meyer
- Jeff D. Williamson
- Jeff Gunter
- Jeff Gunter
- Jeff Gunter
- Jeffrey Kaye
- Jeffrey M. Burns
- Jeffrey R. Petrella
- Jeffrey R. Petrella
- Jennifer Mason
- Jennifer Salazar
- Jerome A. Yesavage
- Jerome Yesavage
- Joanne Allard
- Joanne Allard
- Joanne L. Lord
- John Brockington
- John C. Morris
- John C. Morris
- John C. Morris
- John C. Morris
- John Hsiao
- John Morris
- John Olichney
- John Q. Trojanowki
- John Q. Trojanowki
- John Q. Trojanowki
- John Q. Trojanowki
- John Rogers
- Jordan Grafman
- Joseph Quinn
- Joy L. Taylor
- Joy L. Taylor
- Judith L. Heidebrink
- Kantarci Kejal
- Karen Anderson
- Karen Blank
- Karen Crawford
- Karen Crawford
- Karen Ekstam Smith
- Karen L. Bell
- Karen L. Bell
- Kathleen Johnson
- Kathleen Tingus
- Kaycee M. Sink
- Keith A. Johnson
- Keith A. Johnson
- Kejal Kantarci
- Kejal Kantarci
- Kelley Faber
- Kelley Faber
- Kelley M. Faber
- Kelly Behan
- Kelly Harless
- Kelly M. Makino
- Kelly N. Nudelman
- Kelly Scherer
- Kenneth Spicer
- Kewei Chen
- Kewei Chen
- Ki Won Nam
- Kim Martin
- Kim Poki-Walker
- Kimberly S. Martin
- Konstantinos Arfanakis
- Kris Johnson
- Kristin Fargher
- Kristine Lipowski
- Kwangsik Nho
- Kwangsik Nho
- Kwangsik Nho
- Kyle Womack
- Laura A. Flashman
- Laurel Beckett
- Laurel Beckett
- Lawrence S. Honig
- Lawrence S. Honig
- Lean Thal
- Leon Thal
- Leslie M. Shaw
- Leslie M. Shaw
- Leslie M. Shaw
- Leslie M. Shaw
- Lew Kuller
- Leyla deToledo-Morrell
- Li Shen
- Li Shen
- Liana Apostolova
- Liberty Teodoro
- Lindsey Hergesheimer
- Lingxia Ha
- Lingxia Ha
- Lisa Ravdin
- Lisa Ravdin
- Lisa Ravdin
- Lisa Silbert
- Lisa Taylor-Reinwald
- Lon S. Schneider
- Lon S. Schneider
- Lori A. Daiello
- M. Marcel Mesulam
- M. Saleem Ismail
- Magdalena Korecka
- Magdalena Korecka
- Marc Raichle
- Marc Seltzer
- Marek-Marsel Mesulam
- Maria Carrillo
- Maria Carroll
- Maria Kataki
- Maria T Greig
- Maria T. Greig-Custo
- Marilyn Albert
- Marilyn Albert
- Marissa Natelson Love
- Mark A. Mintun
- Martha G. MacAvoy
- Martin R. Farlow
- Martin Sadowski
- Marwan N. Sabbagh
- Marwan N. Sabbagh
- Mary L. Creech
- Mary L. Hynes
- Mary Quiceno
- MaryAnn Oakley
- MaryAnn Oakley
- Matt Senjem
- Matt Senjem
- Matt Senjem
- Matthew Bernstein
- Matthew Bernstein
- Matthew Bernstein
- Mauricio Becerra
- Meryl Butters
- Meryl Butters
- Michael Borrie
- Michael Donohue
- Michael Donohue
- Michael Donohue
- Michael Donohue
- Michael Lin
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael Weiner
- Michael Weiner
- Michael Weiner
- Michael Weiner
- Michael Weiner
- Michal Figurski
- Michal Figurski
- Michele Assaly
- Michelle Rainka
- Michelle Zmuda
- Michelle Zmuda
- Mike Donohue
- Mimi Dang
- Min Liu
- Min Liu
- Mohammed O. Sheikh
- Munir Chowdhury
- Nadira Trncic
- Nancy Johnson
- Neil Buckholtz
- Neil Kowall
- Neill R Graff-Radford
- Neu Scott
- Nick Fox
- Nigel J. Cairns
- Nigel J. Cairns
- Norbert Schuff
- Norm Foster
- Norm Foster
- Norman Relkin
- Norman Relkin
- Nunzio Pomara
- Olga Brawman-Mintzer
- Olga James
- Oscar L. Lopez
- Oscar L. Lopez
- Owen Carmichael
- P. Murali Doraiswamy
- P. Murali Doraiswamy
- Parianne Fatica
- Partha Sinha
- Patricia Lynn Johnson
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Malloy
- Paul Thompson
- Paula Ogrocki
- Pauline Maillard
- Peter Davies
- Peter Hardy
- Peter J. Snyder
- Peter Snyder
- Pierre Tariot
- Po H. Lu
- Pradeep Garg
- Pradeep Varma
- Prashanthi Vemuri
- Qian Zhao
- Qian Zhao
- Rachelle S. Doody
- Raina Carter
- Raj C. Shah
- Raj C. Shah
- Randall Griffith
- Ranjan Duara
- Ranjan Duara
- Raymond Scott Turner
- Raymond Scott Turner
- Raymundo Hernando
- Reisa A. Sperling
- Reisa A. Sperling
- Rema Raman
- Rema Raman
- Rema Raman
- Richard E. Carson
- Richard Frank
- Rob Bartha
- Robert A. Koeppe
- Robert A. Koeppe
- Robert A. Koeppe
- Robert A. Koeppe
- Robert B. Santulli
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Ronald G. Thomas
- Ronald G. Thomas
- Ronald Killiany
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Rosemary Morrison
- Russell H. Swerdlow
- Saba Wolday
- Saba Wolday
- Salvador Borges-Neto
- Samuel Stark
- Sandra A. Jacobson
- Sandra A. Jacobson
- Sandra Black
- Sandra Harding
- Sandra Weintraub
- Sanjay Asthana
- Sara Dolen
- Sara S. Mason
- Sarah Walter
