85 research outputs found
Numerical Simulation of Asymmetrically Altered Growth as Initiation Mechanism of Scoliosis
- Author
- A. A. White
- A. A. White III
- A. B. Schultz
- A. G. Veldhuizen
- A. G. Veldhuizen
- A. L. Nachemson
- A. Langenskiöld
- A. van der Plaats
- C. Gross
- E. W. Somerville
- F. G. Evans
- G. C. Robin
- G. J. Verkerke
- H. Tkaczuk
- I. A. F. Stokes
- I. A. Stokes
- J. A. Sevastikoglou
- J. Cheung
- J. L. Beguiristain
- K. A. Poelstra
- K. L. Markolf
- K. Subbaraj
- M. A. Alexander
- M. Goto
- M. M. Panjabi
- N. H. Miller
- P. A. Millner
- P. V. Scoles
- R. A. Dickson
- R. A. Dickson
- R. Herman
- R. M. Smith
- S. B. Roberts
- T. Andriacchi
- T. G. Lowe
- T. Pitzen
- V. K. Goel
- Publication venue
- Kluwer Academic Publishers-Plenum Publishers
- Publication date
- 01/01/2007
- Field of study
The causes of idiopathic scoliosis are still uncertain; buckling is mentioned often, but never proven. The authors hypothesize another option: unilateral postponement of growth of MM Rotatores or of ligamentum flavum and intertransverse ligament. In this paper, both buckling and the two new theories of scoliotic initiation are studied using a new finite element model that simulates the mechanical behavior of the human spine. This model was validated by the stiffness data of Panjabi et al. (J. Biomech. 9:185â192, 1976). After a small correction of the prestrain of some ligaments and the MM Rotatores the model appeared to be valid. The postponement in growth was translated in the numerical model in an asymmetrical stiffness. The spine was loaded axially and the resulting deformation was analyzed for the presence of the coupling of lateral deviation and axial rotation that is characteristic for scoliosis. Only unilateral postponement of growth of ligamentum flavum and intertransverse ligament appeared to initiate scoliosis. Buckling did not initiate scoliosis
The Caenorhabditis elegans HEN1 Ortholog, HENN-1, Methylates and Stabilizes Select Subclasses of Germline Small RNAs
- Author
- A Boland
- A Girard
- A Lingel
- A Pelisson
- Allison C. Billi
- Amelia F. Alessi
- B Shen
- B Wightman
- B Yu
- BJ Reinhart
- C Chen
- C Chen
- C Frokjaer-Jensen
- C Notredame
- C Zhang
- CC Conine
- DN Cox
- E Yigit
- F Ibrahim
- G Vilkaitis
- G Wang
- GS Pall
- H Tabara
- HA Hundley
- HM Kurth
- J Brennecke
- J Li
- J Liu
- J Nejepinska
- J Pak
- JB Ma
- JC van Wolfswinkel
- JG Ruby
- JI Gent
- JJ Song
- JJ Vasale
- John K. Kim
- K Forstemann
- K Okamura
- K Saito
- KL Tkaczuk
- L Cerutti
- LM Kamminga
- LM Kamminga
- LR Girard
- M Goujon
- MA Allen
- MA Larkin
- Mallory Freeberg
- MD Horwich
- NC Lau
- O Poirot
- PJ Batista
- PP Das
- RC Lee
- RC Lee
- RS Kamath
- S Crittenden
- S Houwing
- S Kawaoka
- Shohei Mitani
- SL Ameres
- SL Ameres
- Stuart K. Kim
- SW L'Hernault
- T Han
- T Nolan
- T Ohara
- T Sijen
- TA Montgomery
- TF Duchaine
- Ting Han
- V Ambros
- V Reinke
- Vishal Khivansara
- VV Vagin
- W Gu
- W Park
- W Yang
- Y Huang
- Y Kawahara
- Y Kawahara
- Y Kawahara
- Y Kawamura
- Y Kirino
- Y Kirino
- Y Tian
- Y-K Kim
- Z Yang
- Z Yang
- Publication venue
- Public Library of Science
- Publication date
- 19/04/2012
- Field of study