- Sarah Walter
- Scott Herring
- Scott Mackin
- Scott Mackin
- Scott Mackin
- Scott Mackin
- Scott Neu
- Scott Neu
- Sherye A. Sirrel
- Sherye A. Sirrel
- Smita Kittur
- Sonia Pawluczyk
- Sonia Pawluczyk
- Stacy Schneider
- Stephanie Kielb
- Stephanie Reeder
- Stephen Correia
- Stephen Pasternack
- Stephen Pasternak
- Stephen Salloway
- Sterling C. Johnson
- Sterling Johnson
- Steven Chao
- Steven E. Arnold
- Steven G. Potkin
- Steven G. Potkin
- Steven G. Potkin
- Steven Paul
- Steven Paul
- Steven Potkin
- Steven Potkin
- Sungeun Kim
- Sungeun Kim
- Susan K. Schultz
- Susan Landau
- Susan Landau
- Susan Landau
- Susan Landau
- Susan Landau
- Susan Rountree
- T-Y Lee
- Tamie Sather
- Tamie Sather
- Tatiana M. Foroud
- Tatiana M. Foroud
- Tatiana M. Foroud
- Terence Z. Wong
- Teresa Villena
- Teresa Villena
- Thomas Neylan
- Thomas Neylan
- Thomas O. Obisesan
- Thomas O. Obisesan
- Tom Montine
- Tom Montine
- Ulysse Anaztasia
- Valory Pavlik
- Vernice Bates
- Vesna Sossi
- Victoria Shibley
- Virginia Lee
- Virginia Lee
- Walter Martinez
- Ward Chad
- Warren Barker
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William M. Brooks
- William Potter
- William Potter
- Yaakov Stern
- Yaakov Stern
- Yiu Ho Au
- Yuliana Cabrera
- Yun Zhou
- Yun Zhou
- Zaven Khachaturian
- Zaven Khachaturian
- Zaven Khachaturian
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/05/2019
- Field of study
Recent developments of tau Positron Emission Tomography (PET) allows assessment of regional neurofibrillary tangles (NFTs) deposition in human brain. Among the tau PET molecular probes, 18F-AV1451 is characterized by high selectivity for pathologic tau aggregates over amyloid plaques, limited non-specific binding in white and gray matter, and confined off-target binding. The objectives of the study are (1) to quantitatively characterize regional brain tau deposition measured by 18F-AV1451 PET in cognitively normal older adults (CN), mild cognitive impairment (MCI), and AD participants; (2) to evaluate the correlations between cerebrospinal fluid (CSF) biomarkers or Mini-Mental State Examination (MMSE) and 18F-AV1451 PET standardized uptake value ratio (SUVR); and (3) to evaluate the partial volume effects on 18F-AV1451 brain uptake.Methods: The study included total 115 participants (CN = 49, MCI = 58, and AD = 8) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Preprocessed 18F-AV1451 PET images, structural MRIs, and demographic and clinical assessments were downloaded from the ADNI database. A reblurred Van Cittertiteration method was used for voxelwise partial volume correction (PVC) on PET images. Structural MRIs were used for PET spatial normalization and region of interest (ROI) definition in standard space. The parametric images of 18F-AV1451 SUVR relative to cerebellum were calculated. The ROI SUVR measurements from PVC and non-PVC SUVR images were compared. The correlation between ROI 18F-AV1451 SUVR and the measurements of MMSE, CSF total tau (t-tau), and phosphorylated tau (p-tau) were also assessed.Results:18F-AV1451 prominently specific binding was found in the amygdala, entorhinal cortex, parahippocampus, fusiform, posterior cingulate, temporal, parietal, and frontal brain regions. Most regional SUVRs showed significantly higher uptake of 18F-AV1451 in AD than MCI and CN participants. SUVRs of small regions like amygdala, entorhinal cortex and parahippocampus were statistically improved by PVC in all groups (p < 0.01). Although there was an increasing tendency of 18F-AV-1451 SUVRs in MCI group compared with CN group, no significant difference of 18F-AV1451 deposition was found between CN and MCI brains with or without PVC (p > 0.05). Declined MMSE score was observed with increasing 18F-AV1451 binding in amygdala, entorhinal cortex, parahippocampus, and fusiform. CSF p-tau was positively correlated with 18F-AV1451 deposition. PVC improved the results of 18F-AV-1451 tau deposition and correlation studies in small brain regions.Conclusion: The typical deposition of 18F-AV1451 tau PET imaging in AD brain was found in amygdala, entorhinal cortex, fusiform and parahippocampus, and these regions were strongly associated with cognitive impairment and CSF biomarkers. Although more deposition was observed in MCI group, the 18F-AV-1451 PET imaging could not differentiate the MCI patients from CN population. More tau deposition related to decreased MMSE score and increased level of CSF p-tau, especially in ROIs of amygdala, entorhinal cortex and parahippocampus. PVC did improve the results of tau deposition and correlation studies in small brain regions and suggest to be routinely used in 18F-AV1451 tau PET quantification