Small RNAs regulate diverse biological processes by directing effector proteins called Argonautes to silence complementary mRNAs. Maturation of some classes of small RNAs involves terminal 2âČ-O-methylation to prevent degradation. This modification is catalyzed by members of the conserved HEN1 RNA methyltransferase family. In animals, Piwi-interacting RNAs (piRNAs) and some endogenous and exogenous small interfering RNAs (siRNAs) are methylated, whereas microRNAs are not. However, the mechanisms that determine animal HEN1 substrate specificity have yet to be fully resolved. In Caenorhabditis elegans, a HEN1 ortholog has not been studied, but there is evidence for methylation of piRNAs and some endogenous siRNAs. Here, we report that the worm HEN1 ortholog, HENN-1 (HEN of Nematode), is required for methylation of C. elegans small RNAs. Our results indicate that piRNAs are universally methylated by HENN-1. In contrast, 26G RNAs, a class of primary endogenous siRNAs, are methylated in female germline and embryo, but not in male germline. Intriguingly, the methylation pattern of 26G RNAs correlates with the expression of distinct male and female germline Argonautes. Moreover, loss of the female germline Argonaute results in loss of 26G RNA methylation altogether. These findings support a model wherein methylation status of a metazoan small RNA is dictated by the Argonaute to which it binds. Loss of henn-1 results in phenotypes that reflect destabilization of substrate small RNAs: dysregulation of target mRNAs, impaired fertility, and enhanced somatic RNAi. Additionally, the henn-1 mutant shows a weakened response to RNAi knockdown of germline genes, suggesting that HENN-1 may also function in canonical RNAi. Together, our results indicate a broad role for HENN-1 in both endogenous and exogenous gene silencing pathways and provide further insight into the mechanisms of HEN1 substrate discrimination and the diversity within the Argonaute family
Semiquantitative Analysis of Clinical Heat Stress in Clostridium difficile Strain 630 Using a GeLC/MS Workflow with emPAI Quantitation.
- Author
- A Amadasi
- A Antunes
- A Boetzkes
- A Hoffmann
- A Marchler-Bauer
- A Olling
- A Resch
- A Wright
- A Xu
- AG McLennan
- AJ Waligora
- B Liu
- C Janoir
- DA Burns
- DB Weatherly
- DE Voth
- E Deuerling
- EM Brown
- ER Dubberke
- F Schlunzen
- G Akanuma
- G Cagney
- G Kramer
- G Vedantam
- Gayatri Vedantam
- Geoff McMullan
- GP Carter
- H Aoki
- HC Lee
- J Bendtsen
- J Bendtsen
- J Freeman
- J Kim
- J Kim
- J Pepin
- J PĂ©pin
- J Scaria
- JE Emerson
- JG Bartlett
- JL Gardy
- JM Zengel
- JM Zengel
- JT Heap
- JT Heap
- K Li
- K Shinoda
- KL Hockett
- KL Tkaczuk
- L Saujet
- LM Iyer
- M Bradford
- M Chlenov
- M De Angelis
- M He
- M Rupnik
- M Sebaihia
- MH Wilcox
- MS Paget
- NG Ternan
- Nigel G. Ternan
- O Kandror
- OA Soutourina
- P Graumann
- PC Wright
- PD Karp
- PL Ross
- PN Ulrich
- R Kitagawa
- R Olivares-HernĂĄndez
- RA Stabler
- RL Graham
- RLJ Graham
- RLJ Graham
- RLJ Graham
- RLJ Graham
- Robert L. J. Graham
- RP Fagan
- RP Fagan
- RS Ullers
- S Jain
- S Jain
- S Karlsson
- S Pechmann
- S Sirard
- SA Kuehne
- SH Knauer
- Shailesh Jain
- SJ Hersch
- SLJ Stubbs
- SM Twine
- ST Cartman
- T Ali Azam
- T Janvilisri
- T Karjalainen
- TC Dingle
- TD Lawley
- TG Chasteen
- V Bhadauria
- V Forgetta
- X Li
- X Luo
- X Sun
- Y Fu
- Y Ishihama
- Z Weinberg
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2014
- Field of study
<div><p><i>Clostridium difficile</i> is considered to be the most frequent cause of infectious bacterial diarrhoea in hospitals worldwide yet its adaptive ability remains relatively uncharacterised. Here, we used GeLC/MS and the exponentially modified protein abundance index (emPAI) calculation to determine proteomic changes in response to a clinically relevant heat stress. Reproducibility between both biological and technical replicates was good, and a 37°C proteome of 224 proteins was complemented by a 41°C proteome of 202 proteins at a 1% false discovery rate. Overall, 236 <i>C. difficile</i> proteins were identified and functionally categorised, of which 178 were available for comparative purposes. A total of 65 proteins (37%) were modulated by 1.5-fold or more at 41°C compared to 37°C and we noted changes in the majority of proteins associated with amino acid metabolism, including upregulation of the reductive branch of the leucine fermentation pathway. Motility was reduced at 41°C as evidenced by a 2.7 fold decrease in the flagellar filament protein, FliC, and a global increase in proteins associated with detoxification and adaptation to atypical conditions was observed, concomitant with decreases in proteins mediating transcriptional elongation and the initiation of protein synthesis. Trigger factor was down regulated by almost 5-fold. We propose that under heat stress, titration of the GroESL and dnaJK/grpE chaperones by misfolded proteins will, in the absence of trigger factor, prevent nascent chains from emerging efficiently from the ribosome causing translational stalling and also an increase in secretion. The current work has thus allowed development of a heat stress model for the key cellular processes of protein folding and export.</p></div
Predictors of distress in female breast cancer survivors: a systematic review
- Author
- A Mehnert
- AB Kornblith
- AL Stanton
- Ania Syrowatka
- Ari N. Meguerditchian
- Aude Motulsky
- C Burgess
- C Calhoun
- C Pitceathly
- CC Reyes-Gibby
- E Grunfeld
- EE Accortt
- F Ozbay
- F Romito
- F Saboonchi
- F Saboonchi
- FK Ploos van Amstel
- FS Luppino
- G Mammen
- G Morasso
- G Taylor
- G Zhu
- H Badr
- I Henselmans
- J Leung
- J Qiu
- J Wang
- J-M Kim
- James A. Hanley
- JL Wang
- JM Boden
- JR Landis
- K Ashing-Giwa
- KA Donovan
- Kornblith AB Herndon JE, Zuckerman E, Viscoli CM, Horowitz RI, Cooper MR, Harris L, Tkaczuk KH, Perry MC, Budman D, Norton L, Holland JC, Cancer and Leukemia Group B
- L Baider
- M King
- M Vahdaninia
- MA Sprangers
- MG Mens
- MK Lee
- ML Kwan
- Moher D Liberati A, Tetzlaff J, Altman DG, PRISMA Group
- NE Avis
- NK Aaronson
- NK Janz
- NP Suppli
- NP Suppli
- P Brunault
- P Moreno-Peral
- PA Ganz
- R BrÀnström
- R Eversley
- RA Shelby
- Robyn Tamblyn
- S Moylan
- SA Dominick
- SH Kim
- Siyana Kurteva
- U Boehmer
- WA Bardwell
- William G. Dixon
- X Chen
- X Chen
- Y Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
HE-LHC: The High-Energy Large Hadron Collider â Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A.
- Abbrescia M.
- AbdusSalam S. S.
- Abdyukhanov I.
- Abelleira Fernandez J.
- Abramov A.
- Aburaia M.
- Acar A. O.
- Adzic P. R.
- Agrawal P.
- Aguilar-Saavedra J. A.
- Aguilera-Verdugo J. J.
- Ahnen J. von
- Aiba M.
- Aichinger I.
- Aielli G.
- Akay A.
- Akhundov A.
- Aksakal H.
- Albacete J. L.
- Albergo S.
- Alekou A.
- Aleksa M.
- Aleksan R.
- Alemany Fernandez R. M.
- Alexahin Y.
- Alioli S.
- Alipour Tehrani N.
- Allanach B. C.
- Allport P. P.
- Altınlı M.
- Altmannshofer W.
- AlĂa R. G.
- Ambrosio G.
- Amorim D.
- Amstutz O.
- Anderlini L.
- Andreazza A.
- Andreini M.
- Andriatis A.
- Andris C.
- Andronic A.
- Angelucci M.
- Antinori F.
- Antipov S. A.
- Antonelli M.
- Antonello M.
- Antonioli P.