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise Børresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
- Arif O Harmanci
- Arindam Maitra
- Armando Lopez-Guillermo
- Arndt Borkhardt
- Arnoud Boot
- Asger Hobolth
- Ashley Williams
- Ashton A Connor
- Atul J Butte
- Aurélien Chateigner
- Austin J Hepperla
- Axel Aretz
- Aya Sasaki-Oku
- Ayellet V Segre
- B F Francis Ouellette
- Bailey Matthew H
- Barbara Hutter
- Barbara Hutter
- Barbara Kremeyer
- Bartha M Knoppers
- Beifang Niu
- Beifang Niu
- Beifang Niu
- Benedikt Brors
- Benita Kiat Tee Tan
- Benjamin J Raphael
- Benjamin P Berman
- Benjamin Raeder
- Bernardo Rodriguez-Martin
- Bernhard Radlwimmer
- Bernice H Wong
- Beth Karlan
- Bin Tean Teh
- Bin Zhu
- Birgit Burkhardt
- Bishoy M Faltas
- Bodil Bjerkehagen
- Bogdan Czerniak
- Boris Winterhoff
- Borislav C Rusev
- Bradly G Wouters
- Brandi N Davis-Dusenbery
- Brian Craft
- Brian D O'Connor
- Brian Patrick O'Neill
- Brice Aminou
- Calvin Wing Yiu Chan
- Cameron M Soulette
- Carl Herrmann
- Carl Morrison
- Carlo Gambacorti-Passerini
- Carlos Caldas
- Carlos D Bustamante
- Carlos López-Otín
- Carlota Rubio-Perez
- Carmen Gomez
- Carolien H M van Deurzen
- Carolyn M Hutter
- Carolyn M Hutter
- Carrie Cibulskis
- Caterina Vicentini
- Catherine A Shang
- Catherine D Moser
- Catherine J Kennedy
- Catrina C Fronick
- Chad J Creighton
- Chandra Sekhar Pedamallu
- Chang Li
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- Charles Saller
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- Charlie E Massie
- Chawalit Pairojkul
- Chen Hong
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- Cheng-Zhong Zhang
- Chin-Lee Wu
- Chip Stewart
- Chip Stewart
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- Cindy Bell
- Cinzia Cantù
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- Kui Wu
- Kunihito Gotoh
- Kwun M Fong
- Kyle Covington
- Kyle Covington
- Kyle Ellrott
- Kyle Ellrott
- Kyle Ellrott
- L Van't Veer
- Lara Jerman
- Lara Urban
- Lars Feuerbach
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- Laurence B Lovat
- Laurent Arnould
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- Layla Oesper
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- Lei Song
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- Leng Han
- Leonidas Salichos
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- Levi Garraway
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- Li Ding
- Li Ding
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- Li Shantao
- Liang Wen-Wei
- Liangtao Zheng
- Lieven P C Verbeke
- Lihua Zou
- Liis Uusküla-Reimand
- Liliana Greger
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- Lina Sieverling
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- Linda Mileshkin
- Linghua Wang
- LiRehan Akbani
- Lisa Lype
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- Liu Xi
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- Nagarajan Paramasivam
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- Nasra H Giama
- Natalie Jäger
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- Neesha C Dhani
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- Nicola Sperandio
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- Vincenzo Corbo
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- W Kimryn Rathmell
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- Wan Choi
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- Wheeler David A
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- Xingmin Liu
- Xinyue Li
- Xiuqing Zhang
- Xiuqing Zheng
- Xose S Puente
- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
- Yan Zhang
- Yang Wu
- Yang Yang
- Yann Joly
- Yanxun Xu
- Yao He
- Yasin Senbabaoglu
- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
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