- Antusch S.
- Anulli F.
- ApolinĂĄrio L.
- Apollinari G.
- Apollonio A.
- Appelö D.
- Appleby R. B.
- Apyan A.
- Apyan A.
- Arbey A.
- Arbuzov A.
- Arduini G.
- Arı V.
- Arias S.
- Armesto N.
- Arnaldi R.
- Arsenyev S. A.
- Arzeo M.
- Asai S.
- Aslanides E.
- Astapovych D.
- Atanasov M.
- Atieh S.
- Attié D.
- Auchmann B.
- Audurier A.
- Aull S.
- Aumon S.
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- Banerjee S.
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- Honorato C. G.
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- Hrdinka J.
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- Ăzcan V.
- Ăzdemir K.
- Publication venue
- Springer Verlag
- Publication date
- 09/02/2021
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-ee: The Lepton Collider â Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A.
- Abbrescia M.
- AbdusSalam S. S.
- Abdyukhanov I.
- Abelleira Fernandez J.
- Abramov A.
- Aburaia M.
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- Song H.
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- Tanaka J.
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- Taroni S.
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- Teixeira A. M.
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- Uythoven J.
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- Valassi A.
- Valchkova F.
- Valdivia Garcia M. A.
- Vale Silva L.
- Valente P.
- Valente R. U.
- Valente-Feliciano A. -M.
- Valentino G.
- Valet J. M.
- Valizadeh R.
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- Vicini A.
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- Vitrano A.
- Vivarelli I.
- Vlachos S.
- Vogel M.
- Vogt D. M.
- Volkov P.
- Volpini G.
- von Ahnen J.
- Vorotnikov G.
- Voutsinas G. G.
- Vysotsky V.
- Völkl V.
- Wagner U.
- Wallny R.
- Wang K.
- Wang L. -T.
- Wang R.
- Ward B. F. L.
- Watson N. K.
- Watson T. P.
- Weiland C.
- Weinzierl S.
- Welsch C. P.
- Wenninger J.
- Widorski M.
- Wiedemann U. A.
- Wienands H. -U.
- Wilkinson G.
- Williams P. H.
- Winter A.
- Wohlfahrt A.
- WojtoĆ T.
- Wollmann D.
- Womersley J.
- Woog D.
- Ws Z.
- Wu X.
- Wulzer A.
- Yanehsari M. K.
- Yang G.
- Yang H. J.
- Yao W. -M.
- Yazgan E.
- Yermolchik V.
- Yilmaz A.
- Yilmaz A.
- Yoo H. -D.
- Yost S. A.
- You T.
- Young C.
- Yu F.
- Yu T. -T.
- Zaborowska A.
- Zadeh S. G.
- Zahnd M.
- Zanetti M.
- Zanotto L.
- Zawiejski L.
- Zeiler P.
- Zerlauth M.
- Zernov S. M.
- Zevi Dell Porta G.
- Zhang C.
- Zhang H.
- Zhang Y.
- Zhang Z.
- Zhao Z.
- Zhong Y. -M.
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- Zhuang P.
- Zick G.
- Zimmermann F.
- Zinn-Justin J.
- Zivkovic L.
- Zlobin A. V.
- Zobov M.
- Zupan J.
- Zurita J.
- Ăzcan V.
- Ăzdemir K.
- Publication venue
- Springer Verlag
- Publication date
- 14/11/2019
- Field of study
FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agaliotis EL
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alexahin Y
- Alia RG
- Alioli S
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appelo D
- Appleby RB
- Apyan A
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- Arbey A
- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
- Azzi P
- Azzolini O
- Azzurri P
- Bacchetta N
- Bacchiocchi E
- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
- Barducci D
- Barjhoux P
- Barna D
- Barnafoldi GG
- Barnes MJ
- Barr A
- Bartmann W
- Baryshevsky V
- Barzi E
- Bass SA
- Bastianin A
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- Baumgartner T
- Bautista-Guzman I
- Bayindir C
- Beaudette F
- Bedeschi F
- Beguin M
- Behr JK
- Bellafont I
- Bellagamba L
- Bellegarde N
- Belli E
- Bellingeri E
- Bellini F
- Bellomo G
- Belomestnykh S
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- Benedikt M
- Bermudez SI
- Bernardi G
- Bernardi J
- Bernet C
- Bernhardt JM
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- Bruzual HM
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- Buffat X
- Bulyak E
- Burkart F
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- Burnet J-P
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- Butterworth A
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- Chaikovska I
- Chakrabortty J
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- Chanal D
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- Chance A
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- Chehab R
- Chekanov SV
- Chen N
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- Chevalier AB
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- Childers JT
- Chmielinska A
- Cholakian A
- Chomaz P
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- Crespo Garrido I
- Crivellin A
- Croteau JF
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- Cure B
- Curti J
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- D'Ambrosio G
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- David A
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- de Jong SJ
- De Lucia E
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- De Renstrom PB
- de Rijk G
- De Roeck A
- Deandrea A
- Debono CJ
- Deghaye S
- Del Bo C
- Del Duca V
- Delikaris D
- Deliot F
- Dell Porta GZ
- Dell'Acqua A
- Delle Rose L
- Delmastro M
- Delsolaro WV
- Demarteau M
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- Denisov D
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- Dewanjee RK
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- Di Nezza P
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- Diaz VG
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- Doblhammer A
- Dominjon A
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- Drago A
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- du Pree T
- Duarte L
- Dubovyk I
- Duda P
- Dudarev A
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- Ferdeghini C
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- Fernandez RMA
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- Ferrara G
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- Furuseth SV
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- Gascon-Shotkin SM
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- Gerwig H
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- Haerer B
- Hahn K
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- Hannah A
- Harris PC
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- Honorato CG
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- Ishino M
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- Jenny P
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- Jimenez JM
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- Jowett JM
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- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/06/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with todayâs technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics
FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Ahnen JV
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
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- Alexahin Y
- Alia RG
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- Altmannshofer W
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- Eskola KJ
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- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yildiz HD
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
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- Young C
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- Zaborowska A
- Zadeh SG
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
- Zhou J
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- Zick G
- Zimmermann F
- Zinn-Justin J
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- Zlobin AV
- Zobov M
- Zupan J
- Zurita J
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/06/2019
- Field of study
We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics
HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appeloe D
- Appleby RB
- Apyan A
- Apyan A
- Arbey A
- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
- Azzi P
- Azzolini O
- Azzurri P
- Bacchetta N
- Bacchiocchi E
- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
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- Barjhoux P
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- Barnafoldi GG
- Barnes MJ
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- Bastianin A
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- Bautista-Guzman I
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- Bozbey A
- Bozovic Jelisavic I
- Bozzi C
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- De Lucia E
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- de Vivie de Regie JB
- Deandrea A
- Debono CJ
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- Denisov D
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- Denner A
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- Dev PSB
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- Di Micco B
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- Drasal Z
- Drewes M
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- Duarte L
- Dubovyk I
- Duda P
- Dudarev A
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- Eisenhardt S
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- El Khechen D
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- Englert C
- Eriksson H
- Eskola KJ
- Esposito LS
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- Falkowski A
- Falou A
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- Farinon S
- Faroughy DA
- Fartoukh SD
- Faus-Golfe A
- Fawcett WJ
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- Ferrara G
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- Fiascaris M
- Fiorendi S
- Fiorio C
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- Furuseth SV
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- Yao W-M
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- Yilmaz A
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- Yoo H-D
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- Zadeh SG
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- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
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- Zevi Dell Porta G
- Zhang C
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- Zhong Y-M
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- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/07/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
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- Anulli F
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- Appeloe D
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- Avino F
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- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
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- Beaudette F
- Bedeschi F
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- Bellini F
- Bellomo G
- Belomestnykh S
- Bencivenni G
- Benedikt M
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- Bernet C
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- Bishara F
- Blanco-Garcia OR
- Blanquez FR
- Blekman F
- Blondel A
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- Boland MJ
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- Bonvini M
- Boos E
- Bordini B
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- Boscherini D
- Boscolo M
- Boselli S
- Bosley RR
- Bossu F
- Botta C
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- Buffat X
- Bulyak E
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- Cantore-Cavalli D
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- Ciftci AK
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- Collamati F
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- Collier P
- Collot J
- Contino R
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- Cook CTA
- Cooley L
- Corcella G
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
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